Chapter 8
Astrocytes, Oligodendrocytes and Schwann Cells
Malabendu Jana, Subhajit Dasgupta, Anuja Ghorpade, and Kalipada Pahan
QUESTIONS
1. During developmental stage which cell types come last:
a. microglia
b. neuron
c. astrocyte
d. oligodendrocyte
2.
If there is formation of abnormal Shh protein during embryogenesis:
a. genesis of astrocyte will be affected
b. genesis of oligodendrocytes will be affected
c. genesis of neurons will be affected
d. brain development will be impaired
e. all are true
f. none are true
3.
Enzyme glutamine synthase is not found in
a. astrocytes
b. oligodendrocytes
c. none of the above is true
d. all are true
4.
Tripartite synapse is formed by
a. neurons
b. microglia
c. astrocytes
d. microglia and astrocytes
e. neuron and astrocyte
5.
In the central nervous system, major role of astrocyte is to
a. scavange glutamine
b. scavange cell debris
c. produce ATP
d. all the above
e. none the above
6.
In the CNS, glycogen is found only in
a. oligodendrocyte
b. microglia
c. astrocyte
d. neuron
e. all the above
7.
In astrogliosis, astrocytes form
a. cluster all around the CNS
b. bushy network surrounding the injury site
c. all are true
8.
Schwann cells but not oligodendrocytes have phagocytic activity.
a. True
b. False
9.
Unmyelinated axons generally have a smaller diameter than myelinated axons.
a. True
b. False
8.
Astrocytes, Oligodendrocytes and Schwann Cells
Malabendu Jana, Subhajit Dasgupta, Anuja Ghorpade, and Kalipada Pahan
10. A single Schwann cell forms myelin around one and only one axon while a single
oligodendrocyte forms myelin around several separate axons.
a. True
b. False
11. Oligodendrocytes progenitors are identified by A2B5 antibody whereas
pre-oligodendrocytes are identified by O4 antibody.
a. True
b. False
12. Which of the sequential stage is correct for oligodendroglial development?
a. Neural stem cells, progenitors, pre-oligodendrocytes, precursors and mature oligodendrocytes.
b. Progenitors, precursors, pre-oligodendrocytes, mature oligodendrocytes and neural stem cells.
c. Neural stem cells, precursors, progenitors, pre-oligodendrocytes and mature oligodendrocytes.
d. Pre-oligodendrocytes, precursors, mature oligodendrocytes, progenitors and neural stem cells.
e. None of the above.
13. Action potentials are conducted rapidly through (choose one)
a. myelinated axons
b. unmyelinated axons
c. large diameter axons
d. small diameter axon
e. both a and c
14. Which of the following molecule is not a part of the peripheral nervous system?
a. LINGO-1
b. BDNF
c. CNTF
d. PDGF
e. EGF
15. Which of the following functions in the nervous system is not provided by the oligodendrocytes?
a. Ensheath axons
b. Supply neurotrophic factors
c. Form the node of Ranvier
d. Phagocytic properties to remove debris.
16. Non-myelinating Schwann cell is characterized by the following properties EXCEPT
a. Wraps axons greater than 1μm.
b. Appear later than myelinating Schwann cells.
c. Myelinate all postganglionic sympathetic neurons.
d. Produce more p75NTR and GFAP.
e. Provide mechanical and metabolic support to the neuron.
17. Gliogenesis and Neurogenesis during development
a. occur simultaneously during development
b. follow this sequence i.e. gliogenesis followed by neurogenesis
c. occur one after the other after the first is completed
d. occur sequentially with overlapping periods
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8.
Astrocytes, Oligodendrocytes and Schwann Cells
Malabendu Jana, Subhajit Dasgupta, Anuja Ghorpade, and Kalipada Pahan
Answers
1.
a
2.
e
3.
b
4.
e
5.
c
6.
c
7.
b
8.
a
9.
b
10. a
11. a
12. c
13. e
14. a
15. d
16. a
17. d
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