HOUSTON COMMUNITY COLLEGE SPRING BRANCH CAMPUS BIOLOGY 2416 /GENETICS/ SPRING 2013, COURSE NUMBER 32609 Instructor: Dr. Jessica A. Moody Jessica.Moody@hccs.edu TEXTBOOK: Russell, Peter J. 2010, iGenetics: A Molecular Approach, San Francisco: Benjamin Cummings Publishers, 3rd Ed. Please bring your book to each class. You must also bring a bound composition notebook (for lab). LABS: Friday: Room 529 8:00-11:00 a.m. LECTURES: Friday: Room 511 12:00-3:00 p.m. OFFICE HOURS: By appointment only COURSE DESCRIPTION: Study of the principles of molecular and classical genetics and the function and transmission of hereditary material (DNA). Will include genetic engineering (manipulation of DNA in the lab to produce a useful product). May include population genetics (study of genetic variation within populations) and quantitative genetics. EMAIL: You will need an email account. Outside class, I will communicate primarily by email. You are responsible for checking your email frequently. Free internet access is available at TCSC 110 and Westgate 228. Enrollment at HCC automatically triggers a free email account: first.last@student.hccs.edu. PREREQUISITE: BIOL 1406 (General Biology I) GENERAL GUIDELINES 1. ATTENDANCE: Roll will be taken, and I expect students to attend all classes. Good class attendance is absolutely essential to do well in this course! I reserve the right to drop a student after missing in excess of 12.5% of the hours of instruction. It is a good idea to exchange names and phone numbers with others in the class so that you can obtain the information you missed as quickly as possible. In case of a prolonged absence (2 or more class meetings), the instructor should be notified. In the event you are absent, it is your responsibility to check for information you missed as a result of your absence. Please do not contact me to find out what material was covered. 2. NOTES: Notes for each lecture will be posted prior to class on the Learning Web. It is your responsibility to access and print the notes. You MAY NOT share these files with anyone outside of class without express permission of the instructor, nor may you post any part online. Bring the notes to class with you to serve as a discussion outline. You must take your own notes and read the textbook to do well in this class! Anything that I discuss in class is fair game for an exam. 3. EXAMS: Exams will be given at the beginning of class time and you will have 90 minutes to complete the exam. After the first exam has been completed, submitted, and that student has left the room, no more exams will be passed out. DON’T BE LATE TO AN EXAM! Restroom breaks are not allowed during the exam. No make-up lecture exams or quizzes will be offered. 1 4. DUE DATES: If you are absent for any reason, you will not be allowed to make up missed inclass assignments or quizzes from that day. Quizzes are generally given at the beginning of the class period. If you are late to class, you will not be given extra time to complete your quiz. If you arrive after the quiz has ended, you will receive a zero for that quiz. Late homework/lab assignments will be accepted up to the next class meeting and are penalized 50%. 5. All phones and beepers must be turned off or be in silent (courtesy) mode. You may not leave the room during a test to answer a phone call. Should this occur your test will be taken up immediately. There will be no use of cell phones in the laboratory. I will allow the use of laptops in class, but only if you are using them for note taking purposes. 6. LAB NOTEBOOK: You must maintain your own bound lab notebook in accordance with industry rules. I will explain what that entails in class. The notebook MUST be brought to every lab session. The notebook will be graded at the end of the semester, and will total 5% of the course grade. 7. LAB REPORTS: You will have to write a formal lab report for most lab exercises based on the raw data recorded in your lab notebook. Lab reports are due as shown on the tentative schedule. Beware lab exercises may take more than one lab session to complete. We will go over the lab report format in class. Although you may discuss data with your lab partner, each lab report must be an individual effort (NO copying) and must be turned in separately when due (NOT in the lab notebook). The lab reports will total 10% of the course grade. Unstapled lab reports and other assignments will not be accepted. 8. LABORATORY SAFETY. Students are expected to abide by the rules of safety at all times during the laboratory exercises. 9. RESEARCH PAPER: An original paper (a minimum of 1500 words, turned in as a hardcopy) will be due week 15. Topic areas may include 1) a biography of a famous geneticist detailing his/her contribution to the field of genetics, 2) a commercial biotechnology product involving genetics, 3) a genetic disease. Or 4) genetics in the news (in 2011-2012). To avoid duplicate topics, or topics that are too broad to cover in 1500 words, you must submit two potential paper topics for review by week 6. A one-page outline is due week 11 and will be graded as an assignment. For full credit, papers must include a minimum of five references from at least three different types of resources (book, popular magazine, scientific publication, newspaper, personal communication with an established scientist, or (reliable!) web source). The paper will total 20% of the course grade. 10. SCHOLASTIC DISHONESTY: Students caught cheating will receive a grade of ZERO for the exam. Repeat cheaters will receive a letter grade of F for the course. Papers may be checked electronically for plagiarism. Plagiarized papers will be awarded a grade of ZERO. 11. STUDENT CONDUCT. Abusive language or disruptive behavior by a student(s) will not be tolerated. Talking and sleeping in class during lectures is distracting to the professor and to other students. It will not be tolerated. 12. STUDENT HANDBOOK- important information for all students. Also contains the mission statement of the Houston Community College System (available online at HCCS home page.) 13. DISABILITIES: Any student with a documented disability (e.g. physical, learning, psychiatric, vision, hearing, etc.) who needs to arrange reasonable accommodations must contact the Disability Services Office at the respective college at the beginning of each semester. Faculty is authorized to provide only the accommodations requested by the Disability Support Services Office.For questions, contact Donna Price at 713.718.5165 or the Disability Counselor at your college. To visit the ADA Web site, log on to www.hccs.edu, click Future Students, scroll down the 2 page and click on the words Disability Information. District ADA Coordinator – Donna Price – 713.718.516 Central ADA Counselors – John Reno – 713.718.6164, Martha Scribner – 713.718.6164 Northeast ADA Counselor – Kim Ingram – 713.718.8420 Northwest ADA Counselor – Mahnaz Kolaini – 713.718.5422 Southeast ADA Counselor – Jette Friis – 713.718.7218 Southwest ADA Counselor – Dr. Becky Hauri – 713.718.7910 Coleman ADA Counselor – Dr. Raj Gupta – 713.718.7631 14. CORE CURRICULUM. Essential to the learning process are six basic intellectual competencies. Among the objectives covered in this course the following components will be addressed such as reading, writing, speaking, listening, critical thinking and computer literacy. 15. As mandated by the Texas State Legislature students who repeat a course for a third or more times may soon face significant tuition and fee increases at HCC and other Texas public colleges and universities. Please ask your Professor or Counselor about opportunities for tutoring or other possible assistance prior to considering course withdrawal or if you are not receiving passing grades. GRADE DETERMINATION: Your grade will be determined by the following Lecture Exams* Details 4 Exams: T/F, short answer, multiple choice, essay Various times throughout the semester; lecture & lab Homework/Quizzes Lab Reports Paper Lab Notebook Percent of Final Average 60% 5% Secrets of the Rainforest; pGLO Transformation; Restriction Digest; Crime Scene Investigator PCR Research paper- details to be discussed in class 10% Due at the end of the semester 5% Total: 20% 100% *LOWEST EXAM GRADE WILL BE DROPPED LETTER GRADE ASSIGNMENT: Letter Grade A Final Average in Percent > 89.5 B 79.5 – 89.5 C 69.5 – 79.5 D 59.5 – 69.5 F < 59.5 3 Tentative Instructional Outline: *Note: Subject to Change* Week Number 1 JAN 18 LAB: Overview LECTURE: CH1: Genetics: An Introduction. CH2: The Genetic Material. 2 JAN 25 LAB: Lab Safety; How to Keep a Lab Notebook; How to write a lab report; Genes in a Bottle LECTURE: CH3: DNA Replication. CH4: Gene Function. 3 FEB 1 LAB: Online micropipetting; Micropipetting and microcentrifuge practice lab. LECTURE: CH5: Transcription. CH6: Translation. 4 FEB 8 Access Excellence ACTIVITY and WORKSHEET and Micropipetting Practice Sheet due @ 8am LAB: Secrets of the Rainforest: Part 1 LECTURE EXAM 1 @ 12PM. LECTURE: CH7: DNA mutation, repair, and transposable elements. 5 FEB 15 LAB: Secrets of the Rainforest: Part 2 LECTURE: CH8: Mapping and Sequencing of Genomes. CH9: Functional and Comparative genomics. 6 FEB 22 LAB: Secrets of the Rainforest: Part 3 2 PAPER TOPIC SUGGESTIONS DUE @ 8AM. LECTURE: CH10: Recombinant DNA Technology. 7 MAR 1 Lab Report- Secrets of the Rainforest due @ 8am LAB: pGLO Transformation: Part 1 LECTURE: CH12: Mitosis and Meiosis. CH11: Mendelian Genetics. 4 Week Number 8 MAR 8 9 MAR 22 LAB: pGLO Transformation: Part 2 LECTURE EXAM 2 @ 12PM. LECTURE: CH13: Extensions of Mendelian Genetics. SPRING BREAK MAR 11-17 Lab Report- pGLO Transformation due @ 8am LAB: Restriction Digest and Analysis of Lambda DNA LECTURE: CH14: Gene Mapping in Eukaryotes 10 MAR 29 11 APR 5 NO CLASS- Easter Break LAST DAYFOR ADMINISTRATIVE WITHDRAWALS- 4:30 pm APR 1 LAB: Crime Scene Investigator PCR: Part 1 One-page paper outline due @ 8am. LECTURE: CH15: Genetics (gene mapping) of bacteria and bacteriophages. CH16: Variations in Chromosome Structure and Number. 12 APR 12 Lab Report- Restriction Digest and Analysis of Lambda DNA due @ 8am LAB: Crime Scene Investigator PCR: Part 2 LECTURE: CH 17: Regulation of Gene Expression in Bacteria and Bacteriophages. 13 APR 19 LAB: PV92 Informatics: Part 1 LECTURE: LECTURE EXAM 3 @ 12PM. CH18: Regulation of gene expression in Eukaryotes. 14 APR 26 Lab Report- Crime Scene Investigator due @ 8am LAB: PV92 Informatics: Part 2 LECTURE: CH19: Genetic Analysis of development. CH20: Genetics of Cancer. 15 MAY 3 LAB: PV 92 Informatics: Part 3 NOTEBOOK DUE @ 8AM. PAPER DUE @ 8AM. LECTURE: CH21: Population Genetics. CH22: Quantitative Genetics. 16 MAY 10 Final Exam- 8 AM 5 IMPORTANT DAYS See calendar for exact date and time/ withdrawal, drop, holidays…etc. 1/13/20213 Last day drop/add/swap 1/28/2013 Official date of record. 4/1/2013 Last day for administrative withdrawals-4:30 pm 5/5/2013 Instruction ends HCC Course Withdrawal Policy The State of Texas imposes penalties on students who drop courses excessively. Students are limited to no more than six total course withdrawals throughout their educational career at a Texas public college or university. In order to withdraw from your class, you MUST first contact your professor, PRIOR to the withdrawal deadline to receive a “W” on your transcript. After the withdrawal deadline has passed, you will receive the grade that you would have earned. Zeros averaged in for required coursework not submitted will lower your semester average significantly, most likely resulting in a failing grade of an “F”. It is the responsibility of the student to withdraw from the class; however, your professor reserves the right to withdraw you without your request due to excessive absences. If you do not feel comfortable contacting your professor to withdraw, you may contact a counselor. However, please do not contact both a counselor and your professor to request a withdrawal; either one is sufficient. The final withdrawal deadline for regular term is 4/1/13 at 4:30pm. Classes of other duration (mini-term, flex-entry, 8-weeks, etc.) may have different final withdrawal deadlines. Please review HCC’s online “Academic Calendars by Term” or contact the HCC Registrar’s Office at 713.718.8500 to determine mini-term class withdrawal deadlines. It’s your responsibility to contact me regarding withdrawal prior to the withdrawal deadline; your absences or disappearance from the class doesn’t mean you will receive a (W). You will receive a (W) only if you contact me prior to the deadline. EGLS3 -- Evaluation for Greater Learning Student Survey System At Houston Community College, professors believe that thoughtful student feedback is necessary to improve teaching and learning. During a designated time, you will be asked to answer a short online survey of research-based questions related to instruction. The anonymous results of the survey will be made available to your professors and division chairs for continual improvement of instruction. Look for the survey as part of the Houston Community College Student System online near the end of the term. 6 7