SUPPLEMENTARY MATERIAL Lesson III The Structure of DNA A DNA molecule consists of two strands twisted together in a double helix. Each strand is a string of bases, like beads on a string. There are four kinds of bases, which are called Guanine, Cystosine, Adenine, and Thymine. The order, or sequence, of the four bases G, C, A, and T determines the function of the gene. The bases of the two strands line up opposite each other - this is called base pairing. Base pairing has two rules: G always pairs with C, and A always pairs with T. A mutation (change in the sequence) can change the way a gene works. 1