Sources of actual imaging data for mega- or meta-analyses Jessica A. Turner Psychology Dept. Neuroscience Institute Georgia State University OHBM workshop, June 2014 Main point • Where do I get legacy fMRI data to do metaor mega-analyses on? Levels of “openness” 1) Truly open – Click and download, no questions asked • Almost everyone wants you to register… 2) Open, but we want information – Fill out a form/register, get approval, click and download – These vary tremendously in complexity! 3) Closed, but we collaborate if you ask nicely 4) Closed, and don’t even ask Who maintains the repositories? • International collaboration – INCF Dataspace • Maintained directly by/at NIH – DbGap, NDAR • Individual institutions – COINS, LONI, XNAT • Individual labs or projects – Openfmri.org, FBIRN, 1000_FNC/INDI • Federations of individual sources – NIF, SzConnect What kind of data do they have? • Some repositories are disease specific – NDAR: autism – FITBIR: TBI – FBIRN: Schizophrenia • Others are healthy subjects only – openfMRI.org • Others are multiple studies, multiple disorders – COINS: Sz, autism, alcoholism, etc. – LONI: Autism, Parkinson’s, TBI, etc. – XNAT Central: ADHD, AD, Glioma, etc. Types of imaging data • Structural T1 images (most common) • DTI images • fMRI data – Resting state – Task based Institutional databases • • • • COINS 1000_FNC/INDI LONI XNAT Central COINS Data Exchange Coins.mrn.org: Requires registering your email so they can let you know when your files are ready for download. COINS Data Exchange Study Subject types ABIDE Autism, control, unknown COBRE bipolar, szAff, Sz, control CoRR unknown Discoverysci subject_count mr_count 1112 2253 233 1782 1418 4858 children, adults, elderly 371 2719 MCICShare Sz, controls 213 4483 agHyper diabetic, hypertensive, controls 99 More info on Corr Study: http://fcon_1000.projects.nitrc.org/indi/CoRR/html/ COINS Data Exchange 1000 Functional Connectomes/INDI project fcon_1000.projects.nitrc.org 1000 FC LONI XNAT Central Central.xnat.org FBIRN http://fbirnbdr.nbirn.net:8080/BDR/ Email required so they can send you links for downloads. Data from BrainScape and FBIRN studies (multi-site, Sz and controls, function & structure). PING Pingstudy.ucsd.edu openfMRI.org Openfmri.org Openfmri.org US Gov’t hosted • NDAR: National Database for Autism Research • dbGAP: Database for Genotypes and Phenotypes • FITBIR: Federal Interagency Traumatic Brain Injury Research (FITBIR) informatics system NDAR Not the easiest access… Searching for Data FITBIR dBGAP Neurodevelopmental Genomics: Trajectories of Complex Phenotypes Neuroimaging from PNC Satterthwaite, et al. Neuroimaging of the Philadelphia Neurodevelopmental Cohort, NeuroImage, Volume 86, 1 February 2014, Pages 544-553. Other resources • NITRC: www.nitrc.org • NIF: www.neuinfo.org NITRC www.nitrc.org: Lots of data sources listed! NIF www.neuinfo.org Live and learn… Repositories that are coming soon INCF Data Space • http://www.incf.org/resources/data-space INCF Data Space INCF Terms of Use INCF Data Space • Number of available MRI datasets? SchizConnect Mediated queries across repositories of schizophrenia neuroimaging datasets. (coming late2014) SchizConnect The actual list • • • • • • • • • • www.nitrc.org, www.neuinfo.org, http://ndar.nih.gov/ https://dbgap.ncbi.nlm.nih.gov https://fitbir.nih.gov/ coins.mrn.org; loni.usc.edu; central.xnat.org openfmri.org http://fbirnbdr.nbirn.net:8080/BDR/ Pingstudy.ucsd.edu http://www.incf.org/resources/data-space Schizconnect.org (eventually) Acknowledgments With thanks to Neuroimagers everywhere who are willing to share their data!! (and funding sources…)