Product datasheet
Anti-Synapsin I antibody ab128882
Overview
Product name
Anti-Synapsin I antibody
Description
Rabbit polyclonal to Synapsin I
This product is a fast track antibody. It has been affinity purified and shows high
titre values against the immunizing peptide by ELISA.
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Properties
Form
Liquid
Storage instructions
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated
freeze / thaw cycles.
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Target
Function
Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed
to function in the regulation of neurotransmitter release. The complex formed with NOS1 and
CAPON proteins is necessary for specific nitric-oxid functions at a presynaptic level.
Involvement in disease
Defects in SYN1 are a cause of epilepsy X-linked with variable learning disabilities and behavior
disorders [MIM:300491]. XELBD is characterized by variable combinations of epilepsy, learning
difficulties, macrocephaly, and aggressive behavior.
Sequence similarities
Belongs to the synapsin family.
Post-translational
modifications
Substrate of at least four different protein kinases. It is probable that phosphorylation plays a role
in the regulation of synapsin-1 in the nerve terminal. Phosphorylated upon DNA damage,
probably by ATM or ATR.
Cellular localization
Cell junction > synapse. Golgi apparatus.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
Terms and conditions
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Guarantee only valid for products bought direct from Abcam or one of our authorized distributors
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