CATHERINE HYAMS
Address:
The Centre for Respiratory Research, The Rayne Institute, Dept of Medicine, UCL,
London, WC1E 6JJ.
Telephone:
(0207) 679 6976
Nationality:
British,
Email:
Marital Status: Single
catherinehyams@doctors.org.uk
Gender: Female
I have successfully completed the MB PhD program at UCL, and am undertaking the academic
foundation programme training in North Central Thames. I am continuing research in the same lab in
which I undertook my PhD and BSc with Dr Jeremy Brown, investigating role of the polysaccharide
capsule in the virulence of Streptococcus pneumoniae.
Education
2011-Current
North Central Thames: Academic Foundation Programme Training, Foundation Years 1 and 2
2001-2011
Clinical School: University College Hospital, London
Undergraduate: University College London, London
2000-2001
School: The Edinburgh Academy, Edinburgh, Scotland
1997-1999
School: Colchester County High School, Colchester
Qualifications
2011
Bachelor of Medicine, Bachelor of Surgery MBBS, Faculty of Life Sciences, UCL
2010
MB PhD Programme Completion, Faculty of Life Sciences, UCL
Doctor of Philosophy, UCL, Department of Medicine
2006
iBSc
UCL
Intercalated Degree in Immunology and Cell Pathology with Preclinical
Sciences (First Class) (Recommendation to Dean’s List for Academic
Excellence);
2002
Top 10% in First Year Preclinical Medicine, UCL
2001
A-Levels: Biology, Chemistry, Maths (all grade A)
Scholarships and Prizes
2009
Postgraduate
2008
•
The Cordwainer’s Prize for MB PhD Thesis 2009
•
The Horace Joules Prize in Respiratory Medicine 2008-2009 (UCL)
•
The British Association of Lung Researchers Young Scientist Award
•
The British Thoracic Society Medical Student Abstract Prize
•
Full Colours (Honorary) UCL for Ice Hockey
•
First Class degree in Immunology and Cell Pathology (UCL)
•
Recommendation to the Dean’s List for Academic Excellence
•
Graduated member of Duct’s Club for Academic Excellence (top 15%)
2006
Undergraduate
2001
School
Sept 2011Current
Current Position – Foundation Years 1 and 2, North Central Thames
I am currently undertaking clinical Foundation Programme Training on an Academic
Foundation Training allocation in North Central Thames. My rotations include Paediatrics,
Endocrinology, General Surgery, Hepatology and an Accident and Emergency attachment
with research in Virology at the Royal Free Hospital in Prof Paul Griffith’s laboratory.
CATHERINE HYAMS
Page 1 of 6
Jan 2007-Sept
MB PhD Student at The Centre for Respiratory Research, UCL
2011
I have successfully completed my PhD with supervisors Dr Jeremy Brown and Dr Mahdad Noursadeghi
and have multiple first and middle author papers, as well as abstracts at national and international
conferences. I successfully graduated with an MBBS degree in Medicine from the faculty of Life
Sciences, UCL.
Intercalated BSc
Sept 2005
- June 2006
University College London, Dept of Immunology
I took an intercalated degree in Immunology and Cell Pathology as I wanted to further understand this
area, and as part of this degree I undertook a research project at The Centre for Respiratory Research
(UCL), supervised by Dr Jeremy Brown, and entitled ‘Binding of Complement Factors to Different M
Protein Serotypes of Streptococcus pyogenes’. Results presented in my thesis were published in the
Journal of Immunology. I was awarded a First Class Degree, graduating 2nd in my class.
Publications
First Author
2012
Hyams C, Day TG, Ramroop S, Paget S, Howard S, McMillan M, Vora S, de Keyser P. An
Unusual Case of Incomplete Kawasaki Disease in an Adolescent Returning From Holiday in
Montana. Pediatr Cardiol. In Press
2011
Hyams C, Opel S, Hanage WP, Yuste J, Bax K, Henriques-Normark B, Spratt BG, Brown JS.
Effects of Streptococcus pneumoniae strain background on complement resistance. PLoS
One. 2011 Oct. 10.1371/journal.pone.0024581
2010
Hyams C, Yuste J, Bax K, Camberlein E, Wesier JN and Brown JS. Streptococcus
pneumoniae resistance to complement-mediated immunity is dependent on capsular
serotype. Infect Immun. 2010 Feb;78(2):716-25.
2010
Hyams C, Camberlein E, Cohen JM, Bax K and Brown JS. The Streptococcus pneumoniae
capsule has multiple effects on complement activity and bacterial interactions with
neutrophils. Infect Immun. 2010 Feb;78(2):704-15.
2010
Hyams C, Tan JCH, Brown JS and Gordon SB. C3b/iC3b deposition on Streptococcus
pneumoniae is not affected by HIV infection. PLoS One. 2010 Jan 26. 5(1): e8902.
doi:10.1371/journal.pone.0008902
Middle Author
2011
Sanchez CJ, Hinojosa CA, Shivshankar P, Hyams C, Camberlein E, Brown JS, Orihuela CJ.
Changes in capsular serotype alter the surface exposure of pneumococcal adhesins and
impact virulence. PLoS One. 2011 Oct. 10.1371/journal.pone.0026587
2011
Cohen JM, Khandavilli S, Camberlein E, Hyams C, Baxendale HE, Brown JS. Protective
contributions against invasive Streptococcus pneumoniae pneumonia of antibody and Th17cell responses to nasopharyngeal colonisation. PLoS One. 2011 Oct. 10.1371/
journal.pone.0025558
2011
Wilkosz S, Edwards LA, Bielsa S, Hyams C, Taylor A, Davies RJ, Laurent GJ, Chambers
RC, Brown JS, Lee YC. Characterization of a new mouse model of empyema and the
mechanism of pleural invasion of Streptococcus pneumoniae. Am J Respir Cell Mol Biol.
2011 Sept.
CATHERINE HYAMS
Page 2 of 6
2010
Stables MJ, Newson J, Ayoub SS, Brown J, Hyams C, Gilroy DW. Priming innate immune
responses to infection by cyclooxygenase inhibtio kills antibiotic-susceptible and -resistant
bacteria. Blood. 2010 Oct 21;116(16):2950-9.
2010
Yuste J, Sen A, Truedsson L, Jönsson G, Hyams C, Cohen JM, Camberlein E, Sriskandan S,
Brown JS. Impaired opsonization with complement and phagocytosis of Streptococcus
pyogenes in sera from subjects with inherited C2 deficiency. Microbes Infect. 2010
Aug;12(8-9):626-34.
2010
Yuste J, Khandavilli S, Ansari N, Muttardi K, Ismail L, Hyams C, Weiser JN, Mitchell T and
Brown JS. The effects of PspC on complement mediated immunity to Streptococcus
pneumoniae vary with strain background and capsular serotype. Infect Immun. 2010
Jan;78(1):283-92.
2008
Yuste J, Sen A, Truedsson L, Jönsson G, Tay LS, Hyams C, Baxendale HE, Goldblatt F,
Botto M, Brown JS. Impaired opsonisation with C3b and phagocytosis of Streptococcus
pneumoniae in serum from subjects with defects in the classical complement pathway. Infect
Immun. 2008 Jun 9
2007
Yuste J, Ali S, Sriskandan S, Hyams C, Botto M and Brown JS. Roles of the alternative
complement pathway and C1q during innate immunity to Streptococcus pyogenes. J
Immunol. 2006 May 15;176(10):6112-20
Spoken Presentations
2011
Hyams C, Trzcinski K, Weinberger DM, Lipsitch M, Brown JS. Highly invasive capsular
serotypes of Streptococcus pneumoniae bind high levels of Factor H and are resistant to
complement and phagocytosis. British Thoracic Society Winter Meeting Dec 2011
2011
Hyams C and de Keyser P. A Rocky Road to Diagnosis. Chase Farm Hospital Grand
Round October 2011.
2010
Hyams C, Camberlein E, Noursadeghi M, Wesier JN, Brown JS. When it comes to
pneumococcal capsules, it’s not the size that counts. University College Hospital Medical
Grand Round, Feb 2010
2010
Hyams C, Opel S, Hanage W, Yuste J, Bax K, Henriques-Normak B, Spratt BG, Brown JS.
Relationship of Streptococcus pneumoniae strain background, capsular serotype, and attack
rate to resistance to complement-mediated immunity. International Symposium on
Pneumococci and Pneumococcal Disease-7, March 2010
2009
Hyams C, Camberlein E, Noursadeghi M, Wesier JN, Brown JS. The Streptococcus
pneumoniae capsule inhibits macrophage activation through the NFκB and not MAPK
activation pathways. British Thoracic Society Winter Meeting Dec 2009
2009
Hyams C, Bax K, Yuste J, Camberlein EM, Weiser JN, Brown JS. Invasive capsular
serotypes of Streptococcus pneumoniae are relatively resistant to complement compared to
non-invasive serotypes. EuroPneumo 2009
2008
Hyams C, Camberlein EM, Yuste J, Noursadeghi M, Michael C, Wieser JN, Spratt BG,
Brown JS. The Streptococcus pneumoniae capsule is essential for evasion of early alveolarmacrophage pulmonary mediated immunity. BTS Winter Meeting Dec 2008
2008
Hyams C, Opel S, Yuste J, Hanage WP, Henriques-Normark B, Weiser JN, Spratt BG,
Brown JS. Invasive capsular serotypes of Streptococcus pneumoniae are relatively resistant
to complement compared with non-invasive serotypes. BTS Winter Meeting Dec 2008
2007
Hyams C, Yuste J, Weiser JS and Brown JS. Effects of the capsule on the interactions of
Streptococcus pneumoniae with complement. Federation of Infection Societies
Conference, Nov 2007.
CATHERINE HYAMS
Page 3 of 6
Abstracts
2011
Hyams C, Trzcinski K, Weinberger DM, Lipsitch M, Brown JS. Highly invasive capsular
serotypes of Streptococcus pneumoniae bind high levels of Factor H and are resistant to
complement and phagocytosis. British Thoracic Society Winter Meeting, Dec 2011
2011
Wilson RJ, Cohen JM, Hyams C, van Wamel WJ, de Vogel C, van Belkum A, Gordon SB and
Brown JS. Anti-protein serological responses to Streptococcus pneumoniae in diverse
populations. British Thoracic Society Winter Meeting, Dec 2011
2010
Cohen JN, Khandavilli S, Camberlein E, Hyams C, de Vogel C, Giefing C, Nagy E, van
Belkum A, Baxendale H and Brown JS. Previous colonisation protects against pneumococcal
pneumonia: learning from natural immunity. American Thoracic Society International
Conference, Aug 2010
2010
Camberlein E, Hyams C, Weiser JN, Khandavilli S, Cohen JN,. Brown JS. The role of the
alveolar macrophage for early lung innate immunity to Streptococcus pneumoniae. American
Thoracic Society International Conference, Aug 2010
2010
Hyams C, Camberlein E, Tomlinson G, Noursadeghi N, Brown JS. The Streptococcus
pneumoniae capsule inhibits macrophage activation through the NFκB and not MAPK
activation pathways. International Symposium on Pneumococci and Pneumococcal
Disease-7, March 2010
2010
Hyams C, Opel S, Hanage W, Yuste J, Bax K, Henriques-Normak B, Spratt BG, Brown JS.
Relationship of Streptococcus pneumoniae strain background, capsular serotype, and attack
rate to resistance to complement-mediated immunity. International Symposium on
Pneumococci and Pneumococcal Disease-7, March 2010
2010
Hyams C, Tam JHC, Brown JS, Gordon SB. C3b/iC3b deposition on Streptococcus
pneumoniae is not affected by HIV infection. International Symposium on Pneumococci
and Pneumococcal Disease-7, March 2010
2010
Camberlein E, Hyams C, Weiser JN, Khandavilli K, Cohen JM, Noursadeghi M, Brown JS.
Effect of inoculum size, capsule and complement on Streptococcus pneumoniae interactions
with alveolar macrophages during early lung infection. International Symposium on
Pneumococci and Pneumococcal Disease-7, March 2010
2010
Cohen JM, Khandavilli S, Camberlein E, Hyams C, de Vogel C, Giefing C, Nagy E, van
Belkum A, Baxendale H, Brown JS. Previous Colonisation Protects Against Pneumococcal
Pneumonia By Inducing Antibodies To Protein Antigens. International Symposium on
Pneumococci and Pneumococcal Disease-7, March 2010
2010
Camberlein E, Hyams C, Weiser JN, Khandavilli K, Cohen JM, Brown JS. The role of the
alveolar macrophage for early lung innate immunity to Streptococcus pneumoniae. ATS,
2010
2010
Cohen JM, Khandavilli S, Camberlein E, Hyams C, de Vogel C, Giefing C, Nagy E, van
Belkum A, Baxendale H, Brown JS. Previous Colonisation Protects Against Pneumococcal
Pneumonia By Inducing Antibodies To Surface Protein Antigens. ATS, 2010
2009
Hyams C, Camberlein E, Noursadeghi M, Weiser JN, Brown JS. The Streptococcus
pneumoniae capsule inhibits macrophage activation through the NFκB and not MAPK
activation pathways. British Thoracic Society Dec 2009
2009
Camberlein E, Hyams C, Weiser JN, Khandavilli S, Cohen JM, Brown JS. The Streptococcus
pneumoniae capsule protects alveolar macrophage mediated early lung innate immunity.
British Thoracic Society Dec 2009
CATHERINE HYAMS
Page 4 of 6
2009
Hyams C, Bax K, Yuste J, Camberlein EM, Weiser JN, Brown JS. Invasive capsular
serotypes of Streptococcus pneumoniae are relatively resistant to complement compared to
non-invasive serotypes. EuroPneumo 2009
2008
Hyams C, Camberlein EM, Yuste J, Bax K, Weiser JN, Brown JS. The capsule prevents both
alternative and classical pathway activity against Streptococcus pneumoniae and is vital for
systemic infection. EuroPneumo 2009
2008
Hyams C, Camberlein EM, Yuste J, Noursadeghi M, Michael C, Wieser JN, Spratt BG,
Brown JS. The Streptococcus pneumoniae capsule is essential for evasion of early alveolarmacrophage pulmonary mediated immunity. British Thoracic Society Dec 2008
2008
Hyams C, Opel S, Yuste J, Hanage WP, Henriques-Normark B, Weiser JN, Spratt BG,
Brown JS. Invasive capsular serotypes of Streptococcus pneumoniae are relatively resistant
to complement compared with non-invasive serotypes. British Thoracic Society Dec 2008
2008
Hyams C, Camberlein EM, Yuste J, Noursadeghi M, Michael C, Wieser JN, Spratt BG,
Brown JS. The Streptococcus pneumoniae capsule is essential for evasion of alveolarmacrophage pulmonary mediated immunity. British Association of Lung Researchers July
2008
2008
Hyams C, Opel S, Hanage WP, Yuste J, Spratt B, Weiser JN and Brown JS. Effects of the
capsule on interactions of Streptococcus pneumoniae with complement. International
Symposium on Pneumococci and Pneumococcal Disease-6, June 2008
2008
Hyams C, Yuste J, Noursadeghi M, Michael C, Weiser JN and Brown JS. The capsule
prevents both classical and alternative pathway activity against Streptococcus pneumoniae
and is vital for evasion of early pulmonary immune responses. International Symposium on
Pneumococci and Pneumococcal Disease-6, June 2008
2007
Hyams C, Yuste J, Weiser JS and Brown JS. Effects of the capsule on the interactions of
Streptococcus pneumoniae with complement. Federation of Infection Societies
Conference, Nov 2007.
Courses and Meetings Attended
th
July 2012
9 Practical Introduction to Intensive Care Course, UCLH
December 2011
Winter British Thoracic Society Meeting
Sept 2011
Simulation Training Day – Foundation Programme, Bart’s Hospital
Aug 2011
Paediatric Life Support Course, Chase Farm Hospital
Aug 2011
Intermediate Life Support Course, Chase Farm Hospital
June 2010
International Symposium on Pneumococci and Pneumococcal Disease-7
December 2009
Winter British Thoracic Society Meeting
May 2009
EuroPneumo International Meeting
December 2008
Winter British Thoracic Society Meeting
July 2008
British Association of Lung Researchers Summer Meeting
June 2008
International Symposium on Pneumococci and Pneumococcal Disease-6
December 2007
Federation of Infection Societies Conference
March 2007
University College London - Animal Handling Course - Modules 1-4
Jan 2007
UCL H&S course - UCL - Carriage of Diagnostic and Infectious Substances by Air
CATHERINE HYAMS
Page 5 of 6
Skills and Experience
Presentations
I have presented to medical students and doctors, as well as other researchers
•
Feb 2010
Ø
Medical Ground Round, UCH: When it comes to pneumococcal capsules, it’s not the size that counts.....
Sept 2009
Ø
Paediatric Case Presentation, Barnet District Hospital: Transposition of the Great Arteries
Nov 2006
Ø
Junior Clinical Case Presentation, The Whittington Hospital:
July 2006
Ø
Medical Grand Round, University College Hospital: All a puff of smoke? (Moyamoya Disease)
Research
•
I completed a BSc research project during Intercalated BSc at UCL as detailed above. This gave
me useful experience in the collection of quantitative data, the design and optimisation of lab
experiments and data analysis using statistics and computers. I have also successfully completed
my PhD in Immunology and Cell Pathology for the Division of Medicine, UCL.
Lab Techniques
•
I have gained experienced at Western Blotting, FACS Analysis, Insertion-Duplication
Mutagenesis, Electron Microscopy, Confocal Microscopy, Cell Culture and basic
Microbiological Techniques.
IT
•
I am fully competent with Microsoft Office, wireless networking, statistics packages and using
powerpoint for presentations. I am also literate at webpage design, and other graphic packages.
Teaching
Throughout my PhD I have taught summer students, BSc students, PhD students, post-doctoral
researchers and clinical fellows. I have worked on international research collaborations and taught
research techniques to students from universities in the UK and USA. During my FY1 year I have
organized, co-ordinated and participated in the hospital classroom and bedside teaching program for
the final year medical students, aimed at preparing students for final year examinations. Additionally, I
have also organised and run Mock OSCE examinations for medical students across both Barnet and
Chase Farm Hospital sites as well as establishing and running a weekend Finals Revision Course
utilizing an audience response system. I have also been fortunate enough to tutor multiple students
through A-level examinations. Furthermore I have had the opportunity to assist teaching on the
Medipaces Course for MRCP Part II and also have taught horse riding to multiple students of varying
abilities.
Interests
I am an enthusiastic sportswoman (horse riding, ice hockey, scuba diving and represented my County
at Cross Country Running). I was treasurer of the ULU Ice Hockey Club and have set up and am
Treasurer of the UCL Union Ice Skating and Ice Hockey Club, and was awarded Full Honorary Colours
in 2008 from UCL. I also hold a PADI Rescue Diver license and have recently completed Nitrox Scuba
Diving Training with SNSI. I have traveled extensively, lived in America for 2 years and enjoy art,
reading and playing the double bass.
CATHERINE HYAMS
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