J. Daniel Ragland, Ph.D.
Journal Articles
2014 Kappenman ES, Luck SJ, Kring AM, Lesh TA, Mangun GR, Niendam T, Ragland JD,
Ranganath C, Solomon M, Swaab TY, Carter CS. Electrophysiological evidence for
impaired control of motor output in schizophrenia. Cerebral Cortex, (Epub: January
24).
2014 McFarlane W, Levin B, Travis L, Lucas F, Lynch S, Verdi M, Williams D, Calkins R,
Adelsheim S, Carter C, Cornblatt B, Taylor S, Auther A, McFarland B, Melton R,
Migliorati M, Niendam T, Ragland JD, Sale T, Salvador M, Spring E. Clinical and
functional outcomes after 2 years in the Early Detection and Intervention for the
Prevention of Psychosis multisite effectiveness trial. Schizophrenia Bulletin, 41:30-43.
2014 Yoon JH, Westphal AJ, Minzenberg MJ, Niendam T, Ragland JD, Lesh T, Solomon
M, Carter CS. Task-evoked substantia nigra hyperactivity associated with prefrontal
hypofunction, prefrontonigral disconnectivity and nigrostriatal connectivity predicting
psychosis severity in medication naïve first episode schizophrenia. Schizophrenia
Research, 159:521-6.
2014 Tso IF, Taylor SF, Grove TB, Niendam T, Adelsheim S, Auther A, Cornblatt B, Carter
CS, Calkins R, Ragland JD, Sale T, McFarlane WR. Factor analysis of the Scale of
Prodromal Symptoms: data from the Early Detection and Intervention for the
Prevention of Psychosis Program. Early Interv Psychiatry, (Epub: December 21).
2015 Solomon M, Frank MJ, Ragland JD, Smith AC, Niendam TA, Lesh TA, Grayson D,
Beck JS, Matter JC, Carter CS. Feedback-driven trial-by-trial learning in autism
spectrum disorders. American Journal of Psychiatry, 172:173-81.
2015 Lesh TA, Tanase C, Geib BR, Niendam TA, Yoon JH, Minzenberg MJ, Ragland JD,
Solomon M, Carter CS. A Multimodal Analysis of Antipsychotic Effects on Brain
Structure and Function in First-Episode Schizophrenia. JAMA Psychiatry, 72:226-34.
2015 Sheffield JM, Repovs G, Harms MP, Carter CS, Gold JM, MacDonald AM, Ragland
JD, Silverstein SM, Godwin D, Barch DM. Fronto-parietal and cingulo-opercular
network integrity and global cognition in health and schizophrenia. Neuropsychologia,
73:82-93.
Abstracts and Presentations
2014 Lesh T, Maddock RJ, Salo T, Tanase C, Ragland JD, Niendam TA, Solomon M,
Carter CS. Diffusion measures of free water and 1J-MRS measures of glutathione in
first episode patients with schizophrenia – A multi-modal investigation of an
inflammatory model for psychosis. (53rd Annual Meeting of the American College of
Neuropsychopharmacology, Phoenix, AZ, USA).
64
2014 Solomon M, McCauley J, Lesh T, Niendam T, Beck J, Carter C, Ragland JD.
Bootstrapping the hippocampus? Atypical learning characterizes adolescents with
autism spectrum disorders. (53rd Annual Meeting of the American College of
Neuropsychopharmacology, Phoenix, AZ, USA).
2014 Maddock R, Fernandez D, Casazza G, Tanase C, Maddock M, Ragland JD, Rokem
A, Silver M, Yoon J. The brain state induced by physical activity: Effects on cortical
glutamate, GABA and neuroplasticity in humans. (53rd Annual Meeting of the
American College of Neuropsychopharmacology, Phoenix, AZ, USA).
2014 Ragland JD, Hannula DE, Layher E, Phillips J, Carter CS, Lesh TA, Niendam TA,
Solomon M, Ranganath C. Dissociation of Hippocampally Mediated Relational versus
Item-Specific Memory Deficits in Schizophrenia using Eye-Movement Monitoring
During fMRI. (53rd Annual Meeting of the American College of
Neuropsychopharmacology, Phoenix, AZ, USA).
2015 Flegal KE, Ragland JD, Ranganath C. Adaptive task difficulty influences functional
neuroplasticity in cognitive training. (Annual Meeting of the Cognitive Neuroscience
Society, San Francisco, CA, USA).
Research Funding
R01MH084895 (PI: Ragland), NIMH, 3/17/07-2/28/15. Brain Mechanisms of Impaired
Episodic Memory in Schizophrenia: This grant uses a multimodal functional imaging
approach to examine the relationship between the function of prefrontal and hippocampal
circuitry supporting item-specific and relational memory in the brain to schizophrenia
diagnosis, daily function and symptoms in schizophrenia.
5R01MH059883-11 (PI: Carter), NIMH, 6/1/13-6/1/18. Pathophysiology of Cognitive
Disability in Schizophrenia: Using fMRI and two cognitive tasks evaluating unique aspects of
cognitive control and approach motivation we will test the hypothesis that during a first
episode of psychosis both schizophrenia that bipolar disorder patients will show cognitive
control deficits that in schizophrenia will remain as stable trait deficits during the first year of
illness, but that in Bipolar disorder will show substantial improvement with clinical remission.
In contrast Bipolar Disorder patients will show an enhanced sensitivity to repeated rewards
that will be stable across clinical states, while schizophrenia patients will show intact or
reduced responses to incentives across the course of the first year of illness.
5R01MH084826-05 (PI: Carter), NIMH, 10/12/13-10/1/18. Cognitive Neuroscience Task
Reliability and Clinical Application Consortium. Behavioral tasks measuring the RDoC
constructs of reward sensitivity and working memory capacity will be validated, optimized,
and characterized psychometrically. Optimized measures and their psychometric
characteristics will then be publically available for use in treatment development studies.
1R01MH105411-01 (PI: Ragland) NIMH, 1/01/14-12/30/18. Neural mechanisms of impaired
episodic memory in schizophrenia. This grant uses a multimodal functional imaging approach
(EEG, fMRI and MRS) to examine the relationship between the function of prefrontal and
65
hippocampal circuitry supporting item-specific and relational memory in the brain to
schizophrenia diagnosis, daily function and symptoms in schizophrenia.
1R01 MH104235-01 (PI: Carter) NIMH, 9/1/14-8/30/18. Reducing Duration of Untreated
Psychosis Through Rapid Identification and Engagement. This grant will consecutively test
the impact of two interventions to reduce duration of untreated psychosis (DUP). First, we will
test the ability of standard targeted provider education plus novel technology-enhanced
screening to improve early identification. Secondly, we will test the ability of a mobile
community-based, telepsychiatry-enhanced engagement method to promote early and stable
treatment engagement and, thereby, reduce DUP.
Community Service
Ad hoc Reviewer, NIH Peer Review Committee: Special Emphasis Panel, ZRG1 BBBP-T
(04) M
Chair, Special Emphasis Panel, ZRG1 EMNR-R(02), National Institutes of Health, Bethesda,
MD
Member, Academic Senate, Committee on Planning and Budget, UC Davis
Member, Academic Senate Committee on Research, UC Davis
Member, Public Information Committee, American College of Neuropsychopharmacology
(ACNP)
Member, Compensation Committee, UC Davis School of Medicine
Member, Committee on Research Affairs, UC Davis
Member, Faculty Executive Committee, UC Davis School of Medicine
Editorial Board Member, Biological Psychiatry
Editorial Board Member, Biological Psychiatry: Cognitive Neuroscience and Neuroimaging
Editorial Board Member, Psychiatry Research: Neuroimaging
Editorial Board Member, Schizophrenia Research and Treatment
Editorial Board Member, Schizophrenia Research: Cognition
Faculty Member, Faculty of 1000 Medicine (Schizophrenia & Other Psychosis)
66