1(t6NottbTonqPbwRM Ialolla,cA9n37 lNsrrrurs @ mnScnppsRrsnencH TelepbolE 619.455.911|r For information: Robin B. Goldsmith (619)554-8134 For immediaterelease # 110393 Dr. Richard Lerner ReceivesPrestigious Ilumboldt Award La Jolla, CA. November3, L993- RichardA. krner, M.D., Presidentof The Scripps ResearchInstitute, has beennameda recipient of the prestigiousHumboldt ResearchAward for SeniorU.S. Scientists. The award,grantedin recognitionof significantpast scientific accomplishmentsin researchand training, is sponsoredby the Alexandervon Humboldt Foundationin Bonn, Germany. In addition,it is intendedto promotelong-termspecialized cooperationbetweenAmerican and Germanresearchersand their respectiveinstitutions. The awardhonorskrner's internationallyrecognizedcontributionsto biomedicalresearch. He is regardedas one the first scientiststo demonstratethat peptides-- short chainsof amino acids-- could be usedto elicit antibodiesagainstintactprotein molecules,and to suggestthat this technologycould be nrrnedto the productionof synthetic,peptide-based vaccines. This work, in turn, led to the discoverythat the regionsof proteins that are most antigenic share properties. certainphysicaland three-dimensional l.erner also pioneeredthe methodologyof commandeeringthe mammalianimmune systemto manufactureantibodiesthat perform the chemicalfunctionsof enzymecatalysts. Moreover, in the courseof preparingincreasingnumbersof new catalyticantibodies,he and his colleaguesdevelopeda meansby which to screenfor and detectmonoclonalantibodiesseveral thousandtimes more efficiently than by using conventionaltechniques. MORE Page 2 - Dr. Richard Lerner ReceivesPrestigious Humboldt Award Lerner graduatedfrom NorthwesternUniversity and StanfordUniversity Medical School where he studiedchemistry as well as medicine. He servedan internship at Palo Alto Stanford Hospital and receivedpostdoctoraltraining at ScrippsClinic and Research Foundationin experimentalpathology. Following a staff appoinnnentat the Wistar Institute in Philadelphia,he joined the ResearchInstinrteof ScrippsClinic in 1970and became Chairmanof its Departrrentof MolecularBiology in L982. In 1987he was appointed Presidentof The ScrippsResearchInstitute. Under I-erner'sleadership,The ScrippsResearchInstitutehasbecomeone of the world's most advancedcentersfor researchin structuralbiology and the analysisof the threedimensionalstructureof proteins and other macromolecules. A memberof the NationalAcademyof Sciences,Lerner has servedas Consultantto a Special Virus CancerProgram,NCI; as ad hoc Memberof the MolecularBiology Study Section;on the FellowshipScreeningCommitteeof the CaliforniaDivision, ACS; and as a Member of the OrganizationCommitteefor Modern Approachesto Vaccines,Cold SpringHarbor Laboratories. Irrner was the recipientof the ParkeDavis Award in 1978,John A. Muntz Memorial Prae in 1990; SanMarino Prize in 1990;The BurroughsWellcomeFund and the FASEB WellcomeVisiting ProfessorAward in 1990;HonoraryDoctoratefrom the Karolinska Institute, Stockfiolm,Sweden,in 1990;The CollegeDe Francekctureship in l99L; Artlur C. Cope ScholarAward in 1991; The TenthAnnual JeanettePipernoBiomedicalResearch Award in t992; and the SixteenthAnnual CIBA-GEIGY Drew Award in BiomedicalResearch in 1992. MORE Page 3 - Dr. Richard Lerner ReceivesPrestigious Humboldt Award krner holds membershipsin the American Societyof ExperimentalPathology, American Societyof Microbiology, New York Academyof Sciences,BiophysicalSocietyand the pluto Society. He serveson the editorialboardsof The Journalof Virology, MolecularBiology and Medicine, Vaccine,In Vivo, PeptideResearch,Bioorganicand Medicinal Chemistrykuers, Drug Targetingand Delivery, and PNAS. In 1985, Lerner was electeda ForeignMemberof the Royal SwedishAcademyof Sciences; Member of the NationalAcademyof ScienceUSA in t99l; Member of the ScientificPolicy Advisory Committee,UppsalaUniversity, Swedenin 1991;Memberof the Scientific Advisory Board, EconomicDevelopmentBoard, Singapore,in 1991; and rrustee, The Neurosciences ResearchFoundation.1992. He has authoredmore than 250 scientificpublicationsas well as severalbook chaptersand a numberof abstracts. ###