Classification: UNCLASSIFIED
Caveats: NONE
The Defense Health Program
Department of Defense Peer Reviewed Medical Research Program
Funding Opportunities for Fiscal Year 2016
The Fiscal Year 2016 (FY16) Defense Appropriations Act provides $278.7 million to the Department of
Defense Peer Reviewed Medical Research Program (PRMRP). The vision of the PRMRP is to improve the
health and well-being of all military Service members, Veterans, and beneficiaries. The PRMRP challenges
the scientific and clinical communities to address one of the FY16 congressionally directed topic areas with
original ideas that foster new directions in basic science and translational research; novel product development
leading to improved therapeutic or diagnostic tools; synergistic, multidisciplinary research programs; or clinical
trials that address an immediate clinical need.
As directed by the Office of the Assistant Secretary of Defense for Health Affairs, the Defense Health Agency,
Research, Development and Acquisition (DHA RDA) Directorate manages the Defense Health Program (DHP)
Research, Development, Test and Evaluation (RDT&E) appropriation. The managing agent for the anticipated
Program Announcements/Funding Opportunities is the Congressionally Directed Medical Research Programs
(CDMRP).
The PRMRP is providing the information in this pre-announcement to allow investigators time to plan and
develop applications. FY16 PRMRP Program Announcements and General Application Instructions are
anticipated to be posted on Grants.gov by late March 2016. Pre-application and application deadlines will be
available when the Program Announcements are released. This pre-announcement should not be construed
as an obligation by the government.
Congressionally Directed Topic Areas. The FY16 PRMRP will solicit research applications for the following
39 topics areas:
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Acute Lung Injury
Antimicrobial Resistance
Chronic Migraine and Post-Traumatic Headache
Congenital Heart Disease
Constrictive Bronchiolitis
Diabetes
Dystonia
Emerging Infectious Diseases
Focal Segmental Glomerulosclerosis
Fragile X Syndrome
Hepatitis B
Hereditary Angioedema
Hydrocephalus
Inflammatory Bowel Disease
Influenza
Integrative Medicine
Interstitial Cystitis
Lupus
Malaria
Metals Toxicology
Mitochondrial Disease
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Nanomaterials for Bone Regeneration
Nonopioid Pain Management
Pancreatitis
Pathogen-Inactivated Dried Plasma
Polycystic Kidney Disease
Post-Traumatic Osteoarthritis
Psychotropic Medications
Pulmonary Fibrosis
Respiratory Health
Rett Syndrome
Rheumatoid Arthritis
Scleroderma
Sleep Disorders
Tinnitus
Tuberculosis
Vaccine Development for Infectious Disease
Vascular Malformations
Women’s Heart Disease
Military Relevance: Relevance to the healthcare needs of the military Service members, Veterans, and
beneficiaries is a key feature of each FY16 PRMRP award mechanism.
Clinical Trial Award
Assistant Professor level or above (or equivalent)
Supports the rapid implementation of clinical trials of novel interventions with the potential to have a significant
impact on patient care in the topic area(s) of interest.
Proposed projects may range from small proof-of-concept trials through large-scale, definitive trials.
Investigational New Drug or Investigational Device Exemption applications, if needed, should be submitted to
the Food and Drug Administration before the PRMRP Grants.gov application submission deadline.
Preproposal submission is required; application submission is by invitation only
Funding limit not defined; requested funding must be appropriate for the scope of work proposed
Maximum period of performance is 5 years
Discovery Award
All Investigators
Supports the exploration of a highly innovative new concept or untested theory.
Not intended to support the logical progression of an already established line of questioning.
Clinical trials will not be funded.
Reviewers will be blinded to the identity of the Principal Investigator (PI), collaborators, and their
organization(s)
Maximum of $200,000 for direct costs (plus indirect costs)
Maximum period of performance is 18 months
Focused Program Award
Full Professor level or above (or equivalent)
Supports a synergistic, multidisciplinary research program of at least four distinct but complementary projects
addressing an overarching goal in one of the topic areas listed directly above. Projects should work together to
answer critical questions, resolve differing hypotheses, and translate laboratory findings to clinical applications.
Projects may range from exploratory/
hypothesis-developing through small-scale clinical trials that together will address the overarching
goal/question. Research team of highly qualified, multidisciplinary project leaders should be led by a PI with
demonstrated success in directing large, focused projects.
Preproposal submission is required; application submission is by invitation only.
Maximum of $10 million for total costs (includes direct and indirect costs)
Maximum period of performance is 5 years
Investigator-Initiated Research Award
Assistant Professor level or above (or equivalent)
Supports research that will make an original and important contribution to the field of research or patient care
in the topic area(s) of interest.
Partnering PI Option available.
Clinical trials will not be funded.
Preproposal submission is required; application submission is by invitation only.
Maximum of $1.2 million for direct costs (plus indirect costs)
Maximum of $1.5 million for direct costs (plus indirect costs) for applications including a Partnering PI Option
Maximum period of performance is 3 years
Technology/ Therapeutic Development Award
Assistant Professor level or above (or equivalent)
Supports the development of diagnostics or therapies that have the potential to make a strong impact on
patient care in the topic area(s) of interest.
Product-oriented (e.g., device, drug, clinical guidelines).
Clinical trials will not be funded.
Preproposal submission is required; application submission is by invitation only
Maximum of $3.0 million for direct costs (plus indirect costs)
Maximum period of performance is 3 years
A pre-application is required and must be submitted through the electronic Biomedical Research Application
Portal (eBRAP) at https://eBRAP.org prior to the pre-application deadline. All applications must conform to the
final Program Announcements and General Application Instructions that will be available for electronic
downloading from the Grants.gov website. The application package containing the required forms for each
award mechanism will also be found on Grants.gov. A listing of all CDMRP funding opportunities can be
obtained on the Grants.gov website by performing a basic search using CFDA Number 12.420.
Applications must be submitted through the federal government’s single-entry portal, Grants.gov. Submission
deadlines are not available until the Program Announcements are released. Requests for email notification of
the Program Announcements’ release may be sent to help@ebrap.org. For more information about the
PRMRP or other CDMRP-administered programs, please visit the CDMRP website (http://cdmrp.army.mil).
Point of Contact:
CDMRP Public Affairs
301-619-9783
usarmy.detrick.medcom-cdmrp.mbx.cdmrp-public-affairs@mail.mil
Classification: UNCLASSIFIED
Caveats: NONE