AbstractID: 6943 Title: Beam arc setup dependence of dose distribution in Multi-arc Stereotactic Radiosurgery Three types of Multi-arc collimations are currently used in stereotactic radiosurgery: the fixed circular collimator, the fixed conformal shape, and the dynamic conformal shape. The dose distribution of these Multi-arc collimations is influenced by the beam arc setup including the isocenter position, the beam arc length and locations, the collimator size, and the arc weighting factor. The dependence of dose distribution on the beam arc setup for these three collimations has been systematically investigated. Both the conformity index and the dose avoidance to the critical organs are used to evaluate the dose distribution. For fixed circular collimator, the collimator size directly affects the treatment volume. The isocenter position affects the treatment location. The shape of the treatment volume highly depends on the arc locations and weighting factors. For conformal arc with fixed shape, since each beam arc has an individual conformal MLC opening, the treatment volume is automatically adjusted to fit the target. Isocenter position has little influence on the treatment volume location. Beam arc locations and weighting factors still affect the shape of treatment volume, but their influence is significantly decreased. For dynamic shaped arc, the conformal treatment volume is achieved by shaping the beam at each couch and gantry position. Beam arc locations, weights, or isocenter position do not affect treatment volume significantly. For all three collimations, the dose avoidance to the critical organ mainly depends on the beam arc locations. This study provides guidelines for optimizing the dose distribution in Multi-arc stereotactic radiosurgery.