PROGRAMME SPECIFICATION Programme title: Human Tissue Repair Final award (BSc, MA etc): MSc/ MRes (where stopping off points exist they should be detailed here and defined later in the document) UCAS code: N/A (where applicable) Cohort(s) to which this programme specification is applicable: From September 2016 onwards (e.g. from 2015 intake onwards) Awarding institution/body: University College London Teaching institution: University College London Faculty: Medical Sciences Parent Department: Division of Medicine (the department responsible for the administration of the programme) Departmental web page address: http://www.ucl.ac.uk/medicine/ (if applicable) Method of study: One calendar year full-time Full-time/Part-time/Other Criteria for admission to the programme: First or upper second class honours degree or overseas equivalent, in a relevant subject (e.g. Biological Sciences, Biomedical Sciences, Cell Biology and Medicine) from a recognized university, or an appropriate degree level professional qualification. Length of the programme: One calendar year full-time. (please note any periods spent away from UCL, such as study abroad or placements in industry) Level on Framework for Higher Education Qualifications (FHEQ) (see Guidance notes) Relevant subject benchmark statement (SBS) (see Guidance notes) Level 7 At date of production, no relevant postgraduate benchmark. Brief outline of the structure of the programme and its assessment methods: (see guidance notes) Board of Examiners: Outline of the program structure: The structure of this programme is summarised in Appendix 1 (below). Briefly, students will all take 4 core modules (60 credits) in Term 1 which form the foundation of knowledge required for the both the MSc or the MRes degree. During the first term, the students will be asked to select one of three pathways or routes which will determine: a) the name of their degree, ie Human Tissue Repair (Inflammation OR Immunotherapy OR Transplantation Science) b) whether their degree will be MSc or MRes c) their research project There will be a ‘project day’ in term 1 where the students will be presented with research projects for each route. The programme will consist of 180 credits made up from modules worth 15 credits and either a research project worth 60 credits leading to the MSc or 90 credits leading to an MRes/MSc. Completion of the 4 core modules from Term1 can lead to a Postgraduate Certificate (60 credits). Completion of 4 additional modules from Term 2 making a total of 120 credits can lead to a Diploma. Further, the “flip lecture” content of many of the modules will enable them to be packaged as CPD courses. Term 1 - 4 Compulsory Core modules: ‘Principles of inflammation (NEW)’, & ‘Immunology in health and disease (NEW)’, ‘Tissue repair and regeneration (NEW)’, Research Methods (NEW)’, Term 2: - 1 compulsory Core practical module, ‘Practical Research Skills (NEW)’ - 3 Selective Modules: Student will select their ‘Route’ by selecting EITHER ‘Inflammation and disease (NEW) OR Immunological basis of disease (NEW) OR Transplantation science(NEW) If the students opt for a 90 credit research project they will not choose optional modules. If the students opt for the MSc (60 credits) they will choose from 2 optional modules (total 30 credits) from the list provided in their chosen ‘route’/ - ‘Inflammation’ Route Optional modules: 1. Transplantation (NEW, 2. Stem cell therapy,3. Immunological basis of disease (NEW), 4. Ethics, Translation & commercialisation ,5. Biological Molecules as therapies - ‘Immunotherapy’ Route Optional modules: 1. Transplantation (NEW),2. Stem cell therapy, 3. Inflammation & Disease (NEW), 4. Ethics, Translation & commercialisation, 5. Cell & Gene Therapy: Molecular and clinical aspects - ‘Transplantation Science’ Route Optional modules: 1. Stem cell therapy, 2. Tissue engineering, 3. Immunological basis of disease (NEW),4. Ethics, Translation & commercialisation, 5. Applied Biomaterials Term 3: Research project (60credits) for each route. Outline of the assessment methods: Attendance at scheduled lectures/ tutorials on the timetable. Assessment will be made by a mixture of exams (MCQs and long answer), coursework including (literature review, practical skill assessments, presentations, poster sessions and critical evaluation assessments and peer/ group assessment). Completion of a research project. In the event of failure of <25% of the taught components of the programme (eg. failure of coursework OR failure of examination OR failure or journal club presentations), re-sit examinations /assessments will be set. The research project dissertation cannot be failed. Name of Board of Examiners Human Tissue Repair Professional body accreditation (if applicable): N/A Date of next scheduled accreditation visit: EDUCATIONAL AIMS OF THE PROGRAMME: This is an integrated programme designed to link three complementary and interconnected areas of biomedical research, namely inflammation, immunity and regenerative and transplantation sciences, providing the student unsurpassed training and understanding in all aspects of human tissue repair. The programme aims to deliver core training in a) the cell and molecular pathways regulating inflammation, tissue repair, regeneration and the pathogenic mechanisms underlying common and rare inflammatory conditions, b) immune responses underlying these mechanisms c) understanding of current treatments and therapies (pharmacological, immunotherapies, stem cell therapies, organ transplantation, tissue engineering and biomaterials used to repair organs). Studies will bridge both science and medicine/surgery disciplines with particular reference to human health therapy, drug discovery and translational biomedicine. The course will prepare students for further academic study (transfer to PhD programmes) and to work at the highest levels within the biomedical sciences. It will also provide the foundation for careers engaged in public healthcare sector and the NHS, in industry and biopharma, government and research councils, biomedical charities and stakeholders, sports medicine, and scientific media and publishing houses. Inflammation and the immune response are the most important biologic processes in maintaining health and provide a critical link between injury and tissue damage, coordinating effective repair and restoration of organ function. They are also pivotal pathological drivers in almost all human diseases, including autoimmune diseases, cancer, fibrotic diseases, cardiovascular diseases, degenerative diseases and dementia. Key facets of inflammation have been targeted by the pharmaceutical industry to pioneer the development of the most robust treatment modalities now widely adopted for all human diseases, including biologics, such as anti-cytokine therapy, small molecule kinase inhibitors and antibody-based cell depletion strategies. These highlight the importance of understanding the fundamental biology of inflammation and repair in health and in the development of strategies for advanced therapeutics for human disease. The course harnesses basic, biomedical, clinical and surgical expertise and research strengths assembled from across UCL Institutes and Divisions and UCL partner hospitals and together with industrial colleagues will provide world leading teaching and training in inflammation, immunology, tissue remodelling, tissue regeneration, tissue transplantation, drug discovery and in understanding and treating human disease. In addition the students will gain knowledge through undertaking a specialised research project, as well as aspects of ethics, regulation of research and intellectual property. The programme also aims to provide students with additional skills such as organising and managing the project, working as part of a scientific team, communicating their findings in the form of scientific writing as well as orally presentations to a broad audience. Specifically the programme aims to: Provide in-depth knowledge of inflammation in human disease delivered by experts Provide in-depth knowledge of immune responses and immunotherapy in human disease delivered by experts Provide in-depth knowledge of regenerative and transplantation science Provide research experience/training under the supervision of internationally-renowned academic/clinical/ surgical specialists Provide students with a good range of practical laboratory skills Provide students with a broad understanding of both the practical and theoretical aspects of research methodology and ethics, experiment planning, data handling and critical analysis. Provide training in scientific communication and presentation. Provide understanding of translational research from basic bench-top research to commercialization strategies. Enhance the interaction of students with the research community as well as the pharmaceutical industry. Provide overseas graduates with experience of biomedical research and practice in the UK. PROGRAMME OUTCOMES: The programme provides opportunities for students to develop and demonstrate knowledge and understanding, qualities, skills and other attributes in the following areas: A: Knowledge and understanding Knowledge and understanding of: Human tissue repair at the molecular, cellular, tissue and organ levels, involves complex biological process including inflammation, immunity and regeneration. The course will highlight the mechanisms that drive it under normal under normal tissue repair/ regeneration and the abnormal alterations that occur in these processes in human diseases. The core modules ‘Principles of inflammation’, ‘Immunology in health and disease’, ‘Tissue repair and regeneration’, provide the foundation of specific knowledge required to understand human tissue repair. The Selective core modules ‘Inflammation and disease ,Immunological basis of disease, Transplantation will provide the more advanced aspects of human tissue repair especially in the context of disease and will allow the student to choose a pathway following their own specific interests. The practical module ‘Practical Research Skills’ will provide the necessary basic skill required for working in biomedical research laboratory. The taught module ‘Research Methods’ will teach the necessary theoretical and practical skill to work in a scientific manner including, statistical methods, experimental design, scientific presentation skills etc. The optional modules ‘Stem cell therapy’, ‘Tissue engineering,’ ‘Applied Biomaterials’, and ‘Cell & Gene Therapy: Molecular and clinical aspects’ provide the student with the option to specialise in a specific aspect of human tissue repair, regeneration and replacement. Optional modules‘ Biological molecules as therapies’ and ‘Ethics , translation & Commercialisation’ will allow the students to learn about drug design as well as ethics, regulation and the translational pathways towards commercialisation, which is essential for stimulating student “entrepreneurship” and making potential therapies a clinical reality. Teaching/learning methods and strategies: Lectures by active, world class researchers in the field of inflammation in human disease, tissue repair, tissue regeneration and tissue replacement. Recorded ‘Flip’ lectures and face-to-face tutorial groups Student presentations of current ongoing research with discussions led either by course tutor/s and other lecturers within the Faculty. Journal club presentations will be open to discussion at follow-up tutorials, students will write a 250 word abstract of selected presentation Assessment: Unseen examinations, Course-work in the form of essays and presentations. Multiple choice questionnaire examinations, Production and presentation of a dissertation of original research carried out by the student under the supervision of an active, international class researcher. B: Skills and other attributes Intellectual (thinking) skills: Critical appraisal of scientific literature. Critical analysis and interpretation of data. Understanding and application of generated data in the broader context of the field Teaching/learning methods and strategies: Small group seminars and oral presentation. Group and individual discussions. Critical appraisal of journal articles. Research Project design. Group learning Assessment: Marked coursework assignments, projects, reports and presentations. Unseen written exams. Dissertation and oral presentation for Research Project module. Peer assessment C: Skills and other attributes Practical skills (able to): Design, organise and manage a project Manage time efficiently. Present ideas, concepts and original research in a clear and concise scientific manner Present scientific data to business audience Perform cell culture and to plan simple cell based experiments Teaching/learning methods and strategies: Research project design Laboratory work, practical skills Production of high quality scientific dissertation Oral presentations Assessment: Research project dissertation of 10,000 words Practical Assessment Research project laboratory assessment by supervisor’s report Oral Presentations D: Skills and other attributes Transferable skills (able to): Appreciate and understand scientific methodology Perform critical analysis on others’ research Perform analysis and interpretation of numerical data Understand and use statistics effectively Effectively time manage Present and communicate scientific data competently to other scientists and to non-scientists Teaching/learning methods and strategies: Lectures Seminars, Tutorials, Oral and Poster presentations Critical reading of research articles Assigned reading and self-directed learning Group discussions Laboratory work Research project design Assessment: Examinations Coursework assignments Dissertation Oral Presentations Research project supervisor’s report The following reference points were used in designing the programme: the Framework for Higher Education Qualifications: (http://www.qaa.ac.uk/en/Publications/Documents/qualifications-frameworks.pdf); the relevant Subject Benchmark Statements: (http://www.qaa.ac.uk/assuring-standards-and-quality/the-quality-code/subject-benchmark-statements); the programme specifications for UCL degree programmes in relevant subjects (where applicable); UCL teaching and learning policies; staff research. Please note: This specification provides a concise summary of the main features of the programme and the learning outcomes that a typical student might reasonably be expected to achieve and demonstrate if he/she takes full advantage of the learning opportunities that are provided. More detailed information on the learning outcomes, content and teaching, learning and assessment methods of each course unit/module can be found in the departmental course handbook. The accuracy of the information contained in this document is reviewed annually by UCL and may be checked by the Quality Assurance Agency. Programme Organiser(s) Name(s): Dr Markella Ponticos Date of Production*: May 2015 Date of Review: 11 November 2015 Date approved by Chair of Departmental Teaching Committee: Date approved by Faculty Teaching Committee 13 November 2015 Appendix 1 26th November 2015