Product datasheet
Anti-NUMBL antibody - N-terminal ab80119
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Overview
Product name
Anti-NUMBL antibody - N-terminal
Description
Rabbit polyclonal to NUMBL - N-terminal
Tested applications
ELISA, IHC-P
Species reactivity
Reacts with: Human
Immunogen
KLH-conjugated synthetic peptide from the N-terminal region of Human NUMBL
Positive control
Human lung carcinoma tissue
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw
cycles.
Storage buffer
Preservative: 0.09% Sodium Azide
Constituents: PBS
Purity
Ammonium Sulphate Precipitation
Purification notes
Prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against
PBS.
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab80119 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
ELISA
1/1000.
IHC-P
1/10 - 1/50.
Target
Function
Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to
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maintain neural progenitor cells, also called radial glial cells (RGCs), by allowing their daughter
cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural
progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the
subventricular zone (SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal
wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B
activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin
chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and
degradation of TRAF6 in cortical neurons.
Sequence similarities
Contains 1 PID domain.
Domain
The PTB domain is necessary for the inhibition of MAP3K7IP2-mediated activation of NFkappa-B.
Cellular localization
Cytoplasm. Symmetrically distributed throughout the cytoplasm in non dividing neuroblasts of the
CNS.
Anti-NUMBL antibody - N-terminal images
Immunohistochemistry analysis of formalinfixed, paraffin-embedded Human lung
carcinoma tissue using 1/10 ab80122, in
conjunction with a peroxidase-conjugated
secondary antibody, followed by DAB
staining.
Immunohistochemistry (Formalin/PFA-fixed
paraffin-embedded sections) - NUMBL antibody N-terminal (ab80119)
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