Computers in Biology and Medicine 62 (2015) 325–326 Contents lists available at ScienceDirect Computers in Biology and Medicine journal homepage: www.elsevier.com/locate/cbm Honored Papers 2014 Computers in Biology and Medicine publishes papers in the areas of computational biology, biomedical engineering, bioinformatics, and related topics. The journal has become quite competitive, with only about 1 in 5 submitted papers eventually being accepted for publication. Thus there are many outstanding papers published by the journal. We have recently established a protocol to recognize the most outstanding papers published each year. I as editor, go through the reviewer comments and select those papers with the most outstanding comments for a year just ended. I then ask the original reviewers, and the editorial board of the journal, for comments about the selected papers, whether they would suggest a particular paper is suitable for Top Ten Paper of the Year, Honorable Mention Paper (upper 10% of all papers published during the year), or no honors, and if they wish, to score it numerically. Many of the original reviewers do respond, and the editorial board make comments on papers in their areas of expertise. Reviewers and editorial board members can also select additional papers not selected by me as candidates to include in the list of honored papers. If any reviewer or editorial board member objects to a particular paper being honored, it can be removed, depending also on any favorable or unfavorable comments from others. Each person's comments is converted to a numerical score, and the average score for all who commented on a particular paper is used for ranking the paper. The top 10 in rank are selected as Top Ten Papers of the Year, and the others, up to approximately 10% of all papers published during the year, as Honorable Mention Papers. The top five papers are also given one year of free open access on the journal website. During 2014, a total of 223 papers were published in Computers in Biology and Medicine, and I think all were good to excellent in content. As editor, I am very careful to weed out those works with problems like plagiarism and unreadability before the manuscript goes to the reviewers. We try to get at least three experts to review each manuscript, and even four, five, or six experts. More expert reviewers means more errors are caught, to improve the paper overall. I will not accept a paper for publication until everything that was commented about it is corrected, even if it takes multiple revisions to do so. Yet, the process is rapid, as our turnaround time averages less than 4 weeks. The Honored Papers for 2014 are international in scope, and include a wide variety of topics in the field of computers in biology and medicine. We the editorial board and reviewers think these papers will have a substantial impact on their focus area, and can be greatly admired in terms of quality, readability, and interest that will be generated. We hope that you will take the time to take a look at those honored papers in your area of interest, as we think reading them will provide much benefit and insight as you too, work to improve the quality of biomedical research and practice throughout the world. http://dx.doi.org/10.1016/j.compbiomed.2015.04.004 0010-4825/ Top 10 Papers of the Year 3D geometric split-merge segmentation of brain MRI datasets. Marras I, Nikolaidis N, Pitas I. Comput. Biol. Med. 2014 May;48:119–132. Visualizing in vivo brain neural structures using volume rendered feature spaces. Nakao M, Kurebayashi K, Sugiura T, Sato T, Sawada K, Kawakami R, Nemoto T, Minato K, Matsuda T. Comput. Biol. Med. 2014 October;53:85–93. Heartbeat classification using disease-specific feature selection. Zhang Z, Dong J, Luo X, Choi KS, Wu X. Comput. Biol. Med. 2014 Mar;46:79–89. PcHD: Personalized classification of heartbeat types using a decision tree. Park J, Kang K. Comput. Biol. Med. 2014 November;54:79–88. Trans3D: A free tool for dynamical visualization of EEG activity transmission in the brain. Blinowski G, Kamiński M, Wawer D. Comput. Biol. Med. 2014 August;51:214–222. Exploring medical diagnostic performance using interactive, multiparameter sourced receiver operating characteristic scatter plots. Moore HE 4th, Andlauer O, Simon N, Mignot E. Comput. Biol. Med. 2014 April;47:120–129. A novel class dependent feature selection method for cancer biomarker discovery. Zhou W, Dickerson JA. Comput. Biol. Med. 2014 April;47:66–75. A fast hierarchical clustering algorithm for large-scale protein sequence data sets. Szilágyi SM, Szilágyi L. Comput. Biol. Med. 2014 May;48:94–101. Lock-in thermal imaging for the early-stage detection of cutaneous melanoma: A feasibility study. Bonmarin M, Le Gal FA. Comput. Biol. Med. 2014 April;47:36–43. Numerical investigation of ultrasonic attenuation through 2D trabecular bone structures reconstructed from CT scans and random realizations. Gilbert RP, Guyenne P, Li J. Comput. Biol. Med. 2014 February;45:143–156. 326 E.J. Ciaccio / Computers in Biology and Medicine 62 (2015) 325–326 Honorable Mention Papers (upper 10%) An implicit evolution scheme for active contours and surfaces based on IIR filtering. Delibasis KK, Asvestas PA, Kechriniotis AI, Matsopoulos GK. Comput. Biol. Med. 2014 May;48:42–54. The effects of six antipsychotic agents on QTc—an attempt to mimic clinical trial through simulation including variability in the population. Glinka A, Polak S. Comput. Biol. Med. 2014 April;47:20–26. An in silico case study of idiopathic dilated cardiomyopathy via a multi-scale model of the cardiovascular system. Bhattacharya-Ghosh B, Bozkurt S, Rutten MC, van de Vosse FN, Díaz-Zuccarini V. Comput. Biol. Med. 2014 October;53:141–153. Hyperbolic Dirac Nets for medical decision support. Theory, methods, and comparison with Bayes Nets. Robson B. Comput. Biol. Med. 2014 August;51:183–197. Averaging of diffusion tensor imaging direction-encoded color maps for localizing substantia nigra. Ellmore TM, Murphy SM, Cruz K, Castriotta RJ, Schiess MC. Comput. Biol. Med. 2014 August;51:104–110. Label free cell-tracking and division detection based on 2D timelapse images for lineage analysis of early embryo development. Cicconet M, Gutwein M, Gunsalus KC, Geiger D. Comput. Biol. Med. 2014 August;51:24–34. Deficient gaze pattern during virtual multiparty conversation in patients with schizophrenia. Han K, Shin J, Yoon SY, Jang DP, Kim JJ. Comput. Biol. Med. 2014 June;49:60–66. Bayesian reconstruction of projection reconstruction NMR (PRNMR). Yoon JW. Comput. Biol. Med. 2014 November;54:89–99. Prediction of temperature and damage in an irradiated human eye-Utilization of a detailed computer model which includes a vectorial blood stream in the choroid. Heussner N, Holl L, Nowak T, Beuth T, Spitzer MS, Stork W. Comput. Biol. Med. 2014 August;51:35–43. Large eddy simulation of the FDA benchmark nozzle for a Reynolds number of 6500. Janiga G. Comput. Biol. Med. 2014 April;47:113–119. Experimental validation of 3D printed patient-specific implants using digital image correlation and finite element analysis. Sutradhar A, Park J, Carrau D, Miller MJ. Comput. Biol. Med. 2014 September;52:8–17. A preliminary study on the differences in male and female muscle force distribution patterns during squatting and lunging maneuvers. Hale R, Hausselle J, Gonzalez RV Comput. Biol. Med. 2014 September;52:57–65. Effects of offset values for artificial teeth positions in CAD/CAM complete denture. Yamamoto S, Kanazawa M, Iwaki M, Jokanovic A, Minakuchi S. Comput. Biol. Med. 2014 September;52:1–7. Empirical evaluation of consistency and accuracy of methods to detect differentially expressed genes based on microarray data. Yang D, Parrish RS, Brock GN. Comput. Biol. Med. 2014 March;46:1–10. Finding multivariate outliers in fMRI time-series data. Magnotti JF, Billor N. Comput. Biol. Med. 2014 October;53:115–124. Anonymization of DICOM electronic medical records for radiation therapy. Newhauser W, Jones T, Swerdloff S, Newhauser W, Cilia M, Carver R, Halloran A, Zhang R. Comput. Biol. Med. 2014 October;53:134–140. Quadcopter flight control using a low-cost hybrid interface with EEG-based classification and eye tracking. Kim BH, Kim M, Jo S. Comput. Biol. Med. 2014 August;51:82–92. Edward J. Ciaccio, Ph.D. Columbia University, United States