Research Funding California National Primate Research Center, Noctor SC (PI), 8/01/14 – 7/31/15, Identification of Neural Precursor Cells in the Prenatal Macaque Brain. The goals of this project are to identify neural precursor cells in the primate brain before and after formation of the subventricular proliferative zone, and to determine the nature of interactions between neural precursor cells and fetal microglia. NIH R01 Martínez-Cerdeño (PI); Noctor SC (Co-Investigator), 5/01/11 – 4/30/16, Postmortem analysis of cellular subtype density and morphology in the autistic temporal human cerebral cortex. This project will analyze the temporal lobe of autistic and control postmortem human brains, and investigate: 1) Density of total neurons, pyramidal neurons, and interneuronal subtypes in the autistic versus control temporal cortex using unbiased stereological methods for cell quantification. 2) Density of total glial cells, astrocytes, and oligodendrocytes in the autistic versus control temporal cortex using stereological methods. NIH R01 Amaral D (PI); Noctor SC (Co-Investigator), 09/01/14 – 08/31/16, Defecting the Transfer of Maternal Antibodies in the Fetal Rhesus Monkey Brain. The goal of the proposed research is to use positron emission tomography to track exogenously administered maternal antibodies across the placenta and into the fetal brain. NIH R01, Berman (PI); Noctor SC (Co-Inestigator), 4/01/13 – 3/31/18, Mouse Models to Define Critical Periods and Molecular Targets in FXTAS. The goal of this project is to establish criticial developmental ages and molecular targets for treating pathology in Fragile X premutation carriers (PM) and in Fragile X-associated tremor/ataxia (FXTAS) using CGG knock-in mice (CGGex KI) and doxycycline-inducible dox-CGG99 mice. NIH R01 RMH101188A, Noctor SC (PI), 8/1/2013 – 5/31/2018, Microglia regulate development of the cerebral cortex. The goals of this project are to identify factors that regulate microglial function in the prenatal cerebral cortex, including the signaling pathways that regulate phagocytosis of neural precursor cells. Community Service Chair, Cortical Evolution 2015 meeting in Toledo, Spain. (Organized, set up, and ran the meeting of 150+ attendees. Made money! http://ventricular.org/corticalevolution.html) Member, Amanda Nguyen Thesis Committee, CSUS Member, DBD Study Section, NIH Member, Interview Students Neuroscience Graduate Group Member, Kira Spencer Thesis Committee, UC Davis Member, NIH K99/R00 Study Section Member, Robert Lindquist Thesis Committee, UCSF 57 Christine Wu Nordahl, Ph.D. Journal Articles 2015 Nordahl CW, Iosif, AM, Young GS, Perry LM, Dougherty R, Lee A, Li D, Buonocore MH, Simon TJ, Rogers SJ, Wandell B, Amaral DG. Sex differences in the corpus callosum in preschool-aged children with autism spectrum disorder, Molecular Autism, 6:39. Abstracts and Presentations 2015 Johnson RT, Li DD, Amaral DG, Rogers SG, Ozonoff S, Nordahl CW. Sex differences in social impairment in preschool-aged children with autism spectrum disorder, International Meeting for Autism Research, (slide presentation) Salt Lake City, UT. 2015 Libero LE, Nordahl CW, Li DD, Rogers SJ, Amaral DG. Persistence of megalencephaly in early childhood in a subset of children with autism spectrum disorder, International Meeting for Autism Research, (slide presentation) Salt Lake City, UT. 2015 Feng Y, Ota H, Rogers SJ, Amaral DG, Hoeft F, Nordahl CW. Different patterns of cortical brain alterations in preschool-aged boys with autism spectrum disorder with and without intellectual disability, International Meeting for Autism Research, Salt Lake City, UT. 2015 Li DD, Young GS, Lee A, Amaral DG, Nordahl CW. Longtidinal human brain development from 2-5 years of age, Organization for Human Brain Mapping, Honolulu, HI. Research Funding NIMH R01MH104438, Neural Phenotypes of Females with Autism Spectrum Disorder, 20142019, $446,894 (annual direct costs), Nordahl CW (PI). NIMH R01MH104438-01S1, Neural Phenotypes of Females with Autism Spectrum Disorder, 2014-2015, $111,261 (annual direct costs), Nordahl CW (PI). NIMH R01MH103284, Predictors of Cognitive Development in Autism Spectrum Disorder, 2014-2019, $358,179 (annual direct costs), Solomon M (PI), Nordahl CW (Co-Investigator). NIMH R01MH103371, Neurophenotypic Trajectories and Behavioral Outcomes in Autism Spectrum Disorder, 2015-2020, $499,194 (annual direct costs), Amaral D (PI), Nordahl CW (Co-Investigator). Community Service Grant Reviewer, Brain Seed Grant, University of Texas System Neuroscience and Neurotechnology Institute 58