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CONTRIBUTING AUTHORS INCLUDE: Richard C. Boucher, Neil A. Bradbury,
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PUBLISHED BY THE AMERICAN PHYSIOLOGICAL SOCIETY
The Physiology of Cystic Fibrosis reports on one of the
includes historical perspectives on the physiological basis of
most intensively studied proteins in biomedical science:
CF, analyses of the complex events occurring during
the cystic fibrosis transmembrane conductance regulator
disruption of chloride conductance in epithelial cells, reviews
(CFTR). Since the gene was cloned, there has been an
of CFTR function and the clinical manifestations brought on
explosion of scientific interest in its use to explore the
by mutations, and descriptions of how CFTR deletion or
array of cellular processes on which CFTR touches.
mutation leads to the infection and inflammation process
governing the progression of CF airway disease. This grow-
This special supplement to Physiological Reviews focuses
ing understanding of the role of CFTR in the pathophysiology
on essential physiological issues concerning the function
of CF serves as a clinical basis for more effective treatment
of CFTR, concentrating on the nuts and bolts of CFTR and
of the disease.
its contribution to epithelial cell function. The collection
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