VITAMIN D, 25 HYDROXY 12/9/2014 LABP000102

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VITAMIN D, 25 HYDROXY
UPDATE
EFFECTIVE
VITAMIN D, 25 HYDROXY
12/9/2014
LABP000102
Effective December 9, 2014, the Clinical Laboratory will introduce a new lot of Vitamin D
reagent with a change in standardization to be in alignment with the 25(OH)Vitamin D Reference
Measurement Procedure (RMP).1,2 This assay is a certified procedure of the CDC Vitamin D
Standardization-Certification Program (VDSCP).3
The linear range of the assay will remain the same at 4.2 to 150 ng/mL.
As a result of the re-standardization process, when comparing with values prior to
December 9, 2014, the following biases may be observed:
Range (ng/mL)
<15
15 – 30
31 – 50
>50
Expected Difference (ng/mL)
-1.5
2.1
-1.2
-10.0
Average Bias (%)
-15.1%
9.8%
-2.6%
-13.6%
References:
1.
Sempos CT, Vesper HW, Phinney KW, Thienpont LM, Coates PM, Vitamin D Standardization Program
(VDSP).Vitamin D status as an international issue: National surveys and the problem of standardization.
Scandinavian Journal of Clinical & Laboratory Investigation, 2012; 72(Suppl 243): 32–40
2.
Thienpont L, Stepman HCM, Vesper HW. Standardization of measurements of 25-Hydroxyvitamin D3 and D2.
Scandinavian Journal of Clinical & Laboratory Investigation, 2012; 72(Suppl 243): 41–49
3.
CDC website (http://www.cdc.gov/labstandards/hs_procedures.html)
For questions or additional information please contact Laboratory Client Services at
916-734-7373 or email [email protected]
LIS mnemonics: VITD25
www.testmenu.com/ucdavis
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