Product datasheet
Anti-KIR2.3 antibody ab110701
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Overview
Product name
Anti-KIR2.3 antibody
Description
Rabbit polyclonal to KIR2.3
Tested applications
WB
Species reactivity
Reacts with: Mouse, Human
Predicted to work with: Rat
Immunogen
Synthetic peptide derived from an internal region of Human KIR2.3
Positive control
293 and NIH3T3 cell lysates
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
Storage buffer
pH: 7.40
Preservative: 0.02% Sodium azide
Constituents: PBS, 0.88% Sodium chloride, 50% Glycerol
Purity
Immunogen affinity purified
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab110701 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
WB
Abreviews
Notes
1/500 - 1/1000. Predicted molecular weight: 50 kDa.
Target
Function
This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized
by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage
dependence is regulated by the concentration of extracellular potassium; as external potassium
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is raised, the voltage range of the channel opening shifts to more positive voltages. The inward
rectification is mainly due to the blockage of outward current by internal magnesium. Can be
blocked by extracellular barium and cesium.
Tissue specificity
Heart, skeletal muscle, and several different brain regions including the hippocampus.
Sequence similarities
Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ4 subfamily.
Domain
The Val/Gly/Ala/Pro stretch may have a functional role in the conductance or permeation
properties.
Cellular localization
Cell membrane. Cytoplasmic vesicle membrane. TAX1BP3 binding promotes dissociation of
KCNJ4 from LIN7 famaly members and KCNJ4 internalization.
Anti-KIR2.3 antibody images
All lanes : Anti-KIR2.3 antibody (ab110701)
at 1/500 dilution
Lane 1 : 293 cell lysate
Lane 2 : NIH3T3 cell lysate
Lane 3 : NIH3T3 cell lysate with blocking
peptide at 10 µg
Lysates/proteins at 30 µg per lane.
Western blot - KIR2.3 antibody (ab110701)
Predicted band size : 50 kDa
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