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“Parameters for and use of NTCP models in the clinic”
References from 2006-2007
Reviews:
Seminars in Radiation Oncology, Vol 17 # 2 “Late Normal Tissue Injury”
Particularly:
Kong F-M, Pan C, Eisbruch A, and Ten Haken RK (2007). “Physical models and simpler
dosimetric descriptors of radiation late toxicity.” Sem Rad Onc 17: 108-120.
Milano MT, Constine LS, Okunieff P (2007). “Normal tissue tolerance dose metrics for radiation
therapy of major organs.” Sem Rad Onc 17: 131-140.
General:
Jackson A, Yorke ED, Rosenzweig KE (2006) “The atlas of complication incidence: a proposal
for a new standard for reporting the results of radiotherapy protocols.” Sem Rad Onc 16: 260-268.
Hypofractionation
Kavanagh BD, Schefter TE, Cardenes HR, et al (2006). “Interim analysis of a prospective phase
I/II trial of SBRT for liver metastases.” Acta Oncol 45:P 848-855.
Kavanagh BD, McGarry RC, Timmerman RD (2006). “Extracranial radiosurgery (Stereotactic
body radiation therapy) for oligometastasis” Sem Rad Onc 16: 77-84.
Ryu S, Jin J-Y, Jin R, et al (2006). ). “Partial volume tolerance of the spinal cord and
complications of single-dose radiosurgery.” Cancer 109: 628-636.
Sampson MC, Katz A and Constine LS (2006). “Stereotactic body radiation therapy for
extracranial oligometastasis: does the sword have a double edge?”, Sem Rad Onc 16: 67-76
Timmerman R, McGarry R, Yiannoutsos C, et al (2006). “Excessive toxicity when treating central
tumors in a phase II study of stereotactic body radiation therapy for medically inoperable early-stage lung
cancer.” J Clin Oncol 30: 4833-4839.
Spinal Cord Retreatment:
Nieder C, Grosu AL, Andratschke NH and Molls M (2006): “Update of human spinal cord
reirradiation tolerance based on additional data from 38 patients.” Int J Radiat Oncol Biol Phys 66: 14461449.
Parotids
Li Y, Taylor JMG, Tenhaken RK and Eisbruch A (2007). “ The impact of dose on parotid salivary
recovery in head and neck cancer patients treated with radiation therapy.” Int J Radiat Oncol Biol Phys 67:
660-669.
H&N – IMRT clinical outcomes (big improvements seen in xerostomia, especially with IMRT!)
Fang F-M., W-L. Tsai, H-C. Chen, H-C. Hsu, C-Y. Hsiung, C-Y. Chien, and S-F Ko. (2006).
“Intensity-modulated or conformal radiotherapy improves the quality of life of patients with
nasopharyngeal carcinoma.” Cancer 109: 313-321.
Lee, N., D.R. Puri, A.I. Blanco, and K.S. Chao. (2007). “Intensity-modulated radiation therapy in
head and neck cancers: an update”, Head Neck 29: 387-400.
Wei , W.I. and J.S.T. Sham. (2005), “Nasopharyngeal carcinoma.” The Lancet 365: 2041-2054.
Graff P, Layeyre M, Desandes E et al (2007). “Impact of intensity-modulated radiotherapy on
health-related quality of life for head and neck cancer patients: matched-pair comparison with conventional
radiotherapy.” Int J Radiat Oncol Biol Phys 67: 1309-1317.
Lung (importance of low dose volumes)
Allen AM, Czerminska M, Jänne PA et al (2006). “Fatal pneumonitis associated with intensitymodulated radiation therapy for mesothelioma.” Int J Radiat Oncol Biol Phys 65: 640-645.
Hope AJ, Lindsay PE, El Naqa I, et al (2006). “Modeling radiation pneumonitis risk with clinical,
dosimetric, and spatial parameters.” Int J Radiat Oncol Biol Phys 65: 112-124.
Schallenkamp JM, Miller R, Brinkmann DH, et al. (2007). “Incidence of radiation pneumonitis
after thoracic irradiation: dose-volume correlates.” Int J Radiat Oncol Biol Phys 67: 410-416.
Wang SL, Liao Z, Vaporciyan AA et al (2006). “Investigation of clinical and dosimetric factors
associated with postoperative pulmonary complications in esophageal cancer patients treated with
concurrent chemoradiotherapy followed by surgery.” Int J Radiat Oncol Biol Phys 64: 692-699
Wang S, Liao Z, Wei X et al. (2006) “Analysis of clinical and dosimetric factors associated with
treatment-related pneumonitis (TRP) iin patients with non-small-cell lung cancer (NSCLC) treated with
concurrent chemotherapy and three-dimensional conformal radiotherapy (3D-CRT)”. Int J Radiat Oncol
Biol Phys 66: 1399-1407.
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Liver: Asian experience
Kim TH, Kim DY, Park J-W, et al (2007). “Dose-volume parameters predicting radiation-induced
hepatic toxicity in unresectable hepatocellular carcinoma patients treated with three-dimensional conformal
radiotherapy.” Int J Radiat Oncol Biol Phys 67: 225-231.
Liang S-X, Zhu X-D, Xu Z-Y et al (2006). “Radiation-induced liver disease in three-dimensional
conformal radiation therapy for primary liver carcinoma: the risk factors and hepatic radiation tolerance.”
Int J Radiat Oncol Biol Phys 65: 426-434.
Xu Z-Y, Liang S-X, Zhu J et al (2006). “Prediction of radiation-induced liver disease by Lyman
normal-tissue complication probability model in three-dimensional conformal radiation therapy for primary
liver carcinoma.” Int J Radiat Oncol Biol Phys 65: 189-195.
Models for Predicting NTCP
Reviews:
Kong F-M, Pan C, Eisbruch A, and Ten Haken RK (2007). “Physical models and simpler
dosimetric descriptors of radiation late toxicity.” Sem Rad Onc 17: 108-120.
Statistical modeling
El Naqa I, Bradley J, Blanco AI et al (2006). “Multivariable modeling of radiotherapy
outcomes, including dose-volume and clinical factors.” Int J Radiat Oncol Biol Phys 64: 1275-1286
El Naqa I, Suneja G, Lindsay PE, et al. (2006). “Dose response explorer: an integrated opensource tool for exploring and modelling radiotherapy dose-volume outcome relationships.” Phys Med Biol
51: 5719-5735.
New methods or new parameter sets
Rancati T, Wennberg B, Lind P et al. (2006). “Early clinical and radiological pulmonary
complications following breast cancer radiation therapy: NTCP fit with four different models.” Radiother
and Oncol 82: 308-316.
Tucker SL, Liu HH, Wang S, et al (2006). “Dose-volume modeling of the risk of postoperative
pulmonary complications among esophageal cancer patients treated with concurrent chemoradiotherapy
followed by surgery.” Int J Radiat Oncol Biol Phys 66: 754-761.
Improvements needed for current models
Kocak Z, Borst GR, Zeng J, et al. (2007). “Prospective assessment of dosimetric/physiologicbased models for predicting radiation pneumonitis.“ Int J Radiat Oncol Biol Phys 67: 178-186.
Rancati T, Wennberg B, Lind P et al. (2006). “Early clinical and radiological pulmonary
complications following breast cancer radiation therapy: NTCP fit with four different models.” Radiother
and Oncol 82: 308-316.
Molecular biology connections
See Seminars in Radiation Oncology, Vol 17 #2 (2007)
Also
Schultz-Hector S and Trott K-R (2007). “Radiation-induced cardiovascular diseases: is the
epidemiologic evidence compatible with the radiobiological data?” Int J Radiat Oncol Biol Phys 67: 10-18.