Complete Publication List for Rohit Bhargava, M.D.
Refereed Articles (Published)
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Nika C Gloyeske, Anna H Woodard, Esther Elishaev, Jing Yu, Beth Z Clark, David J Dabbs,
Rohit Bhargava. Immunohistochemical profile of breast cancer with respect to Estrogen
Receptor and HER2 status. Appl Immunohistochem Mol Morphol. 2015;23:202-208.
PMID: 25356941.
Zaibo Li, David J Dabbs, Kristine L Cooper, and Rohit Bhargava. Dual HER2 gene protein
assay: Focused study of breast cancers with 2+ immunohistochemical expression. Am J
Clin Pathol. 2015;143:451-458. PMID: 25696805.
Haihui Lu, Karl Clauser, Wai Leong Tam, Julia Frose, Xin Ye, Elinor Eaton, Ferenc
Reinhardt, Vera Donnenberg, Rohit Bhargava, Steven Carr, and Robert Weinberg [Paper
#NCB-W26299D]. A Breast Cancer Stem Cell Niche Supported by Juxtacrine Signaling
from Monocytes and Macrophages. Nature Cell Biology. 2014;16:1105-1117. PMID:
25266422.
Ding Z., Joy M.., Bhargava R., Gunsaulus M., Lakshman N., Miron-Mendoza M., Petroll
M., Condeelis J., Wells A., Roy P. Profilin-1 downregulation has contrasting effects on
early vs late steps of breast cancer metastasis. Oncogene. 2014;33:2065-2074. PMID:
23686314.
Rohit Bhargava, and David J Dabbs. Interpretation Of HER2 In-Situ Hybridization Assays
Using ASCO/CAP HER2 Guidelines 2013 Update. J Clin Oncol. 2014;32:1855. PMID:
24778404.
Bhargava R. Clinical utility of immunohistochemistry and other ancillary techniques in
assessment of uterine tumors. Semin Diagn Pathol. 2014;31:193-194. PMID: 24933036.
Beth Z Clark, Surabhi Beriwal, David J Dabbs, Rohit Bhargava. Semiquantitative GATA-3
Immunoreactivity in Breast, Bladder, Gynecologic Tract, and other Cytokeratin 7 Positive
Carcinomas. Am J Clin Pathol. 2014;142:64-71. PMID: 24926087.
Nika C Gloyeske, David J Dabbs, Rohit Bhargava. Low ER+ Breast Cancer: Is This a
Distinct Group? Am J Clin Pathol. 2014;141:697-701. PMID: 24713741.
Faye F Gao, M.D., PhD., David J. Dabbs, M.D., Kristine L Cooper, M.S. and Rohit
Bhargava, M.D. Bright-field HER2 dual in situ hybridization (DISH) assay versus
fluorescence in situ hybridization (FISH): Focused study of immunohistochemical 2+
cases. Am J Clin Pathol. 2014;141:102-110. PMID: 24343743.
Ashlee L. Smith, Mai Sun, Rohit Bhargava, Nicolas A. Stewart, Melanie S. Flint, William L.
Bigbee, Thomas C. Krivak, Mary A. Strange, Kristine L. Cooper, Kristin K. Zorn. Proteomic
analysis of matched formalin-fixed, paraffin-embedded specimens in patients with
advanced serous ovarian carcinoma. Proteomes. 2013;1(3):240-253. Open access:
http://www.mdpi.com/2227-7382/1/3/240
Xin Li, Amal Kanbour-Shakir, David J Dabbs, Rohit Bhargava. Morphologic features do
not influence response to trastuzumab containing neoadjuvant chemotherapy in HER2-
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positive breast cancer. Appl Immunohistochem Mol Morphol. 2013;21:420-425. PMID:
23165332.
Hahm ER, Lee J, Kim SH, Sehrawat A, Arlotti JA, Shiva SS, Bhargava R, Singh SV.
Metabolic Alteration in Mammary Cancer Prevention by Withaferin A in a Clinically
Relevant Mouse Model. J Natl Cancer Inst. 2013;105:1111-1122. PMID: 23821767.
Rohit Bhargava and David J Dabbs. Cancer of unknown primary origin: Using ancillary
techniques with caution. J Clin Oncol. 2013;31(11):1478-9. PMID: 23439751.
Faye F Gao, MD, PhD, Rohit Bhargava, MD, Haitao Yang, MD, PhD, Zaibo Li, MD, PhD
and Chengquan Zhao, MD. A Clinicopathological Study of Serous Tubal Intraepithelial
Carcinoma with Invasive Carcinoma: Is Serous Tubal Intraepithelial Carcinoma a Reliable
Feature to Determine Organ of Origin? Hum Pathol. 2013;44(8):1534-43. PMID:
23465279.
Beth Z Clark, Kristi Cooper, David J Dabbs, Rohit Bhargava. Impact of Progesterone
Receptor Semiquantitative Immunohistochemical Result on Oncotype DX® Recurrence
Score: A Quality Assurance Study of 1074 Cases. Accepted to be published in Appl
Immunohistochem Mol Morphol. 2013;21:287-291. PMID: 23060300.
Molly E Klein, David J Dabbs, Yongli Shuai, Adam M Brufsky, Rachel Jankowitz, Shannon L
Puhalla, Rohit Bhargava. Prediction of the Oncotype DX® Recurrence Score: Use of
Pathology Generated Equations Derived by Linear Regression Analysis. Mod Pathol.
2013;26:658-664. PMID: 23503643.
Jing Yu MD PhD, Sara E. Monaco MD, Rohit Bhargava MD, David J. Dabbs MD, Kathleen
M. Cieply BS, Jeff L. Fine MD. A Validation Study of Quantum Dot Multispectral Imaging
to Evaluate Hormone Receptor Status in Ductal Carcinoma In Situ (DCIS) of the Breast.
Hum Pathol. 2013;44:394-401. PMID: 23039940.
Beth Z Clark, and Rohit Bhargava. Bright Field Microscopy for HER2 Gene AssessmentNot Just DISH-ful Thinking? Am J Clin Pathol. 2013;139:137-139. PMID: 23355196.
Mirka Jones, Agnieszka Onisko, David J Dabbs, Esther Elishaev, Simion I Chiosea, Rohit
Bhargava. Immunohistochemistry and HPV in situ hybridization in distinction between
endocervical and endometrial adenocarcinoma: A comparative tissue microarray study
of 76 tumors. Int J Gynecol Cancer. 2013;23:380-384. PMID: 23318908.
Rohit Bhargava, M.D., Adam M. Brufsky, M.D., PhD., Nancy E. Davidson, M.D.
Prognostic/Predictive Immunohistochemistry Assays for Estrogen Receptor-Positive
Breast Cancer: Back to the Future? J Clin Oncol. 2012;30:4451-4453. PMID: 23045595.
Cohen DA, Dabbs DJ, Cooper KL, Amin M, Jones TE, Jones MW, Chivukula M, Trucco GA,
Bhargava R. Inter-observer Agreement among Pathologists for Semi-Quantitative
Hormone Receptor Scoring in Breast Carcinoma. Am J Clin Pathol. 2012;138:796-802.
PMID: 23161712.
Cancer Genome Atlas Network (Rohit Bhargava, one of 357 collaborators).
Comprehensive molecular portraits of human breast tumours. Nature. 2012;490:61-70.
PMID: 23000897.
Nidhi Agarwal, Rohit Bhargava, Esther Elishaev. Diagnostic Use of Ki-67 Proliferation
Marker As An Adjunct To Morphologic Diagnosis. Int J of Gyn Pathol. 2012;31:447-452.
PMID: 22833085.
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Rohit Bhargava and David J Dabbs. Reply to M Christgen et al. J Clin Oncol.
2012;30:3314-3315. WebID: http://jco.ascopubs.org/content/30/26/3314.full
Rajan K. Bista, Pin Wang, Rohit Bhargava, Shikhar Uttam, Douglas J. Hartman, Randall E.
Brand, and Yang Liu. Nuclear nano-morphology markers of histologically normal cells
detect the "field effect" of breast cancer. Breast Cancer Research and Treatment.
2012;135:115-124. PMID: 22706633.
Isil Z Yildiz-Aktas, David J Dabbs, and Rohit Bhargava. The Effect of Cold Ischemic Time
on the Immunohistochemical Evaluation of Estrogen Receptor, Progesterone Receptor,
and HER2 Expression in Invasive Breast Carcinoma. Mod Pathol. 2012;25:1098-1105.
PMID: 22460807.
James A Kraus, David J Dabbs, Sushil Beriwal, and Rohit Bhargava. Semi-quantitative
Immunohistochemical Assay versus Oncotype DX® qRT-PCR Assay for Estrogen and
Progesterone Receptors: An Independent Quality Assurance Study. Mod Pathol.
2012;25:869-876. PMID: 22301704.
James A. Kraus, Sushil Beriwal, David J. Dabbs, Gretchen M Ahrendt Kandace P McGuire,
Ronald R Johnson, Preeti Badve, Shannon L Puhalla, and Rohit Bhargava. Predictors of
Pathologic Complete Response after Standard Neoadjuvant Chemotherapy in Triplenegative Breast Carcinoma. Appl Immunohistochem Mol Morphol. 2012;20:334-339.
PMID: 22417856.
Isil Z Yildiz-Aktas, David J Dabbs, Kristine L Cooper, Mamatha Chivukula, Kim McManus,
and Rohit Bhargava. The Effect of 96-Hour Formalin Fixation on the
Immunohistochemical Evaluation of Estrogen Receptor, Progesterone Receptor, and
HER2 Expression in Invasive Breast Carcinoma. Am J Clin Pathol. 2012;137:691-698.
PMID: 22523206.
Rohit Bhargava, Raymond R. Tubbs, Syed K Mohsin, David J Dabbs. Reply to A.M. Gown
et al and F.L. Baehner et al. J Clin Oncol. 2012;30:1728-1729. PMID: 22493420.
Rohit Bhargava and David J Dabbs. Oncotype DX® test on unequivocally HER2 positive
cases: Potential for harm. J Clin Oncol. 2012;30:570-571. PMID: 22231308
David J. Dabbs, Molly Klein, Syed Mohsin, Raymond R. Tubbs, and Rohit Bhargava. High
false-negative rate of HER2 qRT-PCR of the Oncotype DX® test: An independent quality
assurance study. J Clin Oncol. 2011;29:4279-4285. PMID: 21990395.
Bhargava R, Sahoo S, Esposito NN, Chen B. Pathology of breast carcinoma: diagnostic,
prognostic, and therapeutic issues and challenges. Patholog Res Int. 2011;2011:73140.
PMID: 21961079.
Kandace P. McGuire, MD, Jorge Toro-Burguete, MD, Hang Dang, DO, Jessica Young, MD,
Atilla Soran, MD, MPH, Margarita Zuley, MD, Rohit Bhargava, MD, Marguerite
Bonaventura, MD, Ronald Johnson, MD, Gretchen Ahrendt, MD. MRI staging after
neoadjuvant chemotherapy for breast cancer: Does tumor biology affect accuracy? Ann
Surg Oncol. 2011;18:3149-3154. PMID: 21947592.
Anna H Woodard M.D., Jing Yu M.D., David J Dabbs M.D., Sushil Beriwal M.D., Anca V
Florea M.D., Esther Elishaev, M.D., Jon M Davison M.D., Alyssa M Krasinskas M.D., and
Rohit Bhargava M.D. NY-BR-1 and PAX8 immunoreactivity in breast, gynecologic tract
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and other CK7 positive carcinomas: Potential use for determining site of origin. Am J Clin
Pathol. 2011;136:428-435. PMID: 21846919.
Vargo JA, Beriwal S, Ahrendt GM, Soran A, Johnson RR, McGuire K, Bhargava R.
Molecular Class as a Predictor of Locoregional and Distant Recurrence in the
Neoadjuvant Setting for Breast Cancer. Oncology 2011;80:341-349. PMID: 21791944.
http://content.karger.com/ProdukteDB/produkte.aspDOI=10.1159/000330203
Jing Yu, MD, PhD, David J. Dabbs, MD, Yongli Shuai, MS, Leo A. Niemeier, MD, Rohit
Bhargava, MD. Classical Type Invasive Lobular Carcinoma with HER2 Overexpression:
Clinical, Histological and Hormone Receptor Characteristics. Am J Clin Pathol. 2011
Jul;136(1):88-97. PMID: 21685036.
Rohit Bhargava, M.D., Nicole N. Esposito, M.D., David J. Dabbs, M.D. Intracystic papillary
carcinomas of the breast are more similar to in-situ carcinomas than invasive carcinoma.
Am J Surg Pathol. 2011;35:778-779. PMID: 21451361.
Rohit Bhargava M.D., Sushil Beriwal, M.D., Kim McManus, HT (ASCP), David J Dabbs,
M.D. Insulin-Like Growth Factor Receptor-1 (IGF-1R) Expression In Normal Breast,
Proliferative Breast Lesions And Breast Carcinoma. Appl Immunohistochem Mol
Morphol. 2011;19:218-225. PMID: 21217522.
Rohit Bhargava, M.D., David J. Dabbs, M.D., Sushil Beriwal, M.D., Isil A. Yildiz, M.D.,
Preeti Badve, Atilla Soran, M.D., Ronald R. Johnson, M.D., Adam M. Brufsky, M.D., Barry
C. Lembersky, M.D., Kandace McGuire, M.D., and Gretchen M. Ahrendt, M.D.
Semiquantitative hormone receptor level influences response to trastuzumab
containing neoadjuvant chemotherapy in HER2 positive breast cancer. Mod Pathol.
2011;24:367-374. PMID: 21102420.
Bateman, Nicholas; Sun, Mai; Bhargava, Rohit; Hood, Brian; Darfler, Marlene; Kovatich,
Albert; Hooke, Jeffrey; Krizman, David; Conrads, Thomas. Differential Proteomic Analysis
of Late-Stage and Recurrent Breast Cancer from Formalin-Fixed Paraffin-Embedded
Tissues. J Proteome Res. 2011;10:1323-1332. PMID: 21155598.
Amy S Gardiner, William C McBee, Jr., Robert P Edwards, Marshall Austin, Jamie L
Lesnock, Rohit Bhargava, Richard Guido, and Saleem A Khan. MicroRNA analysis in
human papillomavirus (HPV)-associated cervical neoplasia and cancer. Infectious Agents
and Cancer 2010 5(Suppl 1):A55. PMCID: PMC3002716.
Vera S. Donnenberg, Ph.D., Albert D. Donnenberg, Ph.D. Ludovic Zimmerlin, Rodney J.
Landreneau, M.D., Rohit Bhargava, M.D., Ryan A. Wetzel, Per Basse, and Adam M.
Brufsky, M.D. Localization of CD44 and CD90 positive cells to the invasive front of breast
tumors. Cytometry B Clin Cytom. 2010 Sep;78(5):287-301. PMID: 20533389.
David J Dabbs, M.D. and Rohit Bhargava, M.D. Letter Regarding Ibarra et al article titled
“Fixation time does not affect the expression of estrogen receptor (Am J Clin Pathol.
2010; 133:747-755)”. Am J Clin Pathol. 2011 Jan;135(1):171-2. PMID: 21173141.
Wang P, Bista R, Bhargava R, Brand RE, Liu Y. Spatial-domain low-coherence
quantitative phase microscopy for cancer diagnosis. Opt Lett. 2010; 35(17):2840-2842.
PMID: 20808342.
Stergios Moschos, Drazen M. Jukic, Charalambos Athanassiou, Rohit Bhargava, Shih-Fan
Kuan, Sanja Dacic, Shelley L. Fayewicz, Marie Acquafondata, Rajiv Dhir. Expression
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Analysis of Ubc9, the Single SUMO E2 Conjugating Enzyme, in Normal and Malignant
Tissues. Hum Pathol. 2010;41:1286-98. PMID: 20561671.
Jing Yu, Rohit Bhargava and David J Dabbs. Invasive lobular carcinoma with extracellular
mucin production and HER-2 overexpression: a case report and further case studies.
Diagnostic Pathology. 2010;5:36. PMID: 20550696.
Teng, Pang-ning; Rungruang, Bunja; Hood, Brian; Sun, Mai; Flint, Melanie; Bateman,
Nicholas; Dhir, Rajiv; Bhargava, Rohit; Richard, Scott; Edwards, Robert; Conrads,
Thomas. Assessment of Buffer Systems for Harvesting Proteins from Tissue Interstitial
Fluid for Proteomic Analysis. Journal of Proteome Research. 2010;9:4161-4169. PMID:
20518575.
Dana Gingell, Amber Samuel, Denise Haynik, William McBee, Joseph Kelley, Kristen Zorn,
Rohit Bhargava. Metastatic Ovarian Serous Carcinoma Presenting as Inflammatory
Breast Cancer: A Case Report. Int J Gynecol Pathol. 2010;29:243-247. PMID: 20407323.
Siobhan O’Connor, David J Dabbs, Sushil Beriwal, Rohit Bhargava. Concordance
Between Semiquantitative Immunohistochemical Assay and Oncotype DX RT-PCR Assay
for Estrogen and Progesterone Receptors. Appl. Immunohistochem Mol Morphol.
2010;18:268-272. PMID: 20186046.
Rohit Bhargava, M.D., Sushil Beriwal, M.D., David J. Dabbs, M.D., Umut Ozbek, M.S.,
Atilla Soran, M.D., Ronald R. Johnson, M.D., Adam M. Brufsky, M.D., Barry C. Lembersky,
M.D., Gretchen M. Ahrendt, M.D. Immunohistochemical surrogate markers of breast
cancer molecular classes predicts response to neoadjuvant chemotherapy: A single
institutional experience with 359 cases. Cancer. 2010;116:1431-1439. PMID: 20131351.
Leo A. Niemeier, David J Dabbs, Sushil Beriwal, Joan Striebel, Rohit Bhargava. Androgen
Receptor in Breast Cancer: Expression in Estrogen Receptor Positive Tumors and in
Estrogen Receptor Negative Tumors with Apocrine Differentiation. Mod Pathol.
2010;23:205-212. PMID: 19898421.
Rohit Bhargava, Sushil Beriwal, Joan Striebel, David J Dabbs. Breast Cancer Molecular
Class ERBB2: Preponderance Of Tumors With Apocrine Differentiation And Expression
Of Basal Phenotype Markers CK5, CK5/6 And EGFR. Appl Immunohistochem Mol
Morphol. 2010;18:113-118. PMID: 19801938.
Olga L. Bohn, Irem Nasir, Adam Brufsky, George C Tseng, Rohit Bhargava, Kim
McManus, Mamatha Chivukula. Biomarker profile in breast carcinomas presenting with
bone metastasis. Int J Clin Exp Pathol 2010;3(2):139-146. PMID: 20126581.
Cagatay Ersahin, Mamatha Chivukula, Rohit Bhargava, David J Dabbs. Basal-like Subtype
Breast Cancers in Women Older than 40 Years of Age. Int J Surg Pathol. 2010;18:42-47.
PMID: 19372082.
Sushil Beriwal, Bunja Rungruang, Atilla Soran, Darcy Thull, Joseph L Kelley, Rohit
Bhargava, Chyongchiou J. Lin, Paniti Sukumvanich. Comparison of Locoregional
Recurrence with Mastectomy vs. Breast Conserving Surgery in Pregnancy Associated
Breast Cancer (PABC). Cancers. 2009, 1(1), 12-20; doi:10.3390/cancers1010012. PMID:
Hughes SJ, Xi, L, Gooding WE, Cole DJ, Mitas M, Metcalf J, Bhargava R, Dabbs D, Ching J,
Kozma L, McMillan W, Godfrey TE. A Quantitative Reverse Transcription-PCR Assay for
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Rapid Automated Analyses of Breast Cancer Sentinel Lymph Nodes. J Mol. Diagn.
2009;11:576-582. PMID: 19797614.
Mamatha Chivukula, David J Dabbs, Siobhan O’Connor, Rohit Bhargava.PAX2: a novel
müllerian marker for serous papillary carcinomas to differentiate from micropapillary
breast carcinoma. Int J Gynecol Pathol. 2009;28:570-578. PMID: 19851209.
Cagatay Ersahin, Sudeshna Bandyopadhyay, and Rohit Bhargava. Thyroid transcription
factor-1 and “basal-marker” expressing small cell carcinoma of the breast. Int J Surg
Pathol. 2009;17:368-372.
Mamatha Chivukula, Rohit Bhargava, David J Dabbs. Clinicopathologic Implications of
‘Flat Epithelial Atypia’ on Core Needle Biopsies of Breast. Am J Clin Pathol.
2009;131:802-808.
Bulent Unal, A Serhat Gur, Rohit Bhargava, Howard Edington, Gretchen Ahrendt, Atilla
Soran. Bratisl Lek Listy. Intraductal location of the sclerosing adenosis of the breast.
2009;11(4):251-252.
Rohit Bhargava, Joan Striebel, Sushil Beriwal, John C. Flickinger, Agnieszka Onisko,
Gretchen Ahrendt and David J. Dabbs. Prevalence, Morphologic Features and
Proliferation Indices of Breast Carcinoma Molecular Classes Using Immunohistochemical
Surrogate Markers. Int J Clin Exp Pathol 2009;2(5):444-455.
Nicole N Esposito, David J Dabbs, Rohit Bhargava. Are encapsulated papillary
carcinomas of the breast in-situ or invasive? A basement membrane study of 27 cases.
Am J Clin Pathol. 2009;131:228-242. PMID: 19141383.
Rohit Bhargava, M.D. Sushil Beriwal, M.D. Kim McManus, M.D. David J Dabbs, M.D. CK5
is more sensitive than CK5/6 in identifying “basal-like” phenotype of breast carcinoma.
Am J Clin Pathol. 2008;130:724-730.
Rohit Bharagva and David J Dabbs. Luminal B tumors are not HER2 positive. Breast
Cancer Research. 2008;10:404.
Rohit Bhargava, M.D., Mamatha Chivukula, M.D., Sushil Beriwal, David J. Dabbs, M.D.
Estrogen and Progesterone Receptors in Breast Carcinoma: Quantitation is
Therapeutically Important. Adv Anat Pathol. 2008 Sep;15(5):304-305.
Mamatha Chivukula, M.D., Rohit Bhargava, M.D., David J. Dabbs, M.D. Diagnostic,
Theranostic and Genomic Immunohistochemistry: Standardization Issues. Adv Anat
Pathol. 2008 Sep;15(5):302-304.
Kazuya Onuma, David J Dabbs, Rohit Bhargava. Mammaglobin Expression In The
Female Genital Tract: Immunohistochemical Analysis in Benign and Neoplastic
Endocervix and Endometrium. Int J of Gynecol Pathol. 2008;27:418-425.
Akosua B Domfeh, AnnaMarie L Carley, Joan M Striebel, Rouzan G Karabakhtsian, Anca V
Florea, Kim McManus, Sushil Beriwal and Rohit Bhargava. WT-1 immunoreactivity in
breast carcinoma: Selective expression in pure and mixed mucinous subtypes. Mod
Pathol. 2008;21:1217-1223.
Melina B. Flanagan, MD, MSPH, David J. Dabbs, MD, Adam Brufsky, MD, PhD, Sushil
Beriwal, MD, Rohit Bhargava, MD. Histopathologic Variables Predict Oncotype DX™
Recurrence Score. Mod Pathol. 2008;21:1255-1261.
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Chivukula M, Bhargava R, Brufsky A, Surti U, Dabbs DJ. Clinical importance of HER2
immunohistologic heterogenous expression in core-needle biopsies vs resection
specimens for equivocal (immunohistochemical score 2+) cases. Mod Pathol.
2008;21:363-368.
Joan M. Striebel, Rohit Bhargava, Craig Horbinski, Urvashi Surti, David J. Dabbs. The
Equivocally Amplified HER2 FISH Result on Breast Core Biopsy: Indications for Further
Sampling Do Affect Patient Management. Am J Clin Pathol. 2008;129:383-390.
David Coon, Sushil Beriwal, Steven H. Swerdlow, Rohit Bhargava. Mucosa-Associated
Lymphoid Tissue Lymphoma of the Cervix. J Clin Oncol. 2008;26(3):503-504.
Lu Wang, Rohit Bhargava, Tao Zheng, Leonard Wexler, Margaret Collins, Diane
Roulston, Marc Ladanyi (LW and RB contributed equally). Undifferentiated Small Round
Cell Sarcomas with Rare EWS Gene Fusions: Identification of a Novel EWS-SP3 Fusion
and of Additional Cases with the EWS-ETV1 and EWS-FEV Fusions. J Mol Diagn
2007;9:498-509.
Pasquali L, Bedeir A, Ringquist S, Styche A, Bhargava R, Trucco G. Quantification of CpG
island methylation in progressive breast lesions from normal to invasive carcinoma.
Cancer Lett. 2007;257(1):136-144.
David J Dabbs, M.D., Rohit Bhargava, M.D., Mamatha Chivukula, M.D. Lobular versus
ductal breast neoplasms: The diagnostic utility of p120 catenin in the breast and in
metastatic tumors. Am J Surg Pathol. 2007 Mar;31(3):427-437.
Rohit Bhargava, M.D. and David J. Dabbs, M.D.Use of Immunohistochemistry in the
diagnosis of breast epithelial lesions. Adv Anat Pathol. 2007;14:93-107.
Rohit Bhargava M.D., Sushil Beriwal M.D., David J Dabbs M.D. Mammaglobin Versus
GCDFP-15: An Immunohistologic Validation Survey For Sensitivity And Specificity. Am J
of Clin Pathol. 2007 Jan;127(1):103-113.
Dabbs DJ, Chivukula M, Carter G, Bhargava R. Basal phenotype of ductal carcinoma in
situ: recognition and immunohistologic profile. Mod Pathol. 2006 Nov;19(11):1506-11.
Rohit Bhargava, M.D., Beiyun Chen, M.D., Ph.D., David S. Klimstra, M.D., Leonard B.
Saltz, M.D., Cyrus Hedvat, M.D., Ph.D., Laura, Tang, M.D., PhD., William Gerald, M.D.,
PhD., Julie Teruya-Feldstein, M.D., Philip B. Paty, M.D., Jing Qin, Ph.D., Jinru Shia, M.D.
Comparison of two antibodies for immunohistochemical evaluation of epidermal growth
factor receptor expression in colorectal carcinomas, adenomas, and normal mucosa.
Cancer. 2006 Apr 15;106(8):1857-62.
Bhargava R, Gerald WL, Li AR, Pan Q, Lal P, Ladanyi M, Chen B. EGFR gene amplification
in breast cancer: correlation with epidermal growth factor receptor mRNA and protein
expression and HER-2 status and absence of EGFR-activating mutations. Mod Pathol.
2005 Aug;18(8):1027-33.
Bhargava R, Oppenheimer O, Gerald W, Jhanwar SC, Chen B. Identification of MYCN
gene amplification in neuroblastoma using chromogenic in situ hybridization (CISH): an
alternative and practical method. Diagn Mol Pathol. 2005 Jun;14(2):72-6.
Bhargava R, Lal P, Chen B. HER-2/neu and Topoisomerase IIa Gene Amplification and
Protein Expression in Invasive Breast Carcinomas: Chromogenic In Situ Hybridization and
Immunohistochemical Analyses. Am J Clin Pathol. 2005 Jun;123(6):889-95.
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Rohit Bhargava, Priti Lal, Beiyun Chen. Chromogenic in situ hybridization for the
detection of HER-2 gene amplification in breast cancer with an emphasis on tumors with
borderline and low-level amplification. Does it measure up to fluorescence in situ
hybridization? Am J Clin Pathol. 2005;123:237-243.
Bhargava R, Shia J, Hummer AJ, Thaler HT, Tornos C, Soslow RA. Distinction of
endometrial stromal sarcomas from “hemangiopericytomatous” tumors using a panel of
commonly used immunohistochemical stains. Mod Pathol. 2005 Jan;18(1):40-7.
Darvishian, Farbod MD; Hummer, Amanda J. MS; Thaler, Howard T. PhD; Bhargava,
Rohit MBBS; Linkov, Irina BS; Asher, Marina BS; Soslow, Robert A. MD. Serous
Endometrial Cancers That Mimic Endometrioid Adenocarcinomas: A Clinicopathologic
and Immunohistochemical Study of a Group of Problematic Cases. Am J Surg Pathol.
2004;28:1568-78.
Rohit Bhargava, Priti Lal, Beiyun Chen. Feasibility of Using Tissue Microarrays for the
Assessment of HER-2 Gene Amplification by Fluorescence In Situ Hybridization in Breast
Carcinoma. Diagn Mol Pathol. 2004 Dec;13(4):213-6.
Rohit Bhargava, Violetta Barbashina, Daniel A. Filippa and Julie Teruya-Feldstein.
Epstein-Barr Virus Positive Large B-Cell Lymphoma Arising in a Patient Previously
Treated with Cladribine for Hairy Cell Leukemia. Leuk Lymphoma. 2004;45(5):10431048.
Rohit Bhargava, Rizwan Naeem, Sharon Marconi, Jason Luszcz, Jane Garb, Robert
Gasparini and Christopher N Otis. Tyrosine Kinase Activation in Breast Carcinoma With
Correlation to HER-2/neu Gene Amplification and Overexpression. Hum Pathol.
2001;32:1344-50.
Sanjay Dhar, Rohit Bhargava, Michael Yunes, Biao Li, Jaya Goyal, Stephen P Naber, David
E Wazer and Vimla Band. Analysis of Normal Epithelial Cell Specific-1 (NES1)/Kallikrein
10 mRNA Expression by in Situ Hybridization, a novel marker for breast cancer. Clin
Cancer Res. 2001;7:3393-8.
Refereed Articles (Accepted for publication)
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Erica R Ghareeb, Rohit Bhargava, John A Vargo, Anca V Florea, and Sushil Beriwal, MD.
Primary and Radiation Induced Breast Angiosarcoma: Clinicopathological Predictors of
Outcomes and the Impact of Adjuvant Radiation Therapy. Accepted to be published in
American Journal of Clinical Oncology. Epub ahead of print. PMID: 25521258.
David M. Gau, Jamie L. Lesnock, Brian L. Hood, Rohit Bhargava, Mai Sun, Kathleen
Darcy, Soumya Luthra, Uma Chandran, Thomas P. Conrads, Robert P. Edwards, Joseph L.
Kelley, Thomas C. Krivak, Partha Roy. BRCA1 deficiency in ovarian cancer is associated
with alteration in expression of 3 several key regulators of cell motility – A proteomics
study. Accepted to be published in the journal “Cell Cycle”.
Wu Q, Madany P, Akech J, Dobson JR, Douthwright S, Browne G, Colby JL, Winter GE,
Bradner JE, Pratap J, Sluder G, Bhargava R, Chiosea S, van Wijnen AJ, Stein JL, Stein GS,
Lian JB, Nickerson JA, Imbalzano AN. The SWI/SNF ATPases are required for triple
negative breast cancer cell proliferation. J Cell Physiol. Epub ahead of print. PMID:
25808524.
Other Publications
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Rohit Bhargava, M.D. Epidermal Growth Factor Receptor in Breast Carcinoma: An
Overview. Dako Connections Scientific Magazine. 2009;13:40-43.
http://pri.dako.com/connection_13_july09_final_low_res.pdf
Abstracts (Published)
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Aatur Singhi, Rohit Bhargava, Miroslawa W Jones, Kristi L Cressman, Raja R Seethala.
ATRX Loss Is a Poor Prognostic Factor in Extrauterine Leiomyosarcomas. Publication #
93. USCAP annual meeting, Boston, MA. March 21-27, 2015.
Characterization of Molecular Alterations and Clinical Utilization of Targeted NextGeneration Sequencing in Advanced Breast Cancer. Grzegorz T Gurda, Tadeu Ambrose,
Marina Nikiforova, Yuri E Nikiforov, David Dabbs, Shannon L Puhalla, Rohit Bhargava.
Publication # 180. USCAP annual meeting, Boston, MA. March 21-27, 2015.
Incidental Findings of Tubal Intraepithelial Neoplastic Changes in Women With
Gynecologic Surgical Intervention for Non-Malignant Conditions. Esther Elishaev, and
Rohit Bhargava. Publication # 1128. USCAP annual meeting, Boston, MA. March 21-27,
2015.
Jennifer Leidy, Esther Elishaev, Aatur Singhi, Miroslawa W Jones, David Dabbs, Rohit
Bhargava. Can CA IX Be Used To Distinguish Between Gynecologic, Pancreatic and
Cholangiocarcinoma? A Tissue Microarray Study of 757 Tumors. Publication # 1178.
USCAP annual meeting, Boston, MA. March 21-27, 2015.
Zaibo Li, David J. Dabbs and Rohit Bhagava. Dual ERBB2 (HER2) Gene Protein Assay:
Focused Study of Breast Cancers with 2+ Immunohistochemical Expression. Publication
# 247. USCAP annual meeting, San Diego, CA. March 1-7, 2014.
Zaibo Li, Aditi Ranade, Daman Samrao, Jeffrey Fine, David J. Dabbs and Rohit Bhagava.
Interobserver agreement for HER2 gene amplification on Simultaneous Gene Protein
Assay in Breast Cancer. Publication # 2147. USCAP annual meeting, San Diego, CA.
March 1-7, 2014.
Zaibo Li, Rohit Bhargava, Kevin Staton, Hong Wang, Shikhar Uttam, Randall E. Brand,
Atilla Soran,Gretchen M. Ahrendt and Yang Liu. Nuclear Nano-morphology Markers
Predict Breast Cancer Risk in Patients with Atypical Breast Epithelial Hyperplasia.
Publication # 248. USCAP annual meeting, San Diego, CA. March 1-7, 2014.
Daman Samrao, Rohit Bhargava, David J Dabbs, Beth Z Clark. Comparative Study of Ki67
Labeling Index in HER2 Amplified Versus Non-Amplified Estrogen Receptor Positive
Invasive Carcinoma of the Breast. Publication # 308. USCAP annual meeting, San Diego,
CA. March 1-7, 2014.
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Daman Samrao, Aditi Ranade, Esther Elishaev, Rohit Bhargava. Folate Receptor Alpha
Expression in Gynecologic Tumors. Publication # 1256. USCAP annual meeting, San
Diego, CA. March 1-7, 2014.
Beth Z Clark, Surabhi Beriwal, David J Dabbs, Rohit Bhargava. Clinical utility of GATA-3
expression in cytokeratin-7 positive carcinomas. Publication # 157. USCAP annual
meeting, San Diego, CA. March 1-7, 2014.
Amal Kanbour-Shakir, Esther Elishaev, Beth Dudley, Dima Al-Hamdawi, Marilyn Huang,
David J Dabbs, Rohit Bhargava. Universal Mismatch Repair Protein Testing in
Endometrial Cancer: A Single Institutional Experience. Publication # 1194. USCAP annual
meeting, San Diego, CA. March 1-7, 2014.
Treatment decisions and five year outcomes of the oncotype Dx test: An independent
assessment. Bhargava R, Brufsky AM, Lembersky BC, Jankovic R, Puhalla SL, Oesterreich
S, Lee A, Dabbs DJ. 2013 San Antonio Breast Cancer Symposium. December 10-14, 2013.
Program # P6-06-46.
HER2 copy number on FISH as a predictor of disease severity in HER2- breast cancer.
Abedin S, Kruse M, Brufsky A, Bhargava R. 2013 San Antonio Breast Cancer Symposium.
December 10-14, 2013. Program # P3-05-02.
Intra-tumor heterogeneity affects multi-gene test prognostic risk stratification. Lee AV,
Lin Y, Lin H-M, Cooper KL, Normolle DP, Brufsy AM, Fastuca M, Crosson W, Oesterreich
S, Davidson NE, Bhargava R, Dabbs DJ. 2013 San Antonio Breast Cancer Symposium.
December 10-14, 2013. Program # P2-11-10.
Clinical utility of combined brightfield HER2 gene-protein assay in IHC equivocal cases.
Bhargava R, Dabbs DJ. 2013 San Antonio Breast Cancer Symposium. December 10-14,
2013. Program # P1-02-03.
Significance of GRB7 protein expression level in breast cancer. Brandon D Ellsworth,
David J Dabbs, Rohit Bhargava. Publication number 148. Presented at the 102nd Annual
United States and Canadian Academy of Pathology Meeting. March 2-8, 2013.
Baltimore, MD.
Immunohistochemical Profile of Breast Cancer With Respect To ER and HER2 Status.
Nika Gloyeske, Esther Elishaev, David J Dabbs, Anna H Woodard, Jing Yu, Rohit
Bhargava. Publication number 171. Presented at the 102nd Annual United States and
Canadian Academy of Pathology Meeting. March 2-8, 2013. Baltimore, MD.
Low ER+ Breast Cancer: Is this a distinct group? Nika Gloyeske, David J Dabbs, Rohit
Bhargava. Publication number 172. Presented at the 102nd Annual United States and
Canadian Academy of Pathology Meeting. March 2-8, 2013. Baltimore, MD.
DPC4 Immunostaining In Mullerian Tumors With And Without Mucinous Differentiation.
Esther Elishaev MD, Xin Li MD, PhD, Amal Kanbour-Shakir MD, PhD, Sarah E Taylor MD,
Robert P Edwards MD, Jing Yu MD, PhD, Anna H Woodard MD, Mirka W Jones MD, and
Rohit Bhargava MD. Publication number 1133. Presented at the 102nd Annual United
States and Canadian Academy of Pathology Meeting. March 2-8, 2013. Baltimore, MD.
PTEN and P16 expression highlights atypia and malignant transformation in smooth
muscle tumors of the uterus. Mirka W Jones, Rohit Bhargava, Agnieszka Onisko,
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Giuliana Trucco. Publication number 1174. Presented at the 102nd Annual United States
and Canadian Academy of Pathology Meeting. March 2-8, 2013. Baltimore, MD.
Evaluation of Image Analysis for Interpretation of Her-2 Dual in situ Hybridization (DISH).
Jeffery L Fine, David J Dabbs, Kim McManus, Rohit Bhargava. Publication number 1577.
Presented at the 102nd Annual United States and Canadian Academy of Pathology
Meeting. March 2-8, 2013. Baltimore, MD.
Impact of different antibody clones on Ki-67 labeling index assessment in breast
carcinoma. Beth Z Clark, David J Dabbs, Mohahmed Desouki, Rohit Bhargava.
Publication number 1968. Presented at the 102nd Annual United States and Canadian
Academy of Pathology Meeting. March 2-8, 2013. Baltimore, MD.
Impact of 96 hours formalin fixation on assessment of Ki-67 labeling index. Beth Z Clark,
David J Dabbs, Mohamed Desouki, Rohit Bhargava. Publication number 1969. Presented
at the 102nd Annual United States and Canadian Academy of Pathology Meeting. March
2-8, 2013. Baltimore, MD.
Repeat of Estrogen Receptor (ER) on Breast Resection Specimens with “Low ER” on Core
Biopsy – Is it Worth Repeating? Nika Gloyeske, David J Dabbs, Rohit Bhargava.
Publication number 1978. Presented at the 102nd Annual United States and Canadian
Academy of Pathology Meeting. March 2-8, 2013. Baltimore, MD.
Should all endometrial tumors be tested for MSI by IHC? A Pilot analysis. Amal KanbourShakir, Rohit Bhargava, David J Dabbs, Esther Elishaev. Publication number 1983.
Presented at the 102nd Annual United States and Canadian Academy of Pathology
Meeting. March 2-8, 2013. Baltimore, MD.
The Ventana INFORM HER2 dual in situ hybridization (DISH) DNA probe cocktail assay
versus fluorescence in situ hybridization (FISH): Focused study of immunohistochemical
2+ cases. Faye F Gao, David J Dabbs, Rohit Bhargava. Publication number 2051.
Presented at the 102nd Annual United States and Canadian Academy of Pathology
Meeting. March 2-8, 2013. Baltimore, MD.
A proteomic analysis of surgical cytoreduction in patients with advanced ovarian cancer.
Jamie L Lesnock, Brian L Hood, Mai sun, Rohit Bhargava, Thomas P Conrads, Thomas C
Krivak. 2012 ASCO Annual Meeting. J Clin Oncol 30: 2012 (suppl; abstr e15560).
Single institution experience with neoadjuvant chemotherapy for metaplastic breast
cancer (MBC). Anna Kaminsky, Rohit Bhargava, Kandace P McGurie, Shannon Puhalla.
2012 ASCO Annual Meeting. J Clin Oncol 30: 2012 (suppl; abstr 1038).
Metallothionein expression and outcome in patients with metastatic breast cancer
(MBC). Jorge Arturo Rios-Perez, Sameem Abedin, Margaret Quinn Rosenzweig, Su Yon
Jung, Rohit Bhargava. 2012 ASCO Annual Meeting. J Clin Oncol 30: 2012 (suppl; abstr
1085).
Predicting success of breast conservation after neoadjuvant chemotherapy: what factors
affect surgical outcome? Diego, Emilia; McGuire, Kandace P; Soran, Atilla; Zuley,
Margarita; Bhargava, Rohit; Bonaventura, Marguerite; Johnson, Ronald; Ahrendt,
Gretchen M. 2012 Annual Meeting of the Society for Surgical Oncology. March 21-24,
2012. Orlando, FL. Abstract P86.
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Does trastuzumab containing neoadjuvant chemotherapy impact in situ carcinoma?
Diego, Emilia; Ahrendt, Gretchen M; McGuire, Kandace P; Johnson, Ronald R; Badve,
Preeti; Bhargava, Rohit. 2012 Annual Meeting of the Society for Surgical Oncology.
March 21-24, 2012. Orlando, FL. Abstract P52.
Intra-Operative Margin Evaluation Of Breast Specimens: Value Of Gross Evaluation.
Abbie R Mallon, David J Dabbs, Ronald R Johnson, Gretchen M Ahrendt, Kandace P
McGuire, Marguerite Bonaventura and Rohit Bhargava. Annual Meeting, United States
and Canadian Academy of Pathology, Vancouver, BC. March 17-23, 2012. Abstract 206.
Mod Pathol 2012. 25(S2):52A.
Breast Angiosarcoma: A Clinicopathologic Study. Anca V Florea, David J Dabbs, Sushil
Beriwal, Rohit Bhargava. Annual Meeting, United States and Canadian Academy of
Pathology, Vancouver, BC. March 17-23, 2012. Abstract 150. Mod Pathol 2012.
25(S2):39A.
Inter-Observer Agreement Among Pathologists For Semi-Quantitative Hormone
Receptor Scoring In Breast Carcinoma. David Cohen, David J Dabbs, Kristine L Cooper,
Milon Amin, Terrell E Jones, Mirka W Jones, Mamatha Chivukula, Giuliana A Trucco,
Rohit Bhargava. Annual Meeting, United States and Canadian Academy of Pathology,
Vancouver, BC. March 17-23, 2012. Abstract 117. Mod Pathol 2012. 25(S2):31A.
Predictors Of Response To Standard Neoadjuvant Chemotherapy In Estrogen Receptor
Positive, HER2 Negative Breast Cancer. Rohit Bhargava. Annual Meeting, United States
and Canadian Academy of Pathology, Vancouver, BC. March 17-23, 2012. Abstract 194.
Mod Pathol 2012. 25(S2):26A.
Cytokeratin Profile of Breast Carcinoma: Do CK7 negative breast carcinoma exist? Esther
Elishaev and Rohit Bhargava. Annual Meeting, United States and Canadian Academy of
Pathology, Vancouver, BC. March 17-23, 2012. Abstract 141. Mod Pathol 2012.
25(S2):37A.
Breast Carcinoma Ki-67 Labeling Index: Comparison between Image Analysis and Expert
Human Scoring with Discussion about Choosing Tumor Areas to Analyze. Jeffrey L Fine
MD, David J Dabbs MD, Kristine L Cooper MS and Rohit Bhargava MD. Annual Meeting,
United States and Canadian Academy of Pathology, Vancouver, BC. March 17-23, 2012.
Abstract 1636. Mod Pathol 2012. 25(S2):391A.
The Effect of 96-Hour Formalin Fixation on the Immunohistochemical Evaluation of
Estrogen Receptor (ER), Progesterone Receptor (PR), and HER2 Expression in Invasive
Breast Cancer. Isil Yildiz, David J Dabbs, Mamatha Chivukula, Rohit Bhargava. Annual
Meeting, United States and Canadian Academy of Pathology, Vancouver, BC. March 1723, 2012. Abstract 303. Mod Pathol 2012. 25(S2):75A.
Impact of Cold Ischemic Time on Estrogen Receptor, Progesterone Receptor, and HER2
Semi-quantitative Immunohistochemical Scoring. Isil Z Yildiz-Aktas MD, David J Dabbs
MD and Rohit Bhargava MD. Annual Meeting, United States and Canadian Academy of
Pathology, Vancouver, BC. March 17-23, 2012. Abstract 304. Mod Pathol 2012.
25(S2):75A.
How Often Does Positive Peritoneal Wash Cytology Independently Upstage and Impact
Clinical Management of Ovarian Malignancies? Jing Yu, Rohit Bhargava, R. Marshall
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Austin. Annual Meeting, United States and Canadian Academy of Pathology, Vancouver,
BC. March 17-23, 2012. Abstract 1274. Mod Pathol 2012. 25(S2):303A.
Inter-Observer Agreement Among Pathologists For Assessing Ki-67 Labeling Index On
Whole Slides and “Hot Spots” In Breast Carcinomas. Milon Amin, David Cohen, David J
Dabbs, Kristine L Cooper, Terrell E Jones, Mirka Jones, Guiliana A Trucco, Mamatha
Chivukula, Rohit Bhargava. Annual Meeting, United States and Canadian Academy of
Pathology, Vancouver, BC. March 17-23, 2012. Abstract 89. Mod Pathol 2012.
25(S2):24A.
Prediction of Oncotype DX Recurrence Score: Use of Equations Derived by Linear
Regression Analysis. Molly E Klein MD, David J Dabbs MD, Yongli Shuai MS and Rohit
Bhargava MD. Annual Meeting, United States and Canadian Academy of Pathology,
Vancouver, BC. March 17-23, 2012. Abstract 182. Mod Pathol 2012. 25(S2):46A.
Predictors of response to trastuzumab-containing neoadjuvant chemotherapy in HER2
positive breast cancer. Xin Li M.D., Ph.D., Amal Kanbour-Shakir M.D., Ph.D., David Dabbs
M.D. and Rohit Bhargava M.D. Annual Meeting, United States and Canadian Academy
of Pathology, Vancouver, BC. March 17-23, 2012. Abstract 194. Mod Pathol 2012.
25(S2):49A.
Pelvic high grade serous carcinoma and association with serous tubal intraepithelial
carcinoma. Huaitao Yang, Rohit Bhargava, Xiangbai Cheng, Faye Gao, Zaibo Li,
Chengquan Zhao. Annual Meeting, United States and Canadian Academy of Pathology,
Vancouver, BC. March 17-23, 2012. Abstract 1272. Mod Pathol 2012. 25(S2):302A.
Characteristic Features of Serous Tubal Intraepithelial Carcinoma and Its Co-Existing
Invasive Carcinomas. Faye Gao, Huaitao Yang, Rohit Bhargava, Xiangbai Cheng, Zaibo Li,
Chengquan Zhao. Annual Meeting, United States and Canadian Academy of Pathology,
Vancouver, BC. March 17-23, 2012. Abstract 1139. Mod Pathol 2012. 25(S2):272A.
Multicenter quality assurance profile review of lobular breast carcinomas versus the 21
gene recurrence score: assessment of clinical relevance. David J Dabbs, David Hicks,
Raymond R Tubbs, Adam Brufsky, Rohit Bhargava. 2011 San Antonio Breast Cancer
Symposium. December 6-10, 2011.Program # P4-09-22.
Consistent high false negative rate of HER2 qRT-PCR of oncotype DX® in comparison to
ASCO/CAP recommended combined IHC/FISH method. David J Dabbs and Rohit
Bhargava. 2011 San Antonio Breast Cancer Symposium. December 6-10, 2011. Program
# P1-07-20.
Impact of progesterone receptor semiquantitative immunohistochemical result on
oncotype DX recurrence score: A quality assurance study of 1078 cases. Rohit Bhargava
and David J Dabbs. 2011 San Antonio Breast Cancer Symposium. December 6-10, 2011.
Program # P5-14-08.
High false-negative rate of HER2 qRT-PCR of the Oncotype DX test: An independent
quality assurance study. D. J. Dabbs, M. Klein, S. Mohsin, R. R. Tubbs, R. Bhargava. 2011
ASCO Annual Meeting. J Clin Oncol 29: 2011 (suppl; abstr 603).
NYBR1 Expression in Breast and Gynecologic Tract Carcinomas. Anna Woodard, Jing Yu,
David Dabbs, Anca Florea, Sushil Beriwal and Rohit Bhargava. United States and
Canadian Academy of Pathology, San Antonio, TX. February 26-March 4, 2011.
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PAX8 Expression in Gynecologic and Breast Carcinoma. Jing Yu, Anna H. Woodard, Anca
V. Florea, David J. Dabbs, Sushil Beriwal and Rohit Bhargava. United States and
Canadian Academy of Pathology, San Antonio, TX. February 26-March 4, 2011.
Basal Marker Reactivity in Triple Negative Breast Carcinomas Does Not Predict
Pathologic Complete Response Following Neoadjuvant Chemotherapy. James Kraus,
Sushil Beriwal, David Dabbs, Rohit Bhargava. United States and Canadian Academy of
Pathology, San Antonio, TX. February 26-March 4, 2011.
Validation Study of Hormone Receptor Status in Breast Ductal Carcinoma In Situ by
Quantum Dot Multispectral Imaging System. Jing Yu MD PhD, Sara E. Monaco MD, Rohit
Bhargava MD, David J. Dabbs MD, Kathleen M. Cieply BS, Jeff L. Fine MD PhD. United
States and Canadian Academy of Pathology, San Antonio, TX. February 26-March 4,
2011.
Endometrial Adenosarcomas: Diagnostic Use of Ki-67 Proliferation Marker As An Adjunct
To Morphologic Diagnosis. Nidhi Agarwal, Rohit Bhargava, Esther Elishaev. United
States and Canadian Academy of Pathology, Washington, D.C. March 20-26, 2010. Mod
Pathol. 2010;23 (Supplement 1): Abstract 1037.
Human Epidermal Growth Factor Receptor 2 (HER2) status determination using single
color versus dual color fluorescence in-situ hybridization (FISH) assay: Impact of
monosomy and polysomy 17. LA Niemeier, D Dabbs, U Surti, K Cieply, J Yu and R
Bhargava. United States and Canadian Academy of Pathology, Washington, D.C. March
20-26, 2010. Mod Pathol. 2010;23 (Supplement 1): Abstract 275.
Triple Positive Breast Carcinomas: Is Oncotype Dx™ Test Justified? E Marchetti, R
Bhargava and DJ Dabbs. United States and Canadian Academy of Pathology,
Washington, D.C. March 20-26, 2010. Mod Pathol. 2010;23 (Supplement 1): Abstract
265.
Luminal A versus Luminal B Tumors: Significance of Proliferation Index in ER Positive
HER2 Negative Tumors. E Marchetti, D Dabbs, J Yu, S Beriwal and R Bhargava. United
States and Canadian Academy of Pathology, Washington, D.C. March 20-26, 2010. Mod
Pathol. 2010;23 (Supplement 1): Abstract 264.
Validation of the Magee Study Equation in Prediction of Breast Cancer Recurrence Risk
Category by oncotype Dx™. NN Esposito, G Acs, DJ Dabbs, M Flanagan, C Laronga and R
Bhargava. United States and Canadian Academy of Pathology, Washington, D.C. March
20-26, 2010. Mod Pathol. 2010;23 (Supplement 1): Abstract 192.
Semi-Quantitative Estrogen Receptor Expression Level Influences Response To
Trastuzumab Containing Neo-Adjuvant Chemotherapy In HER2 Positive Tumors. Rohit
Bhargava, David J Dabbs, Sushil Beriwal, Ronald R Johnson, Adam M Brufsky, Barry
Lembersky, Atilla Soran and Gretchen M Ahrendt. United States and Canadian Academy
of Pathology, Washington, D.C. March 20-26, 2010. Mod Pathol. 2010;23 (Supplement
1): Abstract 156.
Estimation of risk of recurrence of early stage estrogen receptor positive (ER+) breast
carcinoma (BC) by pathologists compared to the Oncotype Dx Recurrence Score. A
multi-institutional study. Acs, G., Esposito, Reynolds, C., Lawton, T.J., Bleiweiss, I., Nagi,
C., Ioffe, O., Hameed, O., Dabbs, D., Bhargava, R., Quddus, M.R., Sung, C.J., Gilcreast,
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M., Sapino, A., Cserni, G., Jacquemier, J., Kulka, J., Regitnig, P., Baas, I., van Diest, P. and
Quinn, C. United States and Canadian Academy of Pathology, Washington, D.C. March
20-26, 2010. Mod Pathol. 2010;23 (Supplement 1): Abstract 130.
IGF-1R expression in normal breast tissue, benign, proliferative, in-situ breast lesions
and invasive breast carcinoma. Rohit Bhargava, MD, Sushil Beriwal, MD, David J Dabbs,
MD. Presented at the 32nd Annual San Antonio Breast Cancer Symposium, San Antonio,
TX. December 9-13, 2009. Program # 3051. Cancer Res 2009;69(Suppl.):(24). December
15, 2009.
Pregnancy Related Breast Carcinoma: Comparison of Receptor Status with Age-Matched
Controls. Rohit Bhargava, MD, Paniti Sukumvanich, MD, Sushil Beriwal, MD. Presented
at the 32nd Annual San Antonio Breast Cancer Symposium, San Antonio, TX. December 913, 2009. Program # 6012. Cancer Res 2009;69(Suppl.):(24). December 15, 2009.
Breast Cancer Molecular Class ERBB2: Preponderance of Tumors with Apocrine
Differentiation and Expression of Basal Phenotype Markers CK5, CK5/6 and EGFR. R
Bhargava, JM Striebel, DJ Dabbs. Annual Meeting, United States and Canadian Academy
of Pathology, boston, MA. March 7-13, 2009. Mod Pathol. 2009;22 (Supplement 1):
Abstract 122.
Concordance between Semi-Quantitative Immunohistochemical Assay and oncotypeDX
RT-PCR Assay for Estrogen and Progesterone Receptors. R Bhargava, S Beriwal, DJ
Dabbs. Annual Meeting, United States and Canadian Academy of Pathology, boston,
MA. March 7-13, 2009. Mod Pathol. 2009;22 (Supplement 1): Abstract 123.
'Flat Epithelial Atypia': Impact of the Entity with Reference to Number of Levels
Obtained on the Paraffin Embedded Blocks of the Breast Core Needle Biopsies. M
Chivukula, R Bhargava, G Tseng, DJ Dabbs. Annual Meeting, United States and Canadian
Academy of Pathology, boston, MA. March 7-13, 2009. Mod Pathol. 2009;22
(Supplement 1): Abstract 138.
Hormone Receptor Immunohistochemistry: The Prevalence of ER-PR+ Results Are PR
Antibody Clone-Dependent. DC Gingell, R Bhargava, DJ Dabbs. Annual Meeting, United
States and Canadian Academy of Pathology, boston, MA. March 7-13, 2009. Mod Pathol.
2009;22 (Supplement 1): Abstract 178.
Detailed FISH Analysis of HER2 2+ Immunohistochemistry Cases: Rarity of Cases with
High Level HER2 Gene Amplification. DC Gingell, DJ Dabbs, U Surti, R Bhargava. Annual
Meeting, United States and Canadian Academy of Pathology, boston, MA. March 7-13,
2009. Mod Pathol. 2009;22 (Supplement 1): Abstract 179.
Basal-Like Breast Carcinoma: Identifying Estrogen Receptor Positive Cases. DC Gingell, S
O'Connor, R Bhargava, DJ Dabbs. Annual Meeting, United States and Canadian Academy
of Pathology, boston, MA. March 7-13, 2009. Mod Pathol. 2009;22 (Supplement 1):
Abstract 180.
Androgen Receptor Expression in Breast Cancer Molecular Classes: An
Immunohistochemical Study of 190 Consecutive Cases. LA Niemeier, DJ Dabbs, JM
Striebel, R Bhargava. Annual Meeting, United States and Canadian Academy of
Pathology, boston, MA. March 7-13, 2009. Mod Pathol. 2009;22 (Supplement 1):
Abstract 259.
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Expression of Gamma-Laminin, Cytokeratin 5 and Cytokeratin 5/6 in Metaplastic and
Basal-like Breast Carcinomas. SM O'Connor, L Niemeier, R Bhargava, WT Parks, DJ
Dabbs. Annual Meeting, United States and Canadian Academy of Pathology, boston,
MA. March 7-13, 2009. Mod Pathol. 2009;22 (Supplement 1): Abstract 264.
Computer-aided detection of HER2 amplification status using FISH images: a preliminary
study. Bin Zheng, Xiao-Hui Wang, Urvashi surti, Rohit Bhargava, David Gur. SPIE Paper #
7260-78 presented at the “Computer Aided Diagnosis” conference as part of the SPIE
Symposium on Medical Imaging. February 7-12, 2009 in Lake Buena Vista, Florida USA.
(http://spie.org/Documents/ConferencesExhibitions/Medical-Imaging-2009Advance.pdf).
Breast Cancer Molecular Classification Using Immunohistochemical Surrogate Markers
Predicts Response to Neoadjuvant Chemotherapy. Rohit Bhargava, Faith Goldman,
Sushil Beriwal, David J Dabbs, Ronald Johnson, Adam M Brufsky, Barry C Lembersky and
Gretchen M Ahrendt. Presented at the 31st Annual San Antonio Breast Cancer
Symposium, San Antonio, TX. December 10-14, 2008. Program # 6071
ALDH1 Expression in Human Breast Carcinoma. Rohit Bhargava, Sushil Beriwal, Kim
McManus, and David J Dabbs. Presented at the 31st Annual San Antonio Breast Cancer
Symposium, San Antonio, TX. December 10-14, 2008. Program # 5057.
Clinical significance of the entity ‘flat epithelial atypia’ on core needle biopsies of breast.
Dabbs DJ, Bhargava R, Tseng G, Chivukula M. Presented at the 31st Annual San Antonio
Breast Cancer Symposium, San Antonio, TX. December 10-14, 2008. Program # 3006.
Identification of biomarkers associated with metastatic breast cancer to bone by
immunohistochemistry on tissue microarrays. Nasir I, Brufsky A, Bhargava R, McManus
K, Chivukula M. Presented at the 31st Annual San Antonio Breast Cancer Symposium, San
Antonio, TX. December 10-14, 2008. Program # 2065.
The value of immunohistochemistry in distinction between endocervical
adenocarcinoma and adenocarcinoma of endometrium, endometrioid type. A
comparative tissue microarray study of 76 cases. MW Jones, A Onisko, DJ Dabbs, E
Elishaev and R Bhargava. International Academy of Pathology, Athens, Greece. October
12-19, 2008. Histopathol. 2008;53 (supplement 1):1-432. Abstract 427.
The value of CD10, caldesmon, and D2-40 in evaluation of myometrial invasion in
adenocarcinoma of the endometrium. A study of 45 cases. Jones MW, Trucco G,
Bhargava R. International Academy of Pathology, Athens, Greece. October 12-19, 2008.
Histopathol. 2008;53 (supplement 1):1-432. Abstract 426.
Ki-67 labeling index in breast carcinoma: An immunohistochemical study with
correlation to molecular subtypes. Rohit Bhargava, Joan Striebel, Agnieszka Onisko, Kim
McManus, David J Dabbs. J Clin Oncol. 2008;26:May 20 supplement-Abstract 22107.
CK5 Is More Sensitive Than CK5/6 In Identifying “Basal-like” Carcinoma Of The Breast. R
Bhargava and DJ Dabbs. Annual Meeting, United States and Canadian Academy of
Pathology, Denver, CO. March 1-7, 2008. Mod Pathol. 2008;21 (Supplement 1): 23A,
Abstract 92.
The Dynamic Biology Of E-Cadherin And P120 Catenin: Development Of A Dual
Immunostain For Diagnostic Use In Breast Pathology. R Bhargava, D Tast, T Ewing-
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Finchem, K Obrecht, and DJ Dabbs. Annual Meeting, United States and Canadian
Academy of Pathology, Denver, CO. March 1-7, 2008. Mod Pathol. 2008;21 (Supplement
1): 23A, Abstract 93.
Fixation Issues With Breast Carcinoma Hormone Receptors: ER Negative PR Positive
Carcinomas Exist Even With Optimal Fixation Methods. DJ Dabbs, GJ Carter, R Bhargava.
Annual Meeting, United States and Canadian Academy of Pathology, Denver, CO. March
1-7, 2008. Mod Pathol. 2008;21 (Supplement 1): 27A, Abstract 111.
Best Practices In Breast Pathology: Practical Quality Assurance/Patient Safety Program
In A Women’s Hospital. A Descriptive Study. DJ Dabbs, GJ Carter, MW Jones, R
Bhargava. Annual Meeting, United States and Canadian Academy of Pathology, Denver,
CO. March 1-7, 2008. Mod Pathol. 2008;21 (Supplement 1): 355A, Abstract 1619.
Use of PAX-2 antibody to distinguish metastatic ovarian serous papillary carcinoma from
primary breast carcinoma. S O’Connor, R Bhargava, DJ Dabbs, M Chivukula. Annual
Meeting, United States and Canadian Academy of Pathology, Denver, CO. March 1-7,
2008. Mod Pathol. 2008;21 (Supplement 1): 216A, Abstract 986.
WT-1 Expression In Primary Mucinous Carcinomas Of The Breast. AB Domfeh, AM
Carley, J Striebel, A Florea, RG Karabakhtsian and R Bhargava. Annual Meeting, United
States and Canadian Academy of Pathology, Denver, CO. March 1-7, 2008. Mod Pathol.
2008;21 (Supplement 1): 28A, Abstract 118.
The Borderline Amplified HER2 FISH Result on Breast Core Biopsy: Indications for
Further Sampling Do Affect Patient Management. Joan M Striebel, Rohit Bhargava,
Adam Brufsky, Urvashi Surti, David J Dabbs. San Antonio Breast Cancer Symposium, San
Antonio, TX. December 13-16, 2007. Abstract # 3038.
HER2 Immunohistochemistry: Comparison of Image Analysis Based Interpretation of
CB11 and 4B5 Clones Using Reference Fluorescence In-Situ Hybridization. Jeffrey L Fine,
MD, Rohit Bhargava, MD, Urvashi Surti, PhD and David J Dabbs, MD. San Antonio Breast
Cancer Symposium, San Antonio, TX. December 13-16, 2007. Abstract # 2014.
Expression of basal-like markers in male breast cancers. Flanagan MB, Bhargava R,
Dabbs DJ, Thull D, Chivukula M. San Antonio Breast Cancer Symposium, San Antonio, TX.
December 13-16, 2007. Abstract # 5051.
HER2 Immunohistochemistry: Workflow Experience with Image Analysis Based
Interpretation of CB11 and 4B5 Clones. JL Fine, MD, R Bhargava, MD, U Surti, PhD and
DJ Dabbs, MD. Accepted for presentation at 2007 Advancing Practice Instruction and
Innovation Through Informatics (APIII) meeting in Pittsburgh, PA (September 9-12,
2007).
E-Cadherin And P120 Catenin Expression In Basal-Like Invasive Breast Carcinoma. R
Bhargava, M Chivukula, GJ Carter, DJ Dabbs. Annual Meeting, United States and
Canadian Academy of Pathology, San Diego, CA. March 24-30, 2007. Mod Pathol.
2007;20 (Supplement 2): 25A, Abstract 92.
Basal-Like Subtype Breast Cancers in Women Older Than 40 Years of Age. CH Ersahin, M
Chivukula, R Bhargava, DJ Dabbs. Annual Meeting, United States and Canadian Academy
of Pathology, San Diego, CA. March 24-30, 2007. Mod Pathol. 2007;20 (Supplement 2):
30A, Abstract 118.
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EGFR Gene Amplification Is An Uncommon Event In Basal-Like Breast Carcinomas. M
Flanagan, U Surti, M Chivukula, GJ Carter, DJ Dabbs, R Bhargava. Annual Meeting,
United States and Canadian Academy of Pathology, San Diego, CA. March 24-30, 2007.
Mod Pathol. 2007;20 (Supplement 2): 31A, Abstract 121.
Topoisomerase II-Alpha And HER2 Gene Co-Amplification As A Predictor Of Response To
Therapy And Survival In HER2 Positive Metastatic Breast Carcinoma. A Kapoor, A
Brufsky, S Chow, M Rosenzweig, U Surti, R Bhargava. Annual Meeting, United States and
Canadian Academy of Pathology, San Diego, CA. March 24-30, 2007. Mod Pathol.
2007;20 (Supplement 2): 38A, Abstract 150.
WT-1 Expression In Primary Invasive Breast Carcinoma: Occasional Expression In
Micropapillary And Mucinous Subtypes. R Karabakhtsian, R Bhargava. Annual Meeting,
United States and Canadian Academy of Pathology, San Diego, CA. March 24-30, 2007.
Mod Pathol. 2007;20 (Supplement 2): 38A, Abstract 151.
A QRT-PCR Assay for Rapid Analysis of Breast Cancer Sentinel Lymph Nodes. Godfrey,
Tony; Xi, Liqiang; Bhargava, Rohit; David Cole; Mike Mitas; John Metcalf; Gooding,
William E; Dabbs, David; Hughes, Steven. Presented at the Society of Surgical Oncology's
60th Annual Cancer Symposium, March 15-18, 2007, in Washington, DC.
Clinical importance of HER-2/neu immunohistologic expression heterogeneity in core
needle biopsies versus resection specimens. Mamatha Chivukula M.D., Rohit Bhargava,
M.D., Urvashi Surti, PhD., David J Dabbs. San Antonio Breast Cancer Symposium. San
Antonio, TX. December 14-17, 2006. Abstract 2071.
Correlation of Oncotype Dx recurrence score with histologic grading and estrogen
receptor positivity. R Bhargava, D Dabbs, A Brufsky, S Beriwal. International Academy of
Pathology Centennial Meeting. Montreal, QC, Canada (September 16-21, 2006). Mod
Pathol. 2006;19 (Supplement 3): 8-9, Abstract 24.
Evaluation Of EGFR Expression In Colorectal Carcinomas, Adenomas, And Normal
Mucosa: A Comparison Between Two Commonly Used Antibodies. R Bhargava, B Chen,
D S Klimstra, C Hedvat, L Tang, W Gerald, J Teruya-Feldstein and J Shia. Annual Meeting,
United States and Canadian Academy of Pathology, Atlanta, GA. February 11-February
17, 2006. Mod Pathol. 2006;19 (Supplement 1): 325A, Abstract 1515.
Mammaglobin Versus GCDFP-15: An Immunohistologic Validation Survey For Sensitivity
And Specificity. R Bhargava and D J Dabbs. Annual Meeting, United States and Canadian
Academy of Pathology, Atlanta, GA. February 11-February 17, 2006. Mod Pathol.
2006;19 (Supplement 1): 22A, Abstract 88.
Tissue Expression Of P16 In Benign And Malignant Endometria. R Bhargava and E
Elishaev. Annual Meeting, United States and Canadian Academy of Pathology, Atlanta,
GA. February 11-February 17, 2006. Mod Pathol. 2006;19 (Supplement 1): 172A,
Abstract 796.
Mammaglobin Expression in Benign and Neoplastic Endocervix and Endometrium. K
Onuma, DJ Dabbs and R Bhargava. Annual Meeting, United States and Canadian
Academy of Pathology, Atlanta, GA. February 11-February 17, 2006. Mod Pathol.
2006;19 (Supplement 1): 191A, Abstract 886.
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Epidermal growth factor receptor (EGFR) gene amplification and protein expression in
breast carcinoma: A study of 175 tumors. R Bhargava, P. Lal, W. Gerald, B. Chen. Annual
Meeting, United States and Canadian Academy of Pathology, San Antonio, TX. February
26-March 4, 2005. Mod Pathol. 2005;18 (Supplement 1): 26A, Abstract 106.
HER-2 and topoisomerase II-alpha gene amplification and protein overexpression in
invasive breast cancer: Chromogenic in situ hybridization and immunohistochemical
analyses. R Bhargava, P. Lal, B. Chen. Annual Meeting, United States and Canadian
Academy of Pathology, San Antonio, TX. February 26-March 4, 2005. Mod Pathol.
2005;18 (Supplement 1): 26A, Abstract 105.
Identification of MYCN (NMYC) gene amplification in neuroblastoma using chromogenic
in situ hybridization (CISH): An alternative and practical method. R Bhargava, O
Friedman, PA Salazar, W Gerald, SC Jhanwar and B Chen. Presented at the Annual
American Molecular Pathology (AMP) Meeting. Los Angeles, CA. November 10-13, 2004.
Journal of Molecular Diagnostics November 2004;6(4): 428; ST4 Abstracts.
Comparison of fluorescence in situ hybridization (FISH) and chromogenic in situ
hybridization (CISH) for assessment of HER-2 gene amplification in breast cancer. Rohit
Bhargava, Priti Lal, Paulo A. Salazar, Beiyun Chen. Presented at the Fifth International
Symposium on Molecular Diagnostics in Laboratory Medicine. Graz, Austria. June 10-12,
2004. Journal of Molecular Diagnostics May 2004;6(2):151 Abstract.
Distinction of Endometrial Stromal Sarcomas from “Hemangiopericytomatous” Tumors
Using a Panel of Immunohistochemical Stains. R Bhargava, J Shia, I Linkov, C Tornos and
RA Soslow. Annual Meeting, United States and Canadian Academy of Pathology,
Vancouver B.C., Canada. March 6-12, 2004. Mod Pathol. 2004;17(Supplement 1):191A,
Abstract 800.
p53, -catenin and cyclin D1 are superior to p53 alone in distinguishing problematic
uterine serous carcinoma from endometrioid carcinomas. F Darvishian, R Bhargava, DS
Marshall, I Linkov, M Asher, RA Soslow. Annual Meeting, United States and Canadian
Academy of Pathology, Washington D.C. March 22-28, 2003. Mod Pathol.
2003;16(1):187A, Abstract 853.
Localization of diagnostic material within the aspiration device in image- guided fine
needle aspiration (IM-FNA) specimens for rapid and efficient evaluation of adequacy. S
Gorombey, P LaPolice, R Bhargava, R Hicks, R Lorenzana, RA Goulart. Annual Meeting,
United States and Canadian Academy of Pathology, Washington D.C. March 22-28, 2003.
Mod Pathol. 2003;16(1):66A, abstract 288
Loss of expression of a novel tumor suppressor gene, NES1, as an early marker for
infiltrating ductal carcinoma of the breast. S Dhar, R Bhargava, MJ Yunes, B Li, J Goyal,
SP Naber, DE Wazer, and V Band. Forty-third Annual Meeting of American Society for
Therapeutic Radiology and Oncology (ASTRO), San Francisco, CA. November 4-8, 2001.
Abstract ID: 42838. Int. J. Radiat. Oncol. Biol. Phys. 2001;51(3) Supplement 1:185
Tyrosine Kinase Activation in Breast Carcinoma with Correlation to HER-2/neu
Amplification. R Bhargava, R Naeem, S Marconi, J Luszcz, J Garb, R Gasparini and CN
Otis. Annual Meeting, American Society of Human Genetics, San Diego, CA. October 1216, 2001. Am. J. Hum. Genet. 2001;69(4) Supplement 1:261. Abstract 454
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Double minutes in a case of acute megakaryoblastic leukemia (AML-M7). R Bhargava, R
Hasserjian, R Naeem. Annual Meeting, American Society of Human Genetics, San Diego,
CA. October 12-16, 2001. Am. J. Hum. Genet. 2001;69(4) Supplement 1:261. Abstract
306
Review of Negative ThinPrep Pap Tests which subsequently Test Positive by Digene
Hybrid Capture HPV DNA Assay: Cytologic Features, Diagnostic Yield, and Quality
Assurance Value? R Goulart, K Richard, R Lorenzana, R Bhargava, B Dziura, C Rauch, M
Bur. Annual Meeting, United States and Canadian Academy of Pathology, Atlanta, GA.
March 3-9, 2001. Mod Pathol. 2001;14(1):53A. Abstract 296
Correlation of HER-2/neu Amplification with Receptor Overexpression and Tyrosine
Kinase Activity in Breast Carcinoma. R Bhargava, R Naeem, J Luszcz, S Marconi, J Garb, R
Gasparini, CN Otis. Annual Meeting, United States and Canadian Academy of Pathology,
Atlanta, GA. March 3-9, 2001. Mod Pathol. 2001;14(1):53A. Abstract 109
Cytogenetic and SKY Characterization of Malignant Mesenchymoma. SA Ahmed, R
Bhargava, A Anguiano, J Smith, R Lorenzana, J Luszcz, R Naeem. Annual Clinical Genetics
Meeting, Miami, FL. March 1-4, 2001
Tyrosine Kinase Activation in Breast Carcinoma with Correlation to HER-2/neu
Overexpression. R Bhargava, S Marconi, J Garb, CN Otis. Annual Fall Program, 114th
Meeting, New England Cancer Society, Massachusetts General Hospital, Boston, MA.
November 10-12, 2000
Tyrosine Kinase Activation in Breast Carcinoma with Correlation to HER-2/neu
Overexpression. R Bhargava, S Marconi, J Garb, CN Otis. Annual Meeting, United States
and Canadian Academy of Pathology, New Orleans, LA. March 25-31, 2000. Mod Pathol
2000;13(3):18A. Abstract 84
Hemorrhagic Myocardial Infarction. R Bhargava, J Deshpande, A Sivaraman. Platform
Presentation at 46th Annual National Conference of Indian Association of Pathologists
and Microbiologists, Jodhpur, India. November 19-22, 1997.