So how do we build a grand unified theory of health risks? Peter Banthorpe Head of Global Research and Development Background and Context 2 (Re)Insurers have mixed portfolios of different Mortality and Morbidity risks Product Consumer pays Life Assurance Regular Premium Insurer pays Length of contract Example Customer need Large Lump sum on death 10-40 years or Whole of Life To pay off a mortgage Critical Illness Regular Premium Large lump sum on diagnosis of one of a set of medical conditions 10-40 years To pay off a mortgage Income Protection Regular Premium Regular income while policyholder can’t work 10-40 years To maintain quality of life during illness Annuity A large lump sum Regular income for life From retirement till death To provide a guaranteed income for life Private Medical Insurance Regular premium Annual To provide faster access to medical care Cost of medical treatments 3 Longevity Risk Transfer from Company pension schemes to (Re)Insurers is the major growth area Source: Aon Hewitt. UK Risk Settlement Market Update – November 2014 4 Insurance underwriting creates groups of similar risks Underwriting Process • • • Health and Lifestyle Questions GP records Medical Exams • Decisions supported by extensive research • Guards against antiselection Non-disclosure issues • Standard Price/Risk Non-Standard Price/Risk Decline Cover 5 How do Insured Standard Mortality Rates compare to population? 160% Age Standardised % of Population 140% 120% 100% 80% 60% 40% 20% 0% Life Assurance Occupational Pensioners Lower Overall Purchased Annuities Upper UK Population 6 What do we charge someone who has suffered a heart attack for Life assurance? Depends on the relative risk of the individual MI Severity Assessment Current symptoms (Angina) Impact on activity Severity of MI Extent of vessel disease Ejection Fraction Degree of Cardiomegaly +50% RR Demographics Co-Morbidities Age Time Since Last Heart Attack Diabetes, heart failure etc Valvular Heart disease Arrhythmia Stress ECG results Lifestyle risk factors Decline Cover 7 8 Detailed research producing a granular level of understanding Our underwriting manual has 100 different curves for cancer, including 13 for breast cancer and 11 for prostate. 9 A “simple” multistate model to illustrate different products and underwriting combinations Stroke Stroke and Heart Attack Healthy Heart Attack Adverse Lifestyle risk factors Other disease Other disease states Other disease states Other disease states states Death Life assurance Non-Standard Lives could enter anywhere in here Standard Lives Enter Here Stroke Stroke and Heart Attack Healthy Heart Attack Adverse Lifestyle risk factors Other disease Other disease states Other disease states Other disease states states We pay out here Death Critical Illness Non-Standard Lives could enter in here Standard Lives Enter Here Stroke Stroke and Heart Attack Healthy Heart Attack Adverse Lifestyle risk factors Other disease Other disease states Other disease states Other disease states states We pay on the first of one of these Death Better understanding contributes to Wider Access, Fairness of Pricing and Financial stability Access For as many people as possible, whatever the medical history is To new products To premium guarantees Fairness Price This is not a zero-sum game Financial Stability Ability to withstand a 1 in 200 year event Diversification benefits Ability to invest in UK plc. 13 Current Approaches Pricing for the next year 14 Like any research we need relevant, high-quality data UK Insurers own data Representative of the insured population: • Bias to higher SE groups; • Smoker segregated; • Grouped according to risk at entry International Data Publically available Government data Adequate for standard lives in existing products and markets Detailed Care Data Quality Accurate, granular, detailed, long-time series, voluminous, recent 15 Analysis Techniques For Insured data will be familiar • Traditional Actuarial Approach – calculate exposures and actual deaths • Sufficient where small number of risk factors, and… Uni-variate • … risk factors are un-correlated A/E GLM A/E Analysis Survival Analysis • Extension of uni-variate approach; • Copes with multiple risk factors, including correlated risk factors; • Approach limited to lives weighted analyses • Models time to death rather than counts of death • Continuous time model rather than discrete time model 16 Deriving absolute risk estimates from non-insurance data is difficult Rates • Obtain population incidence rates • Possible sources: Medical Papers, National Databases Errors • Understand the data and correct for any known errors • Population sources often include either double counting or under reporting • Insured Definition probably won’t match medical definition; Severity • Adjust for differences. • Adjust for differences between Population and insured experience Insured • In particular, socio-economic bias, self-selection and impact of underwriting • Reduce costs if elements of the definition already covered elsewhere Overlaps 17 Pricing Co-Morbidities is a challenge but very necessary Proportion of applications with disclosures from shown disclosures only (78% of all applications in this case) 13% Smoking (Empty cells mean <0.5%) Other CV Risk Factors 12% 29% 1% 2% 16% 17% Coronary Artery Disease Diabetes 2% 3% 2% 2% 18 Current Approaches Pricing for the next 40 years 19 A history of underestimating life expectancy Source: Fifty Years of United Kingdom national population projections: How accurate have they been? Chris Shaw, Office for National Statistics (2007), © Crown copyright 2007 20 For pricing purposes we need a single best estimate view of the future 2.5% 2.0% 1.5% 1.0% 0.5% 0.0% 2011 Current Improvement Rates 2021 2031 Convergence Period 2041 Long-run improvement rate For reserving and some transactions we need Stochastic Methods 21 No one wants to drive looking only in their rear view mirrior 22 Building All-Cause mortality projections by cause Other Circulatory Heart Disease Year Age 21 - 25 81 - 85 86 - 90 91 - 95 96 - 00 01 - 05 # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 # # 6 # # 6 # # # # # # 6 6 6 6 # 6 6 6 6 6 # # # # # # # # # # 6 6 6 6 6 # # 6 6 6 36 - 40 41 - 45 46 - 50 51 - 55 56 - 60 61 - 65 81 - 85 86 - 90 91 - 95 96 - 100 # # # # # # 4 4 4 # # # # # # # # # # # # # # # # 4 # # # # 4 # # # # 4 4 # # # 4 4 # # # 4 4 # # # 4 4 # # # 4 4 # # # 4 4 # # # 4 # # # # # # # # # # # # # # # # # # # # # # # # # 4 # 4 # 4 # # # # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # 4 4 4 4 # 4 4 4 4 # # 4 4 4 # # # 4 4 # # # # 4 # # # # # # # # # # # 6 6 # # 6 # # 6 # # # # # # 6 6 6 6 # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 81 - 85 86 - 90 91 - 95 96 - 00 01 - 05 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 # 6 6 # # 6 # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # # 4 4 4 4 # # # 4 4 4 # # # 4 4 4 4 # # # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # 4 4 4 4 4 # # # 4 4 4 # # # # 4 4 # # # # # # 6 # # # # # 6 6 6 # # # 6 6 6 6 6 # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # 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# # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 # # # # # # # # # # 6 6 6 # 6 6 6 # # 6 6 # # # 6 # # # 6 # # # # # 4 4 # 4 4 # 4 4 # # 4 # # # # # # 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 # # # # # # # # # 6 6 6 6 # # # # # # # # 6 6 6 6 6 # # # # # # # 6 6 6 6 6 # # # # # # # 6 6 6 6 6 6 # # # # # # 6 6 6 6 6 6 # # # # # # 6 6 6 6 6 6 # # # # # # 6 6 6 6 6 6 # # # # # # 6 6 6 6 6 # # # # # # # 6 6 6 # # # # # # # # # 6 6 # # # # # # # # # # 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 # # # # 6 6 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # 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# # # # # # # # # # # # # # # # # # # # # # # 6 6 # # # # 6 6 6 # # # # 6 6 6 # # # # 6 6 6 6 # # # 6 6 6 # # # # 6 6 # # # # # 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 # # # # 6 6 6 # # # 6 6 6 6 6 # # 6 6 6 6 # # 6 6 6 6 # # # # # # # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 # # # # # # # # # # # # # # 3 3 3 3 3 3 3 3 3 3 3 3 3 3 # # # # # # # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 # # # # # # # # # # # # # # 6 6 # # # # # # # # # # # # 3 3 3 3 3 3 3 3 3 3 3 3 3 # # # # # # # # # 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 # # # # # # # # # # # # # # 6 6 # # # # # # # # # # # 3 3 3 3 3 3 3 3 3 3 3 # # # # # # # # # # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 # # # # 4 4 # # # # # # # # # 6 # # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # 6 6 6 6 6 # # # 6 6 6 # 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4 4 4 4 # # 6 4 4 4 # # 6 # 4 4 # # # # 4 4 # # # # # 4 4 # # 4 # # # # 4 4 4 # # # # 4 4 4 # # # # # # # 4 4 4 4 4 # # # 6 # 5 # # # 5 6 # # # # # 6 # # # # # 5 # # # # 5 4 # 5 5 5 5 # 4 # # 5 5 6 # 4 4 # # 6 6 # # 4 4 4 # 6 # # 5 5 # 4 # 6 # # 4 # 5 5 # 4 6 # # 4 # # 4 # 6 # 4 # 6 6 6 6 # # # 6 6 6 # # 4 4 # # 4 4 4 4 # # # 4 4 4 4 # # # 4 4 4 # # 6 # # 4 # # 6 6 # # # 4 6 6 6 # # 4 # 6 6 6 # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # 4 # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # 4 # 6 6 # # # # 4 # 6 6 # # 6 # # # # 6 6 6 # # # # # # # # 6 # # 5 5 5 5 4 4 4 4 4 4 # 6 6 6 # 6 6 6 # # 6 6 # # # 6 # # # 6 # # # # 5 5 # # # # 4 4 4 4 4 # 6 6 6 6 6 6 # 6 # 6 # 6 # 6 # # # # # 4 4 4 4 4 4 4 4 4 4 # 4 4 4 4 4 # # # # # # # # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 4 4 6 6 6 6 6 6 # # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # 6 6 6 6 6 # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # 4 # # # # 4 4 4 # # # # # # 4 4 # 6 6 # # 6 6 # # # # # # # # # # # # 6 6 # # # # # 6 6 # 6 6 4 # # # # # 6 6 # 6 # 4 4 4 4 6 6 # # # 4 # # 6 # # # # # # 6 6 6 4 4 4 # # # # # # # 6 4 # # 6 6 6 6 6 6 6 6 6 # 6 6 6 6 # # # # # # # # # # # # # # # # # 6 # # # # # 6 6 # # # # 6 6 # 6 6 # # 6 6 6 6 6 6 6 # # # # # # # 6 # 6 6 6 # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # 4 4 4 4 4 4 6 6 # # # 6 5 5 5 # 4 # # # # 4 4 4 4 4 4 6 6 6 6 # # 4 # # # # 6 6 6 6 6 6 6 6 6 6 # # # # # # # # 4 4 4 4 4 6 # # # # 5 # 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # 4 # 4 # 4 # # # 6 6 # 4 4 4 4 4 4 # # 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # 6 6 # # # 4 # # # # # # # 4 4 4 4 # # # # # # # 5 4 4 4 4 4 4 4 # # # # # # # # 4 4 4 # # # # # # # 5 5 6 # # 4 4 4 4 # 4 4 4 4 # # # # # # 5 5 5 3 6 # # # 6 # # # # # # # # # # # # # # # # 6 # # 4 # # # # # # # # # 6 6 # # # # # # # 3 3 # # # # # # 5 # 4 4 4 4 # 4 4 # # # # 4 # # # 6 6 4 # # # # 4 4 # # # # 5 # 5 # # # # # 5 # 4 4 4 # 4 # # # 4 # 5 4 # # # 5 # # # # # 4 # 4 4 4 # # # # # # 4 4 # 3 # # # # # # # # # # # # 4 4 # # # # # # 5 4 4 # # # # # # 6 6 6 # # 6 6 6 # 4 4 # # 6 # 6 # # 6 6 # 4 4 4 # 4 # 4 # # # # 4 5 4 4 4 # # # # # # # # # # 4 5 # 5 5 5 5 5 # # 4 4 4 # # # # # # # # # # # # 6 6 6 6 # # # # 4 # # # 4 # # 6 # # # # 6 6 # # # # # # 6 6 # # # # # # 6 # 5 5 5 5 5 # # 4 4 4 # # # # # # # # # # # # # # # # # # # # 4 4 # # 4 4 # 6 # # # # 6 6 # # # # # # 6 6 6 # # # # # 6 6 4 # 4 # 4 4 4 4 # 4 4 4 4 # # # 4 5 # # 5 4 4 5 5 5 5 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # 6 # # # # # 6 6 6 6 # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # 6 6 # # # # 6 6 # # # # 6 6 # # 4 4 6 6 # # 4 4 # 6 6 # 4 4 # 6 6 # 4 4 # # 6 # # 4 # # 6 6 # 4 # # 6 6 # 4 5 5 5 5 5 # # # 4 4 # # # # # # # # # # # # # # # # # # # # # # # # # # 4 4 4 4 4 4 5 5 # # # # 5 5 5 # # # 5 5 5 5 5 # 5 5 5 5 5 5 # # # # 5 5 # # # # # # # # # # # # 4 4 4 4 4 4 # 4 4 4 4 4 5 5 5 # # # 5 5 5 # # 5 5 5 # # 4 # # # # # # # # # # # # # # 4 # # # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # # # # 4 # # # # # 4 4 # # # # 4 4 # # # # 4 4 4 # # # 4 4 4 4 # # # 5 5 5 # # # 5 5 5 # # 6 6 6 6 6 # # # # # # # 6 6 6 # # # 4 4 4 # # # # # # # # 6 6 6 # # 4 4 4 4 # # # # # 6 6 6 6 # # # # # # # # # # 6 6 6 6 # # # # # # # # # # # # 6 6 6 # # 6 6 6 6 6 6 # # # # # # # # # # # # # 4 4 4 4 4 # # 6 6 6 # # 6 6 6 6 6 6 # # # # # # # # # # # # # # # 4 4 4 4 4 4 6 6 6 # # # 4 4 4 4 # 5 5 5 # # # 5 5 # # # # 5 5 # # 4 5 5 5 # # 4 5 5 # # 4 4 # # # # # # 6 6 # # # # # 6 6 6 # # # # 6 6 # # # # # # 6 # # # # # # # # # # # 4 4 ≥ -100.0% -3.5% -2.5% -1.5% -0.5% 0.5% 1.5% 2.5% 3.5% 4.5% 6.5% < -3.5% -2.5% -1.5% -0.5% 0.5% 1.5% 2.5% 3.5% 4.5% 6.5% 100.0% Colour 13 13 11 11 5 5 33 33 4 4 43 43 6 6 44 44 45 45 46 46 3 3 # # # # # # # # # # # # # # # # 4 4 # 4 4 # 4 4 # # 4 4 4 4 # # 4 4 4 # # # 4 4 # # # # 4 4 # # # # # # 4 4 4 4 4 4 4 # # # 4 # # 5 5 5 4 4 # # # # 5 # # # 4 4 4 # # # # # 4 4 4 4 6 6 # # # 6 6 # # # # # # # 6 6 # # # # 6 6 6 6 6 6 4 4 # 5 # # # # 6 # # 6 6 6 5 5 # # # # # # # # 4 4 # 4 4 4 4 4 4 # # # # # # # 5 # 5 # # # # # # # # 4 4 4 4 4 # 4 4 4 4 4 # # 4 4 4 4 # # 4 4 4 4 # # 4 4 4 4 # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # # # 4 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 5 # 5 # 5 4 4 4 4 # # # # # # # 6 6 6 # # # # # # 4 4 4 4 # # # # # # 6 6 6 6 6 6 6 6 # # # # 4 4 4 # # # # # # 6 6 6 6 6 6 6 6 6 6 # # # # 4 4 4 # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 # # # # 4 4 4 # # # # # 5 5 5 5 5 6 6 # # 6 6 6 # # # # # 6 6 6 6 # # # 4 4 4 4 4 # 6 # # # 6 6 6 6 # # 4 4 4 # # # # 4 4 4 4 4 4 4 # # # # 4 4 4 4 4 # # # # # 6 6 4 4 # # 5 5 # # # # 4 4 4 # # # # # # 4 4 4 4 4 # # # # # # # # # # # # 4 4 # # # # # # # # # # # # 4 4 4 # # # # # # # # # # 4 4 4 4 4 4 # # # # # 4 4 4 4 4 # # # # # 4 4 4 4 # # # # # # # # # # # 4 4 4 # # # # 5 5 # # # # # # # 6 6 6 6 6 6 # # # # # # 4 4 4 # # # # # # # # # 4 4 4 4 4 4 # # # # 6 6 6 6 6 6 6 6 6 # # # # # # 4 4 # # # # # # # # # # # # 4 4 4 4 4 4 4 4 4 4 # # # 6 6 6 6 6 6 # # # # # # 4 4 4 # # # # # # # # # # # # 6 6 # # # 6 6 6 # # # 5 5 5 # # # 6 6 6 6 6 6 # # # # 6 # 4 4 4 4 4 4 4 4 4 4 4 # # 4 # # # 5 5 # # # # # 6 6 6 6 6 6 # # # 6 # # 4 4 4 4 4 4 4 4 4 4 4 # # 4 # # # # # # # # # # # # 6 6 6 6 6 6 # # 6 # # # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # 4 4 # # # # # # # # # # # # # # # 6 6 6 6 6 6 # # 6 # # # 5 # 4 4 # 4 4 # # 6 # # # # 4 # # # # # 4 4 4 4 4 4 4 4 # 6 6 6 6 6 6 6 6 6 6 6 # # # # 5 # 6 6 # # # 4 6 6 # # 4 4 4 4 4 4 4 4 # 6 6 6 6 # 6 6 6 6 6 6 # # # 5 # 4 # # # # # 4 6 6 6 6 6 6 6 6 6 6 # # 6 6 # # # 6 6 6 6 6 # 6 6 6 6 6 6 5 # # # # 4 4 4 # 6 6 6 # # # # 6 6 6 # # # 6 6 6 6 6 # 6 6 6 6 6 6 # 4 # 4 # 4 # 4 # # # # 6 6 6 6 6 6 6 6 6 6 # # # # # 6 6 # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 3 5 5 5 5 # # # 6 6 # # # # # # # # # # # 6 6 6 6 6 6 6 6 3 3 3 3 3 6 6 6 6 # # # # # # # # # # # # # # 6 6 6 6 6 6 6 # # # # # # 6 6 6 6 6 6 6 6 6 6 # # # # # 4 4 # # 4 4 # # # 6 6 6 6 6 6 6 # 5 5 5 5 # 5 # # # # # # # 4 4 # 4 4 # # 5 5 5 5 5 # 6 6 6 6 6 6 6 6 6 6 6 # # # # 4 4 # # # 4 4 4 # # 6 6 6 6 6 6 4 4 4 4 4 # # # # # # # # # # 4 # # # 4 4 4 # # 6 6 6 6 6 6 4 4 # # 5 5 5 5 5 # 4 4 4 4 4 4 4 # # # # # # # # # 5 5 # # # # 4 4 4 # # 6 6 6 6 # # # # # 5 5 # 4 4 4 4 4 4 4 4 4 # # # # # # # 5 5 5 # # # # 4 4 4 4 # 6 # # # # # # # # 5 5 # 4 4 4 4 4 4 4 4 4 4 # # # # # # # # # # # # # 4 4 4 4 # # # # # # # # # # # 4 4 4 4 # # # # # # # 3 3 3 3 3 6 6 6 6 6 6 6 6 # # # # # # # # 6 6 6 # # # # # # # # # # # # # # # 6 6 6 # # # # 3 # 3 # # # # # # 6 6 6 6 6 6 6 # # # # # # # # 6 6 6 # # # # # # # # # # # Key # # # # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 4 4 4 4 4 4 # # # # # # # # 6 6 # # # # 4 # # # 4 4 # # # # # # # # 6 # # # # # # # 6 6 # # # # 4 4 4 4 4 4 6 6 6 # 6 6 6 # # 4 # # # 4 4 # # # # 4 4 # # 6 6 # # # # # # 6 # # # # # 4 4 4 4 4 4 6 6 6 6 6 6 6 # # # # # # # # # # # # # 4 4 # # 6 6 # # # # # # 6 # # # # # 3 3 3 3 3 # # # # # # # # # # 4 4 # # 6 6 # # # # # # # # # # # # 3 3 3 3 3 3 6 6 6 6 6 # # # # # # # # # # # # # # # 4 4 # # # 6 # # # # # # # # # # # # 3 3 3 3 # # 6 6 6 6 # # # # # # # # # # # # # # # # 4 4 # # # 6 # # # # # # # # # # # 6 6 6 # # # # # # # # # # 4 4 4 4 4 # # # 4 4 # # # 6 # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # 4 4 4 4 4 4 4 # # 4 4 # # # # 6 6 6 6 6 6 # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # 3 3 3 3 3 3 3 3 3 3 3 3 # 6 6 # # # # # # # # # # # 4 # # # # # # 4 4 4 6 # # # # # 4 # # # 6 6 # # # 6 6 6 4 # # # 6 6 6 # # # # # # # # # # # # # # # # # # 6 6 # # # # # # # 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # 4 4 4 # # # # # # # # # # # # # # # # # # # # # 6 # # # # # # # # # # # # # # # # # # 6 6 6 # # # 6 6 6 6 6 6 # # # # # # # 6 6 6 6 6 6 # # 6 6 6 6 6 6 # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # 6 6 # 6 6 # # 6 # # 6 # # # # # # 6 6 6 6 6 6 # # # # # 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 # # # # # 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # 6 # # # # # # 4 4 4 4 4 4 4 4 4 # # # # # # # # # # # # # # # # # 6 6 6 6 # # # # # 4 4 4 4 4 4 4 4 4 4 # # # # # # # # # # # # # # # 6 6 6 6 6 6 # # # # # 4 # # # 5 5 5 5 # # # # # # 4 4 4 4 4 4 4 4 # # # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 # 6 # 6 # # # # # # # # # # 4 4 # # # 5 5 5 4 4 4 4 4 4 4 # # # # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 4 # # # # 4 4 # # # 5 5 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 4 4 # 5 5 5 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 4 4 4 5 5 5 5 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 # # # # # # # # # # # 6 6 6 6 6 6 6 6 # 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 # # # # # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 4 # 6 6 6 6 6 6 # # # # 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 4 # 5 # # # # # # # # 4 4 4 # # # # # # 4 # 5 # # # # # # # 4 4 # # # # # # 4 # # # # # # # # # # # # 4 4 4 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 5 5 5 5 # # # # # # # 5 5 5 5 # # 4 4 4 4 4 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 6 # # # # # # 6 6 6 6 6 6 6 6 6 6 6 # # # 5 # # # 6 6 6 6 5 5 5 5 5 # # 5 # # # # # # # 6 6 6 # # # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # # # # 6 6 6 # # # 6 6 6 # # 5 5 5 5 # # # 4 4 # 5 # # 6 6 # # # # 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 4 # # # 6 6 # # # # # # # 4 4 5 5 5 5 # # # 4 4 # 5 # # 6 # # # # # 6 6 6 # # # 6 # # # # # # 4 # # # 4 # # 4 # # # # # # 5 5 5 # # 4 # 5 5 5 # # # # # # 6 6 6 6 # # # # # # # # # # # # # # 5 5 5 # # 6 6 6 6 6 6 # # # # # # 6 6 6 6 # # # # # # # # # # # # 4 # # 06 - 12 5 5 5 # # 5 5 # # # # 6 6 6 6 # # # # # # # # # # 4 4 4 # 5 4 # # # # # # # # # # # # # 4 # 5 4 # # # # # # # # # # # # 5 # 4 # # # # # # # # # # 4 5 # # 4 4 # # # # # # # # 4 # # # # 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 5 # # 5 6 # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 5 # 5 5 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 5 5 5 5 # # # 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 5 5 5 # 4 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # 4 4 4 4 4 4 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 4 4 4 4 4 # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 4 4 4 # # # # 4 4 # # # # 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 4 4 # # # # # 6 # # # # # # # # # # # # 6 6 6 6 6 # # # # # 6 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 4 # # # # # # # # # # # # # # # # # # 6 6 6 6 6 81 - 85 86 - 90 91 - 95 96 - 00 01 - 05 6 6 6 6 6 6 6 6 6 6 4 4 4 4 4 4 4 4 4 4 # # # # # # # # # # # # # # # # # # # 6 6 6 6 6 06 - 12 6 6 6 6 6 6 6 6 6 6 6 # # # # # # # 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # # 6 6 6 6 6 6 6 81 - 85 86 - 90 91 - 95 96 - 00 01 - 05 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 6 # # # 6 6 6 6 6 6 6 6 06 - 12 # 6 6 6 6 6 # # # # # # 4 4 # # # 76 - 80 # # # # # 06 - 12 Other Causes 6 6 6 6 6 6 # # # # # # # # # # # 71 - 75 # # # # # 81 - 85 86 - 90 91 - 95 96 - 00 01 - 05 Other Cancer # # # # # # # # # # # # 4 # # 66 - 70 # # # # 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # # 31 - 35 # # # 6 6 6 6 6 6 6 6 # # # # # # # # # # # # # # # # # # # # # # # 26 - 30 # 6 6 6 6 06 - 12 Lung Cancer # # # # # 4 4 4 # 4 # # # 4 # 6 # # 6 6 # # 6 # 6 # # 4 4 4 # 6 # 4 4 # # # 6 6 6 # # # # 6 6 6 # 4 # 6 # # # # 4 # # # # # 4 # 6 # 4 # # 4 # # 4 # # # 4 # 4 4 # 4 4 # # 4 4 5 # 4 # 6 # # # # # # 4 # 6 # # # # # # # 4 4 4 # # 4 4 4 4 4 4 # 4 4 4 4 4 4 6 4 4 # 6 6 # # # # # # # # # 6 # 6 # # # # # 6 # # # # # 6 # # # # # 6 # # # 6 # # # # # # # 6 6 6 6 # # # 4 # # # # 4 4 4 4 4 4 4 4 # # # 4 4 4 # 4 4 # # 5 4 # # 6 6 6 # # 4 # # # 4 # 6 6 6 6 # 4 5 # # 4 4 4 4 4 4 # 4 4 4 4 4 # # 4 # # 4 # # # # # # 4 4 4 4 4 4 4 4 4 4 # # # 5 # 4 4 4 4 4 # 4 4 4 4 4 4 4 4 4 4 4 6 # # 4 4 4 6 6 # # 4 4 6 6 6 # 4 4 # # # # # 4 5 # 5 # 4 4 4 4 4 4 4 4 4 4 # # # 5 5 4 4 4 4 4 4 4 4 4 # # 5 5 # 4 4 4 4 4 4 4 4 # # 5 5 # 4 4 4 4 4 4 4 4 # 5 5 # 6 # 6 # # # # # # # # # # 6 # # # # # # # # # 5 # # 4 4 4 4 4 6 4 4 # 6 6 # # # # # # # # # # # # # 6 6 6 6 # # # # # 4 # 4 4 # # # # 4 5 6 6 6 6 6 6 6 6 6 # # # # # 6 6 4 4 # # # 4 4 4 # # 4 4 # # # 6 6 6 # 4 4 4 # # # 4 4 4 4 # # # # 6 6 # 4 # 4 4 4 4 4 4 4 4 # # # # # # # # # # 6 6 # 4 4 4 6 # Source RGA analysis of ONS data 23 Models like this are getting towards what we would like…. 24 Lewsey J D et al. Heart 2015;101:201-208 Factoring in global context: Global IHD Trends Source: RGA calculations based on WHO Mortality Database 25 Factoring in global context: Global Cancer Trends Source: RGA calculations based on WHO Mortality Database 26 Cancer deaths will be eliminated for all under 80 by 2050, new research predicts1 “It is realistic to expect that by 2050 nearly all cancer related deaths in children and adults aged up to (say) 80 years will have become preventable through life style changes and because of the availability of protective technologies and better pharmaceutical and other therapies.”(2) 1: The Independent. Accessed online: 16 January 2015 2: UCL School of Pharmacy: Overcoming Cancer in the 21st Century (14 January 2015) 27 Quantifying Socio-economic Differences in trend is a very active area of research 28 So models like IMPACTSEC are very useful… …if only we had something similar for Cancer Bajekal M, Scholes S, Love H, Hawkins N, O'Flaherty M, et al. (2012) Analysing Recent Socioeconomic Trends in Coronary Heart Disease Mortality in England, 2000–2007: A Population Modelling Study. PLoS Med 9(6): e1001237. 29 doi:10.1371/journal.pmed.1001237 In conclusion… 30 We are interested in most things, including lots of things that haven’t been mentioned so far…. Constant Health Monitoring / Quantified Self / Wearables Genetics Wellbeing / Biopsychosocial Maximum Lifespan Changes Regenerative Medicine Healthy Ageing Antimicrobial resistance 31 So as a real conclusion…. Understanding the past is essential But we rarely extrapolate the past without adjustment To adjust for the future requires detailed explanatory modelling Emerging data and modelling techniques hold promise for more accurate pricing of non-standard risks Key areas of research interest are: Models which clearly link morbidity and mortality Socio-economic variations in trends The future incidence and mortality from Cancer Co-morbid mortality Excess mortality as a function of age and duration 32 Thank you for your attention. 33