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O R L A N D O ,F L
catalytic
with
D.
antibodies
Ph.D.,
Janda,
Fourth
The development
Annual
at
is
the
the
of
topic
American
Conference
model
reactions
a June 25 talk
of
Society
on Biotechnology
chemical
for
by Kim
Microbiology's
Research,
in
Orlando,
FIor ida.
a presentation
In
summarize the
results
work he and his
Scripps
Clinic
The
similar
of
not
in
a vast
only
bind
catalyzing
into
proteins
particular
w€ proved
We utilized
Janda said.
types
chemical
useful.
would
describe
of
the
in
Antibodies
can recognize
but
also
a manner
are
a class
and specifically
Enzymesr orr the
In recent
that
antibodies
other
transform
years,
them by
researchers
which
are
hand,
have
artificial
reactions.
antibodies
coul-d be transformed
idea of transition
state
theory
to
as enzymes, and we gave them the term
"Now, werre
reactions
and
branching
looking
out
at
into
how they
different
might
be
"
He noted
create
of
antibodies,
which act
abzymes,"
which
the Research Institute
Janda.
targets,
can speed chemical
antibodies
of
to
compounds.
catalytic
1986 r
use
that
develop
enzymes.
create
the
reactions.
enzymes that
"In
to
papers,
Janda will
California.
chemical
to
worked
have done at
involves
range of
published
three
enzymes, according
to
Antibodi€s,"
"Catalytic
La JoIla,
immune system
bind
in
colleagues
research
to
titled
that
ones which
then
the
"overall
can disrupt
inactivate
the
goal
the
virus.
MORE
for
these
protein
coat
Another
antibodies
is
in
which
a virus
possibility
is
to
to
"CATAI,YTIC ANTIBODIES'
PAGE 2
i
for
as catalysts
industrially
antibodies
utilize
reactions
which
no known enzyme can perform. "
presentation,
his
In
published
Selectivityr"
two
This
configurations.
branch
that
of
do
and
out
future
model
in
of
area
this
recognize
"Science.rl
cut
a molecule
the
opposite
point.
to
lead
Now we can
he notedr
reacLionsr"
could
of
issue
chemically
articl-e
S Substrate
and R or
a beginning
is
types
other
research
and
recent
his
28, I989
could
that
pieces,
different
to
Activity
the ApriI
in
antibodies
"We obtained
into
Lipase
with
Antibodies
"Catalytic
refer
Janda will
adding
deveJ-opment
the
nerd drugs.
the
Catal-yzes
could
since
possibly
disrupt
it.
Other
armor of
its
In the
Formation,"
third
Janda
antibody
brought
Stephen J.
If
outer
the
protein
of
in
peptides
and
an amide bond'
coat
of
the
You
and
virus
be abl-e to
then
that
published
also
made up
you can cut
would
things
paper,
and
"Antibody
in
his
the
it
attack
Benkovic,
of
described
the
a
two nrolecul-es to
together
authors
of Bimolecul"ar Amide
Catalysis
Journal
team
American
situation
Chemical
where
perform
an
a chemical
manner.
in a more efficient
Additional
are
"viruses
an Antibody
defense would be down."
pubtished
Society,
reaction
said
of
"Induction
an Amide Bond,"
of
amide bonds.
contain
inactivate
titled
Hydrolysis
Janda
"sciencer"
peptides
a paper
to
Referring
on
Richard
the
papers
A. Lerner
+
r r*
Janda will
present
and Diane Schloeder.
were