AbstractID: 9494 Title: A graph searching method for MLC leaf sequencing under constraints We have developed a new leaf sequencing method for step-and-shoot IMRT delivery based on a graph searching technique. Variable intensity levels and two collimator angles with a 90º rotation are used for minimizing the number of segments. In an iterative process, one segment is selected at a step as guided by a quantitative complexity measure for the remaining intensity pattern. Under leaf position constraints disallowing leaf interdigitations, we first assume that deliverable field segments form simply connected areas. For each intensity level, the field area with equal or larger intensity is segmented by graph searching into the least number of simply connected fields with each of the two MLC directions. The segment that results in the most reduced complexity of the remaining intensity distribution is selected. For further simplification of the remaining intensity pattern, the shapes of selected segments are modified by leaving out certain beamlets for later delivery with out changing the deliverability of current segment. The deliverable segments are then combined under appropriate constraints for a specific type of MLC. Finally, combined segments are sequenced to minimize the leaf travel. Our algorithm has been tested using randomly generated intensity distributions and clinical cases for the Varian, Siemens, and Elekta MLC systems. The segment number increases only moderately while the MU numbers almost unchanged with increasing the number of intensity levels. Using two collimator angles can considerably decrease the number of segments and thus advantageous if the beam delivery can be automated.