Yang Xiang, Ph.D.
Research/Academic Interests
My research focuses on a group of G-protein coupled receptors responding to hormones and
neurotransmitters in heart and brain during pathogenesis of heart failure and Alzheimer’s disease,
respectively.
We use integrative approaches ranging from single molecular study, in vivo manipulation, to
patient sample examination to understand physiology and pathophysiology of the receptors, and
their implication in drug discovery and clinical therapy.
Title
Associate Professor
Specialty
Pharmacology
Department
Pharmacology
Address/Phone
Genome and Biomedical Sciences Building, Genome & Biomedical Sciences Facility, 451 Health
Sciences Drive Suite 3503 Davis, CA 95616
Phone: 530-752-3200
Additional Phone
Phone: 530-752-6895
Email
ykxiang@ucdavis.edu
Education
Ph.D., Vollum Institute, Oregon Health Science University, Portland OR
B.S., Wuhan University, Wuhan, China
Select Recent Publications
Liu SB, Li Y, Kim S, Fu Q, Parikh D, Sridhar B, Shi Q, Zhang X, Guan Y, Chen X, Xiang YK. (2012)
Activation of the Gs-coupled EP receptor regulates the spatio-propagation of cAMP signal induced
by the Gs-coupled AR in animal hearts. PNAS. 109(17):6578-83
Jain A, Liu R, Xiang YK*, and Ha J*. (2012) Single molecular Pull-down for studying protein
interactions. Nature Protocol, 7: 445–452 * co-corresponding author.
Liu SB, Zhang J, and Xiang YK (2011). FRET-based direct detection of PKA activity in sarcoplasmic
reticulum in cardiac myocytes. BBRC 14;404(2):581-6. PMC3025313
Yang Xiang, Ph.D.
Xiang YK. (2011) Spatiotemporal regulation of beta adrenergic signals in cardiomyocytes.
Circulation Research 109(2):231-44.
Wang D, Yuen EY, Zhou Y, Yan Z and Xiang YK. (2011) Amyloid induce internalization and
degradation of 2 adrenergic receptor in prefrontal cortical neurons. J. Biol. Chem. 286(36):3185263. PMC3173113
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