Cognitive-AffectiveRisk
andProtectionin
Psychosisin22q11.2DS
AbbiePopa,B.S.
FamilyDay2015
Whatwe’redoinginthe
study…
•  Ac8vi8esmeasuring
execu8vefunc8on
•  Par8cularlyin
interac8onwith
posi8ve,nega8veand
neutralemo8ons
•  ERPstoexaminebrain
signals
•  Stressreac8vity
•  MRIofbrainconnec8vity
•  Clinicalinterviews
ms
Let’stryit!
•  GoNoGo
•  Clapifyouseea
mole
•  Donothingifyousee
avegetable
Whydowedothisactivity?
•  Somepar8cipantsmighthave
troublenotpressingthe
buLontothevegetable
•  Thesepar8cipantsmayhave
troublewith“cogni8ve
control”andmentalflexibility
500ms
500ms
emotionalGo-NoGoActivity
•  Canpar8cipants
resisttheurgeto
pressthebuLonfor
molesandveggies,
butnotforemo8onal
faces?
•  Angryfacesmightbe
mildlystressfulfor
par8cipants,
especiallyanxious
ones
emotionalGo-NoGoActivity
•  Arepar8cipantsbehavingdifferentlyontheemo8onaland
un-emo8onalversions?
DistractorTargetActivity
•  Seethreecircles
•  PressonebuLonif
themiddlecircleis
thecolorwetold
themtolookfor
•  Pressasecond
buLonifit’sany
othercolor
600-1000ms
R
200ms
DistractorTargetActivity
•  Thepar8cipantis
onlysupposedto
payaLen8onto
themiddlecircle
•  Buttheymightbe
distractedbythe
circlestothesides
•  Especiallyifthey
arethecolorthe
par8cipantis
lookingfor
600-1000ms
R
200ms
DistractorTargetActivity
•  Somepar8cipantsmighthavemoretroublefocusingonthe
centercircle,especiallywhentheyaredistractedbythecircles
tothesides
•  Inmildcasesthesemightbethesameyoungpeoplewhohave
troublepayingaLen8onintheclassroom
•  Inother,moreseverecasesmightrelatetounusualthinking
AccuracyDistractor
Presentvs.Absent
Lower
2PilotPar8cipants
Equal
2PilotPar8cipants
Greater
1PilotPar8cipant
emotionalDistractorTarget
Activity
•  Perhapspar8cipants
whoareabletostay
focusedwiththe
unemo8onalcircles
wills8llhavetrouble
withemo8onalfaces
•  Ifyourneighborinthe
crowdlooksangryit
mightbeharderfor
youtopayaLen8onto
mypresenta8on
:)
emotionalDistractorTarget
Activity
•  Par8cipantsdoseem
tohavelower
accuracyforAngry
facesthanhappy
faces
•  Maygetevenmore
detailwithERP
Accuracy
Angryvs.Happy
Lower
3PilotPar8cipants
Equal
1PilotPar8cipants
Greater
1PilotPar8cipant
ERPTechnology
ms
•  Thebrainproduces
differentelectricalsignals
whenpar8cipantsare
payingaLen8onto
something,thinkingabout
something,remembering
something,etc.
•  Weuseaspecialheadcap
thatletsusrecordthese
signals
•  Example:Cantellthe
differencebetweena
par8cipantwhoispaying
aLen8ontosomethingon
thele],right,ormiddle
partofthescreen!
ERPFindings
•  Around200msanega8vecurvemeansthechildisdistractedbya
facetotheside,aposi8vecurvemeansthey’restoppingthemself
frombecomingdistracted
•  Whenlookingforhappyfaces,
typicallydevelopingchildrencan
preventdistrac8onbytheangry
face
•  Childrenwith22qarealways
distractedbytheangryface
4Childrenwhoaretypicallydeveloping
2Childrenwith22q
Summary
•  Labac8vi8esmightsimulatechildren’sabilitytoresisturges
ordistrac8ons
•  Childrenmighthavemoretroublewhendealingwith
emo8onalthannon-emo8onalsitua8ons
•  Someyoungpeople,evenwith22q,maybeabletocopewell
withtheemo8onals8muliwhileothersdonot
•  Youngpeople’sabilitytocopemayinformriskorstrategies
forinterven8on
Acknowledgments
Allthepar8cipants
andfamilies!!
•  Dr.TonyJ.Simon
•  KathyAngkustsiri,IngridLeckliter,PaulaWadell,
DanielleHarvey,JohannaKreither,CourtneyDurdle,
JordanGarner,MicheleAmato,HannahMorgan,
JoshCruz,NinaCung,DaveReyes,AndreaQuintero,
HeatherShapiro,LingWong
•  FundingfromNIH,UCDavis,MINDIns8tute,
DempsterFounda8on
Questions?