REPRODUCTIVE BIOLOGY Content Female Reproductive system - External genitalia (vulva). - Internal reproductive organs. - Blood supply for the pelvic organs. Reproductive function. - Menstruation. - Cervical mucus changes. Female genital mutilation. Family planning. Reproductive health. Male reproductive system - External genitalia. - Internal reproductive organs. Sexual response cycle. Sexual dysfunction. Key terms: - Climacteric. - Corpus luteum. - Endometrium. - Epididymis. - Gametes. - Menarche. - Mons pubis. - Myometrium. - Ovulation. - Prepuce. - Seminiferous tubules. - Spermatogensis - Vas deferens. - Vestibule. 1 - Vulva. Introduction The obstetric nurse is called upon to counsel prospective parents before and throughout pregnancy and childbirth. To accomplish this task, the nurse must have a working knowledge of reproductive anatomy and physiology and the menstrual cycle. This knowledge guides the nurse in choosing appropriate interventions for the childbearing woman and her family. The main purpose of the male and female reproductive systems is to produce offspring. Male testes produce and female ovaries gametes or sex cells, spermatozoa (sperm) in the male and ova (eggs) in the female. Each gamete contains one half of the genetic material needed to produce a human baby. However, as you will see some of the structures in the reproductive tract serve dual purposes. Most often these alternate functions have to do with urinary elimination because the urinary system is connected closely with reproductive system. You will notice the most structures in the reproductive tract are paired (e.g., testes, ovaries, labia majora, labia minora) and that male and female reproductive systems are complementary; for example, male testes and female ovaries; male scrotum and female labia majora; and male glans penis and female clitoris. It is important to know that the pituitary gland governs reproductive hormone production and function. 2 Female reproductive system OBJECTIVES: General objective: At the end of this lecture the postgraduate student should be able to upgrade a comprehensive knowledge about anatomy and physiology of female genital tract. Specific objective: At the end of this lecture the postgraduate student should be able to: 1. Identify component of external genitalia 2. Identify component of internal genitalia 3. Discuss Blood supply, nerve supply and lymphatic drainage of External genitalia. 4. Identify perineal body and perineal muscles. 5. Discuss Component of internal genital tract. 6. Explain Structure and function of internal genital tract. 7. Discuss Blood supply, nerve supply, lymphatic drainage of internal genital tract. 3 Female Genital Tract: - The external genitalia, or vulva, and internal reproductive organs compose the female reproductive tract - The purposes of the female reproductive tract is to allowfor sexual intimacy and fulfillment and to produce children through the process of conception, pregnancy; and child birth. - Each part of the female reproductive tract contributes in some way to these purposes. - The mammary glands and bony pelvis are also part of female reproductive anatomy. (1) Externa femalel genitalia (Vulva): 4 The term of vulva applies to the external genital organs. It consists of the following structures: Monos pubis. Labia majora. Labia minora. Clitoris. Vestibule. The uretheral orifice & skine's ducts. Vaginal orifice & bartholin’s glands. Perineal body. * Monos Pubis: - It's called "mons veneris" is the fatty pad that lies over the symphysis pubis. It is covered with pubic hair from the time of 5 puberty.it is triangular in shape; the base of the triangle is toward the symphysis pubis and the apex toward the labia majora and thighs. - The function of mons pubis is to protect the pelvic bones, especially during sexual intercourse. *Labia Majora (greater lips): These are two rounded, fleshy folds of fat and areolar tissue that extend from the mons pubis to the perineum, they have slightly deeper pigmentation than surrounding skin and are covered with pubic hair. Labia majora are covered by stratified squamaus epithelium containing hair follicles and sebaceous glands 6 The chief function of is to protect the structure lying between them. They are 7-8 cm in length and 23cm in width. *Labia Minora (l esser lips): These are paired of erectile tissue folds lying between the labia majora. It extends anteriorly from the clitoris and then joins posteriorly to the fourchette. - The labia minora are thinner than the labia majora, are hairless, contain oil glands that lubricant & water proof the vulvar skin and provide bactericidal secretions &it rich in blood supply and nerve ending. * Clitoris: - At the apex of labia minora is ahooded body composed of 7 erectile tissue called clitoris. It is similar to the glans penis. - It is 5 to 3mm long and 6 to 8 mm across.the hooded structure over the clitoris is called the prepuce. - It is very rich in blood and nerve supplies and allows the women to experience sexual pleasure & orgasm during sexual stimulation. * The vestibule: - this is the area enclosed by the labia minora in which are situated the openings of the urethera, parauretheral (skene's ) glands, vaginal opening or introitus and bartholin's glands. It is boat shape. *The Urethral orifice: 8 - This orifice lies 2.5cm posterior to the clitoris. Its long is 4 cm - On either side lie the openings of skene’s ducts, two small blindended tubules 0.5 c.m long running within the uretheral wall. Their secretions lubricate the vaginal vestibule to facilitate sexual intercourse. *The vaginal orifice: - This is also known as introitus of the vagina and occupies the posterior two thirds of the vestibule. - The orifice is partially closed by the hymen, a thin elastic membrane that tears during sexual intercourse or during the birth of the first child. However, the hymen can be torn in ways other 9 than sexual intercourse, such as during heavy physical exertion or with use of the tempons. - The hymen is a vascular & it varies in shape from woman to woman. * Bartholin’s glands (vulvovaginal glands): - There are two small glands that open on the either side of the vaginal orifice and lies in the posterior part of the labia majora. - These glands secrete mucus that is clear and thick mucus with an alkaline pH that enhances the viability and motility of the sperm deposited in the vaginal vestibule. These glands ducts can harbor (Neisseria gonorrhea) and other bacteria, which can cause 10 pus formation and Barthotin's gland abscess. The vulval Blood supply: - Mainly from the internal & external pudendal arteries - The veins of the vulva from venous plexus. Lymphatic drainage: - This is mainly via the inguinal glands. Nerve supply: - This is derived from branches of the pudendal nerve. The vaginal nerves supply the erectile tissue of the vestibular bulbs and clitoris and their parasympathetic fibers have a vasodilator effect. Pelvic floor:- 11 The pelvic floor is formed by the soft tissues that fill the outlet of the pelvis. The most important of these is the strong diaphragm of muscle slung like a hammock from the wall of the pelvis. Through it pass the urethera, the vagina and the anal canal. Function: - It supports the weight of the abdominal & pelvic organs. - Its muscles are responsible for the voluntary control of micturation and defication & play an important part of the sexual intercourse. - During childbirth it influences the passive movements of the fetus through the birth canal and 12 relaxes to allow the exit of the fetus from the pelvis. Muscles Layers: The superficial layer is composed of five muscles: - The external anal sphincter surrounding the anus and attached behind by a few fibres to the coccyx. - The transverse perineal muscles pass from the ischial tuberosities to the center of the perineum. - The bulbocavernosus muscles pass from the perineum forwards around the vagina to the corpora cavernosa of the clitoris just under the pubic arch. - The ischiocavernosus muscles pass from the ischial tuberosities 13 along the pubic arch to the corpora cavernosa. - The membranous sphincter of the urethra is composed of muscle fibrous passing above and below the urethra and attached to the pubic bones. It is not a true sphincter. The deep layer is composed of three Paris of muscles which together are known as the levator ani muscles. They are so called because they lift or elevate the anus. Each 14 levator ani muscle (left and right) consists of the following: - The pubococcygeus muscle passes from the pubis to the coccyx, with a few fibres crossing over in the perineal body to form its deepest part. - The iliococcygeus muscle passes from the fascia covering the obturator internus muscle (the white line of pelvic fascia) to the coccyx. - The isciococcygeus muscle passes from the ischial spine to the coccyx, in front of the sacrospinous ligament Perineal body: - This is the pyramid of muscle and fibrous tissue situated between the vagina and the anus. 15 The perineal body measures 4 c.m in each direction. - Several site of the superficial & deep muscle groups meet at the perineum to provide support for pelvic structures. - The perineum & muscles of the pelvic floor are capable of great expansion during child birth to allow for delivery of the fetus. The perineum is the site in which the episiotomy is sometimes done.uncontrolled tearing and laceration can also occur.if these are not properly repaired, or if they do not heal appropriately, the woman may experience stress incontinence or prolapse of pelvic organs later in life. Internal female Genitalia 16 It includes the vagina, cervix, uterus, fallopian tubes, and the ovaries *The vagina: - The vagina or birth canal is a muscular tube that leads from the vulva to the uterus. Functions: - The vagina is a passage which allows the escape of the menstrual flow. - The inner folds, or rugae, allow the vagina to stretch during birth to accommodate a full-term infant. - In additionally, normally, the vagina maintains an acidic pH of 4 to 5, which protect the vagina from infection. 17 - It receives the penis and the ejected sperm during sexual intercourse and provides an exit for the fetus during delivery. Position: It is a canal running from the vestibule to the cervix, passing upwards and backwards into the pelvis along a line approximately parallel to the plane of the pelvic brim. Relations: Anterior: In front lie the bladder and the urethra, which are closely 18 connected to the anterior vaginal wall. Posterior: Behind, the pouch of Douglas, the rectum and the perineal body each occupy approximately one-third of the posterior vaginal wall. Lateral: Beside the upper two-thirds are the pelvic fascia and the ureters which pass beside the cervix, while beside the lower third are the muscles of the pelvic floor. Superior: Above the vagina lies the uterus. Inferior: Below the vagina lie the external genitalia. Structure: - The posterior wall is 10cm long while the anterior wall is only 7.5 19 cm in length because the cervix projects at a right angle into its upper part. - The upper end of the vagina is known as the vault. Where the cervix projects into it, the vault forms a circular recess which is described as four arches or fornices. - The posterior fornix is the largest of these because the vagina is attached to the uterus at a higher level behind than in front. - The anterior fornix lies in front of the cervix and the lateral fornices lie on either side. The vaginal walls are pink in appearance and thrown into small folds known as rugae. - These allow the vaginal walls to stretch during intercourse and childbirth. 20 Layers: - The lining is made of squamous epithelium. - Beneath the epithelium lies a layer of vascular connective tissue. - The muscle layer is divided into a weak inner coat of circular fibres and a stronger outer coat of longitudinal fibres. - Pelvic fascia surrounds the vagina, forming a layer of connective tissue. Contents: - There are no glands in the vagina. - It is. However, moistened by mucus from the cervix and a transudate which seeps out from 21 the blood vessels of the vaginal wall. - In spite of the alkaline mucus, the vaginal fluid is strongly acid (pH 4.5) due to the presence of lactic acid formed by the action of Doderlein's bacilli on glycogen found in the squamous epithelium of the lining. - These lactobacilli are normal inhabitants of the vagina. - The acid deters the growth of pathogenic bacteria. Blood Supply: This comes from branches of the internal iliac artery and includes the vaginal artery and a descending branch of the uterine artery. The blood drains through corresponding veins. 22 Lymphatic drainage: This is via the inguinal, the internal iliac and the sacral glands. Nerve supply: This is derived from the pelvic plexus. The vaginal nerves follow the vaginal arteries to supply the vaginal walls and also the erctile tissue of the vulva. *The uterus: Position: It lies in the true pelvis in an anteverted and ante flexed position. 1. Shape: It’s similar to that of English pear. 2. Size: 23 7.5 long, 5cm wide, 2.5cm thick and weight about 60gms. 3. Structure: - The cervix: Froms the lower third of the uterus. - The isthmus: Is the narrowed construction about 7mm thick lying between body of uterus and cervix. - The corpus or body: Forms the upper two thirds of the uterus and is that portion of organ lying above the cervix. - The cornua: Are the areas of uterus where fallopian tubes are inserted the lumen of this tubes opens into the uterine cavity. - The fundus: It’s the portion lies above and between the cornuae. 24 - The cavity: Is a triongular hollow shape in the center of the uterus. The wall of the uterus normally lie in opposition. 4. Layers of uterus: There are 3 layers: 1- Perimetruim: It’s the outer pertoneal layer of double serous membrane that covers most of the uterus. Laterally the perimetruim is continuos with the broad ligaments on sides of the uterus. 2- Myometruim: - Is the middle layer of thick muscle. - Most of the muscle fibres are connected in the upper part of the 25 uterus and progressively diminish toward the cervix. - These are three layers of muscles each has a function in childbirth. A-Longitudinal: Are found mostly in the fundus and are designed to expel the fetus effectively toward the pelvic outlet during birth. B- Interlacing figure 8: They make up the middle layer. These fibers contract after birth to impress blood vessels that pass between them to limit blood loss. C-Circular fibers: They prevent reflux of menstrual blood and tissue into the fallopian tubes, they form a constriction where the fallopian tubes enter the uterus. 26 Promote normal implantation of the fertilized ovum by controlling its into the uterus, and retain the fetus till the appropriate time of birth. 3- Endometrium: Forms a lining of epithelium (mucous membrane) on abase of connective tissue in uterine cavity this endometrium is changing in thickness throughout the menstrual cycle it contain two layers. A-The basal layer: It doesn’t alter but provides the foundation from which the upper layer regenerate. B- The functional layer: - Lies above the basal layer and contains the endometrial arteries, veins and glands. 27 - This gland secrete alkaline mucous. - The epithelial cells are tall and columnar in shape. - The cervical endometrium is thinner them that of the body and is folded into a pattern known as the arbor vitae this is thought to assist the passage of the sperm. - This layer is shed during each menstrual period and after child birth in form of lochia. 5. Blood supply: Ovarian arteries on the right and left from the abdominal aorta supply the fundus of the uterus. They pass downward to meet the uterine artery of the corresponding side. 28 Uterine arteries on the right and left reach the uterus at the level of the internal Os, and send branches to supply the body of the uterus as well as cervix and vagina. Venous drainage is into the ovarian veins, which drain into the inferior a cava on the right hand side, and into the renal vein on the left. 6. Lymphatic drainage: Symphatic drainage is into the internal iliac and the sacral glands. 7. Nerve supply: Nerve supply is via sympathetic and parasympathetic nerves from the Lee-Frankenhauser (sacral) plexus. 8. Supports: The round ligaments: 29 Composed largely of fibrous tissue, maintain the uterus in its position of anteversion and anteflexion. They extend from the cornua at each side, pass downwards and insert into the tissues of the labia majora. However, they allow enough movement for the uterus to rise when the bladder is distended. The broad ligaments: Are not true ligaments but folds of peritoneum extending laterally between the uterus and sidewalls of the pelvis. The cardinal ligament, pubocervical ligaments and uterosacral gaments: Although described as supporting ligaments of the cervix, are piously 30 also uterine supports. Over stretching of these ligaments will result in prolapse of the uterus. They are composed of thickened bands of pelvic fascia, connective tissue and muscle fibres from the pelvic floor and uterus. In particular, the pubocervical ligaments are especially concerned maintaining the angle between the cervix and the horizontal plane. 9. Function: - To keep the uterus in anteverted, anteflexed position. - To prevent genital prolapse. 10. Relations: Anterior: As for the cervix. The intestines lie above the bladder and in front of the body of the uterus. 31 Posterior: Relation of the cervix and the uterosacral ligament. Laterally: Relations of the cervix, the fallopian tubes, ovaries and round ligaments. Inferior: The vagina. Superior: The intestines. I- The cervix: 1. Position: It forms the lower third of the uterus and is the area below the isthmus which includes the internal and external Os. It enters the vagina at aright angle and some times called the neck of the uterus. 2. Size: In adult female is 2.5cm long and forms one third of the total length of the uterus. 32 3. Shape: The cervix as a whole tends to be barrel shaped. 4. Structure: The cervix protrudes into vagina approximately 1 to 3cm. The cervix has an opening or Os leading connection with the isthmus of uterus and external opening (external OS) is a small round opening at the lower and of cervix the cervical canal lies between these 2 or a this canal is shaped like a spindle, narrow at each end and wider in the middle. After vaginal childbirth appears as slit like but before birth it appear as a small dot. 5. Content: - Consists mostly of connective tissue and has few muscle cells, it 33 lined by secretory epithelium which include many glands (cervical glands). - The cervical canal is lined with mucous membrane that secrete alkaline mucous. 6. Blood supply: Uterine arteries, and venous drainage through the uterine veins. 7. Lymphatic drainage: It’s into the internal iliac and sacral gland. 8. Nerve supply: Sympathetic and parasympathetic. 9. Supports: - Transverse cervical ligments: Extend from the cervix to the lateral wall of cervix. 34 - Pubocervical ligments: Run forward from cervix to the pubic bone. - Uterosacral ligments: Extends from the cervix and pass back words to the sacral. 10. Function: - Prevent ascending infection. - Role in vaginal delivery through dilatation and effacement. 11. Relation: Anterior: Utero vesical pouch of peritoneum and the bladder. Posterior: Douglas pouch and rectum. Laterally: The broad ligment and the uterus which are crossed by the uterine arteries. II- The fallopian tubes: 35 1. Situation: - Each tube extends from the cornua of the uterus, travels towards the sidewalls of the pelvis, then turns downwards and backwards before reaching it. - The tubes lie within the broad ligament. 2. Shape: They are tubular, as their name implies. The lumen of each tube communicates with the cavity of the uterus, at its proximal end and the peritoneal cavity at its distal end. 3. Size: The length of each tube is approximately 10cm. The diameter varies in each part of the tube: - Interstitial portion 1mm. - Isthmus 2.5mm. 36 - Ampulla and infundibulum each 6mm. 4. Structure: - The interstitial portion: Lies within the wall of the uterus and is 2.5cm in length. - The isthmus: Is also 2.5cm in length. It is the narrowest portion of the tube and acts as reservoir for spermatozoa because the temperature is lower there than in the rest of the tube. The lumen of the isthmus is under hormonal control and is contracted or dilated according to stimulating hormones which also affect the condition of the uterine endometrium. - The ampulla: Is the widened lateral area of the tube where 37 fertilization normally occurs. It is 5cm in length. - The infundibulum or fimbriated end: Is the terminal and distal portion of the tube which turns backwards and downwards and ends in finger-like projection (fimbriae) which surround the orifice of the tube. One fimbria lies in closer proximity to the ovary than the others. 5. Blood supply: - The blood supply comes from the uterine and ovarian arteries, venous return is by corresponding veins. - The infundibulum has a particularly rich supply and blood vessels, and muscle fibres. At the time of ovulation, the blood 38 vessels become engorged and give the fimbriae increased power of movement so that they can range over the ovary and waft the ovum into the lumen. 6. Lymphatic drainage: The lymphatic drainage is into the lumbar glands. 7. Nerve supply: The nerve supply is from the ovarian plexus. 8. Supports: This is provided by the infundibulopelvic ligaments, these are formed from folds of the broad ligament and run from the infundibulum of the tube to the sidewalls of the pelvis. 9. Function: 39 The tube forms a canal through which the ovum and sperm can pass and unite, where the fertilized ovum can commence early development. 10. Relations: - Anterior: The peritoneal cavity and the intestines. - Posterior: The peritoneal cavity and the intestines. - Superior: The peritoneal cavity and the intestines. - Inferior: The broad ligament and the ovaries. - Laterally: Infundibulopelvic ligaments and round ligaments. - Medial: The uterus. III- The ovaries: 1. Situation: 40 The two ovaries lie within the peritoneal cavity in a small depression of the posterior wall of the broad ligament. They are situated at the fimbriated end of the fallopian tube, at about the level of the pelvic brim. 2. Shape: The ovaries are small, almoundlike organs, dull white in colour and with a corrugated surface. 3. Size: 3cm x 2cm x 1cm. Weight 5-8g. 4. Structure: - Germinal epithelium: Is another name for the peritoneum which encloses the ovary. - Tunica albuginea: Is the tough fibrous outer coat. 41 - Cortex: Consists mostly of vascular fibrous tissue, stroma in which graafian follicles are embedded. These follicles each contain an ovum and can be found at varying degrees of development. The corpus luteum is the scar tissue which forms after a follicle has burst. The cortex is, therefore the working part, of the ovary. - Medulla: Is the central portion and point of entry for blood vessels, lymphatics and nerves. It consists chiefly of fibrous and elastic. 5. Blood supply: The blood is supplied from the ovarian arteries, venous drainage is into the ovarian veins. 6. Lymphatic drainage: 42 The blood is supplied from the ovarian arteries, venous drainage is into the ovarian veins. 7. Nerve supply: The nerve supply is from the ovarian plexus. 8. Supports: - The fossa in which the ovary lies. Where it is attached to the broad ligament is called the mesovarium. - The broad ligament which extends between the fallopian tubes and the ovary is known as the mesosalpinx. 9. Function: - To produce ova for fertilization. - Hormonal production of estrogen and progesterone. 10. Relations: 43 - Anterior: The broad ligament. - Lateral: Fallopian tube. I- The cervix: 1. Position: It forms the lower third of the uterus and is the area below the isthmus which includes the internal and external Os. It enters the vagina at aright angle and some times called the neck of the uterus. 2. Size: In adult female is 2.5cm long and forms one third of the total length of the uterus. 3. Shape: The cervix as a whole tends to be barrel shaped. 4. Structure: 44 The cervix protrudes into vagina Menstrual cycle Hypothalamus pituitary ovarian axis - Toward the end of the normal menstrual cycle, blood levels of estrogen and progesterone decrease. - Low blood levels of these ovarian hormones stimulate the hypothalamus to secrete gonadotropin-releasing hormone (GnRH). - In turn, GnRH stimulates anterior pituitary secretion of folliclestimulating hormone (FSH). 45 - FSH stimulates development of ovarian graafian follicles and their production of estrogen. - Estrogen levels begin to decrease, and hypothalamic GnRH triggers the anterior pituitary to release luteinizing hormone (LH). - A marked surge of LH and a smaller peak of estrogen (day 12) precede the expulsion of the ovum from the graffian follicle by about 24 to 36 hours. - LH peaks at about day 13 or 14 of a 28-day cycle. - If fertilization and implantation of the ovum have not occurred by this time, regression of the corpus luteum follows. 46 - Levels of progesterone and estrogen decline, menstruation occurs, and the hypothalamus is once again stimulated to secrete GnRH. - This process is called the hypothalamic-pituitary cycle. Menstrual cycle Introduction: There are two main components of the menstrual cycle, the changes that happen in the ovaries in response to pituitary hormones, the ovarian cycle, and the variations that take place in the uterus, the uterine cycle. It is important to remember that both cycles work together simultaneously to produce the menstrual cycle. 47 Changes in cervical mucus also take place during the course of the menstrual cycle. Ovarian cycle Cyclical changes in the ovaries occur in response two anterior pituitary hormones: folliclestimulating hormone (FSH) and lutenizing hormone (LH). Each of the three phases of the ovarian cycle is named for the hormone that has the most control over that particular phase. The follicular phase, controlled by FSH, encompasses days 1 to 14 of a 28-days. LH controls the luteal phase, which includes days 15 to 28. Follicular phase - At the beginning of each menstrual cycle, a follicle on one 48 of the ovaries begins to develop in response to rising levels of FSH. - The follicle produces estrogen, which causes the ovum contained within the follicle to mature. - As the follicle grows, it fills with estrogen-rich fluid and begins to resemble a tiny blister on the surface of the ovary. Ovulatory phase - When the pituitary gland detects high levels of estrogen from the mature follicle, it releases a surge of LH. - This sudden increase in LH causes the follicle to burst open, releasing the mature ovum into the abdominal cavity, a process called ovulation. 49 - Ovulation occurs on day 14 of a 28-day cycle. - As the ovum floats along the surface of the ovary, the gentle beating of the fimbriae draws it toward the fallopian tube. Luteal phase - After, ovulation, LH levels remain elevated and cause the remnants of the follicle to develop into a yellow body called the corpus luteum. - In addition to producing estrogen, the corpus luteum secretes a hormone called progesterone. - If fertilization does not take place, the corpus luteum begins 50 to degenerate, and estrogen and progesterone levels fall. - This process leads back to day 1 of the cycle, and the follicular phase begins a new. Uterine cycle Menstrual phase - Shedding of the functional layer of the endometrium is initiated by periodic vasoconstriction in the upper layers of the endometrium. - The basal layer is always retained and regeneration begins near the end of the cycle from cells derived from the remaining glandular remnants or stromal cells in this layer. Proliferative phase 51 - When estrogen levels are high enough, the endometrium begins to regenerate. - Estrogen stimulates blood vessels to develop. - The blood vessels in turn nutrients and oxygen to the uterine lining, and it begins to grow and become thicker. - The proliferative phase ends with ovulation on day 14. Secretory phase: - After ovulation, the corpus luteum begins to produce progesterone. - This hormone causes the uterine lining to become rich in nutrients in preparation for pregnancy. - Estrogen levels also remain high so that the lining is maintained. 52 - If pregnancy does not transpire, the corpus luteum gradually degenerates, and the woman enters the ischemic phase of the menstrual cycle. Ischemic phase: - On days 27 and 28, estrogen and progesterone levels fall because the corpus luteum is no longer producing them. - Without these hormones to maintain the blood vessel network, the uterine lining becomes ischemic. - When the lining starts to slough, the woman has come full cycle and is once again at day 1 of the menstrual cycle. Cervical mucus changes 53 - Changes in cervical mucus take place over the course of the menstrual cycle. - Some women use these characteristics to help determine when ovulation is likely to happen. - During the menstrual phase the cervix does not produce mucus. - Gradually, as hormonal changes transpire and the proliferative phase begins, the cervix begins to produce a tacky, crumby type of mucus that is yellow or white. - As the time of ovulation draws near, the mucus becomes progressively clear, thin, and lubricative, with the properties of raw egg white. 54 - At the peak of fertility (i.e., during ovulation), the mucus has a distensible, stretchable quality called spinnbarkheit. - After ovulation the mucus again becomes scanty, thick, and opaque. Nursing role during menstrual cycle: Nurse must provide health teaching about the following items: Sanitary pads and tampons: - Wash hands before and after giving self perineal care. - Washing or wiping the perineum should be always done from front to back. 55 - Reduce use of tampons by substitute sanitary pads part of the time especially at night. - Apply perineal pad snugly enough so it won't slide back and forth with her movements. - Do not touch the side of the perineal pad that will come in contact with the perineum. - Frequently take warm bath to maintain personal hygiene. Diet: - Decrease intake of caffeine (tea, coffee, coals, chocolate) to reduce anxiety. - Decrease intake of simple sugars. - Decrease intake of salty food to reduce fluid retention. - Eat six small meals a day to prevent hypoglycemia. 56 - Increase fluid intake. - Avoid alcohol which aggravates depression. Nutritional self-care: - Vitamin B complex neutralizes the excessive amounts of estrogen produced by the ovaries thus reduce nervousness that sometimes occur premenstrually. It is present in lean meats, whole grains, dark green leafy vegetables. - Vitamin B6 can relive the heavy bloated puffy feeling that is often experienced before the period. - Vitamin E is a mild prostaglandin inhibitor similar to aspirin but without the side effects. It improve circulation, reduce muscular spasm and pain by 57 reducing the uterus need for O2. It is present the yeast, wheat germ. - Iron is needed to prevent depletion of the female iron stores. - Calcium may also provide relief from menstrual symptoms, it is present in yogurt and cheese. Exercise: - Daily exercise can prevent cramps, relieves constipation. - Deep breathing brings more O2 to the blood which relaxes the uterus. - Aerobic activities as jogging or walking alleviate irritability and tension. Heat and massage 58 - Using any form of hot application such as hot tub, heating pads may be beneficial during painful periods. - Massage can also sooth aching muscles, promote relaxation and blood flow. Female Genital Mutilation General objectives At the end of this lecture each student should be able to acquire a comprehensive knowledge and attitude toward Female genital mutilation. Specific objectives 59 At the end of this lecture each student will be able to: - Define Female genital mutilation. - Determine the incidence of Female genital mutilation. - Describe types of female genital mutilation. - Enumerate short term & long term complications of female genital mutilation. - Explain nursing care of complications of female genital mutilation. Introduction Through history customs harmful to women health have been practiced in order to make women seem more attractive or likely to marry . Female circumcision is one of these customs 60 It is practiced in many communities of Africa and some communities in Middle East and a small number of communities in south east Asia. it involves cutting part of girls or woman's genitals .female circumcision is practiced for a variety of reasons most of them based on culture and tradition . Definition Female genital mutilation constitutes all procedures which involve partial or total removal of the external female genitalia or injury to the female genital organs whether for cultural or any other non Therapeutic reasons Incidence The incidence is higher in rural areas and it declines in high sociocultural classes. The estimated prevalence is well over 80 % in such countries as (WHO 1998): (Djibouti - Egypt - Eritrea - Ethiopia – Sierra Leone – Somalia - Sudan) Egypt → 97 % equal 27,905, 990 woman (WHO 1998) Age incidence The age of girls at time of operation is usually about 10 years , but the range is from 3 to 12 years. Types of FGM Type 1 traditional Excision of prepuce with or without excision of part or the clitoris Type 2 Excision of the prepuce and clitoris together with partial or total excision of the labia minora Type 3 Infibulations Excision of part or all of the external genitalia and stitching / narrowing of the vaginal opening 61 Type 4 Unclassified: - Pricking, piercing or incision of the clitoris and or labia - Stretching of the clitoris and or labia. - Cauterization by burning of the clitoris and surounding tissue. - Scraping (angurya cuts) of the vaginal orifice or cutting (gishiri cuts) of the vagina. - Introduction of the corrosive substances into the vagina. To cause bleeding or herbs into the vagina with the aim of tightening or narrowing the vagina. Short term complications Pain Injury Haemorrhage Shock Death Acute urine retention Urinary tract Infection Fracture or dislocation Infection Failure to heal 62 Long term complications Problems with micturition. Recurrent urinary tract infections. Pelvic infections Keloid scar Abscess Cysts and abscess on thevulva End-stage renal failure(from chronic urinary tract infection). Menstrual problems. Increased risk of vesicovaginal fistula. Sexual dysfunction. Calculus formation. Infertility. Psychological damage. Pregnancy and childbirth possible complications arising from FGM: Difficulty in fetal monitoring and assessing progress of labour. Obstructed labour due to scar tissue. Severe perineal tears. More caesarian sections. FGM doubles the risk of mother death in childbirth(WHO1993). FGM increases the risk of the baby being born dead. Nursing care for immediate Health Effects Of FGM - Infection, Failure, of healing, tetanous and also septicemia may occur as a result of the operation being performed under unhygienic 63 conditions with instruments wich are not sterile and by attendants who are unskilled. Mortality may be high as 50.60% because of tetanous infection. - Pain and shock often from no analgesia and the young girl experiences great pain wich can cause her to get in shock. - Hemorrhage can result from injury to the vulva from cutting of ablood vessels in the area and can cause the young girl to go into shock. - Urine retention is very common in the first Two to Four days after excision and infibulation because of the pain resulting from the wring to mching wound. Which may lead to UTI Working For Change What you can do: If you don’t agree with this practice, there are many ways you can help girls in your community: If you are a mother, help your daughters feel valued and loved, whether they are circumcised or not. Encourage your daughters to continue with their education and to learn enough to make their own decisions. Share the information about the health problems caused by female circumcision with other women and men in your community. Work with them for change. Find out what women's organizations in your community or region are doing. Nursing care of complications of female genital mutilation 1- Heavy bleeding and shock 64 Heavy bleeding from a deep cut or tear can happen quickly And is very dangerous if a girl loses too much blood. She can go into shock and die Warning sings of shock (one or more of the following) Sever thirst. Pale, cold and damp skin. Week and fast pulse (more than 110b/m). Fast breathing (more than 30 breaths /m). Confusion or loss of consciousness (fainting). what to do Get help immediately .shock is an emergency. Press firmly on the bleeding site .keep her lying down while you take her to medical help. Help her drink as much as she can. If she is unconscious and you live far from health services you may need to give her rectal fluids before taking to help. 2-Infection If the cutting tool is not cleaned properly (disinfected) before and after each use .germs can cause a wound infection, tetanus, HIVIAIDS or hepatitis. Signs: Fever, swelling in the genitals, pus or a bad smell from the wound, pain that gets worse. Of tetanus: tight jaw, stiff neck and body muscles, difficulty swallowing and convulsions. Signs of shock. Sepsis. 65 What to do Give an antibiotic. Keep watching for worning signs of tetanus ,sepsis and shock. Give tetanus vaccine for girls who have not had. Give medication for pain. Keep genitals very clean. 3- Urine problems Since circumcision often causes sever pain when a girl passes urine .some girls try to hold their urine back. This can cause infection and damage to the urine tubes and forms stones in the bladder. What to do Watch for signs of bladder and kidney infection. Run clean over the genitals when passing urine . Drinking more liquid will help. Pour water .the sound of the running water sometimes helps the person start to pass urine. Apply a damp towel soaked in worm water to the genitals to relieve the pain 4- Problem with monthly bleeding If the vaginal hole that is left after infibulation is to small or blocked by scarring inside the body. The flow of a girls monthly bleeding can be blocked .this can cause: Very painful monthly bleeding. Long monthly bleeding, lasting 10 to 15 days. No monthly bleeding because the vaginal opening is blocked and the blood cannot get out. 66 Trapped blood that can lead to serious pelvic inflammatory disease and infertility. What to do Apply a towel soaked in hot water to the lower abdomen. It may help to walk around and do a light work or exercise. If the problem are sever, the vaginal opening may need to be larger. 5- Problems with sexual relations and sexual health If a circumcised woman has none of the health problems described above she may be able to enjoy sex. But many woman who have been circumcised, especially those who have been infibulated find sex difficult. If woman have sex before the wound has healed, sex will be very painful and dangerous and the wound may take longer to heal During sex a women may find it difficult to become aroused since the clitoris has been cut off. What to do for problems with sex: A woman can talk with her partner about finding ways to become more sexually aroused and explain that she may need more time to feel aroused. She can also talk about to make sex less painful, having enough wetness can make sex safer and hurtless. 6- Problems with ChildBirth With some types of circumcision, there is a greater risk that the baby will have difficulty getting out of the vagina (blocked birth). If the hole left after infibulation is very small, It must be opened so the baby’s head can pass through. This is called “deifibution”. What to do: 67 Plan in advance for childbirth. During the second half of pregnancy, a pregnant woman should try to see a trained midwife or other health worker trained in helping circumcised women give birth. The midwife can tell her if there is a risk of complications, or if the vaginal opening should be made larger, if there are risks, a woman can make plans for getting medical care ahead of time. 7-Infertility Infection can cause scarring of the womb and tubes, which make it difficult for woman to get pregnant. 8- Leaking urine and stool During a blocked birth the lining of the vagina. Bladder or rectum can tear, causing urine or stool to leak out of the vagina. If a couple has anal sex because the woman's vaginal opening is too small, the anus may become stretched or torn. Stool may leak out of the anus. Leaking urine and stool are terrible problems to live with. Many young women have been rejected by their partners because of the smell and because they cannot control the leaking. Seek medical help as soon as the problem is discovered 9- Mental health problems A girl who has been circumcised can become overwhelmed with fear, worry (anxiety), or sadness. When circumcision is done in front of women that a girl knows and trusts to protect her from harm .she may feel that she can no longer trust anyone. It's worse if the girl did not wish to be circumcised. Chronic pain and suffering can cause other lasting mental health problems, such as deep sadness (depression), and feelings of helplessness and worthlessness. Sexual problems can also cause severe strain between a woman and her parther. A woman may feel she is unable to please him because the pain makes her afraid of sex. What to do: 68 Encourage her to talk about her feelings. If she seems withdrawn, distant, and unable to do dialy activities 10- Effects of excision and infibulation on marriage and childbirth 1. Problems with the Consummation of Marriage A woman who has undergone infibulation often has a very tiny vaginal opening because of the stitching together of the vulva. Tight scarring of the vaginal opining and narrowing of the vaginal opening make the concummation of marriage painful and difficult, or sometimes impossible. The woman may need to have the vaginal opening enlarged by cutting. If this surgery is necessary, she then faces all the health risks and complications she did when she was first circumcised. These complications are shock from pain or hemorrhage, infection, tetanus, septicemia. The emotional impact is tremendous on the woman and reflects on her relationship with her spouse. Among the psychiatric disturbances associated with female circumcision, especially in the event of physical complication such as fistula and dermoid cysts, are anxiety reaction, chronic irritability, episodes of depression, and even frank psychosis anxiety. 69 FAMILY PLANNING Introduction It is estimated that around 500.000 women die each year due to causes related to pregnancy & childbirth most of that death occur to women in developing countries. In Egypt maternal mortality is 174.100.000 live birth according to the national maternal mortality survey by ministry of health. So, family planning is the proper solution to the problem of maternal mortality in developing countries. It improve the health of women by helping them to avoid high risk pregnancy, effective methods of contraception prevent women's from performing dangerous, illegal abortion with it's consequences of post abortion infection, bleeding and death. Studies conducted in Egypt indicated that neonatal, infant & child mortality rates all decline as the birth interval increase. For example birth occurring at less than 2 years intervals associated with high infant mortality rate 194/1000 compared to those occurring at four years or more intervals 52/1000. Definition: Family planning refers to practice that help individuals or couples to attain certain objectives: - Avoid unwanted birth, illegal abortion. - Regulate the intervals between pregnancies. - Control time at which births occur in relation to the age of parents. Hormonal contraception: 1. Oral contraceptive pills: Types: 70 - Combined pills "estrogen & progesterone" 28 pills or 21 pills. - Sequential pill estrogen for 14 days then followed by combined for 7 days. - Minipills progestin only. Effectiveness: 99%. Mechanism of action - Inhibition of ovulation. - Acceleration of ovum transport. - Luteolysis decrease progesterone level & interfere with normal implantation. - Thickening of cervical mucous that interfere with the sperm ability to penetrate cervical mucous. Advantages: - Decrease premenstrual syndromes & endomertiosis. - Little or no menstrual cramping or pain. - Does not interrupt intercourse. - Decrease incidence of ovarian cysts. - Diminished fibrocystic breast disease and fibroadenomass. - Improve anemia and rheumatoid arthritis. - Decrease incidence of endometrium and ovarian cancer. Disadvantages: - Systemic medical risks associated with use. - Remembering to take the pill daily. - Weight gain for some women. Indications: 71 - Women who has desires to use a highly effective methods of contraception. - Women who has anemia from heavy menstrual bleeding. - Women who have severe menstrual cramping. - Women who has benign ovarian cysts. - Women who has history of ectopic pregnancy. - Women who has strong family history of ovarian cancer. Contraindications: Absolute: - Women who has known or suspected pregnancy. - Women who has unexplained abnormal vaginal bleeding. - Women has benign or malignant liver tumors. - Thrombophilebitis or thromboembolic disorders. Relative: - Women who has hypertension. - Women who has DM. - Women who has epilepsy. - Women who has depression. - Women who has more than 40 years and smoker. Client instruction - The first pills should be taken on the fifth day of menses. - A pill should be taken every day at the same time of day. - The last 7 pills "of 28 days pills" contain iron supplements rather than hormones, they should be taken last. Withdrawals bleeding usually occur at this time. 72 - After taken the last pill of the first cycle, start a new pack of pills the very next day and continue to the arrows. If pills contain only 21 pills wait one week before starting the next pack. - Missed pills: 1) If forget one pills, should take as soon as possible and next pill take at the regular time. 2) If forget two pills, should take two pills as soon as possible and two the next day, use back up method finish the pack. 3) If forget three pills, should take two pills for 3 days and use back up method "barrier method" till the end of the cycle before starting new pack. - Return to the clinic immediately if any of the following warning signs occurs, that remembered by ward ACHES: 2. Injectable method: Types: - Depomedrexy progesterone acetate "DMPA": Depoprovera, IM contain 150 mg every 3 months. - Norethiserone enanthate "NET-EN" contain 100 mg every 2 months. - Progesterone-estrogen combination once monthly injection. Effectiveness: 99.5%. Mechanism of action: - Increase viscosity of cervical mucous inhibit sperm transport. - Inhibition of ovulation. - Decrease tubal motility. - Atrophic change in endometrium inhibit implantation. Advantages: - Extremely effective. 73 - Simple delivery. - Independent on coitus. - Contraceptive privacy. - Can use by older women. - Can use by women with sickle cell disease. Disadvantages: - Irregular menstrual patterns. - Amenorrhea. - Delay return for fertility after discontinuation. - Weight gain or weight loss. Contraindications: Absolute: - Women who has known or suspected pregnancy. - Breast cancer or unexplained breast pathology. - Unexplained uterine or vaginal bleeding. - All types of genital cancer. Relative: - Nulliparity. - DM. - History of liver disease or jaundice. - Allergy to injectable method. - Thrombophilebitis or thromboembolic disorders. Side effects: - Amenorrhea. - Increase menstrual bleeding. - Delayed return for fertility. - Depression. 74 - Headache, dizziness, visual problems. - Weight gain or loss. Client instructions: - The first injection should be given between first and seventh day after menses begins. - Client should return to take another injection every 3 months for Depo-Provera and every 2 months for noristerat. - Injection may cause amenorrhea or heavy bleeding. - Return to fertility 2-3 months after injection is stooped. - Warning signs that require return to clinic immediately as: * Bleeding between periods for more than 7 days. * Menstrual period twice as longer or twice as often as usual. 3. Implant: Effectiveness: 99%. Mode of action: - Increase viscosity and decrease amount of cervical mucous inhibit sperm transport. - Inhibit implantation. - Inhibit ovulation. Advantages: - Highly effective. - No estrogen side effect. - Long lasting "continuous for 5 years". - One decision method. - Help to prevent anemia. Disadvantages: 75 - Change in bleeding patterns. - Visible. - Initially more expensive. - Must inserted and removed by health professional. Indications: - Women who desire a method that do not need to be remembered daily. - Women who desire long acting contraceptive method. - Women who desire method not related to intercourse. - Women who do not tolerate IUD or pills. Contraindications: Absolute: - Women who has known or suspected pregnancy. - Undiagnosed vaginal bleeding. - Cancer of breast or genital tract. Relative: - Nulliparity. - DM. - Breast feeding less than 6 weeks. - Liver disease or jaundice. - Thromboembolic or heart disease. Side effects: - Irregular menstruation amenorrhea". "prolonged - Local infection at site of insertion. - Ectopic pregnancy. - Expulsion of implant. 76 menses or spotting, - Weight gain or loss. - Headache. Client instructions: - Inserted during first week of menstrual cycle. - Avoid trauma to area of insertion and keep it dry and clean for 4 days. - Return to clinic after 1 month, 3 months, 6 months, 1 year, then annually for check up. - Norplant capsules should be replaced after 5 years. - Irregular bleeding or amenorrhea may occur at 1st year. - Warning signs that require return to clinic immediately as: * Sever abdominal pain. * Arm pain. * Heavy vaginal bleeding. * Expulsion of norplant. * Pus or bleeding at site of insertion. * Delayed menstruation after regular patterns. * Migraine headache. Mechanical methods 1. Intrauterine device "IUD": Mechanism of action: - Inhibition of implantation by local production prostaglandin. - Increase viscosity of cervical mucous prevent sperm transport. - Accelerate tubal motility. - Decrease estrogen level at 1st half of cycle degeneration of corpus luteium. 77 Advantages: - Inexpensive. - Easy insertion and removal. - Once in place it remain effective for years. - Not interrupt coitus. - Not interfere with breast-feeding. - Not delay return for fertility. Side effects and complications: - Prolonged heavy menstruation and intermenstrual spotting may occur. - Pain and cramps after insertion and at time of menstruation. - Expulsion. - Missing IUD. - Ectopic pregnancy. - Perforation. - PID. Indication: - Breast feeding women. - Women who have difficulty using other method. - Women to whom other method are contraindication. Contraindications: Absolute: - Known or suspect pregnancy. - Known or suspect cervical or uterine malignancy. - Acute or chronic pelvic infection. Relative: 78 - Nulliparity. - Dysmenorrhea. - Anemia. - Vulvular heart disease. - Abnormalities of uterine shape size and position. Client instructions: - Some increase in bleeding and cramping is normal. - Check strings at midcycle and after period. - If strings are missed use another contraceptive method and contact health care provider. - Return for follow up schedule every 3 months in first year then every one-year. - Warning signs that require immediate return for clinic as "remembered by ward PAINS". * Period late. * Abdominal pain. * Infection. * Not feeling well, fever, chills. * Strings misses. 2. Vaginal diaphragm: Definition: is shallow dome shaped rubber cup with flexible rim. Effectiveness: 85-98%. Advantages: - Inexpensive. - No health hazard. - Some protect against STD. 79 - Prevent cancer cervix. Disadvantages: - Difficult in apply and removal. - Require special training for use. - Left in vagina at least 8 hours after intercourse. - Require supplies spermicids. Indications: - Contraindication of other contraceptive method. - Back up for other method. - Has sex only once in while. Contraindications: - Allergy. - Urinary tract infection. - Uterine prolapse, sever cystocele. - History of toxic shock syndrome "TSS". - RVF, vaginal septum. Side effects: - Allergy. - TSS. - Cystitis or urethritis. - Discomfort and pain due to pressure on bladder or rectum. Client instructions: - Use diaphragm with every time of intercourse. - First empty your bladder and wash your hands. - Check diaphragm for holes by pressing it or fill it with water. 80 - Put spermicids at center of diaphragm and around the rim then squeeze the rim together. - Use the following position for insertion: * Raise one foot up on chair and spread the lips of vagina apart. * Hold the diaphragm after squeeze the rim between two fingers, insert it in the vagina and push the front rim behind pubic bone, then put your finger in vagina and fell cervix to ensure it is covered. * Leave it one place 6-8 hours after intercourse. * To remove it place your finger between it and pubic bone to break suction and pull it out. * After use clean with soap and water, dry it and dust with powder before out in container. 3. Condom: Definition: is sheath made of latex or sheep's intestine to collect semen and prevent its passage into vagina. Effectiveness: 85- 95%. Advantages: - Inexpensive. - No side effects. - Protect from STD. - Not require medical prescription or examination. Disadvantages: - Interrupt sex. - Require stock. - Rupture during intercourse. - Require one for each intercourse. 81 - Decrease sensation during sex. Indications: - Newly married couple. - Have sex only once in while. - Immuno-infertility. - Treatment of premature ejaculation in male. - Space children. - Contraindication of other method. Contraindications: - Allergy. - Unreliable use. Client instructions: - Put condom before any genital contact. - Put it on erect penis. - Be sure to leave half inch of latex material at the end of erected penis for collection of semen. - Compress tip between finger and thumb to exclude air during apply it. - Do not use any material for lubrication. - Withdraw when penis still erected and hold the ring of condom firmly at the bases of penis to prevent slip off. - Use it for once and discard. 4. Cervical cap: Definition: it is similar to diaphragm but smaller and applied direct to cervix suction. Effectiveness: 85-95%. 82 Advantages: - No health hazards. - Inexpensive. - No pressure against bladder. - Remain in vagina for long time 48 hour. Disadvantages: - Difficult in applying and removal. - Limited size. - Can be dislodged during intercourse. - Cervical laceration with prolonged use. Indications: - Contraindications of other methods. - Has healthy cervix. - Has erected cervix is RVF. - Has sex only once in while. Contraindications: - History of TSS. - Allergy. - Abnormal pap smear. - Recent delivery. - Acute cervicitis or PID. Side effects: - Increase risk of cervicitis. - Trauma to cervix and vagina. - Infection. Chemical method 83 Types: - Suppositories, cream, jell, foams, tablet. Effectiveness: - 80-90% if use alone and may reach 98% if use with male condom. Advantages: - No systemic side effects. - No medical prescription. - Not require examination. - Serves as lubrication. Disadvantages: - Some fell burning and irritation on their genitals. - May be messy to use. - Increase failure rate may reach to 15%. Indications: - Contraindications of other methods. - Newly married couple. - Have sex only once in while. - Want to space children for limited time. - Perimenopausal women. - Back up when other methods interrupted. Contraindications: - Allergy to spermicids. - Woman who need a highly effective method. - Physical disability that cause difficult in use. - Inability to remember to use consistently. Side effects: 84 - Allergic reaction. - Uncomfortable heat sensation. Client instructions: 1. Foam tablets: - Shake container 20-30 times before uses it. - Place container in up right position and fill it with foam. - Lying down and insert applicator into vagina near cervix and push plunger to release foams. - Foam should be place in vagina before intercourse by 10 minute. - Couple waits 30 minute after insertion and make intercourse. - Vaginal douche should done after 6-8hour of intercourse. - Each intercourse requires new tablet. - Tablet can dip in water to facilitate its insertion. 2. Creams and jell: - Squeeze cream or jell to full into applicator. - Insert applicator into vagina near cervix and push plunger to release creams or jells. - Use it 20-30 minute before intercourse and make sex immediately. - Clean applicator with soap and warm water before store. Surgical methods "sterilization" 1. Tubal ligation: Definition: Surgical procedure in which female is sterilized by occluding or cutting fallopian tubes. Indications: - Woman has more than 4 children or over 45 years. - Recurrent ectopic pregnancy. - RVF. - Recurrent toxemia with pregnancy. 85 - Woman has uncontrolled DM or HIM. - Congenital abnormalities. Effectiveness: 99%. Advantages: - Highly effective, permanent, very private. - No thing to buy or remember. - Not interrupt sex. Disadvantages: - No protection against STD, HIV. - Require surgical and aseptic technique. - Permanent, reversibility difficult. Complications: - Infection. - Hemorrhage. - Hematoma. - Perforation of uterus. - Bladder or bowel injury. 2. Vasectomy: Definition: surgical procedure for interruption or ligation of vas deference to prevent passage of sperm. Effectiveness: 99.5%. Advantages: - Permanent, very safe. - Quickly performed. - Highly effective, inexpensive on long time. - Relieve female of contraceptive burden. Disadvantages: - Permanent. - Expensive on short time. 86 - No protection against STD, HIV. - Require surgical and aseptic technique. Complications: - Inflammation. - Pain. - Epididymitis. - Hematoma. - Infection. Natural method 1. Safe period through: Calendar method: - Ovulation occurs at 14 days before onset of next menses. - Sperm can survive for 3 days after intercourse and still fertilize for ovum. - Ovum can be fertilizing for no more than 24 hours following ovulation. - Menstrual cycle are charted for 6-12 months, 18 days are subtracted from the shortest cycle to determine the first day of fertile phase and 11 days are substracted from the longest cycle to determine the last day of fertile phase. Basal body temperature "BBT": - One to two days after a woman ovulate, her basal body temperature raise 0.2-0.3 degree as result of a raise in the level of progesterone in her body. The BBT use this signal to make the end of fertile period. - A woman records her BBT after at least 6 hours of uninterrupted sleep, through the cycle. A usual body temp thermometer is used. 87 Which has an expanded scale compared to the fever thermometer. Intercourse is not permitted until 3 days after rise in temperature. Cervical mucus: - AT the time of ovulation cervical mucus becomes transparent, slippery and capable of considerable, so it become stretching between finger and thumb. This fertile mucus looks like raw egg white. Fertile phase begins when mucus is first noticed and ends 4 days after the last day of fertile mucus. 2. Breast feeding "prolonged lactation" - This method mentions in lecture of breast-feeding and has great failure rate. 3. Coitus interruption: - This involves with drawl of penis prior to ejaculation and necessitates tremendous self-control. This method has a high failure rate as semen leakage can occur prior to ejaculation. Definition of counseling: - It is face to face communication to help the client to make free, informed and voluntary choice abut family planning method and reproductive health. Element of counseling: Is summarized in ward "GATHER" G Greets client in friendly and helpful way. Great client: - As soon as you meet client, give them your full attention. - Ask how you can help. - Tell client that you will not tell other what she says. - Conduct counseling where no one else can hear. 88 Ask client about her self and her needs: - Help client talk about her needs, wants and any doubts, concerns or question she has about family planning. - If client is new obtain complete history: (demographic, medical, surgical, obstetric and gynecological, ……). - Explain that you are asking for this information to help to her to choose the best method. - If client is not new ask her if any thing has changed since the last visit. Tell client abut family planning method: - Tell your new client which methods are available and where. - Ask your client which method interest to her. - Ask your client what she knows about her interest method. - Briefly describe each method that client want to hear about it, talk about: (how it work, advantages, disadvantages, side effects,….). Help client choose a method: - Ask the client about her needs and her family situation, if uncertain about the future start with present. - Ask client what her husband want, what method he wants her to use? - Ask client if there is any thing she did not understand, repeat information if necessary. - Some method is not safe for some client, when method unsafe tells the client and explains clearly, then help to choose another method. - Check whether client made a clear decision specially ask "what method have you decided to use?" Explain how to use method: - After the client chooses the method give her supplies. 89 - If the method can not given immediately, tell the client how, when and where it will provide. - Explain how to use the method. - Ask the client to repeat instruction to make sure understanding. - Describe possible side effects and warning signs. - Tell the client when come back for follow up. Return for follow up: At the follow up visit: - Ask client if still using the method. - If yes, ask client if has any problem with use. - Ask client if has any side effects then find out how sever they are, reassurance of client with minor side effects and explain what she can do to relieve them, if side effect is sever refer to treatment. - Ask the client how she/he use the method to ensure correct use. - Ask if the client has any questions. 90 Reproductive Health Introduction: Every year, at least 585.000 women die from complications of pregnancy, childbirth, and postpartum period. About 99% of these women die in the reproductive age (19-44 years) in developing countries. In Egypt, 84 women die per 100.000 every year. In addition, the causes of maternal death often have some of their roots in the woman's life before pregnancy. They may start from infancy, or even before her birth. The woman is source of the nation and a basic unit of the society. Hence, the reproductive health of women should be supported and protected, and considered a crucial part of general health. Not only it is a key element of health during adolescence period, but also it set the pace for health beyond reproductive years, and has an effect on generations. Definition: Reproductive health is a status of complete physical, mental and social wellbeing and not merely the absence of disease or disability in all matters relating to the reproductive system and to its function and processes. Benefits of reproductive health interventions - Improving adolescent reproductive health reduces unwanted pregnancies and the risk of contracting HIV and other sexually transmitted infections. It improves the chances of girls continuing school and expands their life options. - Providing life coping skills including RH education for boys and girls. 91 - Prevention and management of sexual transmitted infections (STLs) prevents sexual spread of HIV. - Integrating HIV prevention activities in mother and child health (MCH) and family planning (FP) programs addresses missed opportunities to curb the HIV epidemic. - Being able to choose when to get pregnant, apart from being health issue, greatly influences population growth, and environmental conditions. - Increasing contraceptive choices and access leads to fewer unsafe abortions-arguably the most easily avoidable cause of maternal death. - Life-saving care for complications from abortion is an excellent opportunity to provide contraception, avoiding another unwanted pregnancy. - Reducing pregnancy-related deaths and illness in mothers increases newborn and child survival, and improves productivity. - Reducing maternal deaths depends on a functioning death system. Strengthening the system to improve maternal health benefits in many other areas of death. Factors affecting reproductive health and women's right: - Economic circumstance. - Education. - Employment. - Living conditions. - Family environment. - Social and gender relationships and the traditional and legal structures within which they live. 92 - Sexual and reproductive behaviors are governed by complex biological, cultural and psychosocial factors. Basic elements of reproductive health: - Employment of women. - Woman's nutrition. - Care of adolescent. - Safe sexual behavior. - Safe motherhood. - Widely available family planning services. - Elimination of unsafe abortion. - Prevention of unwanted pregnancy. - Prevention and management of infertility. - Male involvement. - Prevention and treatment of malignancies and post menopausal care. Women's and men's reproductive health needs: Women's reproductive health need are: - A continuum from sexual health. - Prevention and management of infertility. - Fertility by choice, not by chance. - Pre-conceptional care. - Keeping labour normal. - Pregnancy and child birth, post natal care. - In addition, it covers menopausal and postmenopausal health care. Men's reproductive health needs include: 93 - Sexuality. - Protection against sexually transmitted infectious. - Infertility prevention and management and fertility regulation. - Protection against prostatic hypertrophy and prostatic cancer is another concern. Reproductive health index: It included the following: - Maternal mortality ration. - Birth attended by trained personnel. - Percentage of women receiving antenatal care. - Percentage of pregnancy women with anemia. - Contraceptive prevalence. - Availability of safe abortion services. - Prevalence of infertility. - Level of HIV and aids in women. Reproductive health rights: - Right to be free from all forms of discrimination. - Right to life, liberty and security. - Right to marry and found a family. - Right to education and information. - Right to benefit from scientific progress. - The right of sexual equality. - Right to health and health care. - The Egyptian women work law. - Right of adolescents to meet their needs. 94 Strategies for improving reproductive health and assuring women's rights: - Efforts to delay early marriage and/or childbearing through good reproductive health education. - Effective prenatal care and safe management of routine deliveries. - Access to emergency medical care and dealing with complications of childbirth. - Access to high quality of family planning services and a choice of contraceptive methods. - Emergency care for complications that accompany unsafe abortion. - Public education and counseling to prevent the spread of AIDs and STDs. - Diagnosis and treatment of STDs and reproductive cancers, where resources and circumstances permit. - Effective and accessible infertility treatment. - Efforts to educate local communities about harmful cultural practices that influence the health as female circumcision. - Elimination of all forms of violence against women, female youth and children. - Improvement of women's status and enhancement of quality. - Applying human rights in national constitutions and international conventions to advance safe motherhood (e.g. by requiring states to take effective preventive and curative measures to reduce mortality and to treat women with respect and dignity). - Reducing inequalities in social and economic policies. 95 - Protecting and promoting women's rights, choices and autonomy are critical to reduce maternal deaths and ill health. Male Reproductive System Objectives - Discuss structure and function of external male genitalia. - Identify structure and function of internal male genitalia. - Determine the location and function of accessory a glands. - Trace the pathway of the sperm from the tests to the outside of the body. - Describe the composition of semen. Introduction: The male reproductive anatomy consists of external reproductive organs & internal reproductive organs. The purposes of male reproductive tract are to allow for sexual intimacy and reproduction of offspring, and to provide a conduit for urinary elimination. External Genitalia: The external genitalia consists of the penis and scrotum *The Penis Functions: 1- The penis serves a dual role as the male organ of reproduction. 2- During sexual excitement it stiffens (an erection) in order to penetrate the vagina and deposit sperms near the woman’s cervix. 3- It carries the urethera, which is Passage for urine & semen. Position: 96 The roots lies in the perineum, where it passes forward below the symphysis pubis, the lower two- thirds are outside the body in front of the scrotum. Structure: It is an elongated cylindrical structure consisting of the body (shaft) and the glans. The glans: - It is the most sensitive area on the penis because this is where the greatest concentration of nerve endings is found. - This part of the penis is analogous to the clitoris in the female. At birth a layer of tissue, prepuce, or foreskin, covers the glans, it is the part removed during circumcision. The shaf: - It is composed of three column of sponge like erectile tissue, two corpora cavernosum & one corpus spongiosum. The cavernous bodies are parallel, and the spongy body lies atop theme in the midline. The spongy body is cradled in the channel created where the cavernous bodies meet.each column is encased in a thick sheat called the tunica albuginea. Support system: The suspensory ligament is the main support for the penis extended from the symphysis pubis and merges with the deep fascia of the penis. Nerve Supply : - The penis innervated by pudendal nerve. - Sympathetic fibers from hypo gastric & pelvic plexus, while parasympathetic fibres from third sacral nerve. - When the parasympathetic fibers are stimulated the ischiocavernous muscle contracts, preventing the return of venous blood from the 97 cavernous sinuses , the blood vessels of the penis engorge causing erection and it elongates , thickens & stiffens & if stimulation is intense enough , the forceful & sudden expulsion of semen occur through the rhythmic contraction of the penile muscles (ejaculation). *Scrotum The scrotum is an external sac that houses the testes in two internal compartments. Functions - The main functions of the scrotum are to protect the testes from trauma & to regulate the temperature within the testes, a process that important to the production of healthy male gametes. Structure -It is formed of pigmented skin and has two compartment, one for each testis. Internal Genitalia : Male internal reproductive organs include the testes and the system of glands & ducts that are involved in the formation of nutrient plasma and the transport of semen out of the man's body. *The testes ( or testicles ) - The testes are a pair of oval organ housed in the scrotum. Functions: - The testes are the male gonads and produce spermatozoa . - Secrete male hormones androgens (Testosterone). - Testosterone is responsible for the development of the secondary sex characteristics together with follicle stimulating hormone ( FSH ), it also promote the production of the sperm Position 98 The testes are situated in the scrotum. In order to achieve their proper function, they must be kept below the body temperature, and this is why they are situated outside the body. Structure: - The testes are oval structure , with in color , about 4 cm long , 2.5 cm wide, & 3 cm thick .They each weigh between 10 to 14 gm. - The testes are enclosed in a protective fibrous capsule, the tunica albuginea, and covered by a serous membrane, the tuinca vaginalis which enables each testis to move freely within its scrotal cavity. Layers of testes: Tunica vasculosa: This is the inner layer of connective tissue containing a fine net warke of capillaries. Tunica albiginia: This is fibrous covering in growths of with divide the testes into 250-400 lobules Tunica vaginalis: This is the outer layer which is made of peritoneum brought down which the descending testes when it migrate from the lumber region in fetal life. *The seminiferous tubules These are where spermatogenesis or production of the sper take place. There are three of them in each lobule. Between the tubules are interstial cells that secrete testosterone. The tubules join to form a system of channels that lead to the epididymis. Epididymis Function 99 - The epididymis provides a reservoir where spermatozoa can survive for long period. Spermatozoa are immobile and incapable of fertilizing an ovum. Spermatozoa remain in the epididymis for 2 – 10 days and become motile and fertile. Position It lies behind each testis, it arises from the top of the testis, extends down ward and then passes upward, where it becomes the vas deferens. Structure: - These are fine convoluted tubules, each about 6 ml in length which connect the testes & the vasa deference - The tubules have ciliated bithelial lining which helps the sperm to migrate to the vas deferens. *Vas deferense It is the muscular tube in which the sperm begin their journey out of the man's body It connects the epididymis with the ejaculatory duct. The vas deferense is sheathed in the spermatic cord, which also contains the blood vessels, nerves, and lymphatic that serve the testes. The left spermatic cord is usually longer than the right so that the left testis hangs lower than the right. *The spermatic cord Function ● The spermatic cord transmits deferent duct or vas deferens up into the body, along with other structures. 100 ● the function of the deferent duct is to carry the sperm to the ejaculatory duct. Position - The cord passes upwards through the inguinal canal, where the different structures diverge. - The deferent duct then continues upwards over the symphysis pubis and arches backwards besides the bladder. - Behind the bladder it merges with the duct from the seminal vesicle and passes through the prostate gland as the ejaculatory duct. Structure - The spermatic cord consists of the deferent duct, the testicular blood vessels, lymph vessels, and nerves. Blood supply - The testicular artery, a branch of the abdominal aorta, supplies the testis, scrotum, and attachments & testicular veins. Lymphatic drainage - This is to lymph nodes round the aorta. Nerve supply - This is from the 10th and 11th thoracic nerves. *The ejaculatory duct These small muscular ducts carry the spermatozoa and the seminal fluid to the urethera. Each duct is formed by the union of the vas deferens and the seminal duct. The ejaculatory ducts are approximately 2.5 cm long. They pass through the prostate gland & join the urethra .They connect the vast deferens and urethra. 101 *The urethera - The male urethera is a passage way for urin and semen. The urethera begins in the bladder and passer through the prostate gland, where is called the prostatic urethera. - The urethera emerges from the prostate gland to becom the membranous urethera. - It terminate in the penis where it is called the penile uretheral, in the penile uretheral goblet secretory cells are present and smooth muscle is replaced by erectile tissue. Accessory glands Seminal vesicles glands: Function - The function of the seminal vesicles is production of a viscous secretion to keep the sperm alive and motile. Position - The seminal vesicles are two pouches situated posterior to the bladder. Structure - The seminal vesicles are 5 cm long and pyramid shaped. they are composed of columnar epithelium, muscle tissue and fibrous tissue. Prostate gland Function - The prostate gland produces a thin lubricating fluid that enters the urethera through ducts. Position 102 - It surrounds the urethera at the base of the bladder, lying between the rectum and the symphysis pubis. Structure - It is 4 cm transversely, 3 cm in its vertical diameter and 2 cm deep. It composed of columnar epithelium, muscle tissue and fibrous tissue. Bulbo – Urethral (Cowper’s) gland These are two small glands about the size of pee, yellowish color lying just below the prostate gland, their ducts about 3 cm long open into the urethra & its secretions are added to the seminal fluid. The bulbo – urethral glands release a small amount of fluid prior to ejaculation & this lubricates the penis & facilitating its entry into the vagina. N.B: The alkaline fluids secreted by these glands are nutrient plasma with several functions, including: ● Enhancement of sperm motility. ● Nourishment of the sperm (i.e, provides a ready source of energy with the simple sugar Fructose). ● Protection of the sperm (i.e, sperm are maintained in an alkaline environment to protect them from the acidic environment of the vagina). Seminal Fluid: This fluid in which the spermatozoon as suspended .It nourishes them & aids their motility. 103 The prostatic secretion is the largest component of it. But secretions of seminal vesicles & Cowper’s glands all help to nourish as will as provide mean of transport for the sperm Normal semen analysis: Average amount: of ejaculate is 3.5 ml but the normal range lies between 2 and 6 ml. Average density: is 60-150 000 000 sperm per milliliter of seminal fluid of these 75% are mobile and 20- 25 % will be malformed. Rate of movement: a speed of 2, 3 mm per minute but reach to 0.5 mm per minute in acidic vaginal secretion. Semen: - Semen is a thick, whitish fluid ejaculated by the man during orgasm It contains spermatozoa and fructose rich nutrients. - During ejaculation, semen receives contributions of fluid from the seminal vesicles and the prostate gland. - Combined semen is alkaline (average pH, 7.5). - The average mount of semen released during is ejaculation is 2.5 to 3.5 ml. - About 60-120 millions spermatozoa per ml. - If the sperm count less than 20 millions male is considered infertile Composition of Semen Origin Testes and Epididymis Seminal vesicles Component Some fluid. Sperm (hundred of million). Fructose. Thick mucus. Prostaglandin. Functions Fertilization of ova. Energy source. Increase motility of uterus. 104 Percent of ejaculate Under 5% 30 % Nutrition for the sperm. Prostate gland Bulbourethra l gland Alkaline fluid. Thin mucus. Fibrinolysin. Citrate – zinc. Magnesium-acid phosp . Piprinolysin Alkaline fluid. Support sperm motility. Liquefies semen 10 min. After ejaculation to release sperm. Assist the prostate gland in its function. 60 % 5% The male hormones: - The control of the male gonads is similar to that in the female, but it is not cyclical. - The hypothalamus produces gonadotrophin- releasing factors. These stimulate the anterior pituitary gland to produce FSH and luteinising hormone (LH). - FSH acts on the seminiferous tubulesto bring about the production of yhe sperm, whereas LH acts on the intrestetial cells that produce testosterone. - Testosterone. This hormone is responsible for the secondary sex characteristics – namely depending on the voice, growth of genitalia and growth of hair on the chest, pubis, and axilla and face. Spermatogenesis process : Full Spermatogenesis is achieved in most male by their 16 th years and then continues throughout life. Spermatogenesis takes place in the seminiferous tubules under the effect of FSH and testosterone. As the spermatozoa develop, they take about 10 days to be mature. - Spermotogonia: are the primitive structure and reproduce by mitosis then they nourish by sertoli cell and develop into. 105 - Primary spermatocytes: containing diploid number of chromosomes in their nuclei & undergo meiosis (reduction division ) one spermatocytes produces two daughter cells. - Secondary spermatocytes: which has haploid number, undergo a second meiotic division in order to make further re arrangement of genetic material. - Spermatids: are the celsls produced by the second meitic division the largest part of the spermatid the nucleus become the head of mature spermatozoon. Mature spermatozoon: Four mature spermatozoa have developed from one original spermatogonia. Amature sperm consists of: 1- Head: containing the nucleus & covered by acrosome, which contains hyaluronidase enzyme, which facilitates fertilization of ovuim. 2- Neck: Which units the head to the body. 3- Body: Which is concerned with the production of energy required for motility? 4- Tail: it is specialized for motility. Sperm store in genital system 42 days in male genitalia & can live only 2 or 3 days in the female genital tract. Sperm Production & Transportation Passage of sperm through the male reproductive system Organ Function 106 Testes - Produce spermatogenic cells. - Produce testosterone . Seminiferous Trubules Epididymis - Divide spermatocytes by meiosis . - Stores mature spermatozoa . - Moves sperm along tract by smooth muscle action. - Contributes secretions to seminal fluid . Ductus deferens - Stores spermatozoa and tubal fluid in its Ampulla . - Carries spermatozoa to duct of seminal vesicle by muscular contraction . - Contribute nutrient – laden secretion and prostaglandins to semen . Seminal vesicles - Join ducts deferens to become ejaculatory duct . - Extends from junction of ducts deferens and seminal vesicles through prostate gland to prostatic urethra, carrying sperm. Ejaculatory duct - Secrete viscid alkaline fluid, contributing to semen and deacidifying vaginal environment. Bulbourethral Glands - Counteracts acidity of semen by addition of alkaline secretions to increase sperm motility. (Cowper’s glands) - Allows excretion of ejaculate to exterior . Prostatc urethra - Permits exit of semen . Pentile urethra 107 (Corpus Spongiosum) External urethral Orifice Function of the male reproductive system: As in the female, the male reproductive organs are stimulated by the gonadotrophic hormones from the anterior lobe of the pituitary gland . The follicle stimulating hormone stimulates the seminiferous tubules of the tubules of the testes to produce the male germ cell the spermatozoa (Fig . 15:20 ). The spermatozoa then pass through the epididymis, the urethra coitus and consists of : 1- Spermatozoa 2- A viscid fluid which helps to nourish the spermatozoa , secreted by the seminal vesicles 3- A thin lubricating fluid produced by the prostate gland 4- Mucus secreted by glands in the lining membrane of the urethra. Puberty in the Male: This occurs between the ages of 13 and 16 years. Luteinising hormone or , as it called in the male , the interstitial cell stimulating hormone (ICSH) from the anterior lobe of the pituitary gland stimulates the interstitial cells of the testes to produce the hormone testosterone . This hormone influences the development of the body to sexual maturity. The changes which occur at puberty are: 1- Growth of muscle and bone and a marked increase in height. 2- The voice ‘breaks’ due to enlargement of the axillae, the prostste gland. 108 3- Growth of hair on the face, on the axillae, the chest, the abdomen and the pubis. 4- Enlargement of the penis, the scrotum and the prostate gland. 5- Maturation of the seminiferous tubules and the production of spermatozoa. In the male fertility and sexual ability tend to decline gradually with ageing. There is no period comparable to the menopause in the female. SEXUAL HEALTH Outline: - Objectives. - Introduction. - Definition of sexual health. - Source of sexual arousal. - Sexual responses cycles. - Factors affecting sexual function. 109 SEXUAL HEALTH Objectives: General objectives: At the end of this lecture each student should be able to acquire complete scientific knowledge about sexual health. Specific objectives: At the end of this lecture each student should be able to: - Define sexual health. - Enumerate source of sexual arousal. - Explain sexual response cycles. - List factors affecting sexual function. 110 Sexual Health Introduction: Human sexuality response is complicated: Biopsycho-social phenomena in which internal and external stimuli are modulated by brain through central and peripheral nervous system, it result in cascade of biochemical hormone and circulatory changes that lend to cognitive and physical sexual arousal. Sexual self-concept: How individuals perceive themselves in terms of gender, masculinity or feminity, and their adoption of effectives sex-role behaviors has an effect on their relationship with peers, adult, and members of the opposite sex. Gender: Is a biologic concept that refers simply to an individual's sex, male or female. Children's idea of their gender is usually fixed by 3 years of age. Biological differences between males and females include: primarily 111 chromosomal and anatomic differences and physiologic differences in the endocrine and genitourinary systems. Non biologic concepts also are important for an understanding of sexuality. Masculinity and femininity: Are culturally prescribed, reinforced characteristics of the sexes that are independent of gender. Sex-role behaviors: Are behaviors commonly assigned to men and women; these are more likely to change in response to situational demands. Definition of sexual function: The physiological response to sexual stimulation follows the same pattern in the male and female, a four stage. Normal sexual intercourse: Defined as anything erotic which gives pleasure to both partner, who are consenting adults, and doesn't hurt anyone. Masturbation: The response follows the same pattern regardless of the source of stimulation and orgasm achieved by hetro-or hemo-sexual coitus. Definition of sexual health: The World Health Organization defines sexual health as "the positive integration of somatic, emotional, intellectual, and social aspects of sexual being in ways that are positively enriching and that enhance personality, communication, and love". Woods suggests that sexual health function sexual self-concept, and sexual relationship, which are interrelated over the life span. 112 Sexual health ahs always been apart of human life and is a complex phenomena that involve physical, psychological, cultural, and social aspects. Source of sexual arousal: Some stimuli may lead to sexual arousal without any prior experience or learning called (primary erotic stimuli) as light touch on any body surface and particularly on the genitalia (secondary erotic stimuli) are learned as kissing by all types or mouth to mouth stimulation touching. The arousal lead to sexual excitation when stimulation the genitals in male and female, breasts are the most obvious example but erogenous zones can be found all-over the body. Many people the lips, neck, and inner thighs are erogenous zones. And inner surface of the forearm, ears, armpit, clitoral stimulation is often more intense than vaginal stimulation and is more likely to induce multiple orgasm. Sexual response cycles: The human sexual response cycle, or how the human body responds to sexual arousal, is composed of four distinct phases: 1. Excitement phase: a. In women, the following occur: - Vaginal lubrication increases. - The inner two-thirds of the vagina begins to lengthen and distend, the outer one-third undergoes slight thickening, and the body pf the uterus is pulled upward. The vaginal walls become congested with blood and darken in color, and the clitoris increases in diameter, possibly with slightly increased tumescence of the glans clitoris. - The labia minora become engorged with blood and increase in size. 113 - The libia majora flatten somewhat and retract away from the middle of the vulva. - The nipples become erect, and breast size increases. - Flushing occurs in approximately 75% of women. b. In men, the following occur: - Penile erection beginning. - Scrotal skin becomes congested and thick. - Testes elevate into the scrotal sac. - Some nipple erection may occur. - Flushing may occur. - Heart rate and blood pressure begin to. - Generalized muscle tension increase increases, with a tendency toward involuntary muscle contractions. 2. Plateau phase: a. In women, the following occur: - The walls of the outer one-third of the vagina become further engorged with blood, decreasing the internal vaginal diameter. - The labia minora become further engorged with blood and darken and swell. - The clitoris retracts and is covered by the clitoral hood; the clitoral body decreases in size by about 50%. - The nipple become further engorged. - Flushing may spread to the abdomen, thigh, and back. - Muscle tension increases. Breathing becomes deeper; heart rate and blood pressure increase markedly as tension rises toward orgasm. b. In men, the following occur: 114 - The penis further enlarges sometimes undergoing color changes, corresponding to reddening of the female labia. - Preorgasmia emission may from cowper glands. - The testes continue to be elevated, enlarge, and rotate (approximately 30% degrees). - Heart rate, blood pressure, and respiratory rate continue to increase. - Muscle tension increases. 3. Orgasmic phase: a. In women, the following occur: - Strong muscular contractions occur in the outer one-third of the vagina, and the inner two-thirds expands. - The uterine muscles contract. - No observable changes occur in the labia majora, labia minora, clitoris, or breasts. - Flushing reaches a peak of color intensity and distribution. - Possibly strong muscular contractions, both voluntary and involuntary, may occur in many parts of the body, including the rectal sphincter muscle. - Respiratory rate may reach a peak of two to three times normal, heart rate may double, and blood pressure may increase as much as one-third above normal. b. In men, the following occur: - Rhythmic contractions expel semen from the epididymis through the vas deferens, seminal vesicles, prostate gland, urethra, and urethral meatus. - Testes are at maximum elevation, size and rotation. 115 - Flushing reaches its peak. - Heart and respiratory rates also peak. - A general loss of voluntary control occurs. - A refractory period being as the final contractions of the urethral walls occur. 4. Resolution phase: a. In women, the following occur: - Blood engorging the walls of the outer one-third of the vagina disperses rapidly. - The inner two-thirds of the vagina gradually shrinks, and color returns to pre-excitement shade. - The uterus descends, and the cervix dips into the seminal pool. - The libia minora and majora return to unstimulated thickness and close toward the midline. - The clitoris protrude from under the clitoral hood, and eventually returns to pre-stimulated size. - Flushing disappears. - Muscles relax quickly. - Heart rate and blood pressure return to normal. b. In men, the following occur: - More than 50% of the erection is lost rapidly in the first stage of resolution, with the penis gradually returning to its unstimulated size during the second stage. - The scrotum gradually loses its congested and thick status. - The testes descend and return to normal size. - Nipple erection subsides. 116 - Flushing disappears. - Heart rate, blood pressure, and respiratory rate return to normal. - General muscle relaxation occurs. Factors affecting sexual function: 1. Child hood experience: This affects adult sexuality and is linked with unconscious motivation and the Oedipus-Electra conflict. 2. Partner rejection: An unsuitable relationship with partner rejection and failure to communicate is clearly unlikely to be associated with good sexual function. 3. Ignorance and inadequate techniques: Satisfactory sexual function depends on both partners receiving adequate stimulation and being free to respond to this. Ignorance may lead to sexual anxiety and fears of failure. In the male this may cause premature ejaculation which enhances the fear of failure and may lead to impotence; in the female such fears, often allied to inadequate understanding of the clitoral stimulation and communication about this in a partnership, cause a dry vagina, dyspareunia and eventually frigidity. 4. Disease: General ill health and chronic pain decrease libido in both sexes long standing uncontrolled diabetes mellitus may be associated with partial impotence; vaginal or pelvic pathology may cause dyspareunia, and the pain experienced during intercourse leads to fear and rejection of coitus. Many other disorders alter sexual function, from the rigid limbs of the spastic to the problems following ileostomy. Chronic and progressive disease such as multiple sclerosis poses a special problem because genital 117 sensation disappears in the female. A couple may be helped to understand the pleasure of oral sex and so prolong a happy sexual relationship. 5. Drugs: Drugs usually diminish rather than enhance sexual pleasure, and most aphrodisiacs are pharmacologically inactive. If they do enhance erotic behavior it is by placebo effects. Small doses of alcohol, barbiturates and amphetamines may release inhibitions and apparently enhance sexuality, but chronic abuse of all of them causes sexual depression. Impotence is a frequent complication of methylodopa, and many other drugs also depress sexual function. 6. Pregnancy: - During pregnancy, the woman's desire for sex may be altered owing to fatigue, nausea, and discomforts of pregnancy. - Breasts may be painful to touch, especially during the first trimester. Some men may find the normal increase in the amount and odor of vaginal discharge during pregnancy "a turn of", others do not. - Other sexual concerns during pregnancy include dyspareunia and male erectile dysfunction. - Some women and couple need "permission" to be sexuality active during pregnancy, long with reassurance that female orgasm will not harm the fetus. - For a couple who cannot have or who choose not to have intercourse during pregnancy, kissing, hugging, and oral or manual genital stimulation can be satisfying expressions of closeness and intimacy. 7. Menstruation: 118 During the second half of the menstrual cycle, the luteal phase there is increased fluid retention and vaso congestion in the woman's lower pelvic, because some vaso congestion is already present at the beginning of the excitement stage of the sexual response, women appear to reach the plateau stage more quickly and achieve orgasm more readily during this time women also seen to be more interested in initiating sexual relation at this time. 8. Cultural factors: Cross-cultural studies have supported the existence of sex differences in the areas of aggressiveness and dominance. SEXUAL DYSFUNCTION Objectives: General Objective: At the end of this lecture the student should be able to acquire complete knowledge about sexual dysfunction. Specific objectives: - Define of sexual dysfunction. - Explain the causes of sexual dysfunction. - Recognize the classification of sexual dysfunction. - Explain the types of sexual dysfunction. - Enumerate the sexual activity with aging. 119 SEXUAL DYSFUNCTION Outlines: Introduction. Definition of sexual dysfunction. Incidence. Etiology. Classification. - Primary sexual dysfunction. - Secondary sexual dysfunction. - Situational sexual dysfunction. Types of sexual dysfunction. Female sexual dysfunction. A. Sexual desire disorder. - Hypoactive sexual desire. 120 - Sexual aversion. B. Sexual arousal disorder. - Frigidity. C. Orgasmic disorder. - Life long an orgasmia (primary). - Intermittent an orgasmia. D. Sexual satisfaction disorder. - Dyspareunia. - Vaginismus. Male sexual dysfunction. A. Sexual desire disorder. B. Sexual arousal disorder. - Impotence. C. Orgasmic disorder. - Premature ejaculation. Sexual Dysfunction Introduction: The human sexual response is a complex process that is made up of leamed responses based on cultural, religious and socioeconomic factors, it may be affected by organic diseases, pharmacological agents, or by situational and psychological factors of the individual's life. Women had been so inhibited by their culture that some had lived through courtship marriage, child bearing, and men's pause without ever experiencing their bodies in sexual arousal, orgasm or a sense of sexual freedom. Definition of sexual dysfunction: Is the decreased, disturbed or absence of sexual interest or sexual responses to adequate stimulation. Incidence: 121 There is insufficient data to determine the incidence or prevalence of sexual dysfunction according to age group. It can be range of 18-73 years as follows: - Lack of sexual desire (33% - 38%). - Lack of excitement (lubrication) – (14%-18%). - Lack of orgasm (an orgasmia) – (15% - 24%). - Lack of pleasure (16% - 21%). Etiology: The cause of sexual dysfunction are un known, but there are multifactors: - Health (physical & emotional). - Life style. - Sociocultural characteristics. - Sexual experience. Risk predictors for sexual dysfunction in women: - Decrease in household income. - Emotional problems or stress (ex. mastectomy). - Sexual forced by man. - Sexually touched as a child (ex. rape). - History of STDs. - Urinary tract symptoms. - Poor to fair health. - Previous abortion. Classification: Sexual dysfunction can be classified as follows: 122 - Primary sexual dysfunction: has sexual dysfunction with the first time sexual intercourse. - Secondary sexual dysfunction: has sexual dysfunctions after successful times of previous sexual intercourse. - Situational sexual dysfunction: the functions of sexual responses are present in some situations but not in others. Female sexual dysfunction: A. Sexual desire (libido) disorder: Traumatic head injury, temporal lobe epilepsy, acromegaly and back injury decrease libido, sexual desire can be categorized as follow: Hypoactive sexual desire: Is characterized by a persistent or recurrent insufficient or absence of sexual fantasies or desire for sexual activity. This form can be affected by woman's general physical and psychological health, hormonal abnormalities, medication (ex. antidepressant). Sexual aversion: Is recurrent or persistent avoidance of coitus. This form can be associated with the following: - History of physical; or sexual abuse. - Vaginismus. - Dyspareunia (superficial or deep dyspareunia). - Extensive negative feeling about relationship. - Aversion of semen (a phobic form of disorder and is very difficult to treat). Sexual desire disorder: can also be categorized as: - Primary inhibited sexual desire. - Secondary inhibited sexual desire. 123 B. Sexual arousal disorder: Is defined as the absence or partial lack of physical signs of arousal during the excitement phase of the sexual response cycle, with other phases being intact. Frigidity: Lack or insufficient lubrication during sexual intercourse. Pathophysiology: Oestrogen deficiency compromises blood flow within the vaginal mucosa and results in decreases lubrication. Causes: Related to physical as (vaginal stenosis, scarring, infection…), emotional as (lack of stimulation, poor partner relationship, stress …..). C. Orgasmic disorders: Is defined as the persistent or chronic recurrent inability to reach orgasm (an orgasmia). This condition can be classified as follows: - Life long an orgasmia or primary an orgasmia (the woman never reaches orgasm during sexual intercourse) affect about 10% of women. - Intermittent an orgasmia (situational an orgasmia) is reported in approximately 50% of women. The causes of female anorgasmia: - Traumatic sexual experiences (rape). - Psychotropic medications (thioridazine, fluphenazine or major tranquilizers and anti depressants). - Alcohol consumption and recreational drugs. 124 - Environmental contact with pesticides lead. - Physical origin (pelvic surgery, spinal cord injury or surgical intervention). - Emotional disorders or poor partner relationship. D. Sexual satisfaction disorder: Causes: Psycho-social interpersonal, environmental, cultural, general health, current and past medication, religious and family characteristics. Dyspareunia: Is chronic recurrent genital pain generated before, during or after sexual intercourse. It is disorder which leads to depression, anxiety and sexual dysfunction. Causes: Post delivery or post surgical scarring, vaginal stenosis, PID, or endometriosis. Dyspareunia is sub classified as follow: - Superficial dyspareunia: Is pain during pineal insertion and is usually caused by vulvo-vestibular or vaginal disorder. - Deep dyspareunia: Occurs upon deep pineal penetration and is frequently experienced after surgery, PID and pelvic endometriosis. - Diffuse dyspareunia: Is the presence of superficial and deep penetration pain. Long-lasting diffuse dyspareunia is highly refractory to treatment. Vaginismus: Is recurrent chronic involuntary contraction of the distal third of the vagina and makes pineal penetration of the vagina difficult. Causes: Unpleasant sexual experience, rape. Un expressed negative feeling toward a sex partner, fear of pain, fear of pregnancy. 125 Male sexual dysfunction: Normal male coital function requires arousal through mental, visual or tactile stimulation, erection (parasympathetic), penetration, ejaculation (sympathetic) and resolution. Causes of male sexual dysfunction are related to organic, pharmacological or psychological. A. Sexual desire disorder: Causes: Physical or organic as (illness, surgery). Psychological as anxiety, fear of woman poor partner relationship, mental illness. B. Sexual arousal disorder: Importance: is defined as absence or inability of maintain erection for the end of the sexual intercourse. Causes: - Congenital anomalies such as spina bifida or acquire neurological problems as tumours or trauma in spinal cord. - Psychological problem as anxiety, depression or stress. - Medical disorders as DM, liver failure, myxoedema or hyper prolactinemia. - Drugs as hypotensive, psychotropic, alcohol. - Infection in urogenital tract. C. Orgasmic disorder: Premature ejaculation. Causes: - Congenital abnormalities such as hypospadias. 126 - Drugs which affect neurological control. - Psychological problems as stress, anxiety. 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