COURSE SYLLABUS - Spring 2012 PMD 604 - Anatomy, Physiology & Pathophysiology II Spring 2012 4.0 CREDIT HOURS Class Hours: 1:00 PM to 3:00 PM Mondays & Fridays COURSE PREREQUISITE(s): Enrollment in Spring P-1 Curriculum CONTACT INFORMATION: Course Instructor Dr. D. E. Hart Professor, Department of Mathematics & Natural Sciences Office - ALT 226 Email - hartde@dyc.edu Telephone: 716-829-7847 Office hours by appointment Secretary Ms. Kathleen Anderson Department of Mathematics & Natural Sciences Office - ALT 230 Email - andersk@dyc.edu Telephone: 716-829-8163 Course Description: • Graduate Catalog Description Comprehensive Anatomy, Physiology and Pathophysiology II + laboratory provides a sequel to PMD 603 and 613; the course continues examination of organ systems. Material includes anatomical description, physiological explanations, and pathological states, considered as disruptions of the normal anatomy and physiology. Etiology, pathogenesis, and treatment approaches will be discussed. This course will undertake coverage of: cell physiology and response to injury, inflammation, fever, healing, cell cycle and neoplasia, musculoskeletal and joint disorders, neurological & psychological disorders, pathophysiology of selected endocrine glands, physiology and disorders of the digestive system and selected auxiliary glands (liver and pancreas). • Relation of Course to School Mission and Values Course provides the student with fundamental knowledge supporting his/her professional role of advising and delivering quality service to patients. • Relation of Course to Other Courses in the Professional Curriculum Course provides the student with fundamental knowledge enabling students to progress to upper level courses, relying on notes and texts from this course as reference materials. EXPECTED EDUCATIONAL OUTCOMES AND COMPETENCIES AND ABILITIES-BASED OUTCOMES: I. Scientific Foundation: Student must acquire comprehension of scientific methods and in-depth understanding of scientific principles to enable her/his identification of problems related to drug therapies and their solutions. The graduate is expected to be able to: • Comprehend concepts of biomedical and pharmaceutical sciences COURSE OBJECTIVES: Upon successful completion of this course, the student will know and understand: 1. Anatomy and histology of each organ system (Scientific Foundation) 2. Physiology of organ systems (Scientific Foundation) 3. Pathophysiology of organ systems (Scientific Foundation) COURSE CALENDAR: DATE TOPIC Week 1 Jan 9, 13 Week 2 Jan. 16, Jan. 20 1. Review cellular A & P - endomembrane system & bioenergetics 2. DNA, chromosomes, RNA, ribosomes, protein synthesis & mutations Holiday 3. Cellular responses to stress - adaptive changes, apoptosis & necrosis; causes of cellular injury 4. Inflammation (acute & chronic), mechanisms of inflammatory response, fever & healing 5. Immune response, T & B lymphocytes, clonal selection & expansion 6. Hypersensitivities, immunodeficiencies & autoimmune disorders``` EXAM 1 (no class Friday) 7. Regulation of cell cycle, disorders of cellular proliferation, neoplasia & oncogenesis 8. Endocrine system: hormones, pituitary-hypothalamus-target organ relationship 9. Endocrine disorders - diabetes, adrenal, pituitary & thyroid disorders 10. Reproductive physiology - male hormones & spermatogenesis; female hormones, oogenesis & menstrual cycle Holiday 11. Pregnancy - fertilization, implantation, placental development; hormonal changes in pregnancy; lactation 12. Reproductive disorders in male (cryptorchidism, prostate) & female (disorders of ovaries, uterus, breast & disorders of pregnancy) EXAM 2 (no class Friday) IPPEs Week 3 Jan 23, 27 Week 4 Jan 30, Feb 3 Week 5 Feb 6, 10 Week 6 Feb 13, 17 Week 7 Feb 20, Feb. 24 Week 8 Feb 27, Mar 2 Weeks 9, 10 Mar 5 - 16 Week 11 Mar 19, 23 Week 12 Mar 26, 30 Week 13 Apr.9, 13, Week 14 Apr 16, 19 Week 15 Apr 23, 27 Week 16 Apr. 30, May 4 Week 17 13. Nervous system organization, neurotransmission, sensory & pain pathways; referred pain 14. Motor systems - spinal reflexes, brainstem, basal ganglia, cerebellum & motor cortex; autonomic nervous system & adrenal medulla 15. Neurological disorders - cerebral circulation & cerebrovascular disorders; brain & spinal cord injuries 16. Neurological disorders - infections, tumors, diseases of myelin & degenerative diseases Holiday 17. Bone metabolism, Ca homeostasis, disorders of bone growth Osteoarthritis, rheumatoid arthritis & gout Loose ends, review EXAM 3 (no class Friday) 18. Digestive system anatomy & physiology; myenteric nervous system, secretions, propulsion; chemical digestion & absorption 19. Physiology of liver - metabolism of carbohydrates, fats & proteins, other metabolic functions; physiology of pancreas & its regulation 20. Disorders of alimentary canal - constipation, vomiting, diarrhea; regional disorders 21. Liver disorders & pancreatic disorders Loose ends, review May 7, 11 Week 18 May 14 FINAL EXAM (Part I is on topics covered during weeks 15 - 17 and Part II is Comprehensive) No scheduled classes, course completed GRADING: Your final grade will be the average of your scores on four topic exams plus a comprehensive final exam, all equally weighed for a total of 500 points. Letter grades will be assigned using the guideline published in the DYC Catalog. (A: 93-100; A-: 90 – 93; B+: 87 – 89; B: 83 – 86; B-: 80 - 82; C+: 77 – 79; C: 73 – 76...) SPECIFIC COURSE & INSTRUCTOR POLICIES 1. Please turn off or silence your cell phone before you enter the room 2. Examination questions are based on lectures, assigned reading, powerpoints and handouts. During exams, students are expected to “Act with honesty and integrity” as stipulated by the SOP’s Professional Code of Conduct (contact Dr. Donegan for copy). Exams 1, 2 and 3 are on Friday mornings 3. Makeup examinations will not normally be offered 4. The Master Course Calendar is provided to help keep up with the minimum material presented. Students are expected to be ready for class and should read the texts/handouts before class. It is recommended that you form study groups to discuss the subject matter and information that is missed. If extra help is needed, see the appropriate instructor during office hours or by appointment. 5. Course materials (syllabus, lecture outlines, powerpoints and assignments…) are posted on Department of MNS website http://campus.dyc.edu TEXTBOOKS: 1. Textbook of Medical Physiology, Guyton and Hall (12th Edition): Required 2. Robbins Basic Pathology, Kumar, Abbas, Fausto and Mitchell (8th Edition): Required 3. Netter’s Clinical Anatomy, Hansen JT: Required 4. Stedman’s Concise Medical Dictionary (Illustrated): Required KEYWORDS: Structure and Function of major body systems, cell biology, cell physiology, cellular structure, basic principles and mechanisms of disease All students are expected to read the syllabus, understand its implications, and abide by it. The course coordinator has the right to make changes to the syllabus as needed. For all topics not covered in this syllabus, please refer to the most recent version of the student handbook.