AbstractID: 9760 Title: Image reconstruction with improved noise properties for asymmetric conebeam CT Cone-beam CT with a displaced 2D detector array, which is referred to as asymmetric cone-beam CT, can be used for increasing the size of the field of measurement (FOM) in micro-CT or in megavoltage CT for patient localization in radiation therapy. From the data acquired with such configuration, images can be reconstructed by use of the conventional FDK algorithm with data weighted by a smooth weighting function. With the displacement of detector and increase of the FOM size, however, the FDK algorithm may significantly amplify data noise and aliasing artifacts because it involves a spatially-variant weighting factor. In this work, we propose an algorithm to reconstruct images from asymmetric conebeam data. This algorithm eliminates the spatially-variant weighting factor involved in the FDK algorithm, and thus reconstructs images with improved noise properties. It maintains the image spatial resolution by use of a shift-variant filtration scheme to avoid interpolation along the radial direction. Additionally, the proposed algorithm can compensate for the intensity-drop effect resulted from the missing-data problem in the FDK algorithm. This algorithm is particularly robust when applied to asymmetric cone-beam CT with large size of FOM and/or small focal lengths. Supported by the National Institutes of Health