Overview
Product name
Description
Tested applications
Species reactivity
Immunogen
Positive control
Anti-SLC19A3 antibody
Rabbit polyclonal to SLC19A3
WB
Reacts with: Human
Synthetic peptide corresponding to a region within internal sequence amino acids 225-255 of
Human SLC19A3, conjugated to KLH.
NIH-H292 cell lysate
Properties
Form
Storage instructions
Storage buffer
Purity
Purification notes
Clonality
Isotype
Liquid
Shipped at 4°C. Store at 4°C (up to 6 months). Store at -20°C long term.
Preservative: 0.09% Sodium Azide
Constituents: PBS
Immunogen affinity purified
Purified through a protein A column, followed by peptide affinity purification.
Polyclonal
IgG
Applications
Our Abpromise guarantee covers the use of ab103950 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 56 kDa.
Target
Relevance SLC19A3 is a member of the reduced folate family of micronutrient transporter genes. It is a ubiquitously expressed transmembrane thiamine transporter that lacks folate transport activity yet mediates high affinity thiamine uptake propably via a proton anti-port mechanism. Mutations
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Cellular localization
Anti-SLC19A3 antibody images in this gene cause biotin-responsive basal ganglia disease (BBGD); a recessive disorder manifested in childhood that progresses to chronic encephalopathy, dystonia, quadriparesis, and death if untreated. Patients with BBGD have bilateral necrosis in the head of the caudate nucleus and in the putamen. Mutations in this gene also cause a Wernicke's-like encephalopathy.
Plasma membrane
Anti-SLC19A3 antibody (ab103950) at 1/100 dilution + NIH-H292 cell lysate at 35 µg
Predicted band size : 56 kDa
Western blot - SLC19A3 antibody (ab103950)
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