COURSE SYLLABUS - Spring 2012
PMD 604 - Anatomy, Physiology & Pathophysiology II
Spring 2012
4.0 CREDIT HOURS
Class Hours: 1:00 PM to 3:00 PM Mondays & Fridays
COURSE PREREQUISITE(s):
Enrollment in Spring P-1 Curriculum
CONTACT INFORMATION:
Course Instructor
Dr. D. E. Hart
Professor, Department of Mathematics & Natural Sciences
Office - ALT 226
Email - hartde@dyc.edu
Telephone: 716-829-7847
Office hours by appointment
Secretary
Ms. Kathleen Anderson
Department of Mathematics & Natural Sciences
Office - ALT 230
Email - andersk@dyc.edu
Telephone: 716-829-8163
Course Description:
• Graduate Catalog Description
Comprehensive Anatomy, Physiology and Pathophysiology II + laboratory
provides a sequel to PMD 603 and 613; the course continues examination of organ
systems. Material includes anatomical description, physiological explanations, and
pathological states, considered as disruptions of the normal anatomy and physiology.
Etiology, pathogenesis, and treatment approaches will be discussed. This course will
undertake coverage of: cell physiology and response to injury, inflammation, fever,
healing, cell cycle and neoplasia, musculoskeletal and joint disorders, neurological &
psychological disorders, pathophysiology of selected endocrine glands, physiology and
disorders of the digestive system and selected auxiliary glands (liver and pancreas).
• Relation of Course to School Mission and Values
Course provides the student with fundamental knowledge supporting his/her
professional role of advising and delivering quality service to patients.
• Relation of Course to Other Courses in the Professional Curriculum
Course provides the student with fundamental knowledge enabling students to
progress to upper level courses, relying on notes and texts from this course as reference
materials.
EXPECTED EDUCATIONAL OUTCOMES AND COMPETENCIES AND
ABILITIES-BASED OUTCOMES:
I. Scientific Foundation: Student must acquire comprehension of scientific methods
and in-depth understanding of scientific principles to enable her/his identification of
problems related to drug therapies and their solutions.
The graduate is expected to be able to:
• Comprehend concepts of biomedical and pharmaceutical sciences
COURSE OBJECTIVES:
Upon successful completion of this course, the student will know and understand:
1. Anatomy and histology of each organ system (Scientific Foundation)
2. Physiology of organ systems (Scientific Foundation)
3. Pathophysiology of organ systems (Scientific Foundation)
COURSE CALENDAR:
DATE
TOPIC
Week 1
Jan 9, 13
Week 2
Jan. 16, Jan. 20
1. Review cellular A & P - endomembrane system & bioenergetics
2. DNA, chromosomes, RNA, ribosomes, protein synthesis & mutations
Holiday
3. Cellular responses to stress - adaptive changes, apoptosis & necrosis;
causes of cellular injury
4. Inflammation (acute & chronic), mechanisms of inflammatory response,
fever & healing
5. Immune response, T & B lymphocytes, clonal selection & expansion
6. Hypersensitivities, immunodeficiencies & autoimmune disorders```
EXAM 1 (no class Friday)
7. Regulation of cell cycle, disorders of cellular proliferation, neoplasia
& oncogenesis
8. Endocrine system: hormones, pituitary-hypothalamus-target organ
relationship
9. Endocrine disorders - diabetes, adrenal, pituitary & thyroid disorders
10. Reproductive physiology - male hormones & spermatogenesis; female
hormones, oogenesis & menstrual cycle
Holiday
11. Pregnancy - fertilization, implantation, placental development; hormonal
changes in pregnancy; lactation
12. Reproductive disorders in male (cryptorchidism, prostate) & female
(disorders of ovaries, uterus, breast & disorders of pregnancy)
EXAM 2 (no class Friday)
IPPEs
Week 3
Jan 23, 27
Week 4
Jan 30, Feb 3
Week 5
Feb 6, 10
Week 6
Feb 13, 17
Week 7
Feb 20, Feb. 24
Week 8
Feb 27, Mar 2
Weeks 9, 10
Mar 5 - 16
Week 11
Mar 19, 23
Week 12
Mar 26, 30
Week 13
Apr.9, 13,
Week 14
Apr 16, 19
Week 15
Apr 23, 27
Week 16
Apr. 30, May 4
Week 17
13. Nervous system organization, neurotransmission, sensory & pain
pathways; referred pain
14. Motor systems - spinal reflexes, brainstem, basal ganglia, cerebellum &
motor cortex; autonomic nervous system & adrenal medulla
15. Neurological disorders - cerebral circulation & cerebrovascular disorders;
brain & spinal cord injuries
16. Neurological disorders - infections, tumors, diseases of myelin &
degenerative diseases
Holiday
17. Bone metabolism, Ca homeostasis, disorders of bone growth
Osteoarthritis, rheumatoid arthritis & gout
Loose ends, review
EXAM 3 (no class Friday)
18. Digestive system anatomy & physiology; myenteric nervous system,
secretions, propulsion; chemical digestion & absorption
19. Physiology of liver - metabolism of carbohydrates, fats & proteins, other
metabolic functions; physiology of pancreas & its regulation
20. Disorders of alimentary canal - constipation, vomiting, diarrhea; regional
disorders
21. Liver disorders & pancreatic disorders
Loose ends, review
May 7, 11
Week 18
May 14
FINAL EXAM (Part I is on topics covered during weeks 15 - 17 and Part II is
Comprehensive)
No scheduled classes, course completed
GRADING:
Your final grade will be the average of your scores on four topic exams plus a
comprehensive final exam, all equally weighed for a total of 500 points. Letter grades
will be assigned using the guideline published in the DYC Catalog. (A: 93-100; A-: 90 –
93; B+: 87 – 89; B: 83 – 86; B-: 80 - 82; C+: 77 – 79; C: 73 – 76...)
SPECIFIC COURSE & INSTRUCTOR POLICIES
1.
Please turn off or silence your cell phone before you enter the room
2. Examination questions are based on lectures, assigned reading, powerpoints and
handouts. During exams, students are expected to “Act with honesty and integrity”
as stipulated by the SOP’s Professional Code of Conduct (contact Dr. Donegan for
copy). Exams 1, 2 and 3 are on Friday mornings
3.
Makeup examinations will not normally be offered
4. The Master Course Calendar is provided to help keep up with the minimum
material presented. Students are expected to be ready for class and should read the
texts/handouts before class. It is recommended that you form study groups to
discuss the subject matter and information that is missed. If extra help is needed, see
the appropriate instructor during office hours or by appointment.
5. Course materials (syllabus, lecture outlines, powerpoints and assignments…) are
posted on Department of MNS website http://campus.dyc.edu
TEXTBOOKS:
1.
Textbook of Medical Physiology, Guyton and Hall (12th Edition): Required
2.
Robbins Basic Pathology, Kumar, Abbas, Fausto and Mitchell (8th Edition):
Required
3.
Netter’s Clinical Anatomy, Hansen JT: Required
4.
Stedman’s Concise Medical Dictionary (Illustrated): Required
KEYWORDS:
Structure and Function of major body systems, cell biology, cell physiology, cellular
structure, basic principles and mechanisms of disease
All students are expected to read the syllabus, understand its implications, and abide
by it. The course coordinator has the right to make changes to the syllabus as needed.
For all topics not covered in this syllabus, please refer to the most recent version of the
student handbook.