MBI® Programme 2015-2016 Principles of Fermentation Processes 5-7 October 2015 Industrial Biotechnology: Biocatalysis through to Synthetic Biology 18-20 April 2016 Rapid Fermentation Process Design: From Development to Manufacture 26-28 October 2015 Analytical Data Analysis for the Bioprocessing Industry 25-28 April 2016 (CPI, Darlington) Downstream Processing – From Cell to Column 16-19 November 2015 Stem Cell Training Course: Human Pluripotent Stem Cells in Culture 25-27 April 2016 Downstream Processing –Chromatography 30 November-3 December 2015 Vaccines Bioprocess Development and Commercialisation 17-19 May Current Challenges in Mammalian Cell Processing 25-27 January 2016 Bioprocess Design & Economic Evaluation 6-9 June 2016 Quality by Design for Effective Bioprocess Characterisation and Validation 22-25 February 2016 Cell and Gene Therapy Manufacturing 1-3 March 2016 (Cell Therapy Catapult, London) Design of Experiments for Bioprocess Optimisation 7-9 March 2016 Bioprocess Facility Design 27-30 June 2016 Single Use Technology for Rapid Manufacturing 11-13 July 2016 All courses held at the department of Biochemical Engineering, University College London unless otherwise specified. ® For up-to-date information on all MBI courses, visit www.ucl.ac.uk/mbi MBI® Awards 2012 IChemE Award for Training Innovation 2014 UCL Life Learning Enterprise Award for CPD and Short Courses Downstream Processing: From Cell to Column Learn how to select the best recovery options for your bioprocess 16-19 November 2015 Est. 1994 Downstream Processing: From Cell to Column This module focuses on the biological product recovery stage and, through a series of lectures, case studies and pilot plant practical sessions, will enable you to: 72.3736 • Understand the principles • • • • of all the major recovery operations: Centrifugation, Membrane Systems, Filtration, Cell Disruption, Precipitation, Flocculation Compare these unit operations for suitability within the process and study them in our unique pilot plant Determine the most appropriate equipment for separations and specify the right operating conditions Learn to use Ultra Scale Down tool for prediction of large scale separation performance Understand the interaction among fermentation, recovery and purification and learn the integrated solutions for bioprocess development 83.7474 Who should attend? This module is designed for scientists and engineers involved in design, development and operation of primary recovery steps as well as associated steps in upstream and purification processes. • Bioprocess developer • R&D scientist • Manufacturing technologist • Manufacturing operational manager 95.1211 Day 1 • Introduction to module • Principles of precipitation and design of precipitation reactors • Centrifugation • Ultra scale down centrifugation • Case study: design of precipitation reactor • S ocial networking dinner organised for delegates and speakers. Day 2 • Pilot-plant studies: centrifugation • Intracellular product release • Filtration • Microfiltration and ultrafiltration • Ultra scale down microfiltration Module Leader Dr Yuhong Zhou UCL Day 4 • Simulation studies: the role of microfiltration in whole bioprocess studies • Cell engineering to ease primary recovery • Use flocculation to remove key mpurities to prepare feed material for purification • Primary recovery process development with an integrated approach • Viral product recovery in vaccine processing 117.869 UCL Experts Prof Mike Hoare Prof Eli Keshavarz-Moore Prof Nigel Titchener-Hooker Dr Darren Nesbeth Day 3 • Pilot-plant studies: microfiltration • Bioprocess applications of centrifuges • From lab scale to manufacturing: microfiltration technology for product recovery and purification • Use of adsorptive depth filtration in biopharmaceutical manufacturing Industrial Expert Speakers Include Millipore Westfalia Pall Life Sciences UCB For further information and bookings please contact: E: mbi-training@ucl.ac.uk I Visit: www.ucl.ac.uk/mbi T: +44 (0) 20 7679 9619 I +44 (0) 203 549 5619 Please note the agenda maybe subject to change.