AbstractID: 6582 Title: Calculations of Dose Profiles Under Wedges, Using Spatially Dependent Attenuation Coefficients Wedge filters are routinely used in radiation therapy to modify x-ray beams to produce more uniform dose distributions in target tissue. These wedge filters are generally made out of steel or lead and have a sloped surface in the wedge direction. In the non-wedge direction the wedge filter has uniform thickness. Generally it is assumed that the dose distribution in the non-wedge direction is the same as an open field. Numerous reports have shown that dose away from the central axis is 5 to 10% below that of an open-field. This so-called sagging of dose is due to the oblique path through the wedge and the softening of the beam energy-spectra for position away from the central axis. In this work the correct dose distribution in a wedged field is predicted by calculating the transmission through the wedge, using the thickness of the wedge and the attenuation coefficient. The attenuation coefficient is modeled for its dependence on wedge thickness and on the distance of the calculation point away from the central axis of the field. This modeling is based on commonly available wedge factors and thickness measured on the central axis and transmission measured along the non-wedge direction of a 30º wedge. Measured data and calculations in the wedge and non-wedge direction are compared for a 6 MV beam with 15, 30, 45 and 60º wedges. Differences between measurements and calculations are less than 2% for fields as large as 25 cm x 25 cm.