C H A P T E R
4
Neural Crest Cell Migration: Guidance,
Pathways, and CellCell Interactions
Eric Theveneau and Roberto Mayor
Department of Cell and Developmental Biology, University College London, UK
O U T L I N E
Pathways of Neural Crest Cell Migration:
An Overview
Cephalic Neural Crest Cell Migration
Inhibitors
Positive Regulators of Cephalic Neural
Crest Cell Migration
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75
Trunk Neural Crest Cell Migration
The Ventromedial Pathway
The Dorsolateral Pathway
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CellCell Interactions During Neural
Crest Cell Migration
Neural CrestNeural Crest Interactions
and Cell Polarity
Neural CrestNeural Crest Interactions
Promote Collective Guidance
CIL-Based Dispersion Is Counterbalanced
by Mutual Attraction to Promote
Collective Cell Migration
Dialogue Between Neural Crest
Cells and Their Local
Environment
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Conclusion and Perspectives
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Acknowledgments
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References
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PATHWAYS OF NEURAL CREST
CELL MIGRATION: AN OVERVIEW
surrounding tissue by activating an epitheliumto-mesenchyme transition (EMT) program
and migrate extensively throughout the embryo
[2]. They depart as a continuous cell population, progressively dispersing away from
the neuroepithelium, and organize into discrete
streams. Along the way toward their target
The neural crest cells (NCC) are induced
at the interface between the neuroepithelium
and the prospective epidermis [1]. Shortly
after induction, NCC delaminate from their
Neural Crest Cells.
DOI: http://dx.doi.org/10.1016/B978-0-12-401730-6.00004-1
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© 2014 Elsevier Inc. All rights reserved.