FOUNDATIONS IN MICROBIOLOGY AND IMMUNOLOGY
Microbial Genetics and Pathogenesis (M&IM 332)
Location: A5305 MCN
Course Directors: Borden Lacy and Timothy Cover
2013 Summer Schedule
Mondays, Tuesdays, Thursdays, & Fridays at 3 pm
WEEK 1
July 8
3-4:50
Course leaders (3 pm to 3:30 pm)
Introduction to Foundations in Microbiology and Immunology
Lacy (3:30 pm)
Didactic Overview of Pathogenesis, Virulence factors, Toxins
July 8
3-4:50
Lacy
Gatsogiannis, et. al., (2013) A syringe-like injection mechanism in
Photorhabdus luminescens toxins. Nature. 495(7442):520-3.
July 11
3-4:20
Spiller
Didactic Overview of Intracellular Pathogens and Mechanisms of
Motility
July 12
3-4:50
Spiller
Orchard, et. al. (2012) Identification of F-actin as the Dynamic Hub in
a Microbial-Induced GTPase Polarity Circuit Cell 148, 803–815.
July 15
3-4:20
Bordenstein
Didactic Overview of Evolutionary Relationships in Microbes
July 16
3-4:50
Bordenstein
Lieberman et al. (2011) Parallel bacterial evolution within multiple
patients identifies candidate pathogenicity genes. Nature Genetics
43:1275-80
July 18
3-4:20
Cover
Didactic Overview of Secretion systems
Fronzes et al., The structural biology of type IV secretion systems,
Nature Rev Microbiol 2009; 7: 703-714.
July 19
3-4:50
Cover
Kwok et al., (2007) “Helicobacter exploits integrin for type IV
secretion and kinase activation”. Nature 2007 449: 862-6
July 22
3-4:20
Skaar
Didactic Overview of Bacterial Immune Systems
July 23
3-4:50
Skaar
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WEEK 2
WEEK 3
Bikard, et. al., (2012) CRISPR Interference Can Prevent Natural
Transformation and Virulence Acquisition during In Vivo Bacterial
Infection Cell Host and Microbe 12, 177-186.
July 25
3-4:20
Skaar
Didactic Overview of Immune Evasion Strategies
July 26
3-4:50
Skaar
Alonzo, et. al. (2013) CCR5 is a receptor for Staphylococcus aureus
leukotoxin ED. Nature 493, 51–55
Jul 29
3-4:20
Hadjifrangiskou
Didactic overview of Two-component signalling
REVIEW ARTICLE: Goulian and Laub, “Specificity in twocomponent signal transduction pathways.“ Annu Rev Genet.
2007;41:121-45.
Jul 30
3-4:50
Hadjifrangiskou
WEEK 4
Capra et al., “Adaptive mutations that prevent crosstalk enable the
expansion of paralogous signaling protein families.” Cell. 2012 Jul
6;150(1):222-32.
AND/OR
Skerker et al., “Rewiring the specificity of two-component signal
transduction systems.“ Cell. 2008 Jun 13;133(6):1043-54.
Aug 01
3-4:20
Link
Didactic Overview of Antibiotic mechanisms and mechanisms of
resistance, bacterial translation?
Aug 02
3-4:50
Link
Sommer, M. O., Dantas, G., and Church, G. M. (2009). Functional
characterization of the antibiotic resistance reservoir in the human
microflora. Science 325, 1128-1131.
Aug 05
3-4:50
Gomez
Didactic Overview of Pili/Adherence/Colonization
Aug 06
3-4:50
Gomez
Jennings MP, Jen FE, Roddam LF, Apicella MA, Edwards JL.
Neisseria gonorrhoeae pilin glycan contributes to CR3 activation
during challenge of primary cervical epithelial cells. Cell Microbiol.
2011 Jun;13(6):885-96.
WEEK 5
And
Chamot-Rooke J, et. al. (2011) Posttranslational modification of pili
upon cell contact triggers N. meningitidis dissemination. Science.
331(6018):778-82.
Aug 08
3-4:50
Review
Aug 09
3-4:50
FINAL EXAM