Dilation Julius Špičák, Jan Martínek Institute for Clinical and Experimental Medicine, Prague Complications - terminology Immediate complications Technical failure Ineffectiveness Costs Extended hospitalization Patient dissatisfaction Complications Adverse effects Unplanned effects Dilation - indications 9 All kinds of GI and BP strictures which can be visualised endoscopically 9 Benign strictures 9 Malignancies - temporary relief only, stenting and debulking techniques should be preferred Stenoses of GIT Schatzki ring M.Crohn peptic stenosis Dilation - techniques 9 Balloons: Through-the-scope (TTS) Over-the-wire (OTW) Controlled-radial-expansion (CRE) 9 Bougies, olives 9 Temporary stenting 9 Electrocautery 9 Combined techniques Dilation of esophageal strictures without fluoroscopy Savary-Gilliard dilators, rule of three, 2-3 sessions within 10 days Malignant 30, benign 25 strictures N patients N sessions Immediate success Stent Complications 55 177 100% 5 0 Conclusions: Safe and effective in various conditions. Wang YG et al., World J Gastroenterol 2002;8:766-768. Esophageal dilation – comparison of balloon and bougienage TTS vs. Savary bougies, end point dilation: 45F / 15mm N Sessions/patient Balloon Bougie 17 1.1±0.1 17 1.7±0.2 Saed ZA et al. Gastrointest Endosc 1995;41:189-195 Esophageal balloon dilation - review Study Year Allmendiger Babu Goldthorn Hoffer Jayakhrisnan Johnsen Kukkady Lang Lisy Said Sandgren Sato Shah Yeming Lan 1996 2001 1984 1984 2001 1986 2002 2001 1998 2003 1998 1988 1993 2002 2003 Injury Noncaustic 5 5 8 9 35 10 0 34 21 25 33 17 16 13 74 Caustic 3 0 0 0 2 0 10 0 3 0 3 3 1 7 3 Perforation % 0 0 0 3.8 1.6 0 0.47 3.8 0 1.7 0 0 0.75 5 1.5 Failure % 0 20 25 33 0 0 0 0 0 0 21 0 5.8 10 97 Predictors of early recurrence of esophageal strictures 9 Heartburn 9 Hiatal hernia 9 Nonpeptic strictures 9 Narrow stricture diameter Said A et al. Am J Gastroenterol 2003;98:1252-1256 Esophageal dilatation in children Balloon dilatation, postesophagial atresia repair 63, reflux7, caustic 3 N, patients N, sessions Perforations Surgery Success 77 260 (3.4) 4 (1.5%) 1 75 (97%) Conclusions: safe and effective . Lan BLCL et al. J Pediatric Surg 2003;38: 1713-1715 Esophageal dilatation in children 4 Complications 2 Learning curve 2 Larger size balloon catheter than recomended Therapy: chest drainage, fasting, antibiotics collection on CT – surgery – 1 Lan BLCL et al. J Pediatric Surg 2003;38: 1713-1715 Endoscopic dilation in epidermolysis bullosa TTS dilation, 75% single (1-6) strictures, median 20 cm from incisors, Dilation 2-4x, appropriate pressure maintained 30 sec N patients N procedures Success Complications 53 182 49 0 Conclusions: safe and effective. Anderson SHC et al. Gastrointest Endosc 2004;59:28-32 Dilation of cervical web of esophagus Savary-Gilliard N Success Recurrence Minimal (self limited) hematemesis 16 100 % 0 3 (18%) Conclusions: simple, safe, effective. Sreenivas DV et al. Hepato-Gastroenterol 2002;49:188-190 Factors influencing application of endoscopic balloon dilatation for benign esophageal strictures TTS, CRE, 1-1.5 minutes, ↑3mm→15mm (rule of three) Effective treatment – solid or semisolid diet was sustained for more thatn 12 months Groups N Stricture length Success 11 2.6±1.1 Relapse 11 5.7±3.4 Failure 3 8< Mild complications:(oozing (self limited) bleeding, chest pain only Conclusions: Diameter and length of the stricture are predictive factors. Chiu YC et al. Endoscopy 2004;36:595-600 Temporary placement of an expandable polyester silicone-covered stent for treatment of benign esophageal strictures Polyflex stent, polyvinyl dilation prior stenting, etiology caustic 5, radiotherapy 4, surgery 3 N Mean N of dilations Success Complications 15 9.5 100% 0 Conclusions: enormously safe and effective. Repici A et al. Gastrointest Endosc 2004;60:513-519. Endoscopic treatment of benign esophageal stenosis with electrocautery Esophagojejunostomy due gastric carcinoma, sphincterotomy, six radial incisions N/succeess Complications 6/6 0 Brandimare G et al. Endoscopy 2002;34:399-401 Dysphagia without evident disease: dilate? TTS, 0.5-1 min Dilation N 6 months improvement Complications 43 84% 0% Sham 40 73% 0% Conclusions: Results do not support empiric dilation without evident cause of dysphagia. Scolapio JS et al. Am J Gastroenterol 2001;96:327-330 Evaluation of three interventional procedures in achalasia Fluoro control Dilation N Dysphagia relaps, 12 m Dysphagia relaps, 36 m Pain Reflux Bleeding 60 60% 90% 50% 26.7% 10% Stent Un/covered Partially/temporary 8 50% 66.7% 62.5% 62.5% 37.5% 65 9.2% 14.5% 40% 20% 12.3% Conclusions: Temporary partially covered metal stent was the best method. Complications were not characterized. Cheng Y-S et al. World J Gastroenterol 2003;9:2370-2373. Botulinum toxin vs. balloon dilation for treatment of achalasia Witzel dilation N Remission, 1 y Additional dilation Perforation Dilation Botulotoxin 18 89% 16 38% 9 2 Conclusions: Both methods had excellent immediate relief, but much better long-term outcome after dilation. Bansal R et al. J Clin Gastroenterol 2003;36:209-214. Botox Czech experience: N 49, long-term response 41 % Martínek J… Špičák J. Diseases of Esophagus 2003;16:204-209 Balloon dilation in achalasia Author Year N Success West 2002 125 → 50% Sabharwal Cheng 2002 2003 76 60 89% 40→ 10% Dobrucali 2004 43 79→ 54% Karamanolis 2005 260 88→ 66% Boztas 2005 50 83% Gockel IKEM 2005 2006 64 > 100 83% Complications perforations 2 surgery 7 0 pain 50% reflux 26% bleeding 10% perforation 1 reflux 4 perforation 1 tears 9 (4.2%) surgery 13% immediate 0 reflux 12 surgery 5 NR perforations 3 surgery 2 clipps 1 esophagitis easy to control Balloon dilation in achalasia 9 12 → hours fasting 9 Sedation, air ways protection 9 Fluoro/endo control 9 30-mm balloon, 1-2 minutes 9 Further sessions: on demand, according to manometry? 9 Contrast, endoscopy, to exclude perforation 9 Perforation treatment: ATB, fasting, surgery, clipps? Pyloroduodenal peptic stenosis TTS N 19 Symptoms improvement Stenosis resolution Scintigraphy confirmed improved gastric emptying Artifon EL et al. Surgical Endosc 2006;20: 243-248 Dilation of gastric outlet obstruction with/without Hp infection TTS, , CRE, 3 minutes, 12→16 mm N 33, immediate dilation success 76%, recurrence 36% within 2 years 2 perforations after 16-mm balloon perforation Conclusions: Results better in Hp eradicated patients, in Hp negative and recurrent patients the surgery should be the first choice. Lam YH et al, Gastrointest Endosc 2004;60:229-233 Strictures following laparoscopic Roux-en-Y gastric bypass (LRYGB) for obesity Pneumatic balloons, Savary-Gilliard bougies LRYGB Anastomotic stricture Stricture resolution Microperforation 369 19 (5.1%) 90% 1 Conclusions: symptoms free at a mean follow-up 21 months. Goiten D et al. Surg Endosc 2005;19:628-632 Colonoscopic balloon dilation of Crohn´s strictures Baloon dilation: 3 minutes, 18 mm N Success > 2 sessions Surgery (unsuccess) Complications 22 16 15 6 0 Dear KLE et al. J Clin Gastroenterol 2001;33: 315-318 Colonoscopic balloon dilation of Crohn´s strictures TTS dilation N patients/procedures Recurrence/surgery Complications Perforation – surgery Fever Hematochezia Pain 38/53 43% 5 (9.4%) 1 2 1 1 Conclusions: Safe, dilation can avoid or postpone surgery. Sabaté JM et al. Aliment Pharmacol Ther 2003 Ileal pouch strictures Through-scope-balloons N patients Inlet/outlet strictures Mean sesseions p/p Complications 19 14/14 1.74 0 Conclusions: safe and effective Shen B et al. Am J Gastroenterol 2004;99: 2340-2347 Stenosis after stapled colorectal anastomosis N Stenosis Endoscopic dilation Relaps 179 8 5/8 1 Conclusions: early stenosis is often asymptomatic and disappears spontaneously. Dilation is a method of choice. Bannura GC et al. World J Surg 2004;28:921-925 Colorectal stricture after low anterior resection Prospective controlled trial, two balloon types, TTS, OWB, 24-months follow-up N Mean N of sessions Response, mean, days TTS OWB 15 2.6 294.2 15 1.6 560.8 Conclusions: Better results with OWB. Di Giorgio P et al. Gastrointest Endosc 2004;60:347-350 Stenosis after stapled colorectal anastomosis 9 Incidence depends on the criteria 9 Clinically relevant in < 5% 9 Stenosis is often asymptomatic and can disappear 9 Dilation – excellent choice Colorectal cancer - stenting-dilation-perforation Summary metaanalysis – perforation rate 3% Early / delayed 71 / 19% Stenting and dilation With Without N Perforation 65 14% 718 2.6% EST - consequences 9 Bacterial colonization of bile ducts 9 Increased rate of primary choledocholithiasis 9 Increase risk of bile duct tumor 9 Clinical relevancy? Histological analysis of the papilla after endoscopic dilation N patients balloon dilation Histology Muscle disruption Architectural distortion Inflammation Fibrosis 467 10 1 1 9 9 Kawabe T et al. Hepato-Gastroenterology 2003;50:919-923 Influence of papillary dilation and sphincterotomy on sphincter Oddi function Pure bile collection: Before, 1 week, 1 year after the procedure No difference in pancreatic enzymes before and after procedures Both dilation and sphincterotomy preserve sphincter Oddi function Takezawa M et al. Endoscopy 2004;36:631-637. Balloon dilation of the sphincter of Oddi - increased risk of pancreatitis? N Stones removal Mechanical lithotripsy Early complications Pancreatitis Hyperamylasemia EBD EST 93 88% 31% 17% 8% 23% 87 93% 13%* 22% 8% 8% Conclusions: No difference in pancreatitis, hyperamylasemia in EBD may indicate more irritation. Bergman JJGHM et al. Endoscopy 2001;33:416-420 Balloon dilation for common bile duct stones A metaanalysis: Velavinous, Fujita, Arnold, Minami, Bergman, Ochi, Natsui, Yasuda Stones removal Complications, total Bleeding Pancreatitis Severe Death Lithotripsy need EBD EST 94.3 10.5 7.4% 5 1 20.9% 96.5 10.3 2.0%* 4.3%* 2 1 14.8% Conclusions: EBD should be preferred in coagulopathy only. Baron TH et al. Am J Gastroenterol 2004;99:1455-1460 Balloon dilation of the sphincter of Oddi N Success Complications, total Severe Pancreatitis Deaths EBD EST 117 97.4% 17.9% 6.8% 15.4% 2 120 92.5% 3.3% 0 0.8% Conclusions: dilation is unsafe. DiSario JA et al. Gastroenterology 2004;127: 1291-1299 Stent placement in the pancreatic duct prevents pancreatitis after dilation Stent removed 3 days later (38/40) N Pancreatitis (mild) Stent Controls 40 0 92 6 Conclusions: pancreatitis and hyperamylasemia was prevented by pancreatic stent insertion. Aizawa T et al. Gastrointest Endosc 2001;54:209-213 Papillary balloon dilation from percutaneous approach Fragments after lithotomy removal N Stones removal (one session) Complications 16 12 0 Conclusions: simple and effective Moon Jong Ho et al. Gastrointest Endosc 2001;54: 232-236 Endoscopic balloon dilation for specific indications only 9 Coagulopathy 9 Anatomy – B II Endoscopic treatment of patients with PSC Author Johnson Craig Gaing Lee Van Milligen Wagner Petersen Baluyut Stiehl Year 1987 1992 1993 1995 1996 1996 2001 2001 2002 Stent 11 16 15 22 21 0 37 32 5 Dilation 24 18 6 31 0 12 34 140 210 Enteroscopic balloon dilatation of hepaticojejunostomy after liver transplantation 9 7-year-old boy, 6 years after OLT 9 Double-balloon-enteroscopy 9 Successful dilation (2-years follow-up) Haruta H et al. Liver transplantation 2005;11:1608-10 Dilation - risk factors Stricture Etiology Long Caustic Irregular Achalasia Hard Malignancy Bowel/esophageal wall involved, Radiation scaring Conclusions - complications - how to prevent 9 Patients selection (vs. other techniques) 9 Equipment cannot be significantly improved 9 To avoid unadequate overpressure 9 Most of complications are not reported, they are caused by incorrect approach 9 Declared guidelines will not be principally changed, the goal is to respect them