Course Code:
BENG 311P
Credits:
15 UCL credits
(7.5 ECTS)
Term delivered:
Term 1
Year of study:
3
Aims and
Learning
Outcomes:
Course Title:
Advanced Materials,
Devices and
Manufacturing Processes
for Regenerative
Medicine
Teaching Team:
Dr Ivan Wall
Prof Chris Mason
Dr Farlan Veraitch
Pre-requisites:
The aim of the module is to provide students with a working understanding of advanced
biomaterials and process discovery devices that are used for regenerative medicines
manufacture and the considerations regarding infrastructure requirements for clinical grade
manufacture of regenerative medicines. This will provide students with the skills that would be
highly desirable by a growing regenerative medicine manufacture industry and the Cell Therapy
Catapult.
By completing this module, students will:
 Understand the physical, mechanical and thermal properties of different materials and
their application to manufacturing processes for emerging regenerative medicines.
 Appreciate novel technologies currently employed for regenerative medicine
manufacture, with specific emphasis on the utility and application of microfluidic devices
to process discovery.
 Develop an understanding of how new manufacturing processes for stem cells rely
upon clinical grade manufacturing.
Synopsis:
In this module, students will learn about the importance of biomaterials, as part of implanted,
tissue-engineered devices and also as physical substrates for the attachment and growth of
stem cells during manufacturing processes.
Materials are also an important consideration for devices that are created to support process
development. Examples of such devices include microfluidic devices, which are gaining
substantial ground as process development tools to support regenerative medicine translation.
These devices will be examined from a materials and engineering perspective and students will
develop an understanding of the utility and power of these tools for stem cell culture.
Finally, building on earlier lectures in this module and BENG212P, principles of clinical grade
manufacturing will be taught and a trip to a regenerative medicines manufacturing facility will
also provide a real world learning experience that helps students familiarize with large scale
processes and regulatory requirements.
Method of
delivery:
Assessment:
Fundamental information will be delivered in the form of lectures. Then, interactive workshops
will be the main forum by which clinical case studies are used to generate and exchange ideas
about the defined needs of industrial processes and automation in small groups and as a whole
class. The workshops will be used to develop the student’s understanding of the utility of
different biomaterial substrates and subsequently the benefits and limitations of different
technology platforms for GMP manufacture. A total of 40 hours contact time over the 10 weeks
of term 1 are timetabled.
Examination (2hr written exam) 60%
Coursework (2 written courseworks) 30%
Workshop engagement 10%
1