Course Code:
BENG 212P
Credits:
15 UCL credits
(7.5 ECTS)
Term delivered:
Term 2
Year of study:
2
Aims and
Learning
Outcomes:
Course Title:
Manufacturing
Regenerative Medicines:
from lab bench to
industry
Teaching Team:
Dr Ivan Wall
Prof Chris Mason
Dr Farlan Veraitch
Pre-requisites:
The aim of the module is to introduce engineering students to tools and technologies that
underpin manufacture of stem cell-based regenerative medicine products, which are becoming
increasingly important for 21st Century healthcare and which will require talented multidisciplinary engineers to create sustainable manufacturing pathways for. Specific aims will be to
ensure all students irrespective of their discipline will have a fundamental understanding of the
cell biology that underpins stem cell manufacture and an understanding of the process options
and challenges for moving into industrial systems.
By completing this module, engineering students from different disciplines will:
1. Develop an understanding of fgndamental biology that underpins stem cell behavior and that
is critical to understand for successful manufacture of regenerative medicines.
2. Develop an understanding and working knowledge of manual cell handling, including those
that are typically used at research scale.
3. Develop an understanding and working knowledge of typical technology platforms and unit
operations used in regenerative medicine manufacturing pathways.
Synopsis:
This module will introduce engineering students to the fundamental biologic properties and
manufacturing requirements for regenerative medicines for 21st Century healthcare.
It will begin with the fundamental biology that underpins human cells and then explore the way
in which they can be harvested, expanded, differentiated and then delivered to the patient for
regenerative medicine applications.
Technology platforms that are used for each of the key unit operations in regenerative
medicines manufacture will be considered and technology gaps in the manufacturing space,
such as reliable in-process analysis and control tools, will be identified and discussed.
Cell expansion technologies will be considered in terms of requirements for different types of
therapy requiring different doses. Cost of goods case study will be used to determine technoeconomic feasibility of different cell expansion platforms.
Downstream processing including cell purification and concentration processes will be
considered theorectically via lectures and case study.
Method of
delivery:
Assessment:
The course is timetabled for 40 hours of contact time for the 10 weeks of term 2. This includes
industry case studies that will link core teaching of fundamental biology underpinning
regenerative medicine to real world examples of the manufacturing challenges for stem cells.
Examination (2hr written exam) 60%
Coursework (2 written courseworks) 30%
Mid-term test 10%
1