CLINIC Fm]SCRIPPS l r- | ^\D titSI ARi I I uU\L,Al l(r\ ( ( ) \ 1 , \ 1 l r \ l ( . { l I ( ) N \ | ) t 1 , , \ RI \ 1 t r N t l ( ) r , r ,\lo) J { i l t l o l l R t \ l , l \ t \ l t ( ) ; \ t ) I \ Jllll,\ (.\lltoR\i.\(r11)ll r ) 1 , l, i l news Sl(rlL ) j t( , 1 9- 1I t S l I ; For Infornation: Andrevl Jovlers Manager, llevls Bureau ( 6 1 9 ) 5 5 4 - 8 2 9 0 ,5 5 4 - 8 1 3 3 rOR II'II'IFDII{I'E RF,LTNSE *100788-3 lilot for release before Ocb. 7r 1988 Scripps Clinic researchers nake key find in blood-clottinq process IA JOLIA, OcL. 7 -- Research InsLitute of Scripps Clinic investigators have located the section of a blood plat,elet protein inplicat.ed in the recognition and binding of fibrinog€nr a key process in the fornntion of bloocl clots. pubtished today in the journal Scierce, nay lead to the develoSnrert of antibodies and qnthetic peptides tlnt. jrterfere wilh the thrcnrbotic process, producing ne!,/treatrnents for stroke and heart attack. Efforts to produce these agents are underwayat the Research Instrtlrte. The finding, A1so, since the protein segmenthas a similar structure to regions on other proteins concerned with cell adhesion, it may be trrcssible to produce antibodies and other agents to control processes in which cell adiresion plays a role, such as inflarmmtion, tissue developnrart and the netastatic spread of turnors. Ttre authors of the article were Drs. Stanley D'Souza' I'lark Ginsberg, Stephen lam and EdrrrardP1cn, and Tinpthy Burker al-l of the Researctt Instituter s inmunologlz department. (More) Page 2 Oct. 7, 1988 #100788-3 "This is a basic finding, dnd clinical applications of this work are a long way off rn said Ginsberg. 'Hov,rever,the potential is there." In ttre norrml process b' which bleeding is stopped, called henrostasis' fibrinogen binds to platelet receptors. Foll-owing this, the platelets aggregateT forming the initial plug that stops blood leakage. Howeverr slznthetic peptides could block this process. l'lan-nnde peptides mimicking the structures in platelet receptors that recognize fibrinogen would be bound to fibrinogen - thry would competitively inhibit the plateletes' ability to bind to fibrirogen. Alsor since researchers kncr,.lthe structure of the receptor region involved in recognizing a specific site on fibrinogen, they nny be able to produce nonoclonal antibodies that react with tlnt thrombus formation. #** site' inhibiting