American Journal of EPIDEMIOLOGY Volume 160 Number 1 July 1, 2004 Copyright © 2004 by The Johns Hopkins Bloomberg School of Public Health Sponsored by the Society for Epidemiologic Research Published by Oxford University Press EDITORIAL Seeing the Forest and the Trees: New Visions in Social Epidemiology Lisa F. Berkman From the Department of Society, Human Development, and Health, Harvard School of Public Health, Boston, MA. Received for publication May 28, 2004; accepted for publication May 28, 2004. Social epidemiology, disguised in other forms and known by other names, has been with us for decades, if not centuries. However, the upcoming issue of Epidemiologic Reviews, the Journal’s sister publication, is devoted to a fresh examination of this area, reflecting the enormous advances that have been made in this field over the last several decades. The contributors to the issue build historically on the body of work that has been produced since the 19th century focused on the health consequences of the political economy and rapid social change (1–4). They add to the work of demographers who described the social forces that shaped mortality, fertility, and population profiles. They advance the work of epidemiologists and social scientists who, early in the 20th century, helped us understand how social and economic conditions influenced the emergence and decline of specific diseases from pellagra and tuberculosis to heart disease (5–8). So, what will you see that is new in this upcoming issue? What have epidemiologists contributed to our understanding of the ways in which society influences population health? In the broadest sense, social epidemiologists are able to see both the forest and the trees. At the macro level, the authors frame the social determinants of population health. At the level of the “trees,” they start to identify during which periods of human development these conditions become “embodied” to influence biology and the ways in which they interact with other risks to shape the course of disease. They emphasize a number of recent theoretical and methodological issues that advance epidemiology as a whole. Discussions of multilevel analysis (9), integration of group and individual-level exposures (10), human development and life-course approaches (11), and identification of mediating pathways (12) dominate the volume. Increasing use of causal modeling, counterfactuals, and a fuller use of experimental and quasi-experimental study designs are discussed (13). These topics are central to the entire field of epidemiology, not just to social epidemiology. The authors address the major health issues of our time—new infectious diseases such as human immunodeficiency virus/acquired immunodeficiency syndrome (14), health in developing countries (15), the growing epidemic of diabetes mellitus (16), mental disorders (17), substance abuse (18), and human growth and development (19). Again, the relevance for all epidemiologists is striking. Social epidemiologists are developing new frameworks with which to examine the etiology of disease, patterns of population health, and modes of intervention. They are able to integrate “upstream” social dynamics and ecologic exposures with “downstream” biologic responses and interactions into their modeling of disease causation. The “black box” approach typical of earlier epidemiologic investigations (20, 21) is being transformed. Social and environmental contexts in which behaviors and risks are shaped are becoming clearer. These approaches hold promise for all of us as we search for ways to understand and ultimately to improve population health. I trust that you will find the upcoming issue of Epidemiologic Reviews on social epidemiology (to be published along with this July 1, 2004, issue of the Journal) helpful to you as you frame your ideas about research and training. Correspondence to Dr. Lisa F. Berkman, Department of Society, Human Development, and Health, Kresge 709, Harvard School of Public Health, 677 Huntington Avenue, Boston, MA 02115 (e-mail: lberkman@hsph.harvard.edu). 1 Am J Epidemiol 2004;160:1–2 2 Berkman REFERENCES 1. Villerme LR. De la mortalite dans divers quarters de la ville de paris. Annales d’hygiene publique 1830;3:294–341. 2. Virchow R. Report on the typhus epidemic in Upper Silesia. In: Rather LJ, ed. Collected essays on public health and epidemiology. Canton, MA: Science History Publications, 1848:205–20. 3. Engels F. The condition of the working class in England (1845). Stanford, CA: Stanford University Press, 1958. 4. Durkheim E. Suicide. Reprint ed. (1897). New York, NY: Free Press, 1951. 5. Frost WH. How much control of tuberculosis? Am J Public Health 1937;27:759–66. 6. Goldberger J, Wheeler GA, King WI, et al. A study of endemic pellagra in some cotton-mill villages of South Carolina. Washington, DC: Hygienic Laboratory, 1929. (Bulletin no. 153). 7. Sydenstricker E. Health and environment. New York, NY: McGraw-Hill, 1933. 8. Faris REL, Dunham HW. Mental disorders in urban areas. Chicago, IL: University of Chicago Press, 1939. 9. Subramanian SV, Kawachi I. Income inequality and health: what we have learned so far? Epidemiol Rev 2004;26:78–91. 10. Diez Roux AV. The study of group-level factors in epidemiology: rethinking variables, study designs, and analytical approaches. Epidemiol Rev 2004;26:104–11. 11. Galobardes B, Lynch JW, Davey Smith G. Childhood socioeconomic circumstances and cause-specific mortality in adulthood: systematic review and interpretation. Epidemiol Rev 2004;26:7–21. 12. Kaplan GA. What’s wrong with social epidemiology, and how can we make it better? Epidemiol Rev 2004;26:124–35. 13. Berkman LF. Introduction: seeing the forest and the trees— from observation to experiments in social epidemiology. Epidemiol Rev 2004;26:2–6. 14. Poundstone KE, Strathdee SA, Celentano DD. The social epidemiology of human immunodeficiency virus/acquired immunodeficiency syndrome. Epidemiol Rev 2004;26:22–35. 15. Myer L, Ehrlich RI, Susser ES. Social epidemiology in South Africa. Epidemiol Rev 2004;26:112–23. 16. Brown AF, Ettner SL, PietteJ, et al. Socioeconomic position and health among persons with diabetes mellitus: a conceptual framework and review of the literature. Epidemiol Rev 2004; 26:63–77. 17. Muntaner C, Eaton WW, Miech R, et al. Socioeconomic position and major mental disorders. Epidemiol Rev 2004;26:53– 62. 18. Galea S, Nandi A, Vlahov D. The social epidemiology of substance use. Epidemiol Rev 2004;26:36–52. 19. Krieger N, Davey Smith G. “Bodies count,” and body counts: social epidemiology and embodying inequality. Epidemiol Rev 2004;26:92–103. 20. Cook T. Why education evaluators chose not to do randomized experiments. Ann Am Acad Polit Soc Sci 2003;589:114–49. 21. Susser M, Susser E. Choosing the future for epidemiology. II. From black box to Chinese boxes and eco-epidemiology. Am J Public Health 1996;86:674–7. Am J Epidemiol 2004;160:1–2