I'd like to thank Malcolm Atkinson for inviting me to participate in the grand opening of the National eScience Center. As Director of the San Diego Supercomputer Center, I've had the opportunity to talk with a number of e-Science center scientists who have visited us recently -including Tony Hey, Malcolm Atkinson, Anne Trefethen, Jim Flemming, and Stuart Anderson – to discuss the possibilities and opportunities for bridging international boundaries with advances in e-Science. I am talking to you today from the San Diego Supercomputer Center, located on the campus of the University of California, San Diego. The mission of our center, SDSC, is to develop and use technology to advance science. Through leadership in the computational biosciences, data and knowledge systems, grid computing, and high-performance computing, SDSC, together with US and worldwide partners such as the UK e-Science community are involved in building a global information infrastructure that will change the face of science and technology over the next decade. SDSC is the leading edge site for the National Partnership for Advanced Computational Infrastructure (NPACI) a 48-institution U.S. e-Science partnership funded by the National Science Foundation (NSF) and one of the four sites building the TeraGrid, an exciting and extensible national grid which will help forward the vision of a global information infrastructure. The TeraGrid project was announced last year and was awarded $53M by NSF to build a cutting edge comprehensive grid environment for open scientific research. SDSC is involved in many collaborations with the UK, especially in the area of Grid data services and dataintensive applications. Researchers at SDSC have talked with Tony Hey and others about our experiences in building computational grids and data systems, and we are currently sharing software such as SDSC’s Storage Resource Broker and Information Integration Testbed. In fact, Reagan Moore, co-director of SDSC's Data and Knowledge Systems activities will be visiting NeSC next week and Reagan, Chaitan Baru and myself will be in Edinburgh this summer for the Global Grid Forum. The Global Information Infrastructure must be built by the whole community and activities in the US and UK will be integrated to provide a worldwide computational and data management fabric. The potential impacts of eScience on scientific advances are virtually unlimited. I'm looking forward to visiting NeSC in July and strengthening the relationship between our two centers, and to working with you to address the challenges of science and technology over the next decade. Thank you for the opportunity to participate today in this important event, and on behalf of NPACI and SDSC -wish NeSC every success in its scientific endeavors.