AbstractID: 6613 Title: Characterization of an extrapolation chamber for dose measurements in heterogeneous phantoms A phantom-embedded extrapolation chamber (PEEC) is used for determining dose in Solid Water™ and in bone-equivalent materials irradiated with clinical 6 and 18 MV photon and 9 and 15 MeV electron beams. The dose is determined with the Spencer-Attix cavity theory, using an indirect determination of the chamber air-mass through a capacitance and ionization gradient measurement. Cavity correction factors accounting for scatter deficit, air cavity dimensions, and electrode composition are determined. The three perturbation factors are calculated with Monte Carlo techniques, the last one is also determined through relative air cavity dose measurements for three different polarizing electrode materials: graphite, steel and brass, while a graphite collecting electrode is used. The air cavity perturbation is negligible in the range of electrode separations used (2.0 to 3.0 mm). Scatter deficit due to loss of lateral scatter is found to underestimate the dose for the bone PEEC by less than 1% for all beams studied. In megavoltage photon beams, graphite electrodes do not affect the dose measurement with Solid Water™ PEEC but cause an underestimation of up to 4% in the dose measured in the bone PEEC even for very thin graphite electrodes (< 0.0025 cm). The collecting electrode material has a greater effect than the polarizing electrode material. The best electrode combination for dose determination with bone PEEC was obtained with an aluminum polarizing electrode and a graphite collecting electrode. The thickness of thin electrodes has a negligible effect on dose determination.