Product datasheet
Anti-IL36RN antibody ab105743
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Overview
Product name
Anti-IL36RN antibody
Description
Rabbit polyclonal to IL36RN
Tested applications
WB, ELISA
Species reactivity
Reacts with: Cow
Predicted to work with: Mouse, Rat, Horse, Dog, Human, Chimpanzee, Macaque Monkey
Immunogen
Recombinant full length protein raised in yeast, corresponding to Bovine IL1F5
(NP_001069243).
Positive control
Purified recombinant bovine IL1F5
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long
term.
Storage buffer
pH: 7.20
Preservative: 0.01% Sodium azide
Constituents: 0.42% Potassium phosphate, 0.88% Sodium chloride
Purity
Protein A purified
Purification notes
Protein A purified from monospecific antiserum by chromatography.
Clonality
Polyclonal
Isotype
IgG
Applications
Our Abpromise guarantee covers the use of ab105743 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Application
Abreviews
Notes
WB
Use a concentration of 1 µg/ml. Predicted molecular weight: 17 kDa.
ELISA
1/8000.
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Target
Function
Is a highly and a specific antagonist of the IL-1 receptor-related protein 2-mediated response to
interleukin 1 family member 9 (IL1F9). Could constitute part of an independent signaling system
analogous to interleukin-1 alpha (IL-1A), beta (IL-1B) receptor agonist and interleukin-1 receptor
type I (IL-1R1), that is present in epithelial barriers and takes part in local inflammatory response.
Tissue specificity
Predominantly expressed in keratinocytes but not in fibroblasts, endothelial cells or melanocytes.
Detected also in the spleen, brain leukocyte and macrophage cell types. Increased in lesional
psoriasis skin.
Involvement in disease
Defects in IL36RN are the cause of psoriasis generalized pustular (PSORP) [MIM:614204].
PSORP is a life-threatening disease defined by repeated flares of sudden onset consisting of
diffuse erythematous skin eruption characterized by rapid coverage with pustules, high-grade
fever, asthenia, marked leukocytosis, and elevated serum levels of C-reactive protein.
Sequence similarities
Belongs to the IL-1 family.
Cellular localization
Secreted.
Anti-IL36RN antibody images
Anti-IL36RN antibody (ab105743) at 1 µg/ml
+ Recombinant Bovine IL-1F5
Secondary
IRDye800™ Conjugated Goat Anti-Rabbit
IgG
Predicted band size : 17 kDa
Additional bands at : 36 kDa. We are
Western blot - Anti-IL1F5 antibody (ab105743)
unsure as to the identity of these extra bands.
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Terms and conditions
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