AbstractID: 7110 Title: Effect of the Lung Inhomogeneity Correction in Breast Irradiation Using Various Algorithms The effect of the dose inhomogeneity correction for radiotherapy treatment of the intact breast has been studied using Helax-TMS treatment planning system (TPS) and Monte Carlo (MC) calculations. The TPS calculations are based on the two available algorithms: a pencil beam (PB) algorithm and a Collapsed cone (CC) algorithm. We have calculated the dose for a medium size breast patient with CT scans and tangential isocentric beam arrangements with wedges. Dose distributions and cumulative dose volume histograms (DVHs) have been obtained for the above algorithms with and without the inhomogeneity correction using the intact breast as the planning treatment volume (PTV) and the lung volume. All the calculations are normalized at the isocenter. There is a close agreement between the MC and CC calculations for the lung DVH. Both of these algorithms show a higher volume of the lung receiving lower and intermediate levels of dose than the PB with and without inhomogeneity corrections. In the region of the highest dose the CC and MC calculations show a lower volume than the PB algorithm with inhomogeneity correction. For PTV, The MC calculations show same level of coverage as CC calculations. However, both MC and CC show a lower level of coverage than PB calculations with and without inhomogeneity corrections. This study shows a close agreement between MC and CC calculations for the breast geometry.