MARTIN LOTZ, M.D.
EDUCATION
1974-1980
Degrees:
Medical School, Universities of Marburg, Vienna and Heidelberg
University of Heidelberg - MD, 1981
University of Heidelberg - Doctor of Medicine (Dr. med.), 1982
POSTGRADUATE TRAINING
1980-1982
Internship and Residency in Internal Medicine
University Hospital, Heidelberg Germany
1983-1987
Research Fellowship
Department of Basic and Clinical Research
Scripps Clinic and Research Foundation, La Jolla, California
1986-1988
Clinical Rheumatology Fellowship
University of California, San Diego, California
PREVIOUS APPOINTMENTS
1987-1990
1990-1996
Assistant Professor
Department of Molecular and Experimental Medicine
Scripps Clinic and Research Foundation, La Jolla, California
Associate Professor
Department of Molecular and Experimental Medicine
University of California, San Diego, California
CURRENT APPOINTMENTS
1997 – Present
Professor, Department of Molecular and Experimental Medicine,
The Scripps Research Institute, La Jolla, California
1997 – Present
Research Professor, Department of Medicine,
University of California, San Diego, California
2011 – Present
Adjunct Professor, Inflammatory and Infectious Disease Center
Sanford-Burnham Medical Research Institute, La Jolla, California
HONORS
Arthritis Foundation Investigator Award
American Society for Clinical Investigation
Board of Directors, Osteoarthritis Research Society International
President, Osteoarthritis Research Society International
Kappa Delta Award, Orthopedic Research Society
Basic Science Award, Osteoarthritis Research Society International
1988
1994
2000-2008
2004-2006
2005
2010
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Curriculum Vitae
Martin Lotz, M.D.
Page 4
PUBLICATIONS
1.
LOTZ M. Psychosomatische Aspekte beim Mammakarzinom. Dissertation, University of Heidelberg,
1982.
2.
Tsoukas CD, Valentine M, LOTZ M, Vaughan JH, Carson DA. The role of the T3 molecular complex in
antigen recognition and subsequent activation events. Immunol Today 5:311-3, 1984.
3.
Tsoukas CD, Lambris J, LOTZ M, Valentine MA, Vaughan JH, Carson DA. Lymphocyte mitogenesis
induced by monoclonal antibodies to the T3 complex. Differential modulation by human IgG. Cell Immunol
89:66-74, 1984.
4.
Tsoukas CD, Valentine M, LOTZ M, Vaughan JH, Carson DA. The role of the T3 molecular complex
on human T lymphocyte-mediated cytotoxicity. Adv Exp Med Biol 184:365-85, 1985.
5.
Fox RI, LOTZ M, Rhodes G, Vaughan JH. Epstein-Barr virus in rheumatoid arthritis. Clin Rheum Dis
11:665-88, 1985.
6.
Tsoukas CD, Landgraf B, Bentin J, Valentine M, LOTZ M, Vaughan JH, Carson DA. Activation of
resting T lymphocytes by anti-CD3 (T3) antibodies in the absence of monocytes. J Immunol 135:1719-23,
1985.
7.
LOTZ M, Tsoukas CD, Fong S, Carson DA, Vaughan JH. Regulation of Epstein-Barr virus infection by
recombinant interferons. Selected sensitivity to interferon-gamma. Eur J Immunol 15:520-5, 1985.
8.
Valentine M, LOTZ M, Dinarello CA, Carson DA, Vaughan JH. Lymphoblastoid B cell lines produce an
interleukin-1-like activity that can be serologically distinct from macrophage interleukin-1. Lymphokine Res
5:173-83, 1986.
9.
LOTZ M, Tsoukas CD, Fong S, Dinarello CA, Carson DA, Vaughan JH. Release of lymphokines after
Epstein Barr virus infection in vitro. I. Sources of and kinetics of production of interferons and interleukins in
normal humans. J Immunol 136:3636-42, 1986.
10. LOTZ M, Tsoukas CD, Fong S, Dinarello CA, Carson DA, Vaughan JH. Release of lymphokines after
infection with Epstein Barr virus in vitro. II. A monocyte-dependent inhibitor of interleukin 1 downregulates
the production of interleukin 2 and interferon-gamma in rheumatoid arthritis. J Immunol 136:3643-8, 1986.
11. LOTZ M, Tsoukas CD, Robinson CA, Dinarello CA, Carson DA, Vaughan JH. Basis for defective
responses of rheumatoid arthritis synovial fluid lymphocytes to anti-CD3 (T3) antibodies. J Clin Invest
78:713-21, 1986.
12. LOTZ M, Tsoukas CD, Hench PK, Carson DA, Vaughan JH. Release of lymphokines following
Epstein-Barr virus infection in vitro of blood lymphocytes from patients with autoimmune diseases. Trans
Assoc Am Phys 99:114-24, 1986.
13. LOTZ M, Carson DA, Vaughan JH. Substance P activation of rheumatoid synoviocytes: neural
pathway in pathogenesis of arthritis. Science 235:893-5, 1987.
14. LOTZ M, Tsoukas CD, Curd JG, Carson DA, Vaughan JH. Effects of recombinant human interferons
on rheumatoid arthritis B lymphocytes activated by Epstein-Barr virus. J Rheumatol 14:42-5, 1987.
15. LOTZ M, Tsoukas CD, Carson DA, Vaughan JH. Interleukins and interferons during EBV infection. In:
Epstein-Barr Virus and Human Diseases, Levine PH, Ablashi DV, Nonoyama M and Pearson GR [Eds.]
Clifton, New Jersey, The Humana Press, p. 349-53, 1987.
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Martin Lotz, M.D.
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16. Kurki P, LOTZ M, Ogata K, Tan EM. Proliferating cell nuclear antigen (PCNA)/cyclin in activated
human T lymphocytes. J Immunol 138:4114-20, 1987.
17. LOTZ M, Zuraw BL. Interferon-gamma is a major regulator of C1-inhibitor synthesis by human blood
monocytes. J Immunol 139:3382-7, 1987.
18. LOTZ M, Jirik F, Kabouridis P, Tsoukas C, Hirano T, Kishimoto T, Carson DA. B cell stimulating factor
2/Interleukin 6 is a costimulant for human thymocytes and T lymphocytes. J Exp Med 167:1253-8, 1988.
19. Fox RI, LOTZ M, Carson DA. Structure and function of synoviocytes. In: Arthritis and Allied Conditions,
McCarty, DJ [Ed.] Philadelphia, Lea & Febiger, 11th Edition, p. 273-88, 1988.
20. LOTZ M, Vaughan JH. Rheumatoid Arthritis. In: Immunological Diseases, Samter M, Talmadge DW,
Frank MM, Austen KF, Claman HN [Eds.] Vol. II, p. 1365-416, Little, Brown and Co., Boston, 1988.
21. LOTZ M, Vaughan JH, Carson DA. Effect of neuropeptides on production of inflammatory cytokines by
human monocytes. Science 241:1218-21, 1988.
22. Jirik FR, Podor TJ, Hirano T, Kishimoto T, Loskutoff DJ, Carson DA, LOTZ M. Bacterial
lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J
Immunol 142:144-7, 1989.
23. Guerne PA, Zuraw BL, Vaughan JH, Carson DA, LOTZ M. Synovium as a source of interleukin 6 in
vitro. Contribution to local and systemic manifestations of arthritis. J Clin Invest 83:585-92, 1989.
24. Podor TJ, Jirik FR, Loskutoff DJ, Carson DA, LOTZ M. Human endothelial cells produce IL-6. Lack of
responses to exogenous IL-6. Ann NY Acad Sci 557:374-87, 1989.
25. LOTZ M, Vaughan JH. Neuroimmunological interactions. In: Yearbook of Science and Technology. p.
169-71, McGraw-Hill, 1989.
26. Carrera CJ, Yamanaka H, Piro LD, LOTZ M, Carson DA. Profound toxicity of deoxyadenosine and 2chlorodeoxyadenosine toward human monocytes in vitro and in vivo. Adv Exp Med Biol 253B:219-25, 1989.
27. LOTZ M, Zuraw B, Carson D, Jirik FR. Hepatocytes produce interleukin-6. Ann NY Acad Sci 557:50911, 1989.
28. LOTZ M, Roudier J. Epstein-Barr virus and rheumatoid arthritis: cellular and molecular aspects.
Rheumatol Intl 9:147-52, 1989.
29. Guerne PA, Vaughan JH, Carson DA, Terkeltaub R, LOTZ M. Interleukin-6 (IL-6) and joint tissues.
Ann NY Acad Sci 557:558-61, 1989.
30. Guerne PA, Terkeltaub R, Zuraw B, LOTZ M. Inflammatory microcrystals stimulate interleukin-6
production and secretion by human monocytes and synoviocytes. Arthritis Rheum 32:1443-52, 1989.
31. Guerne PA, Carson DA, LOTZ M. IL-6 production by human articular chondrocytes. Modulation of its
synthesis by cytokines, growth factors, and hormones in vitro. J Immunol 144:499-505, 1990.
32. LOTZ M, Kekow J, Carson DA. Transforming growth factor-beta and cellular immune responses in
synovial fluids. J Immunol 144:4189-94, 1990.
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33. Zuraw BL, LOTZ M. Regulation of the hepatic synthesis of C1 inhibitor by the hepatocyte stimulating
factors interleukin 6 and interferon gamma. J Biol Chem 265:12664-70, 1990.
34. Carrera CJ, Terai C, LOTZ M, Curd JG, Piro LD, Beutler E, Carson DA. Potent toxicity of 2chlorodeoxyadenosine toward human monocytes in vitro and in vivo. A novel approach to
immunosuppressive therapy. J Clin Invest 86:1480-8, 1990.
35. Kekow J, Wachsman W, McCutchan JA, Cronin M, Carson DA, LOTZ M. Transforming growth factor
beta and noncytopathic mechanisms of immunodeficiency in human immunodeficiency virus infection. Proc
Natl Acad Sci U S A 87:8321-5, 1990.
36. Tighe H, Silverman GJ, Kozin F, Tucker R, Gulizia R, Peebles C, LOTZ M, Rhodes G, Machold K,
Mosier DE, et al. Autoantibody production by severe combined immunodeficient mice reconstituted with
synovial cells from rheumatoid arthritis patients. Eur J Immunol 20:1843-8, 1990.
37. Villiger PM, Cronin MT, Amenomori T, Wachsman W, LOTZ M. IL-6 production by human Tlymphocytes. Expression in HTLV-1-infected but not in normal T cells. J Immunol 146:550-9, 1991.
38. LOTZ M, Guerne PA. Interleukin-6 induces the synthesis of tissue inhibitor of metalloproteinases1/erythroid potentiating activity (TIMP-1/EPA). J Biol Chem 266:2017-20, 1991.
39. Kekow J, Wachsman W, McCutchan JA, Gross WL, Zachariah M, Carson DA, LOTZ M. Transforming
growth factor-beta and suppression of humoral immune responses in HIV infection. J Clin Invest 87:1010-6,
1991.
40. Delcayre AX, Salas F, Mathur S, Kovats K, LOTZ M, Lernhardt W. Epstein Barr virus/complement C3d
receptor is an interferon alpha receptor. EMBO J 10:919-26, 1991.
41. Kekow J, Gross WL, Carson DA, LOTZ M. Modulation of immunocompetent cells in the synovial fluid
TGF-beta. Immun Infekt 9:60-1, 1991.
42. Kuis W, Villiger PM, Leser HG, LOTZ M. Differential processing of proenkephalin-A by human
peripheral blood monocytes and T lymphocytes. J Clin Invest 88:817-24, 1991.
43. LOTZ M, Villiger PM. Neuroimmune interactions in homeostasis and pathophysiology of connective
tissues. EBSCO Media 261-7, 1991.
44. Guerne PA, LOTZ M. Interleukin-6 and transforming growth factor-beta synergistically stimulate
chondrosarcoma cell proliferation. J Cell Physiol 149:117-24, 1991.
45. Maisel AS, Murray D, LOTZ M, Rearden A, Irwin M, Michel MC. Propranolol treatment affects
parameters of human immunity. Immunopharmacol 22:157-64, 1991.
46. LOTZ M, Roudier J. Epstein Barr virus and rheumatoid arthritis. In: Rheumatoid arthritis. Smolen JS,
Kalden JR, Maini RN [Eds.] Springer Verlag, Berlin, Heidelberg, New York. p. 257-80, 1992.
47. Mandler RN, Kerrigan DP, Smart J, Kuis W, Villiger P, LOTZ M. Castleman’s disease in POEMS
syndrome with elevated interleukin-6. Cancer 69:2697-703, 1992.
48. Broide DH, LOTZ M, Cuomo AJ, Coburn DA, Federman EC, Wasserman SI. Cytokines in symptomatic
asthma airways. J Allergy Clin Immunol 89:958-67, 1992.
49. LOTZ M. Regulation of the chondrocytes in aging. In: Biological regulations of the chondrocytes.
Adolphe M. [Ed.] CRC Press, Boca Raton. p. 237-73, 1992.
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Martin Lotz, M.D.
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50. LOTZ M, Terkeltaub R, Villiger PM. Cartilage and joint inflammation. Regulation of IL-8 expression by
human articular chondrocytes. J Immunol 148:466-73, 1992.
51. Villiger PM, LOTZ M. Expression of prepro-enkephalin by human articular chondrocytes is linked to
cell proliferation. EMBO J 11:135-43, 1992.
52. Villiger PM, LOTZ M. Differential expression of TGFbeta isoforms by human articular chondrocytes in
response to growth factors. J Cell Physiol 151:318-25, 1992.
53. Villiger PM, Terkeltaub R, LOTZ M. Production of monocyte chemoattractant protein-1 by inflamed
synovial tissue and cultured synoviocytes. J Immunol 149:722-7, 1992.
54. Villiger PM, Terkeltaub R, LOTZ M. Monocyte chemoattractant protein-1 (MCP-1) expression in
human articular cartilage. Induction by peptide regulatory factors and differential effects of dexamethasone
and retinoic acid. J Clin Invest 90:488-96, 1992.
55. LOTZ M, Moats T, Villiger PM. Leukemia inhibitory factor is expressed in cartilage and synovium and
can contribute to the pathogenesis of arthritis. J Clin Invest 90:888-96, 1992.
56.
LOTZ M. Inflammatory mediators in osteoarthritis. Internal Medicine 13:56-66, 1992.
57. Villiger PM, Fey MF, LOTZ M, Tobler A. IgG2 and IgG4 subclass deficiency and Evan's syndrome in
an adult patient. J Allergy Clin Immunol 90:693-4, 1992.
58. LOTZ M. The cytokine network. In: Inflammatory Bowel Diseases, Pathophysiology as a Basis of
Treatment. Schölmerich J, Kruis W, Goebell H, Hohenberger W, and Gross V. [Eds.] Kluwer Academic
Publishers, Dordrecht, Boston, London. p. 103-13, 1993.
59.
LOTZ M, Seth P. TGFbeta and HIV infection. Ann NY Acad Sci 685:501-11, 1993.
60.
LOTZ M. Prospects for immunotherapy of rheumatoid arthritis. Rev Rheum Ed Fr 60:3-9, 1993.
61. Villiger PM, Geng Y, LOTZ M. Induction of cytokine expression by leukemia inhibitory factor. J Clin
Invest 91:1575-81, 1993.
62. Machold KP, Carson DA, LOTZ M. Transforming growth factor-beta (TGF beta) inhibition of EpsteinBarr virus (EBV)- and interleukin-4 (IL-4)-induced immunoglobulin production in human B lymphocytes. J
Clin Immunol 13:219-27, 1993.
63. Delcayre AX, LOTZ M, Lernhardt W. Inhibition of Epstein-Barr virus-mediated capping of CD21/CR2
by alpha interferon (IFN-alpha): immediate antiviral activity of IFNalpha during the early phase of infection. J
Virol 67:2918-21, 1993.
64. Raz E, Watanabe A, Baird SM, Eisenberg RA, Parr TB, LOTZ M, Kipps TJ, Carson DA. Systemic
immunological effects of cytokine genes injected into skeletal muscle. Proc Natl Acad Sci U S A 90:4523-7,
1993.
65. Gross V, Villiger PM, Zhang B, LOTZ M. Retinoic acid inhibits interleukin-1 induced cytokine synthesis
in human monocytes. J Leukoc Biol 54:125-32, 1993.
66. Gross V, Zhang B, Geng Y, Villiger PM, LOTZ M. Regulation of interleukin-6 (IL-6) expression:
evidence for a tissue-specific role of protein kinase C. J Clin Immunol 13:310-20, 1993.
67. Villiger PM, Kusari AB, ten Dijke P, LOTZ M. IL-1beta and IL-6 selectively induce transforming growth
factor-beta isoforms in human articular chondrocytes. J Immunol 151:3337-44, 1993.
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68. Maier R, Ganu V, LOTZ M. Interleukin-11, an inducible cytokine in human articular chondrocytes and
synoviocytes, stimulates the production of the tissue inhibitor of metalloproteinases. J Biol Chem 268:2152732, 1993.
69. Gross V, Villiger PM, LOTZ M. Retinoic acid inhibits IL-1 induced IL-6 expression in HEp-2 cells.
Inflammopharmacology 2:111-20, 1993.
70.
LOTZ M. Interleukin-6. Cancer Investigation 11:732-42, 1993.
71. Wisniewski HG, Maier R, LOTZ M, Lee S, Klampfer L, Lee TH, Vilcek J. TSG-6: a TNF-, IL-1-, and
LPS-inducible secreted glycoprotein associated with arthritis. J Immunol 151:6593-601, 1993.
72. Schwarz H, Tuckwell J, LOTZ M. A receptor induced by lymphocyte activation (ILA): a new member of
the human nerve-growth-factor/tumor necrosis factor receptor family. Gene 134:295-8, 1993.
73. Geng Y, Zhang B, LOTZ M. Protein tyrosine kinase activation is required for lipopolysaccharide
induction of cytokines in human blood monocytes. J Immunol 151:6692-700, 1993.
74. LOTZ M. Clinical value and limitations of measuring cytokines in the diagnosis and management of
autoimmune rheumatic diseases. In: Advanced Immunoassays in Rheumatology. Teodorescu, M, Froehlich,
C.J [Eds.] CRC Press, Boca Raton, p. 267-82,1994.
75. Woods VL, Schreck P, Amiel D, Akeson WH, LOTZ M. The role of integrin adhesion receptors in
aging of cartilage and osteoarthritis. In: Musculoskeletal Soft-Tissue Aging: Impact on Mobility. Am Acad
Orthop Surg, p. 165-78, 1994.
76. LOTZ M, Clark-Lewis I, Ganu V. HIV-1 transactivator protein Tat induces proliferation and TGF-beta
expression in human articular chondrocytes. J Cell Biol 124:365-71, 1994.
77. LOTZ M, Ranheim E, Kipps TJ. Transforming growth factor-beta as endogenous growth inhibitor of
chronic lymphocytic leukemia cells. J Exp Med 179:999-1004, 1994.
78. Woods VL Jr, Schreck PJ, Gesink DS, Pacheco HO, Amiel D, Akeson WH, LOTZ M. Integrin
expression by human articular chondrocytes. Arthritis Rheum 37:537-44, 1994.
79. LOTZ M. Experimental models of arthritis. Rationale for using topical capsaicin to suppress substance
P in order to manage arthritis pain. Seminars Arthritis Rheum 23:10-7, 1994.
80. Weisman MH, Flynn P, Yaksh TL, LOTZ M. Effects of topical capsaicin on substance P and
prostaglandin E2 levels in synovial fluid: a double blind study. Sem Arthritis Rheum 23:18-24, 1994.
81. Guerne PA, Sublet A, LOTZ M. Growth factor responsiveness of human articular chondrocytes:
distinct profiles in primary chondrocytes, subcultured chondrocytes, and fibroblasts. J Cell Physiol 158:47684, 1994.
82. Schwarz H, Villiger PM, von Kempis J, LOTZ M. Neuropeptide Y is an inducible gene in the human
immune system. J Neuroimmunol 51:53-61, 1994.
83. Broor S, Kusari AB, Zhang B, Seth P, Richman DD, Carson DA, Wachsman W, LOTZ M. Stimulation
of HIV replication in mononuclear phagocytes by leukemia inhibitory factor. J Acquir Immune Defic Syndr
7:647-54, 1994.
84. Rediske JJ, Koehne CF, Zhang B, LOTZ M. The inducible production of nitric oxide by articular cell
types. Osteoarthritis Cartilage 2:199-206, 1994.
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85. LOTZ M, Villiger P, Hugli T, Koziol J, Zuraw BL. Interleukin-6 and interstitial cystitis. J Urol 152:86973, 1994.
86. Zuraw BL, Sugimoto S, Parsons CL, Hugli T, LOTZ M, Koziol J. Activation of urinary kallikrein in
patients with interstitial cystitis. J Urol 152:874-8, 1994.
87. Geng Y, Gulbins E, Altman A, LOTZ M. Monocyte deactivation by interleukin-10 via inhibition of
tyrosine kinase activity and the Ras signaling pathway. Proc Natl Acad Sci U S A 91:8602-6, 1994.
88. Maier R, Bilbe G, Rediske J, LOTZ M. Inducible nitric oxide synthase from human articular
chondrocytes: cDNA cloning and analysis of mRNA expression. Biochim Biopys Acta 1208:145-50, 1994.
89. Schwarz H, Blanco FJ, LOTZ M. Anadamide, an endogenous cannabinoid receptor agonist inhibits
lymphocyte proliferation and induces apoptosis. J Neuroimmunol 55:107-15, 1994.
90. Maier R, Geng Y, Zhang B, Rediske J, Bilbe G, LOTZ M. Inducible nitric oxide synthesis in human joint
tissue cells. In: The Biology of Nitric Oxide Volume 4 Enzymology, Biochemistry and Immunology. Moncada
S, Freelisch M, Busse R and Higgs EA [Eds.] Portland Press, London, 1994.
91. Blanco FJ, Ochs RL, Schwarz H, LOTZ M. Chondrocyte apoptosis induced by nitric oxide. Am J
Pathol 146:75-85, 1995.
92. LOTZ M, Blanco FJ, von Kempis J, Dudler J, Maier R, Villiger PM, Geng Y. Cytokine regulation of
chondrocyte functions. J Rheumatol Suppl 43:104-8, 1995.
93. Schwarz, H, Valbracht J, Tuckwell J, von Kempis J, LOTZ M. ILA, the human 4-1BB homologue, is
inducible in lymphoid and other cell lineages. Blood 85:1043-52, 1995.
94. Blanco FJ, Geng Y, LOTZ M. Differentiation-dependent effects of IL-1 and TGF-beta on human
articular chondrocyte proliferation are related to inducible nitric oxide synthase expression. J Immunol
154:4018-26, 1995.
95. Geng Y, Maier R, LOTZ M. Tyrosine kinases are involved with the expression of inducible nitric oxide
synthase in human articular chondrocytes. J Cell Physiol 163:545-54, 1995.
96. Blanco FJ, LOTZ M. IL-1 induced nitric oxide inhibits chondrocyte proliferation via PGE2. Exp Cell Res
218:319-25, 1995.
97. Guerne PA, Blanco F, Kaelin A, Desgorges A, LOTZ M. Growth factor responsiveness of human
articular chondrocytes in aging and development. Arthritis Rheum 38:960-8, 1995.
98. Geng Y, LOTZ M. Increased intracellular Ca2+ selectively suppresses IL-1-induced NO production by
reducing iNOS mRNA stability. J Cell Biol 129:1651-7, 1995.
99. Raz E, Dudler J, LOTZ M, Baird SM, Berry CC, Eisenberg RA, Carson DA. Modulation of disease
activity in murine systemic lupus erythematosus by cytokine gene delivery. Lupus 4: 286-92, 1995.
100. Geng Y, Blanco FJ, Cornelisson M, LOTZ M. Regulation of cyclooxygenase-2 expression in human
articular chondrocytes. J Immunol 155:796-801, 1995.
101. LOTZ M, Rosen F, McCabe G, Quach J, Blanco F, Dudler J, Solan J, Goding J, Seegmiller JE,
Terkeltaub R. Interleukin 1 beta suppresses transforming growth factor-induced inorganic pyrophosphate
(PPi) production and expression of the PPi-generating enzyme PC-1 in human chondrocytes. Proc Natl Acad
Sci U S A 92:10364-8, 1995.
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102. Setareh M, Schwarz H, LOTZ M. A mRNA variant encoding a soluble form of 4-1BB, a member of the
murine NGF/TNF receptor family. Gene 164:311-5, 1995.
103. LOTZ M. Interleukin-6. In: Cytokines: Interleukins and Their Receptors. Kurzrock R and Talpaz M.
[Eds.] Kluwer Academic Publishers, Norwell, MA. p. 209-34, 1995.
104. Maier R, Wisniewski HG, Vilcek J, LOTZ M. TSG-6 expression in human articular chondrocytes.
Possible implications in joint inflammation and cartilage degradation. Arthritis Rheum 39:552-9, 1996.
105. Schwarz H, Blanco FJ, von Kempis J, Valbracht J, LOTZ M. ILA, a member of the human nerve
growth factor/tumor necrosis factor receptor family regulates T-lymphocyte proliferation and survival. Blood
87:2839-45, 1996.
106. LOTZ M, Setareh M, von Kempis J, Schwarz H. The nerve growth factor/tumor necrosis factor
receptor family. J Leukoc Biol 60:1-7, 1996.
107. Sato Y, Roman M, Tighe H, Lee D, Corr M, Nguyen MD, Silverman GJ, LOTZ M, Carson DA, Raz E.
Immunostimulatory DNA sequences necessary for effective intradermal gene immunization. Science
273:352-4, 1996.
108. LOTZ M, Villiger PM. Cellular Responses to Cytokines. In: Cytokines and the CNS. Ransohoff RM and
Benveniste EN [Eds.] CRC Press, p. 47-62, 1996.
109. Geng Y, Valbracht J, LOTZ M. Selective activation of the mitogen-activated protein kinase subgroups
c-Jun NH2 terminal kinase and p38 by IL-1 and TNF in human articular chondrocytes. J Clin Invest 98:242530, 1996.
110. LOTZ M. Cytokines and Their Receptors. In: Arthritis and Allied Conditions, 13th Edition. Koopman W
[Ed.] Williams and Wilkins, Baltimore, MD, p. 439-78, 1997.
111. Zvaifler NJ, Tsai V, Alsalameh S, von Kempis J, Firestein GS, LOTZ M. Pannocytes: distinctive cells
found in rheumatoid arthritis articular cartilage erosions. Am J Pathol 150:1125-38, 1997.
112. Rosen F, McCabe G, Quach J, Solan J, Terkeltaub R, Seegmiller JE, LOTZ M. Differential effects of
aging on human chondrocyte responses to transforming growth factor beta: increased pyrophosphate
production and decreased cell proliferation. Arthritis Rheum 40:1275-81, 1997.
113. Schwarz H, Arden K, LOTZ M. CD137, a member of the tumor necrosis factor receptor family, is
located on chromosome 1p36, in a cluster of related genes, and colocalizes with several malignancies.
Biochem Biophys Res Comm 235:699-703, 1997.
114. Cai J, Zheng T, LOTZ M, Zhang Y, Masood R, Gill P. Glucocorticoids induce Kaposi's sarcoma cell
proliferation through the regulation of transforming growth factor-beta. Blood 89:1491-500, 1997.
115. Shiraishi A, Dudler J, LOTZ M. The role of IFN regulatory factor-1 in synovitis and nitric oxide
production. J Immunol 159:3549-54, 1997.
116. Hashimoto S, Setareh M, Ochs R, LOTZ M. Fas/Fas ligand expression and induction of apoptosis in
chondrocytes. Arthritis Rheum 40:1749-55, 1997.
117. von Kempis J, Schwarz H, LOTZ M. Differentiation-dependent and stimulus-specific expression of ILA,
the human 4-1BB-homologue, in cells of mesenchymal origin. Osteoarthritis Cartilage 5:394-406, 1997.
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118. LOTZ M. Mechanisms of pain in arthritis. In: Anesthesia: Biologic Foundations. Biebuyck JF, Lynch C,
Maze M, Saidman LJ, Yaksh TL, and Zapol W [Eds.] Lippincott-Raven Publishers, Philadelphia, PA, p. 81928, 1998.
119. LOTZ M. Mechanisms of tissue destruction in rheumatoid arthritis. In: Rheumatology, 2nd Edition.
Klippel JH and Diepe PA [Eds.] Mosby London, p. 11.1-10, 1998.
120. Hashimoto S, Ochs RL, Rosen F, Quach J, McCabe G, Solan J, Seegmiller JE, Terkeltaub R, LOTZ
M. Chondrocyte-derived apoptotic bodies and calcification of articular cartilage. Proc Natl Acad Sci U S A
95:3094-9, 1998.
121. Hashimoto S, Takahashi K, Amiel D, Coutts RD, LOTZ M. Chondrocyte apoptosis and nitric oxide
production during experimentally induced osteoarthritis. Arthritis Rheum 41:1266-74, 1998.
122. Hashimoto S, Ochs RL, Komiya S, LOTZ M. Linkage of chondrocyte apoptosis and cartilage
degradation in human osteoarthritis. Arthritis Rheum 41:1632-8, 1998.
123. Geng Y, Zhou L, Thompson WJ, LOTZ M. Cyclic GMP and cGMP-binding phosphodiesterase are
required for interleukin-1-induced nitric oxide synthesis in human articular chondrocytes. J Biol Chem
273:27484-91, 1998.
124. Terkeltaub R, LOTZ M, Johnson K, Deng D, Hashimoto S, Goldring MB, Burton D, Deftos LJ.
Parathyroid hormone-related proteins is abundant in osteoarthritic cartilage, and the parathyroid hormonerelated is selectively induced by transforming growth factor beta in articular chondrocytes and suppresses
generation of inorganic pyrophosphate. Arthritis Rheum 41:2152-64, 1998.
125. Shalom-Barak T, Quach J, LOTZ M. Interleukin-17-induced gene expression in articular chondrocytes
is associated with activation of mitogen-activated protein kinases and NF-kappaB. J Biol Chem 273:2746773, 1998.
126. LOTZ M, Hashimoto S, Ochs R, Kühn K. Chondrocyte Apoptosis. In: Apoptosis and Inflammation.
Winkler JD [Ed.] Birkhäuser, Basel, p. 101-19, 1999.
127. Olee T, Hashimoto S, Quach J, LOTZ M. IL-18 is produced by articular chondrocytes and induces
proinflammatory and catabolic responses. J Immunol 162:1096-100, 1999.
128. LOTZ M. The role of nitric oxide in articular cartilage damage. Rheum Dis Clin North Am 25:269-82,
1999.
129. LOTZ M, Hashimoto S, Kühn K. Mechanisms of chondrocyte apoptosis. Osteoarthritis Cartilage 7:38991, 1999.
130. Kühn K, Hashimoto S, LOTZ M. Cell density modulates apoptosis in human articular chondrocytes. J
Cell Physiol 180:439-77, 1999.
131. Hashimoto S, Takahashi K, Ochs RL, Coutts RD, Amiel D, LOTZ M. Nitric oxide production and
apoptosis in cells of the meniscus during experimental osteoarthritis. Arthritis Rheum 42:2123-31, 1999.
132. Kühn K, Hashimoto S, LOTZ M. IL-1 beta protects human chondrocytes from CD95-induced
apoptosis. J Immunol 164:2233-9, 2000.
133. Shikhman AR, Brinson DC, LOTZ M. Profile of glycosaminoglycan-degrading glycosides and glycoside
sulfatases secreted by human articular chondrocytes in homeostasis and inflammation. Arthritis Rheum
43:1307-14, 2000.
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134. Dudler J, Renggli-Zulliger N, Busso N, LOTZ M, So A. Effect of interleukin-17 on proteoglycan
degradation in murine knee joints. Ann Rheum Dis 59:529-32, 2000.
135. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, LOTZ M, Amiel D. Effect of hyaluronan on
chondrocyte apoptosis and nitric oxide production in experimentally induced osteoarthritis. J Rheumatol
27:1713-20, 2000.
136. Jin G, Sah RL, Li YS, LOTZ M, Shyy JY, Chien S. Biomechanical regulation of matrix
metalloproteinase-9 in cultured chondrocytes. J Orthop Res 18:899-908, 2001.
137. LOTZ M. Cytokines and their Receptors. In: Arthritis and Allied Conditions. Koopman W. [Ed.]
Lippincott Williams & Wilkins, New York, 436-77, 2001.
138. Johansen JS, Olee T, Price PA, Hashimoto S, Ochs RL, LOTZ M. Regulation of YKL-40 production by
human articular chondrocytes. Arthritis Rheum 44:826-37, 2001.
139. Shikhman AR, Kühn K, Alaaeddine N, LOTZ M. N-acetylglucosamine prevents IL-1 beta-mediated
activation of human chondrocytes. J Immunol 166:5155-60, 2001.
140. Liu J, Shikhman AR, LOTZ MK, Wong CH. Hexosaminidase inhibitors as new drug candidates for the
therapy of osteoarthritis. Chem Biol 8:701-11, 2001.
141. Alaaeddine N, Olee T, Hashimoto S, Creighton-Achermann L, LOTZ M. Production of the chemokine
RANTES by articular chondrocytes and role in cartilage degradation. Arthritis Rheum 44:1633-43, 2001.
142. Kühn K, LOTZ M. Regulation of CD95 (Fas/Apo-1)-induced apoptosis in human chondrocytes.
Arthritis Rheum 44:1644-53, 2001.
143. LOTZ M. Cytokines in cartilage injury and repair. Clin Orthop Relat Res 391:S108-15, 2001.
144. Kobayashi K, Mishima H, Hashimoto S, Goomer RS, Harwood FL, LOTZ M, Moriya H, Amiel D.
Chondrocyte apoptosis and regional differential expression of nitric oxide in the medial meniscus following
partial menisectomy. J Orthop Res 19:802-8, 2001.
145. Komuro H, Olee T, Kühn K, Quach J, Brinson DC, Shikhman A, Valbracht J, Creighton-Achermann L,
LOTZ M. The osteoprotegerin/receptor activator of nuclear factor kappaB/receptor activator of nuclear factor
kappaB ligand system in cartilage. Arthritis Rheum 44:2768-76, 2001.
146. Shikhman AR, Brinson DC, Valbracht J, LOTZ M. Cytokine regulation of facilitated glucose transport in
human articular chondrocytes. J Immunol 167:7001-8, 2001.
147. Takahashi K, Hashimoto S, Kubo T, Hirasawa Y, LOTZ M, Amiel D. Hyaluronan suppressed nitric
oxide production in the meniscus and synovium of rabbit osteoarthritis model. J Orthop Res 19:500-3, 2001.
148. D’Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, LOTZ M. Human chondrocyte apoptosis in
response to mechanical injury. Osteoarthritis Cartilage 9:712-9, 2001.
149. D'Lima DD, Hashimoto S, Chen PC, Colwell CW Jr, LOTZ M. Impact of mechanical trauma on matrix
and cells. Clin Orthop Relat Res 391:S90-9, 2001.
150. D’Lima DD, Hashimoto S, Chen PC, LOTZ M, Colwell CW Jr. Cartilage injury induces chondrocyte
apoptosis. J Bone Joint Surg Am 83-A Suppl:19-21, 2001.
151. D’Lima DD, Hashimoto S, Chen PC, LOTZ M, Colwell CW Jr. In vitro and in vivo models of cartilage
injury. J Bone Joint Surg Am 83-A Suppl 2:22-24, 2001.
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152. D’Lima DD, Hashimoto S, Chen PC, LOTZ M, Colwell CW Jr. Prevention of chondrocyte apoptosis. J
Bone Joint Surg 83-A Suppl 2:25-6, 2001.
153. Johnson K, Hashimoto S, LOTZ M, Pritzker K, Goding J, Terkeltaub R. Up-regulated expression of the
phosphodiesterase nucleotide pyrophosphatase family member PC-1 is a marker and pathogenic factor for
knee meniscal cartilage matrix calcification. Arthritis Rheum 44:1071-81, 2001.
154. Colwell CW Jr, D'Lima DD, Hoenecke HR, Fronek J, Pulido P, Morris BA, Chung C, Resnick D, LOTZ
M. In vivo changes after mechanical injury. Clin Orthop Relat Res 391:S116-23, 2001.
155. Johnson K, Hashimoto S, LOTZ M, Pritzker K, Terkeltaub R. Interleukin-1 induces pro-mineralizing
activity of cartilage tissue transglutaminase and factor XIIIa. Am J Pathol 159:149-63, 2001.
156. Yamada K, Healy R, Amiel D, LOTZ M, Coutts R. Subchondral bone of the human knee joint in aging
and osteoarthritis. Osteoarthritis Cartilage 10:360-9, 2002.
157. Hashimoto S, Creighton-Achermann L, Takahashi K, Amiel D, Coutts RD, LOTZ M. Development and
regulation of osteophyte formation during experimental osteoarthritis. Osteoarthritis Cartilage 10:180-7,
2002.
158. Gemba T, Valbracht J, Alsalameh S, LOTZ M. Focal adhesion kinase and mitogen-activated protein
kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment. J Biol
Chem 277:907-11, 2002.
159. LOTZ M. Neuropeptides, free radicals and nitric oxide. In: Rheumatology, 3rd Edition. Hochberg M et
al [Eds.]. Keyword Publishing Services Ltd, Essex UK, 2003.
160. Kühn K, Shikhman AR, LOTZ M. Role of nitric oxide, reactive oxygen species, and p38 MAP kinase in
the regulation of human chondrocyte apoptosis. J Cell Physiol 197:379-87, 2003.
161. Zemmyo M, Meharra EJ, Kühn K, Creighton-Achermann L, LOTZ M. Accelerated, aging-dependent
development of osteoarthritis in alpha 1 integrin-deficient mice. Arthritis Rheum 48:2873-80, 2003.
162. Kühn K, LOTZ M. Mechanisms of sodium nitroprusside-induced death in human chondrocytes.
Rheumatol Intl 23:241-7, 2003.
163. Seitz M, Valbracht J, Quach J, LOTZ M. Gold sodium thiomalate and chloroquine inhibit cytokine
production in monocytic THP-1 cells through distinct transcriptional and posttranslational mechanisms. J Clin
Immunol 23:477-84, 2003.
164. Shikhman AR, Brinson DC, LOTZ M. Distinct pathways regulate facilitated glucose transport in human
articular chondrocytes during anabolic and catabolic responses. Am J Physiol Endocrinol Metab 286:E980-5,
2004.
165. Kühn K, D’Lima DD, Hashimoto S, LOTZ M. Cell death in cartilage. Osteoarthritis Cartilage 12:1-16,
2004.
166. Alsalameh S, Amin R, Gemba T, LOTZ M. Identification of mesenchymal progenitor cells in normal
and osteoarthritic human articular cartilage. Arthritis Rheum 50:1522-32, 2004.
167. D'Lima DD, Kuhn K, LOTZ M. Detection of apoptosis in cartilage in situ and in isolated chondrocytes.
Methods Mol Med 100:275-90, 2004.
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168. Sen M, Cheng YH, Goldring MB, LOTZ M, Carson DA. WISP3-dependent regulation of type II collagen
and aggrecan production in chondrocytes. Arthritis Rheum 50:488-97, 2004.
169. D’Lima D, LOTZ M, Colwell CW Jr. Cartilage mechanical properties after injury. J ASTM Intl 67-76,
2004.
170. D’Lima DD, Bergula A, Chen PC, Colwell CW Jr, LOTZ M. Age related differences in chondrocyte
viability and biosynthetic response to mechanical injury. J ASTM Intl 77–83, 2004.
171. Shikhman AR, Amiel D, D’Lima D, Hwang SB, Hu C, Xu A, Hashimoto S, Kobayashi K, Sasho T,
LOTZ M. Chondroprotective activity of N-acetylglucosamine in rabbits with experimental osteoarthritis. Ann
Rheum Dis 64:89-94, 2005.
172. Kinney RC, Schwartz Z, Week K, LOTZ M, Boyan BD. Human articular chondrocytes exhibit sexual
dimorphism in their responses to 17beta-estradiol. Osteoarthritis Cartilage 13:330-7, 2005.
173. Kawakami Y, Tsuda M, Takahashi S, Taniguchi N, Esteban CR, Zemmyo M, Furumatsu T, LOTZ M,
Belmonte JC, Asahara H. Transcriptional coactivator PGC-1alpha regulates chondrogenesis via association
with Sox9. Proc Natl Acad Sci U S A 102:2414-9, 2005.
174. Cecil DL, Johnson K, Rediske J, LOTZ M, Schmidt AM, Terkeltaub R. Inflammation-induced
chondrocyte hypertrophy is driven by receptor for advanced glycation end products. J Immunol 175:8296302, 2005.
175. Daouti S, Latario B, Nagulapalli S, Buxton F, Uziel-Fusi S, Chirn GW, Bodian D, Song C, Labow M,
LOTZ M, Quintavalla J, Kumar C. Development of comprehensive functional genomic screens to identify
novel mediators of osteoarthritis. Osteoarthritis Cartilage 13:508-18, 2005.
176. D’Lima D, Hermida J, Hashimoto S, Colwell C, LOTZ M. Caspase inhibitors reduce severity of
cartilage lesions in experimental osteoarthritis. Arthritis Rheum 54:1814-21, 2006.
177. Hiraoka K, Grogan S, Olee T, LOTZ M. Mesenchymal progenitor cells in adult human articular
cartilage. Biorheology 43:447-54, 2006.
178. Taniguchi N, Yoshida K, Ito T, Tsuda M, Mishima Y, Furumatsu T, Ronfani L, Abeyama K, Kawahara
K, Komiya S, Maruyama I, LOTZ M, Bianchi ME, Asahara H. Stage-specific secretion of HMGB1 in cartilage
regulates endochondral ossification. Mol Cell Biol 27:5650-63, 2007.
179. Temple MM, Bae WC, Chen MQ, LOTZ M, Amiel D, Coutts RD, Sah RL. Age- and site-associated
biomechanical weakening of human articular cartilage of the femoral condyle. Osteoarthritis Cartilage
15:1042-52, 2007.
180. LOTZ M. Nitric oxide and other radicals in the pathogenesis of osteoarthritis. In: Osteoarthritis,
Inflammation and Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press, p. 182-91,
2007.
181. Stoltz JF, LOTZ M, Buckwalter J. Cartilage engineering. In: Osteoarthritis, Inflammation and
Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press, p. 280-86, 2007.
182. Buckwalter J, LOTZ M, Stoltz JF. Therapeutics and osteoarthritis. In: Osteoarthritis, Inflammation and
Degradation: A Continuum. Buckwalter J, LOTZ M, Stoltz JF [Eds.] IOS Press, p. 287-98, 2007.
183. Otsuki S, Nakajima M, LOTZ M, Kinoshita M. Hyaluronic acid and chondroitin sulfate content of
osteoarthritic human knee cartilage: site-specific correlation with weight-bearing force based on femorotibial
angle measurement. J Orthop Res 26:1194-8, 2008.
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184. Otsuki S, Brinson DC, Creighton L, Kinoshita M, Sah RL, D’Lima D, LOTZ M. The effect of
glycosaminoglycan loss on chondrocyte viability: a study on porcine cartilage explants. Arthritis Rheum
58:1076-85, 2008.
185. Grogan SP, Olee T, Hiraoka K, LOTZ M. Repression of chondrogenesis through binding of notch
signaling proteins HES-1 and HEY-1 to N-box domains in the COL2A1 enhancer site. Arthritis Rheum
58:2754-63, 2008.
186. Otsuki S, Taniguchi N, Grogan SP, D’Lima D, Kinoshita M, LOTZ M. Expression of novel extracellular
sulfatases Sulf-1 and Sulf-2 in normal and osteoarthritic articular cartilage. Arthritis Res Ther 10:R61, 2008.
187. Wong BL, Bae WC, Chun J, Gratz KR, LOTZ M, Sah RL. Biomechanics of cartilage articulation:
effects of lubrication and degeneration on shear deformation. Arthritis Rheum 58:2065-74, 2008.
188. Haudenschild DR, Nguyen B, Chen J, D’Lima DD, LOTZ M. Rho kinase-dependent CCL20 induced by
dynamic compression of human chondrocytes. Arthritis Rheum 58:2735-42, 2008.
189. Mishima Y, LOTZ M. Chemotaxis of human articular chondrocytes and mesenchymal stem cells. J
Orthop Res 26:1407-12, 2008.
190. Haudenschild DR, D’Lima DD, LOTZ M. Dynamic compression of chondrocytes induces a Rho kinasedependent reorganization of the actin cytoskeleton. Biorheology, 45:219-228, 2008.
191. Garcia-Gonzalez A, LOTZ M, Ochoa JL. Anti-inflammatory activity of superoxide dismutase obtained
from from Debaryomyces hansenii on type II collagen induced arthritis in rats. Rev Invest Clin 61:212-20,
2009.
192. Taniguchi N, Caramés B, Ronfani L, Ulmer U, Komiya S, Bianchi ME, LOTZ M. Aging-related loss of
the chromatin protein HMGB2 in articular cartilage is linked to reduced cellularity and osteoarthritis. Proc
Natl Acad Sci U S A 106:1181-6, 2009.
193. Steklov N, Srivastava A, Sung KLP, Chen PC, LOTZ M, D’Lima DD. Aging-related differences in
chondrocyte viscoelastic properties. Mol Cell Biomech 6:113-20, 2009.
194. Grogan SP, Miyaki S, Asahara H, D’Lima DD, LOTZ M. Mesenchymal progenitor cell markers in
human articular cartilage: normal distribution and changes in osteoarthritis. Arthritis Res Ther 11:R85, 2009.
195. Haudenschild DR, Chen J, Steklov N, LOTZ M, D’Lima DD. Characterization of the chondrocyte actin
cytoskeleton in living three-dimensional culture: response to anabolic and catabolic stimuli. Mol Cell
Biomech 6:135-44, 2009.
196. Shikhman AR, Brinson DC, Valbracht J, LOTZ M. Differential metabolic effects of glucosamine and Nacetylglucosamine in human articular chondrocytes. Osteoarthritis Cartilage 17:1022-8, 2009.
197. Miyaki S, Nakasa T, Otsuki S, Grogan SP, Higashiyama R, Inoue A, Kato Y, Sato T, LOTZ M, Asahara
H. MicroRNA-140 is expressed in differentiated human articular chondrocytes and modulates interleukin-1
responses. Arthritis Rheum 60:2723-30, 2009.
198. Ito T, Yadav N, Lee J, Furumatsu T, Yamashita S, Yoshida K, Taniguchi N, Hashimoto M, Tsuchiya M,
Ozaki T, LOTZ M, Bedford MT, Asahara H. Arginine methyltransferase CARM1/PRMT4 regulates
endochondral ossification. BMC Dev Biol 9:47, 2009.
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199. Taniguchi N, Caramés B, Kawakami Y, Amendt BA, Komiya S, LOTZ M. Chromatin protein HMGB2
regulates articular cartilage surface maintenance via beta-catenin pathways. Proc Natl Acad Sci U S A
106:16817-22, 2009.
200. Temple-Wong MM, Bae WC, Chen MQ, Bugbee WD, Amiel D, Coutts RD, LOTZ M, Sah RL.
Biomechanical, structural, and biochemical indices of degenerative and osteoarthritic deterioration of adult
human articular cartilage of the femoral condyle. Osteoarthritis Cartilage 17:1469-76, 2009.
201. Otsuki S, Grogan SP, Miyaki S, Kinoshita M, Asahara H, LOTZ M. Tissue neogenesis and STRO-1
expression in immature and mature articular cartilage. J Orthop Res 28:96-102, 2010.
202. Haudenschild DR, Chen J, Pang N, LOTZ M, D’Lima DD. Rho kinase-dependent activation of SOX9 in
chondrocytes. Arthritis Rheum 62:191-200, 2010.
203. Bae WC, Payanal MM, Chen AC, Hsieh-Bonassera ND, Ballard BL, LOTZ M, Coutts RD, Bugbee WD,
Sah RL. Topographic patterns of cartilage lesions in knee osteoarthritis. Cartilage 1:10-19, 2010.
204. Higashiyama R, Miyaki S, Yamashita S, Yoshitaka T, Lindman G, Ito Y, Sasho T, Takahashi K, LOTZ
M, Asahara H. Correlation between MMP-13 and HDAC7 expression in human knee osteoarthritis. Modern
Rheumatol 20:11-17, 2010.
205. Caramés B, Taniguchi N, Otsuki S, Blanco F, LOTZ M. Autophagy is a protective mechanism in
normal cartilage and its aging-related loss is linked with cell death and osteoarthritis. Arthritis Rheum
62:791-01, 2010.
206. Oyama Y, Hashiguchi T, Taniguchi T, Tancharoen S, Uchimura T, Biswas KK, Kawahara K, Nitanda
T, Umekita Y, LOTZ M, Maruyama I. High-mobility group box-1 protein promotes granulomatous nephritis in
adenine-induced nephropathy. Lab Invest 90:853-66, 2010.
207. Miyaki S, Sato T, Inoue A, Otsuki S, Ito Y, Yokoyama S, Kato Y, Takemoto F, Nakasa T, Yamashita S,
Takada S, LOTZ M, Ueno-Kudo H, Asahara H. MicroRNA-140 plays dual roles both in cartilage
development and homeostasis. Genes Dev 24:1173-85, 2010.
208. Otsuki S, Hanson SR, Miyaki S, Grogan SP, Kinoshita M, Asahara H, Wong C-H, LOTZ M.
Extracellular sulfatases support cartilage homeostasis by regulating BMP and FGF signaling pathways. Proc
Natl Acad Sci USA 107:10202-07, 2010.
209. Haudenschild, D, Chen J, Steklov N, Grogan S, LOTZ M, D’Lima DD. Vimentin contributes to changes
in chondrocyte stiffness in osteoarthritis. J Orthop Res 29:20-25. 2010.
210. LOTZ M, Otsuki S, Grogan SP, Sah R, Terkeltaub R, D’Lima D. Cartilage cell clusters. Arthritis Rheum
62:2206-18, 2010.
211. LOTZ M, Kraus V. Posttraumatic Osteoarthritis: Pathogenesis and pharmacological treatment options.
Arthritis Res Ther 12:408, 2010.
212. Schelwies M, Brinson D, Hong Y-H, LOTZ M, Wong C-H, Hanson S. Glucosamine-6-sulfamate
analogues of heparan sulfate as inhibitors of endosulfatases. ChemBioChem 11:2393-97, 2010.
213. Terkeltaub R, Yang B, LOTZ M, Liu-Bryan R. Chondrocyte AMP-activated protein kinase activity
suppresses matrix degradation responses to inflammatory cytokines IL-1β and TNFα. Arthritis Rheum
63:1928-37, 2011.
214. Itou J, Taniguchi N, Oishi I, Kawakami H, LOTZ M, Kawakami Y. HMGB factors are required for
posterior digit development through enhancing ß-catenin pathway activity, Dev Dyn 240:1151-62, 2011.
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215. Pauli C, Grogan SP, Patil S, Otsuki S, Hasegawa A, Koziol J, LOTZ M, D’Lima D. Macroscopic and
histopathologic analysis of human knee menisci in aging and osteoarthritis. Osteoarthritis Cartilage 19:113241, 2011.
216. LOTZ MK, Caramés B. Autophagy and cartilage homeostasis mechanisms in joint health, aging and
osteoarthritis, Nature Rev Rheumatol 7:579-87, 2011.
217. Taniguchi N, Caramés B, Cherqui S, Kawakami Y, LOTZ M. Expression patterns and function of
chromatin protein HMGB2 during mesenchymal stem cell differentiation. J Biol Chem 286:41489-98, 2011.
218. LOTZ M, Caramés B. Autophagy, a new therapeutic target in cartilage injury and osteoarthritis. J Am
Acad Orthop Surg 20:261-2, 2012.
219. Caramés B, Hasegawa A, Taniguchi N, Blanco F, LOTZ M. Autophagy activation by rapamycin
reduces severity of experimental osteoarthritis, Ann Rheum Dis 71:575-81, 2012.
220. Caramés B, Taniguchi N, Seino D, Blanco F, D’Lima DD, LOTZ M. Mechanical injury suppresses
autophagy regulators and its pharmacological activation results in chondroprotection. Arthritis Rheum
64:1182-92, 2012.
221. Hasegawa A, Otsuki S, Pauli C, Miyaki S, Patil S, Steklov N, Kinoshita M, Koziol J, D’Lima DD, LOTZ
M. Anterior cruciate ligament changes in human joint in aging and osteoarthritis. Arthritis Rheum 64:696704, 2012.
222. Chan EF, Harjanto R, Asahara H, Nozomu I, Masuda K, Bugbee WD, Firestein GS, Hosalkar H, LOTZ
M, Sah RL. Structural and functional maturation of distal femoral cartilage and bone during postnatal
development and growth in humans and mice. Orthop Clin North Am 43:173-85, 2012.
223. LOTZ M. Chondrocyte differentiation and osteoarthritis. OARSI Primer, 2011. www.OARSI.ORG.
224. LOTZ M. Osteoarthritis year 2011 in review: biology. Osteoarthritis Cartilage 20:192-6, 2012.
225. Monemdjou R, Vasheghani F, Fahmi H, Perez G, Blati M, Taniguchi N, Lotz M, St-Arnaud R, Pelletier
JP, Martel-Pelletier J, Beier F, Kapoor M. Association of cartilage-specific deletion of peroxisome
proliferator-activated receptor γ with abnormal endochondral ossification and impaired cartilage growth and
development in a murine model. Arthritis Rheum 64:1551-61, 2012.
226. Cui X, Breitenkamp K, Finn MG, LOTZ M, D'Lima D. Direct human cartilage repair using threedimensional bioprinting technology. Tissue Eng Part A 18:1304-12, 2012.
227. Grogan SP, Pauli C, Chen P, Du J, Chung CB, Kong SD, Colwell Jr CW, LOTZ M, Jin S, D'Lima D. In
situ tissue engineering using magnetically guided 3D cell patterning. Tissue Eng Part C Methods 18:496506, 2012.
228. Cui X, Hasegawa A, LOTZ M, D’Lima D. Structured three-dimensional co-culture of mesenchymal
stem cells with meniscus cells promotes meniscal phenotype without hypertrophy. Biotechnol Bioeng
109:2369-80, 2012.
229. Cui X, Boland T, D'Lima DD, LOTZ MK. Thermal inkjet printing in Tissue Engineering and regenerative
medicine. Recent Pat Drug Deliv Formul 6:149-55, 2012.
230. LOTZ M, Loeser R. Effects of aging on articular cartilage homeostasis. Bone 51:241-8, 2012.
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231. Pauli C, Whiteside R, Las Heras F, Nesic D, Koziol J, Grogan SP, Matyas F, Pritzker KPH, D’Lima D,
LOTZ M. Comparison of cartilage histopathology assessment systems on human knee joints at all stages of
osteoarthritis development. Osteoarthritis Cartilage 20:476-85, 2012.
232. Grogan SP, Sovani S, Pauli C, Chen J, Hartmann A, Colwell CW, LOTZ MK, D’Lima DD. Effects of
perfusion and dynamic loading on human neocartilage formation in alginate hydrogels. Tissue Engineering
18:1784-92, 2012.
233. Cui X, Breitenkamp K, LOTZ M, D'Lima D. Synergistic action of fibroblast growth factor-2 and
transforming growth factor-beta1 enhances human neocartilage formation in bioprinted 3D hydrogels.
Biotechnol Bioeng 109:2357-88, 2012.
234. Pauli C, Lee M, Bae W, LOTZ M, Bydder G, D’Lima D, Chung C, Du J. Ultrashort-echo time MR
Imaging of the patella with bicomponent analysis: Correlation with histopathologic and polarized light
microscopic findings. Radiology 264:484-93, 2012.
235. Levy YD, Hasegawa A, Patil S, Koziol J, LOTZ MK, D’Lima D. Histopathological changes in the human
posterior cruciate ligament during aging and osteoarthritis.
Ann Rheum Dis 72:271-7, 2012.
236. Chan EF, Farnsworth CL, Koziol JA, Hosalkar HS, Sah RL: Statistical shape modeling of proximal
femoral shape deforormities in Legg-Calve-Perthes disease and slipped capital femoral epiphysis.
Osteoarthritis Cartilage 21:443-9, 2012.
237. Grogan SP, Duffy S, Pauli C, Koziol JA, Su A, D’Lima DD, LOTZ MK. Zone specific gene expression
patterns in articular cartilage. Arthritis Rheum 65:418-28, 2013.
238. Matsukawa T, Sakai T, Yonezawa T, Hiraiwa H, Hamada T, Nakashima M, Ono Y, Ishizuka S,
Nakahara H, LOTZ MK, Asahara H, Ishiguro N. MicroRNA-125b regulates the expression of aggrecanase-1
(ADAMTS-4) in human osteoarthritic chondrocytes. Arthritis Res Ther 15:R28, 2013.
239. Hasegawa A, Nakahara H, Asahara H, Kinoshita M, Koziol J, LOTZ MK. Cellular and extracellular
matrix changes in anterior cruciate ligament during human knee aging and osteoarthritis. Arthritis Res Ther
15:R29, 2013.
240. van Loosdregt J, Spreafico R, Rossetti M, Prakken BJ, LOTZ M, Albani S. Hydroxychloroquine
preferentially induces apoptosis of CD45RO+ effector T cells by inhibiting autophagy: A possible mechanism
for therapeutic modulation of T cells. J Allergy Clin Immunol 131:1443-6, 2013.
241. Grogan SP, Chung PH, Soman P, Chen P, LOTZ MK, Chen S, D’Lima DD. Digital-Micromirror-Device
projection printing system for meniscus tissue engineering. Acta Biomater 9:7218-26, 2013.
242. LOTZ M, Martel-Pelletier J, Christiansen C, Brandi M-L, Bruyère O, Chapurlat R, Collette J, Cooper C,
Giacovelli G, Kanis JA, Karsdal MA, Kraus V, Lems WF, Meulenbelt I, Pelletier J-P, Raynauld J-P, ReiterNiesert S, Rizzoli R, L. Sandell LJ, Spector T, Van Spil WE, Reginster J-Y. Value of biomarkers in
osteoarthritis: current status and perspectives. Postgrad Med J 201:171-8, 2014 reprint: first appeared in
Ann Rheum Dis 72:1756-63, 2013.
243. Petursson F, Husa M, June R, LOTZ M, Terkeltaub R and Liu-Bryan R. Linked decreases in liver
kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to Biomechanical
Injury in Chondrocytes. Arthritis Res Ther 15:R77, 2013.
244. Nakahara H, Hasegawa A, Otabe K, Ayabe F, Matsukawa T, Onizuka N, Ito Y, LOTZ MK, Asahara H.
Transcription factor Mohawk and the pathogenesis of human anterior cruciate ligament degradation. Arthritis
Rheum 65:2081-9, 2013.
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245. Caramés B, Kiosses WB, Akasaki Y, Brinson D, Koziol J, LOTZ M. Glucosamine activates autophagy
in vitro and in vivo. Arthritis Rheum 65:1843-52, 2013.
246. Husa M, Petursson F, LOTZ M, Terkeltaub R, Liu-Bryan R. C/EBP homologous protein drives procatabolic responses in chondrocytes. Arthritis Res Ther. 2013 Dec 19;15(6):R218.
247. Yoshitaka T, Kawai A, Miyaki S, Numoto K, Kikuta K, Ozaki T, LOTZ M, Asahara A. Analysis of
microRNAs expressions in chondrosarcoma. J Orthop Res 31:1992-8, 2013.
248. Grogan S, Chen X, Sovani S, Taniguchi N, Colwell C Jr, LOTZ M, D’Lima D. Influence of cartilage
extracellular matrix molecules on cell phenotype and neocartilage formation. Tissue Eng Part A 20:264-74,
2014.
249. Olee T, Grogan SP, L M, Colwell CW, Snyder E, D'Lima D. Repair of cartilage defects in arthritic
tissue with differentiated human embryonic stem cells. Tissue Eng Part A Tissue Eng Part A 20:683-92,
2014.
250. Onizuka N, Ito Y, Takada S, Nakahara H, LOTZ M, Toyama Y, Asahara H. The Mohawk homeobox
transcription factor regulates the differentiation of tendons, tendon sheaths and volar plates. J Orthop Sci
19:172-80, 2014.
251. Akasaki Y, Hasegawa A, Saito M, Asahara H, Iwamoto Y, LOTZ MK. Dysregulated FOXO
transcription factors in articular cartilage in aging and osteoarthritis. Osteoarthritis Cartilage 22:162–170,
2014.
252. Shapiro I, Layfield R, LOTZ M, Settembre C, Whitehouse C. Boning up on autophagy. The role of
autophagy in skeletal biology. Autophagy 10:1-13, 2013.
253. Alvarez-Garcia O, Rogers NH, Smith RG, LOTZ MK. Palmitate has proapoptotic and proinflammatory
effects on articular cartilage and synergizes with interleukin-1. Arthritis Rheumatol 66:1779-88, 2014.
254. Kato T, Miyaki S, Ishitobi H, Nakamura Y, Nakasa T, LOTZ MK, Ochi M. Exosomes from IL-1β
stimulated synovial fibroblasts induce osteoarthritic changes in articular chondrocytes. Arthritis Res Ther
16:R163, 2014. [Epub ahead of print].
255. Zhao X, Petursson F, Viollet B, LOTZ M, Terkeltaub R, Liu-Bryan R. PGC-1α and FOXO3a mediate
chondroprotection by AMP-activated Protein Kinase. Arthritis Rheumatol. 2014 Jul 21. [Epub ahead of print].
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Curriculum Vitae
Martin Lotz, M.D.
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