AbstractID: 7173 Title: Effect of Radiographic Exposure on Texture Features Extracted from Bone Densitometry Images Bone structure is an important component that determines bone strength and therefore fracture risk. Recent bone densitometers may have adequate spatial resolution to characterize bone structure by performing texture analysis on the acquired images. In this study we investigate the effect of exposure on texture features. A PIXI (GE Medical Systems) peripheral densitometer with 0.2 mm pixel size was used to image the heel of an Alderson Phantom Patient. Multiple scans were performed using the default protocol. Additionally, images were acquired with up to 2.5 times the default relative exposure. Regions of interest (ROIs), 64x64 pixels in size, were selected for calculation of the texture features. The ROIs encompassed approximately the same region from which the BMD was calculated. The texture analysis included Fourier-based features such as RMS variation and first moment of the power spectrum. The ROIs were analyzed individually and by averaging their Fourier transforms prior to calculation of the features. Averaging in the spatial-frequency domain avoids problems that might occur due to a slight shift of the heel between scans. The first moment decreased by 23% with the doubling of the mAs and by 13% with the averaging of the Fourier transforms of ROIs from two scans. These decreases are expected due to the corresponding decrease in quantum mottle with increasing exposure. The difference in the decrease of the first moment between the two methods may be due to system characteristics that affect different noise components in the image. MLG, shareholder R2 Technology