2013 Summer Research Projects
Prof
Bebej, Ryan
Dept.
Biology
Funded by Student
Jansma
Melissa Braun
Family
Research
Fund in the
Sciences and
Business
Fellowship
Project Title and Abstract
A Whale of a Tale: The Origin of Tail-Powered Swimming in Early Cetaceans Modern whales are aquatic
mammals, but the fossil record indicates that they are descended from ancestors that lived on land. In recent
decades, this strange and seemingly counterintuitive transition has become one of the most prominent examples of
macroevolution, but many details remain to be elucidated. This project aims to explore one key aspect of this
transition: the evolution of tail-powered swimming. Quantitative comparison of fossil skeletons with those of
modern mammals will provide the framework for assessing the functional capabilities of these early whales,
providing insight into how ancient whales became increasingly adapted for efficient modes of swimming. Research
will involve trips to the University of Michigan Museums of Zoology and Paleontology, work with modern and
fossil skeletal material, and learning how to analyze data using select multivariate statistical analyses.
DeJong,
Randall
Biology
Jansma
Kelsey
Family
Veldkamp
Research
Fund in the
Sciences and
Business
Fellowship
Genomic and niche characterization of bacteriophages in the microbial communities of the aquatic snails
Biomphalaria and Helisoma Most multicellular organisms rely on symbiotic relationships with prokaryotes
(bacteria), especially within the digestive tract, where they assist in digestion and provide essential nutrients and
energy. Even in the small guts of invertebrates, these bacterial communities can be robust, unique, and critical to
survival. Gut bacteria play an important role in the host immune response, and have even been shown to alter
disease transmission in invertebrates that vector pathogens. One aspect of invertebrate microbial communities that
has been largely unexamined is the potential role of bacteriophage, which putatively could play a large role in
regulating community composition and function. We have isolated phages from the gut microbial fauna of aquatic
Biomphalaria snails (which are the intermediate hosts for a human parasite, Schistosoma), Helisoma snails (local
to campus), and sequenced their genomes. We have also begun to quantify the prevalence and abundance of phage
in the snail gut using quantitative PCR. The student will begin and finalize existing genome annotations, perform
quantitative assays of phage populations, continue characterization of the diverse bacterial communities from
Helisoma, and implement new efforts to isolate novel phage.
Dornbos,
David
Biology
Integrated
Andrew DeVries
Science
Research
Institute
(ISRI-HHMI)
Specificity of Frankia Bacteria in Symbiosis with Native Speckled Alder and Non-Native Autumn Olive
Autumn olive (Elaeagnus umbellata) is a non-native invasive shrub from Asia that is increasingly problematic in
much of the U.S. Midwest. Much of the competitiveness of autumn olive is due to its ability to fix atmospheric
nitrogen in nutrient-poor soils. This nitrogen is used to optimize photosynthesis rates allowing autumn olive to
grow significantly faster than native shrubs. Autumn olive engages in a symbiotic relationship with Frankia
bacteria in root nodules, the location where nitrogen fixation occurs. Previous research has demonstrated that
autumn olive is capable of high nitrogen fixation rates. This is surprising because symbiotic relationships among
plant and bacterial species are often quite specific. For example, Rhizobium japonicum has been developed
specifically for soybean (Glycine max) and seed inoculation is required to optimize nitrogen fixation rates. Frankia
also believed to interact with native alder species, notably speckled alder (Alnus incana). The objectives of this
research program are to characterize the phylogenetic relationships among the Frankia bacteria responsible for
nitrogen fixation in autumn olive and speckled alder in comparison with the nitrogen fixation rates of these plant
species.
Prof
Grasman,
Keith
Dept.
Biology
Funded by
US Fish and
Wildlife,
Clarence
(Bud) Star
and Arlene
Talen Star
Student
Research
Fellowship
Grasman,
Keith
Biology
Jansma
Stacy Hooker
Family
Research
Fund in the
Sciences and
Business
Fellowship
Impact of Mercury on Immune Function in Common Loons of New York's Adirondack Park The deposition
of airborne mercury into lakes in the northeastern US and Canada presents significant health risks to fish-eating
wildlife such as common loons. This mercury comes primarily from coal-fired power plants and cement kilns. In a
previous laboratory study, dietary mercury exposure suppressed immune function in young loons. Field studies
conducted during the past 4 years suggest significant immunological effects in young wild loons but minimal
effects in adults. This study will continue investigations into immunological effects in wild loons living in New
York's Adirondack Park (and possibly other locations in North America such as New Brunswick, Wisconsin,
Maine, and Michigan, depending on funding). Loons will be captured at night by spotlighting and netting them
from boats and canoes. White blood cells will be isolated from blood samples and cryopreserved for transport
back to the laboratory at Calvin. Immunological functions of these white blood cells will be assessed using cell
culture assays in the laboratory. Students will have the opportunity to work with biologists, rangers, and
veterinarians from the New York Department of Environmental Conservation, the Bronx Zoo, and the
BioDiversity Research Institute.
National
Science
Foundation
Enhancing Learning Through Research in Biology 225 Two students will join an interdisciplinary team of
faculty seeking to strengthen student research projects in Biology 225, promote interdisciplinary STEM learning,
and integrate assessments that support scientific teaching. The project will involve development and optimization
of research methods, production of a new laboratory/field manual, and design of appropriate assessment
instruments. There will also be opportunities in the fall of 2013 to assist with data collection and analyses that
measure the effectiveness of these reforms as they are implemented.
Koetje, Dave Biology
Student
Monica
Langeland,
Sylvia Fuhrman
Jon Knott,
Paige Stephens
Project Title and Abstract
Effects of Pollutants on the Health of Colonial Waterbirds in Great Lakes Areas of Concern Fish-eating
birds are effective “sentinel species” for assessing toxic effects on the health of the Great Lakes ecosystem. Our
previous studies have shown associations between pollutants and suppressed immune and hormonal functions in
gulls, terns, and herons of the Great Lakes. The objective of the current study is to continue the assessment and
monitoring of these health effects at contaminated sites around the Great Lakes. Specifically, this project is funded
by the US Fish and Wildlife Service under the Great Lakes Restoration Initiative to measure the current health and
population status of birds at specifically designated Areas of Concern. The data from this and other studies will
help help the USFWS and other government agencies determine whether water quality at these sites has improved
enough to remove them from the list of impaired sites, or whether they should remain designated as Areas of
Concern. This project involves travel and boating for field work around the Great Lakes and follow-up laboratory
work at Calvin. Students will have the opportunity to interact with USFWS scientists.
Prof
Proppe,
Darren
Dept.
Biology
Funded by Student
Plaster Creek Jenna Kennedy,
Stewards,
Dean Pettinga
Integrated
Science
Research
Institute
(ISRI-HHMI)
Project Title and Abstract
Avian and Water Quality Assessments along Plaster Creek We are looking for two students to do research in
the Plaster Creek Watershed collecting data on bird behavior and water quality. The objective of the bird project is
to investigate whether human produced noise affects the foraging behavior of songbirds. Theoretically, if birds
cannot hear predators they must spend more time looking for them. This could reduce the amount of food a bird is
able to procure and thereby decrease their fitness. To assess whether noise is affecting foraging behavior we will
set up bird feeders at multiple locations along Plaster Creek that are exposed to various levels of noise (primarily
from roads) to assess whether foraging behavior is altered in noisy areas. This project will involve placement and
maintenance of bird feeders, video recording of foraging behavior, and collecting behavioral data from the video
recordings. As we do this work, we will also be generating a bird inventory for the Plaster Creek corridor.
The water quality project will continue research begun in the summer of 2012. We will be collecting data from
multiple locations in the watershed throughout the summer. The primary focus will be to assess bacterial levels
over time and space, as well as sediment, nutrient loading, pH, conductivity, and discharge volume. These data
will be organized, processed, and compared among the different sites, and between this year and last year. Our
objective is that these data will help identify the most problematic and dangerous sites in the stream, thereby
informing the prioritization of restoration plans.
Shen, Anding Biology
National
John Morris,
Institutes of Anne Barron,
Health (NIH), Wei Wang
Clarence
(Bud) Star
and Arlene
Talen Star
Student
Research
Fellowship
The roles of endothelial cells on HIV infection and latency formation in resting T helper cells In many
patients with HIV-1 infection, highly active antiretroviral therapy (HAART) successfully suppresses viral loads
and restores the immune system. However, a major latent reservoir identified in resting T helper cells (a type of
white blood cells) poses a great barrier to viral eradication and ensures viral persistence in patients. A more
complete understanding of the mechanisms contributing to the establishment of the reservoir will influence the
strategies in battling viral persistence.Some recent studies demonstrated that endothelial cells increased the level
of HIV infection in resting T helper cells and might play a significant role in latency formation in these cells. In
this study, a replication incompetent pseudotyped virus system is used to investigate how endothelial cells interact
with resting T helper cells to promote HIV infection and latency formation. Students who have taken Bio333
(Immunology Course) are preferred.
Van Dragt,
Randy
Fritz and
Carol
Rottman
Student
Research
Fellowship
Impacts of Fire on Insect Populations in Created Prairie Prairie grasslands are maintained as biological
communities largely through the regular occurrence of fire. Fire discourages the growth of woody plants and
promotes a selection of grasses and wildflowers adapted to the prairie environment. Beyond the impact on plants,
however, fire affects a range of other organisms, including insects. Half of the 20-acre created prairie at Calvin's
Flat Iron Lake is burned each year, and this project will compare the two halves of the prairie to nearby unburned
grasslands to identify the impacts that burning has on the species composition of the prairie insect community and
the success of common species which compose that community. Since insects perform many essential functions on
the prairie and in nearby ecosystems, it is important to understand the impacts of fire so that insect populations can
be appropriately managed.
Biology
Lauren
Verstraete
Prof
Van Dragt,
Randy
Dept.
Biology
Funded by
Eco system
preserve
Warners,
David
Biology
William H.
Ian Noyes,
and Celia I. Katie
Dornbush
Westergren
DeVries
Family
Student
Research
Fellowship,
Jansma
Family
Research
Fund in the
Sciences and
Business
Fellowship
Restoring Native Habitats In Urban Landscapes In this project, students will work in the greenhouse, nursery
and at sites on and off campus investigating the reintroduction of native plants and native habitats into urban areas.
Part of this work will involve assessing data from controlled experiments to elucidate optimal germination and
growing conditions for a group of particularly desirable native species. These students will also become invested
in a focused campus restoration project in which native short grass prairie will be established in place of lawn
between DeVries Hall and Spoelhof Cafe, a project that will include replicated outplanting treatments and the
generation of an extensive baseline dataset. Students interested in this project will be willing to work outdoors in
all kinds of weather and willing to invest in challenging physical labor.
Warners,
David
Biology
Fritz and
Carol
Rottman
Student
Research
Fellowship
Plant Responses to Climate Change at Flat Iron Lake Preserve This project will take place at Flat Iron Lake,
during which time the student will be expected to live in a Calvin-owned house at Flat Iron Lake with one other
student. This project is an ongoing flower phenology study, investigating the timing of flowering period for a
variety of native prairie plants. The student who takes on this project will also evaluate a variety of planting
strategies that were employed during a 2011 prairie restoration effort in a former feed plot located within the
larger Flat Iron Lake prairie.
Student
Emily Fuller,
Seth Hanstra,
Jesse Vander
Wees,
Annaka
Scheeres
Dorthea
Leisman
Project Title and Abstract
Stewardship of the Calvin College Nature Preserves Each summer three students serve for 12 weeks as
stewards of the Ecosystem Preserve and the Flat Iron Lake Nature Preserve. The stewards are involved in a variety
of land management, monitoring, and research projects. Land management activities include control of non-native
species, restoration plantings, trail maintenance. Breeding birds, small mammal populations and vernal pool
invertebrates are monitored annually, and current research projects are examining restoration strategies for
different communities on both preserves. Work begins in late May and typically concludes in mid-August.
Prof
Wertz, John
Dept.
Biology
Funded by Student
Integrated
Abigail
Science
Streelman
Research
Institute
(ISRI-HHMI)
Project Title and Abstract
HTMAD: Software Design for MALDI-TOF Mass Spectrometry-Based Microbial Community Analysis
Scientific computing and the ability to write specific programs to analyze large datasets of biological information
has become an increasingly important skill with regards to advancing biological research. DNA-based
technologies to identify individual bacterial species and communities, place them phylogenetically, and compare
them statistically are time-consuming and expensive. Our matrix-assisted laser desorption/ionization mass
spectrometer (MALDI-TOF MS) can generate high-throughput, low cost protein-derived data of biological
samples, and we are currently finalizing a novel software program (HTMAD) written in Python that is able to
convert protein-derived data to answer questions previously reserved only for DNA-based methodologies. As we
are now in the final stages of writing and testing the HTMAD program, research will be focused on using HTMAD
to (i) statistically compare and de-replicate cultivated microbial communities (real and artificial) grown under
different environmental conditions (ii) compare and de-replicate microbial communities without a priori
cultivation and (iii) construct a database of microbial isolates to which future unknown bacteria can be compared
and identified. Even in its nascent stages, this program has demonstrated it is a powerful tool that enhances the
ability of microbiologists, microbial ecologists, and those interested in proteomics to do high-throughput
experiments and gain valuable data far more quickly and cheaply than ever before. The individual working on this
project must have good knowledge computer science and programming but also an aptitude and interest for
working with biological systems (i.e. proteomics, phylogenetics, bacterial cultivation and isolation).
Wilstermann, Biology
Amy
Dr. Daniel J. Margot Oliver
Visser
Student
Resdearch
Fellowship in
the Medical
Sciences
Investigating the Dynamics of Bacterial Communities in the Female Reproductive Tract A student working
in my laboratory will have the opportunity to investigate the dynamics of bacterial communities found in the
female reproductive tract. Normal flora, dominated by a variety of Lactobacillus species, serve to protect the
vaginal tract from colonization by pathogenic species such as Gardnerella vaginalis that characterize an infected
state known as bacterial vaginosis (BV). We are seeking to gain an understanding the factors that trigger a shift in
this bacterial community from protective to pathogenic organisms. This shift is of particular importance in
pregnant women since bacterial vaginosis is a risk factor for premature rupture of fetal membranes and resulting
preterm births. This study aims to (i) determine whether pH changes in the reproductive tract trigger shifts in
bacterial communities or are a result of such shifts and (ii) explore the differences that exist in the protective
abilities of the Lactobacillus species that comprise the normal vaginal microflora.
Wilstermann, Biology
Amy
Gift from Mr. Sara Conrad,
and Mrs.
Karyssa
Dick Haworth Schrouder
Cancer Curriculum Initiative (collaboration with Helen DeVos Children's Hospital) The Cancer Curriculum
Initiative is an educationally based project to address specific needs within current grade-school biology
instruction. Most children experience cancer, as nearly everyone knows someone with the disease. Despite the
common incidence of cancer, we found that most of the age-appropriate resources for classrooms focus on the
emotional and social aspects of a cancer diagnosis as applied to a child’s family or circle of friends. Few resources
offer opportunities to explore the science of cancer. Our goal has been to develop age-appropriate, scientifically
accurate, and engaging educational resources for children to gain comprehension of cancer-related topics.
Prof
Anderson,
Carolyn
Dept.
Chemistry
Funded by
National
Science
Foundation
Student
John LaGrand
Anderson,
Carolyn
Chemistry
National
Science
Foundation
David Wierenga Organic Chemistry: Synthesis of N-Alkyl Pyridone Containing β- and γ-Amino Acids Organic synthesis is a
powerful technique that allows access to a wide range of different structural motifs. In this project, we are working
to develop a method for the synthesis of N-alkyl pyridone containing β- and γ-amino acids – homologues of the
natural amino acids, which contain an interesting functional group, found in a series of pharmacologically active
compounds. To date, we have discovered an important intermediate in route to these species and have begun to
optimize its synthesis. The students working in this area will continue to seek conditions for the preparation of this
intermediate and its conversion into the desired amino acids.
Arnoys, Eric Chemistry
Barbachyn,
Michael
Chemistry
Project Title and Abstract
Organic Chemistry: Gold-catalyzed Rearrangement of N-Propargyloxypyridines Organic synthesis is a
powerful technique that allows access to a wide range of different structural motifs. In this project, we are
working to advance a method for the synthesis of N-substituted pyridones; an interesting functional group found in
a series of pharmacologically interesting compounds. To date, we have developed a new gold(III)-catalyzed
method for accessing this motif by rearranging a related system. The student working in this area will be
responsible for exploring and optimizing a related gold(I)-catalyzed rearrangement.
Integrated
Riemer
Watching Membrane Proteins in Real Time We will characterize the behavior of several membrane-bound
Science
Praamsma,
proteins in living cells with state-of-the-art techniques to examine their cellular localization, mobility, and
Research
Kathryn Wrobel interactions with other proteins. Protein targets have been tagged with fluorescent proteins so that they can be
Institute
viewed in living systems. We will also examine what effect extracellular signals have on the proteins' behavior.
(ISRI-HHMI)
The student will serve as a research collaborator, learning both common and state-of-the-art biochemistry
experimental techniques. In addition to learning about how research works, he or she will also gain valuable
experience and will have the opportunity to serve as a co-author on research papers. No previous research
experience or biochemistry coursework is required; a love of lab work and at least one college-level chemistry
course are a must. First year science students interested in a multi-year research experience are strongly
encouraged to apply.
Integrated
Niecia Flikweert
Science
Research
Institute
(ISRI-HHMI)
Preparation of Bicyclo[1.1.1]pentyl Stannanes, Silanes and Trifluoroborates and Applications in PalladiumCatalyzed Cross Coupling Reactions This research proposal focuses on the preparation of bicyclo[1.1.1]pentyl
(BCP) stannanes, hypervalent silanes and trifluoroborates followed by an exploration of the palladium-mediated
cross-coupling reactions of these substances. Initially, reliable synthetic protocols for the preparation of a range of
BCP stannanes, silanes and trifluoroborates will be explored and optimized. The targeted BCP cross-coupled
products are envisioned as useful intermediates for further synthetic transformations, leading to potential
applications in a variety of distinct research areas. Of greatest interest is the incorporation of selected BCP
subunits into known LpxC inhibitor scaffolds to yield antibacterial agents with potentially potent activity against
multidrug-resistant Gram-negative bacteria such as Pseudomonas aeruginosa. LpxC [UDP-3-O-(R-3hydroxymyristoyl)-GlcNAc deacetylase] is an essential metalloamidase that catalyzes the first committed step in
the biosynthesis of the lipid A component of lipopolysaccharides in the bacterium's outer membrane. Any
synthesized LpxC inhibitors will be evaluated for their antibacterial activity potential, potentially by a
microbiologist at Calvin but most likely at the University of Notre Dame (Marvin Miller's lab).
Prof
Barbachyn,
Michael
Dept.
Chemistry
Funded by Student
Integrated
John Elenbaas
Science
Research
Institute
(ISRI-HHMI)
Project Title and Abstract
Synthesis of Novel QPT Antibacterial Agents Bearing Substitution at the Benzylic Position The quinoline
pyrimidinetriones (QPTs) are a novel class of bacterial topoisomerase inhibitors that were discovered in 2002 and
subsequently reported in the open literature in 2008 (Miller, A.A.; et al. Antimicrob. Agents Chemother. 2008, 52,
2806-2812). The initial lead compound, PNU-286607, exhibited excellent in vitro activity and in vivo efficacy
against problematic Gram-positive pathogens, including methicillin-resistant Staphylococcus aureus (MRSA). This
research project will focus on developing new synthetic methodology to synthesize QPT analogs substituted at the
benzylic position, an area that has not been previously explored. Any synthesized analogs will be evaluated for
their antibacterial activity potential, potentially by a microbiologist at Calvin but most likely at the University of
Notre Dame (Marvin Miller's lab).
Benson,
David
Chemistry
National
Science
Foundation
Taylor Hegg
Benson,
David
Chemistry
National
Science
Foundation
Brett DeVries
Anti-Oxidant Nature of Tyrosine-Cysteine Crosslinks in BF4112 The covalent bond between tyrosine and
cysteine amino acid sidechains in proteins could potentially provide anti-oxidant chemistry. This project will
characterize how the covalent bond (crosslink) between a tyrosine and cysteine in an orphan protein (BF4112)
occurs. Our research group found this crosslink for the first time, but we are using this protein to "test drive" a
variety of formation chemistries. We are interested in copper, iron, and manganese-based oxidations that are
biologically inspired.
Anti-Oxidant Nature of Tyrosine-Cysteine Crosslinks in Cysteine Dioxygenase The covalent bond between
tyrosine and cysteine amino acid sidechains in proteins could potentially provide anti-oxidant chemistry. This
project will characterize how the covalent bond (crosslink) between a tyrosine and cysteine in human cysteine
dioxygenase (CDO) functions. Mammalian CDOs contain a tyrosine-cysteine crosslink where cysteine is oxidized
but it is not clear if this crosslink contributes to the chemistry or if it contributes an additional function. We believe
an additional anti-oxidant function in CDO controls how long the protein survives in the cell which is used to
regulate cysteine concentrations in the cell. Some cysteine is necessary for protein production but too much
cysteine contributes to neurological diseases.
Benson,
David
Chemistry
National
Science
Foundation
Emily Golz
Analysis of Tyrosine-Cysteine Crosslinks Concentrations in Proteins The covalent bond between tyrosine and
cysteine amino acid sidechains in proteins could potentially provide anti-oxidant chemistry. To date, the most
quantitative assay for tyrosine-cysteine crosslink concentration comes from a mobility shift assay in gel
electrophoresis. A more quantitative assay needs to be developed. Our research group has explored absorbance,
fluorescence, colorimetric, and electrochemical assays and has found encouraging results from a fluorescence
assay. This project will collect the final data for calibration curve and apply this assay to BF4112, cysteine
dioxygenase, and hemoglobin.
Benson,
David
Chemistry
National
Science
Foundation
Matt Hollowell
Computational Analysis of Tyrosine-Cysteine Crosslinks in Proteins The covalent bond between tyrosine and
cysteine amino acid sidechains in proteins could potentially provide anti-oxidant chemistry. We have found at least
one new tyrosine-cysteine crosslinked protein from a simplistic computational search of the protein databank
(PDB), which houses all reported protein structures. Our research group is looking for better method to refine this
list of potential proteins, and find additional proteins from the PDB, that might contain tyrosine-cysteine
crosslinks. The work will involve running molecular dynamics calculations on Unix operating systems; which I
have experience with.
Prof
Benson,
David
Dept.
Chemistry
Funded by
National
Science
Foundation
DeKock,
Roger
Chemistry
Jansma
John Strikwerda
Family
Research
Fund in the
Sciences and
Business
Fellowship
DeKock,
Roger
Chemistry
Luke and
Pauline
Schaap
Summer
Research
Fellowship
Jared Weidman Sequential Ionization Energies of Atoms For several years we have performed theoretical studies in order to
obtain insight into the electronic structure of atoms. Specifically we aim to provide a theoretical underpinning as to
why the sequential ionization energies of atoms roughly follow an arithmetic progression. We employ the
GAMESS software, and the Restricted Open Shell Hartree Fock model within GAMESS (General Atomic and
Molecular Electronic Structure System).
Fynewever,
Herb
Chemistry
Pfizer
Fellowship,
National
Science
Foundation
Paula Kuiper,
Rachel
VanOeffelen
Louters,
Larry
Chemistry
Integrated
Ola-Oluwakiti
Science
Alabi
Research
Institute
(ISRI-HHMI)
Student
Andrew Roth
Project Title and Abstract
NMR Analysis of Tyrosine-Cysteine Crosslinks in Proteins The covalent bond between tyrosine and cysteine
amino acid sidechains in proteins could potentially provide anti-oxidant chemistry. To date, the only structural
information for tyrosine-cysteine crosslink has been derived from X-ray crystallography. We are pursuing X-ray
structure analysis of a new protein with a tyrosine-cysteine crosslink, but NMR can provide more rapid
information. This work will use the 500 MHz NMR at Calvin to directly demonstrate formation of a tyrosinecysteine crosslink within an intact protein and additional structural information.
Cooperativity in Hydrogen Bonding For several years we have performed theoretical studies that relate to
cooperativity in hydrogen bonding. For example, we examine molecular cubes with the formula NH3(H2O)7. We
believe that these small cubes can serve as prototypes for cooperativity in hydrogen bonded networks in real
chemical systems, such as ammonia, NH3, in water. We have completed similar studies on the thirty nine cubes of
HF(H2O)7. Additional studies on these systems need to be completed. Those additional studies would be the focus
of the summer 2013 work.
Faculty approaches to student interaction in teaching science, math, and engineering Usually when students
are learning science, math, and engineering they reveal their thinking to the instructor and the instructor uses this
information to give feedback to the students. Often, however, this two-way communication is limited to formal
assessments such as quizzes and exams, which happen after most of the learning has happened. Research has
shown that there are many effective ways to better integrate this communication into the learning process (e.g.
interactive classroom delivery and activity) realizing significant gains in student learning. Further research is
needed to determine what the barriers are to two-way communication and to devise strategies to remedy these
barriers. In this research, students will analyze data from classroom observations and interviews with faculty and
students to detect and classify these barriers.
Detection of oligomers of GLUT1 and its relationship to the activity of the transporter One model to explain
the activation of GLUT1 is that it becomes more active if the transporter aggregates, likely as a tetramer. We will
use two techniques to try to isolate GLUT1 tetramers and determine if the concentration of these tetramers changes
when glucose uptake is activate. The first method is called blue native PAGE, which, in contrast to SDS-PAGE, is
an electrophoretic technique capable of isolating membrane protein complexes intact. The second method will be
using chemical crosslinking reagents that covalently link the GLUT1 proteins together, which can be then
separated and sized by SDS-PAGE.
Prof
Louters,
Larry
Dept.
Chemistry
Funded by Student
Integrated
Sam Kerk
Science
Research
Institute
(ISRI-HHMI)
Project Title and Abstract
Relationship of GLUT1 tethering to the cytoskeleton and its influence on its activity GLUT1, like many
membrane proteins, can be tethered to the cell cytoskeleton by connector proteins. Typically this tethering is
involve in the recycling of the protein to and from the membrane surface. We will measure the fraction of GLUT1
tethered to the cytoskeleton and determine if that fraction changes when GLUT1 is activated.
Louters,
Larry
Chemistry
Integrated
Stephen
Science
Gunnink
Research
Institute
(ISRI-HHMI)
Effects of curcumin (from the spice, tumeric) on glucose uptake Curcumin, an ingredient in the Indian spice,
tumeric, has a molcular structure that is reactive with thiols. GLUT1, the major glucose transporter, is thought to
be activated by the formation of a disulfide bond. We hypothesize that curcumin will alter the glucose transport
activity of GLUT1 in L929 fibroblast cells.
Muyskens,
Mark
Chemistry
Enno
Wolthuis
Summer
Student
Research
Fellowship,
Thedford P.
Dirkse
Summer
Research
Fellowship
Andrea
Bootsma,
Alexandria
Hoerr
Photochemistry: Research in Fluorescence in Sycamore Wood and Photoelimination in Acetylacetone There
are two areas of photochemistry that will be investigated. One area is to investigate the chemical structure of the
highly fluorescent components of the aqueous extract of sycamore wood. This project continues an effort to
identify the fluorescent compounds from sycamore wood. The work involves liquid chromatography for separation
and fluorescence spectroscopy. The other project will use computational tools to model the kinetic and molecular
structural details of a gas-phase photochemical reaction. My research has experimental results from the ultraviolet
laser photoelimination of hydrogen fluoride fromfluorine containing acetylacetone in the gas phase. The work will
be greatly assisted by developing models related to the data.
Sinniah,
Kumar
Chemistry
National
Science
Foundation
Maggie Van
Winkle,
Nicole
Michmerhuizen,
Amanda Witte
Investigating the Binding of Insulin with G-Quadruplex DNA G-quadruplexes are noncanonical DNA
structures formed from guanine-rich DNA sequences in the presence of monovalent cations such as potassium or
sodium ions. These structures are of significant interest due to their role in biological processes. The human
genome contains hundreds of thousands of sequences that have the potential to form quadruplexes. Proteins that
bind to G-quadruplex DNA are likely to provide a clue to the role of G-quadruplex DNA in biology. Our group is
currently studying the biophysical interactions between the protein insulin and the various sequences of Gquadruplex DNA found in the insulin linked polymorphic region. This project is suitable for a student interested
in biochemistry, chemistry, or biology.
Sinniah,
Kumar
Chemistry
Integrated
Abby Leistra,
Science
Jong Hyun Han
Research
Institute
(ISRI-HHMI)
Characterizing Riboflavin Conjugated Nanoparticles for Targeted Drug Delivery in Cancer Therapy
Riboflavin (RF) receptors have been found to overexpress in prostate and breast cancer cells. RF receptors can be
targeted for selective delivery of anticancer drug molecules. Our group has characterized RF conjugated
dendrimer series for targeting the RF receptor. We determined that one series of dendrimer conjugates based on
the orientation of RF attachment to the dendrimer performed better at binding to the RF receptor. This summer we
hope to extend this work to study both monovalent and multivalent interactions between RF and its receptor using
single molecule and bulk ensemble methods. This project is suitable for a student interested in
biomedicine/biochemistry/chemistry/biology/bioengineering.
Prof
Tatko, Chad
Dept.
Chemistry
Funded by
Thedford P.
Dirkse
Summer
Research
Fellowship
Student
Caleb Uitvlugt
Vander
Griend,
Douglas
Chemistry
SeongEun Kim, Nanomolecular Building Projects Understanding and controlling the synthesis of supramolecules is a key goal of
Emily Rhude,
nanotechnology. Students working on this project will use UV-vis spectroscopy and mass spectrometry to
Matt Haveman investigate the solution chemistry of various inorganic and biochemical systems in which individual molecules
associate in solution to form larger structures. Students may also get involved with computer programming and
modeling if so desired.
Nelesen,
Serita
Computer
Science
American
Chemical
Society /
Petroleum
Research
Fund (ACSPRF)
Integrated
Science
Research
Institute
(ISRI-HHMI)
De Jong,
Rich
Engineering
Thomas
Wodarek
Engineering Lukas Woltjer
Department's
Program for
Sustainability
Engineering
Project Title and Abstract
Perturbation of Acidity via Noncovalent Interactions A structured environment or lipid association can result
in a significant alteration. This project will construct a series of folded peptides into a beta-hairpin conformation.
This co-localizes a queried amino acid proximal to an acid. Through NMR methods the pKa of the acid will be
determined to elaborate the noncovalent impact of the neighbor.
HTMAD: Software for Analyzing MALDI-TOF Data The ability to write programs to analyze large datasets of
empirically gathered data has become an increasingly important skill with regards to advancing research in
biology, chemistry, and physics. A student working on this project will continue the development of a program
(HTMAD) to analyze data from the MALDI-TOF mass spectrometer. The current version of HTMAD needs to be
prepared for publication and distribution, and there are several extensions we would also like to implement.
Previous programming experience is required (ideally CS 112, but perhaps not required).
Development of a Thermal Test Chamber As energy becomes more precious and expensive, technologies that
reduce energy consumption become more interesting to engineers, homeowners, and anyone who has payed an
energy bill. One vital component of developing new technologies is the ability to compare the performance of new
developments with current technologies, as well as competing developments. Standards for testing help to meet
this need, and the use of standardized testing methods helps engineers and entrepreneurs make honest
improvements that help everyone in the long run.
The purpose of this project is to build, calibrate, and test a testing unit, hereafter “hotbox”, to be used for testing
new window technologies. We are building the hotbox to conform with ASTM (American Society for Testing and
Materials) and NFRC (National Fenestration Rating Council) standards regarding hotbox construction and
operation. This will allow the hotbox to give comparable results to other hotboxes meeting ASTM specifications,
and will allow Calvin to be a destination for companies and inventors looking to test and validate new fenestration
products.
Prof
Kim, Yoon
Dept.
Engineering
Funded by Student
Integrated
Kevin Vu,
Science
Aldo Daniel
Research
Institute
(ISRI-HHMI)
Project Title and Abstract
Development of portable battery-operated wireless devices for environmental monitoring This project is to
develop palm-size wireless computing devices for environmental monitoring. The device measures environmental
factors, such as noise, temperature, relative humidity, atmospheric pressure, and soil moisture through sensors and
performs logging data for a month-long period without recharging a battery. Although a conventional automated
recording system could record data, one needs to bring the system to a lab to retrieve its data. This method is not
only cumbersome, but also invasive to nature if repeated. There is more work that needs to be done to retrieve data
conveniently. Using the proposed device, the saved data could be retrieved remotely through a wireless link. It
reduces human intervention, and therefore, it would be less-invasive to nature and be more environmental friendly.
Having a microphone and camera embedded, it can also stream a live audio and video of wildlife without
disturbing nature. This project involves literature search, data measurements, designing of computer hardware and
analog electronics, programming, system integration, and testing.
Kim, Yoon
Engineering
Engineering Okkar Moe
Department's Myint
Program for
Sustainability
Engineering
Development of Maximum Power Point Tracking Controller for Photovoltaic Cells The sun is the most
abundant, and promising source for renewable energy, and harvesting technology for solar power has been
developed rapidly over the last decade. Maximum power point tracking (MPPT) technology was one of the latest
technology being developed, and supposedly improves the efficiency of the power supply system. Most
photovoltaic (PV) systems are not able to utilize all power supply from PV arrays, and as a result, power loss is
occurred. MPPT technology will be able to recover up to 75% of it. In short, MPPT is an electronic system that
changes the operating points/parameters based on voltage supply (from solar modules) to deliver maximum power.
The focus of the research was on the algorithm of MPPT technology and its performance on the MPPT circuit.
Si, April
Engineering
Engineering
Department
Electrophoretic Focusing and Navigation for Intranasal Target Drug Delivery Delivering drugs from the
nose to the brain has multiple advantages over the current intravenous delivery method. The reason that this is not
the current method of treatment is because of the deficiency in methods to ensure the drug can navigate the nasal
passage to the appropriate location where the tissue between the brain and the nasal cavity is thinnest called the
olfactory epithelium. While there are vast options of nasal delivery devices available on the market, devices
designed for selective olfactory deposition have not yet been found. Therefore, it is critical to search for more
effective drug-delivery strategies that can directly deliver drugs to the olfactory region.
Wunder,
David
Engineering
Engineering Jerome Navarro
Department's
Program for
Sustainability
Engineering
Rachel Gaide
Fluoride Sorption onto Bagasse Charcoal Wood charcoal (WC) is broadly used in developing global regions
(DGR) for heating and cooking. In many regions, WC production contributes to deforestation which can
exacerbate global climate change and increase the adverse effects of soil erosion and flooding. Bagasse, the
sugarcane residual from processing, is an alternative and sustainable source for charcoal. Although studied as a
fuel source, bagasse charcoal (BC) also has potential value for water treatment. Treating water of DGR has
focused largely on biological pathogens. However, there remains a need to develop novel and sustainable methods
for removing non-biological contaminants. This work focuses on BC column studies of the removal of fluoride
from water supplies.
Prof
Wunder,
David
Dept.
Engineering
Project Title and Abstract
Funded by Student
Integrated
Julie Swierenga, Fate and Impact of Antibiotics in Denitrifying Biofilters Nitrate contamination of water supplies is caused by
Science
Jeremiah Rocha widespread use of fertilizers, erosion due to changes in land use, and leaching. One of the most cost effective and
Research
environmentally responsible processes used to remove nitrates from groundwater is fixed-film biological
Institute
denitrification. A possible concern with this process is the presence of antibiotics at in water supplies and their
(ISRI-HHMI)
impact on dentrifying biofilm bacteria and their ability to reduce nitrate. . Interestingly, recent work has shown that
some antibiotics that might impede the activity of denitrifying bacteria may also be abiotically transformed in
reducing conditions necessary for biological denitrification. This research attempts to understand whether grouped
antibiotics at environmentally-relevant concentrations will impact the activity and community structure of
denitrifying biofilm bacteria, and whether the response of individual antibiotics to reducing environmental
conditions will partially mitigate their impact(s). Using substrate utilization kinetic studies, a continuous-feed
rotating annular bioreactor would be used to better understand the fate and impact of grouped antibiotics
ondenitrifying biofilm bacteria used for water treatment.
van Dijk,
Deanna
Geology,
Geography &
Environmental
Studies
Integrated
Linden Brinks,
Science
Lucas
Research
VanderBilt
Institute
(ISRI-HHMI)
How does human activity affect coastal dune activity? This project will investigate how human impacts and
management strategies affect the geomorphic activity of Lake Michigan coastal dunes. At North Beach dune and
Mt. Pisgah in Ottawa County, the investigation will build on preliminary results from First-Year Research in Earth
Sciences (FYRES) research students showing that management efforts are stabilizing these dunes. This summer,
we will collect and analyze data to see whether it is possible to determine the relative contributions of different
management strategies to the overall stabilization of the two dunes. We will also generate a list of promising
research questions for future FYRES projects by exploring other dune sites for interactions between dune activity
and human impacts and/or management strategies.
van Dijk,
Deanna
Geology,
Geography &
Environmental
Studies
Van Buren
County
James Karsten
Syndicate Park Dune Study A dune area in Van Buren County is advancing inland, burying houses and
threatening others. Because Van Buren County owns most of the dune area, the Van Buren County Commission
requested that a study be done on this area. Research focused on assessing human activities on the dune area and
visitor and resident perceptions of the dune area.
van Dijk,
Deanna
Geology,
Geography &
Environmental
Studies
National
Science
Foundation
Merideth
Beukelman
Evaluating the FYRES Project A new course at Calvin known as the “First-Year Research in Earth Sciences:
Dunes course, or just simply “FYRES: Dunes” was started two years ago. The FYRES course includes content
specifically about dunes, but also allows the first-year students to engage in undergraduate research alongside
upper-level research mentors. The second year of this course finished in the fall 2012 semester. A couple of the
goals of this course include learning content about dunes, and also learning how to conduct good scientific
investigations. The goal of the research this summer was to see if engaging students in a scientific research course
would allow them to improve in their ability to apply scientific research skills and knowledge in a unique context.
Prof
VanHorn,
Jason
Dept.
Geology,
Geography &
Environmental
Studies
Project Title and Abstract
Funded by Student
Plaster Creek Chengbi Liu,
GIS and Remote Sensing of Plaster Creek Watershed Over the course of 10 weeks, we will engage in the
Stewards
William SooHoo development of a more sophisticated GIS system than is currently available for the Plaster Creek watershed.
Gathering and developing a variety of spatial layers for the watershed and collecting an historical view of the
watershed through aerial imagery will be the primary goal. Adding this GIS data to the existing watershed GIS @
gis.calvin.edu and developing new tools for the online application will be a secondary goal. Lastly, we will build a
series of technical briefs to assist individuals interested in conducting spatial analysis using the layers we add to
the GIS Server at Calvin College as an outreach to the Calvin Community.
Bolt, Michael Math
National
Science
Foundation,
Jack and Lois
Kuipers
Applied
Mathematics
Endowment
Timothy
DeVries,
Conrad Blom,
Andrew Hayes,
David Zhang
Analytic functions of a generalized complex variable This is a continuation of a program in which students have
participated since 2008 and which already has resulted in five publications with students as coauthors. This year's
effort will center around properties shared and not shared by analytic functions of a complex variable with analytic
functions of a dual or double variable. In general, the variable has form z = x + e y where e^2 = -1 for a complex
variable, = 0 for a dual variable, and = +1 for a double variable. The applied math component is reflected in the
recent appearance of double numbers in the study of nonlinear dynamics; students will be expected to gain
familiarity with this application. The line of inquiry most closely resembles the work done by two students in
summer 2011.
Kapitula,
Todd
National
Science
Foundation
Eric Yu,
Shamuel
Auyeung
The Krein function - a new characteristic polynomial It is well-known that the eigenvalues of a matrix are
found by determining the zeros of the characteristic polynomial. In many problems of physical/mathematical
interest the goal is to not find all of the eigenvalues, but only those few that have some special significance. The
Krein function is a different type of characteristic function - no longer a polynomial - which accomplishes
precisely this task. The Krein function can be constructed in many different ways. The student researchers will
explore the various ways of creating the Krein function, and attempt to determine a criteria which says which one
is "best" for solving a particular problem.
Math
Turner, James Math
National
Nicholas Visser,
Science
Kate Ardinger,
Foundation, HwaPyeong Kim
Jack and Lois
Kuipers
Applied
Mathematics
Endowment
Utilizing algebra to address problems in the geometry of polynomials Certain problems in geometry can be
studied through hypersurfaces, that arise as the zeroes of multivariable polynomials, as well as their intersections.
Such problems can often be resolved through knowledge of the dimension of such intersections. A device that
facilitates the computation of such a dimension is the Hilbert function. The aim this summer will be to explore one
or both of the following:
1. Use Hilbert functions to measure the extent a planar graph is rigid. A first step would involve giving an
algebraic proof of Laman's theorem for characterizing rigid planar graphs.
2. Associated to a Hilbert function is its Hilbert series. Such a series has a lower bound and a conjecture of
Froberg indicates when the Hilbert series is this lower bound. We will examine the next open case.
Prof
Ayoola,
Adejoke
Dept.
Nursing
Funded by
Robert Wood
Johnson
Foundation,
Alumni
Grant,
Science
Division
Student
Kendra
Pennings,
Erika Bosch,
Lyndsay
DeGroot,
Laura Schipper,
Emily Johnson,
Samantha
Orozco,
Rebecca Vander
Wall,
Megan Rietema,
Colleen Skeba,
Megan De
MaagdRodriguez
Project Title and Abstract
Preconception reproductive knowledge promotion (PREKNOP) Unplanned pregnancy continues to be an
ongoing public health problem in the United States which has a relatively higher rate than other developed
countries. The social and economic cost of unplanned pregnancy and its associated adverse health outcomes on
individuals and the society is enormous. Unplanned pregnancy rates and their adverse effects are even worse
among minority and low-income women. The long-term objective of this research is to promote women’s
reproductive health and positive pregnancy outcomes by examining the effectiveness of the “Preconception
Reproductive Knowledge Promotion (PREKNOP)”, an intervention to increase women’s knowledge of their body,
while reducing the risk of unplanned pregnancy and delayed pregnancy recognition. The social cognitive theory
and the health promotion model guide this study. Based on a community-based participatory research approach,
this study builds on residents’ reported concerns and recommendations as well as a longstanding partnership
between the Calvin College nursing department and three racially diverse medically underserved low-income
communities in southwest Michigan. The hypothesis is that the PREKNOP program will reduce the risk of
unplanned pregnancy and improve women’s ability to manage their reproductive health. A sample of 120 women,
18-44 years old will be randomly assigned into two groups, one control and one intervention at the time of
recruitment. A pre-intervention survey will be conducted to establish a baseline.
The PREKNOP intervention will consist of 8 home visits during which women will receive information on the
female reproductive system and the expected monthly cyclical changes. Teams of nursing students and community
health workers will administer the 12 month intervention and surveys in face-to-face interviews. The PREKNOP
intervention will consist of 6 ovulation test kits (participants can request refills at any time), a 12 month menstrual
calendar, a digital thermometer, and educational brochures covering: the female reproductive anatomy, hormones
and menstrual cycle, how to recognize ovulation period, various methods of birth control and how they work, early
pregnancy symptoms, and how to confirm pregnancy symptoms. Women of childbearing age, especially minorities
and the medically underserved, need continuous monitoring and on-going educational approach to reduce disparity
in health and improve pregnancy outcomes. Promoting better understanding of the reproductive changes in their
bodies and actively involving women in their own care is a logical place to start.
Haan, Stan
Physics
National
Science
Foundation
Nathan
Harkema,
Christian
Woolley
Computer modeling of double ionization of atoms by visible and infrared lasers
Haarsma,
Loren;
Nelesen,
Serita
Physics,
Computer
Science
Integrated
James Lamine
Science
Research
Institute
(ISRI-HHMI)
Developing a computer model of evolution of interlocking complexity in biology We have developed and are
expanding a computer model which investigates one possible strategy for the gradual evolution of increasing
interlocking complexity in biological systems. Artificial organisms called Pykaryotes gather resources from their
environment, move, and build proteins and protein complexes based on their genetic code. Through mutation and
selection their genetic code gradually becomes more complex. While the focus of the project is biological, some of
the model's details are also relevant to questions of self-organized complexity in other fields. A student will work
with professors in biophysics and computer science to run the computer program, modify the program, and
evaluate how the model performs.
Prof
Haarsma,
Loren;
Haney,
Becky;
Norman, Vic
Dept.
Physics,
Economics,
Computer
Science
Funded by Student
Integrated
Jiaming Jiang
Science
Research
Institute
(ISRI-HHMI)
Project Title and Abstract
Programming and optimizing an agent-based computer simulation of a self-organized, interdependent
economy Over the last three summers, Calvin undergraduates have programmed an “agent-based” computer
simulation similar to computer games such as SimCity and Life. In this simulation, computer agents gather
resources, invent tools and trade with other agents. Over time a complex network of interdependencies develops
among the agents. This is a model of the development of economic relationships that exist in modern,
technologically-advanced economies. The purpose of this model is to investigate the variables which affect wealth
and inequality within an economy. This summer, a student will work with professors in economics, computer
science, and physics to add functionality to the existing computer model by adding human virtues and vices to
agent behavior and social institutions to the trading scenarios. The programming project will also include
“parallelizing” the code, to vastly reduce runtime. Students should know or be able to quickly learn the C++
programming language. Students having had at least one economics course are preferred.
Harper, Paul Physics
Integrated
Zach Strango,
Science
Chris Ver Hoef
Research
Institute
(ISRI-HHMI)
DSC and Temperature Jump Studies of Lipid Phase Transitions Lipid phase transitions among the many types
of lipid phases are highly relevant to understanding the behavior of membrane proteins and the cellular processes
of pore formation, division, fusion, and infection. Likewise, sugars play a key role in stabilizing membranes
against freezing and dehydration. Last summer, we found that the disaccharide sucrose appears to be excluded
from the surface of the frozen lamellar and hexagonal phases of the lipid SOPE, but partially included in the
surface of the fluid lamellar phase. Over the fall, we started to study the lipid monoolein and sucrose, which forms
exotic minimal surface based phases. In monoolein, we’ve seen the greatest phase transition shifts yet. This
summer, we’ll use DSC, differential scanning calorimetry, to investigate effects of other sugars, such as glucose,
trehalose, and raffinose. Concurrently, we’ll also build a temperature jump apparatus that will use optical methods
to monitor the phase transitions.
Molnar, Larry Physics
Sam Van
Michigan
Space Grant Kooten
Consortium,
Integrated
Science
Research
Institute
(ISRI-HHMI)
Asteroid Collisions To a remarkable degree, the history of our solar system is recorded in the details of the orbits
of the numerous small bodies that are left over: the asteroids. In the last few years, we have developed new
techniques to read this history, especially in identifying the age and membership of asteroidal collisional families.
One key parameter in models of the collisional history of the asteroid belt is the impact energy required to disrupt
an asteroid. Theoretical estimates of this parameter vary widely. The main goal of this summer's work is to
establish this parameter observationally by careful study of the collisions that have occurred in the Koronis zone,
an isolated region in the outer portion of the main asteroid belt. Towards this end we have written software to
compute collisional speeds and probabilities along with software to combine several catalogs of asteroid
information. This summer we will put these together to get a final answer.
Prof
Steenwyk,
Steven
Dept.
Physics
Project Title and Abstract
Funded by Student
Dan Van Noord Modeling Fast and Unusual Binary Stars Though they often appear as a single star, even when magnified,
Michigan
Space Grant
binary stars are two stars held in mutual orbit around one another by gravity. Contact binary stars are so close
Consortium,
together that their atmospheres touch as they rapidly orbit one another. While these so called “W UMa” systems
Integrated
are not uncommon, many aspects of their life cycle remain poorly understood, from formation to final state. They
Science
are identified by characteristic shapes of the light curves obtained with Calvin's telescopes. Using powerful search
Research
and analysis software, student researchers have already found and typed many new variable stars over the last two
Institute
years. Several of these are quite extraordinary and thus of significant interest to the astronomical community. One
(ISRI-HHMI)
is one of the fastest contact binaries known that we call V0811+3119. Another is a complex system consisting of a
contact binary that is itself orbited by a third star (V859 Cyg). While fast contact binaries remain the primary
interest, the proposed ten week project will also follow up on a very rare blue sub dwarf in an eclipsing orbit with
a red dwarf star (V2008-1753). Finally continued follow up is needed on a contact binary we call V0738+2950
that exhibits extraordinary variations in the shape and period of its light curve. This behavior may be due to
activity of monstrous starspots or even presage a catastrophic stellar merger.
Walhout,
Matthew
Physics
Hubert A.
Vander Plas
Memorial
Student
Research
Fellowship,
National
Science
Foundation,
John Van
Zytveld
Summer
Student
Research
Fellowship
TOTALS
Jake Lampen,
Margeaux
Carter,
Nathan
McReynolds,
Jonathan
Shomsky
Experiments with trapped krypton atoms We will use laser light to trap a small cloud of atoms, and then we
will use various tools to study atomic collisions in the cloud. The goal is to understand the collisional dynamics in
terms of diatomic molecular potentials that characterize the pairwise interactions between atoms. The work will
involve optics, electronics, vacuum equipment, and computer programs for data acquisition and molecular
modeling.
58 projects
73% were externally funded (grants from outside Calvin College)
41 professors
21% were funded by private donors
9 departments
100 students (51 men, 49 women)
6% were funded from within Calvin College
2013 Off-campus researchers
Student
Antonides,
Kendra
Hui, Esther
Supervisor
Prof. Rob Keys,
Prof. Sam
Riffle, and Fred
Van Dyke
Professor Daisy
KY Shum
(Biochemistry
department),
Professor YS
Chan
(Physiology
department), Dr.
Anthony Tam
(post-doctorate),
Mr. Lam Fung
Kwok (research
assistant)
Funded by
Innovative
Technology
Fund
Mustert,
Marie
Dr. Dan
Michele
Niyibizi,
Auguste
Dr. Emily Smith U. S.
Department
of Energy
Dr. JP Steibel
What is the relationship between sculpin abundance and water quality in northwestern Michigan?
Au Sable Institute, Mancelona, MI
Production of Purified Chondroitinase ABC II in use for Studies of Spinal Cord Nerve Regeneration
University of Hong Kong
Summer
The induction of dystrophin-glycoprotein complex function in differentiating iPSCs for the development of a model for the
muscular dystrophies
UnderUniversity of Michigan, Physiology Department
graduate
Research in
Physiology
Program at U
of M
Polet, Rachel Dr. Curtis
U. S.
Wilkerson,
Department
Jacob Jensen,
of Energy
Nathan Johnson
VandeHaar,
Peter
Project Title and Location
funded by
supervising
professor
Using Raman and Fourier Transform Infrared Spectroscopy to Obtain Quantitative and Qualitative Data on Polystyrene
and Polycarbonate Films
Ames Lab Department of Energy, Ames, Iowa
Investigating the biosynthetic pathway of xylan for the development of biofuel crops
Great Lakes Bioenergy Research Center, Michigan State University
Exploration and Exploitation of Linkage Disequilibrium
Michigan State University
Several other students did off campus research, for a total of 9 off campus researchers
Ahn, Isaac
Chan, Erica
Pagel,
Hannah
Chemistry
Physics
Physics
Colorado State
Laser Interferometer Gravitational-Wave Observatory at the California Institute of Technology
Great Lakes Eye Care (St. Joseph, MI)