Table S2. Top 25 of genes modulated 1.5-fold or more (p<0.01) by CoCl2 than by WC-Co in PBMC (15 min)
Gene Name
Systematic Name
Description
function
Fold
change
10,27
RIN2
NM_018993
Ras and Rab interactor 2
Inhibitor of Ras mediated signalling
CD93
NM_012072
CD93 molecule
Cell surface glycoprotein and type I membrane protein involved
in clearing of dying cells
LRRC25
NM_145256
Leucine rich repeat containing 25
Unclear function
G0S2
NM_015714
G0/G1switch 2
Regulator of cell cycle
MCEMP1
NM_174918
Mast cell-expressed membrane protein 1 Transmembrane protein involved in degranulation
PTGS2
NM_000963
Prostaglandin-endoperoxide synthase 2
Key enzyme in biosynthesis of prostaglandins, prostacyclins
and thromboxanes and acts as dioxygenase and peroxidase
during inflammation and mitogenesis
7,62
IL1RN
NM_173842
Interleukin 1 receptor antagonist
Inhibits IL-1 signalling
7,13
MARCH1
AK000675
Membrane-associated ring finger
(C3HC4) 1
E3 ubiquitin ligase, key mediator for cytokine controlled
modulation of CD4T cell dependent immune response
6,57
CXCL5
NM_002994
Chemokine (C-X-C motif) ligand 5
Cytokine belonging to the CXC chemokine family
6,56
FPRL1
NM_001462
Formyl peptide receptor-like 1
G protein coupled receptor involved in chemotaxis
6,26
ANGPTL4
NM_139314
Angiopoietin-like 4
Glycosylated protein involved in glucose homeostasis, lipid
metabolism and insulin sensitivity
6,17
MMP10
NM_002425
Involved in the breakdown of the extracellular matrix
6,09
P2RY2
NM_176072
Matrix metallopeptidase 10 (stromelysin
2)
Purinergic receptor P2Y, G-protein
coupled, 2
G protein coupled receptor participating in cell cycle control
5,62
PTX3
NM_002852
Pentraxin-related gene, rapidly induced
by IL-1 beta
Protein able to bind selected pathogens and to activated the
classical complement pathway
5,42
LILRB1
NM_006669
Leukocyte immunoglobulin-like receptor, Inhibits stimulation of the immune response
subfamily B (with TM and ITIM domains),
member 1
9,42
9,41
7,95
7,76
5,37
CA12
AK000158
Carbonic anhydrase XII
Type I, membrane protein, zinc metalloenzyme that catalyzes
the reversible hydration of CO
5,25
TNFRSF21
NM_014452
Activates NFκB and MAPK/JNK and induces apoptosis
4,97
CMKOR1
NM_020311
Tumor necrosis factor receptor
superfamily, member 21
Chemokine orphan receptor 1
G protein coupled receptor
4,92
TGM2
NM_004613
Catalyzes the formation of a bond between lysine and
glutamine
4,84
FCRLM2
NM_001002901
Transglutaminase 2 (C polypeptide,
protein-glutamine-gammaglutamyltransferase)
Fc receptor-like and mucin-like 2
Unclear function
4,65
CXCL3
NM_002090
Chemokine (C-X-C motif) ligand 3
Cytokine belonging to CXC chemokine family controlling
migration and adhesion of monocytes
4,48
FPR1
NM_002029
Formyl peptide receptor 1
G protein coupled receptor involved in chemotaxis
4,35
HCK
NM_002111
Hemopoietic cell kinase
Protein tyrosine kinase
4,34
CLEC4D
NM_080387
C-type lectin domain family 4, member D Unclear function
4,32
SLPI
NM_003064
Secretory leukocyte peptidase inhibitor
4,32
Secreted inhibitor of serine proteases