Table of Contents Technology Transfer Advisory Committee . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 2 Message from the Executive Director . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 3 Technology Transfer Activity and Financial Information: Introduction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 4 Technology Transfer Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Invention Reporting . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 5 Patent Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 6 Licensing and Related Activity . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 8 Startup Company Formation . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 13 Technology Transfer Income . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Total Income From Licensing . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 14 Royalty and Fee Income . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 16 Payments to Joint Holders . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Income Associated With Patent/Legal Expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 17 Technology Transfer Expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Legal and Other Direct Expenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 18 Income Distributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Inventor Shares . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 General Fund Share . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Research Allocation Share . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 Income After Mandatory Distributions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 21 UC Technology Transfer on the Web . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 28 1 2010 Technology Transfer Advisory Committee General oversight of the UC Technology Transfer Program is under the purview of the Technology Transfer Advisory Committee (TTAC). This standing committee is chaired by the Executive Vice President for Academic Affairs, and meets periodically to advise the UC President on technology transfer policy and guide the direction of the overall program. Barbara H. Allen-Diaz Associate Vice President, Agricultural & Natural Resources, UCOP Kathryn A. Atchison Vice Provost, Intellectual Property and Industry Relations, and Associate Vice Chancellor for Research, UCLA Steven V.W. Beckwith Vice President for Research and Graduate Studies, UCOP Alan B. Bennett Professor, Plant Sciences, UCD Arthur B. Ellis Vice Chancellor for Research, UCSD Sherylle Mills Englander Director, Office of Technology & Industry Alliances, UCSB Cheryl A. Fragiadakis Department Head, Technology Transfer and Intellectual Property Management, LBNL Warren M. Gold Professor, Medicine, UCSF Charles F. Louis Vice Chancellor for Research, UCR Bruce H. Margon Vice Chancellor for Research, UCSC Richard Miller Associate Vice Chancellor for Research, UCM Lawrence H. Pitts Provost and Executive Vice President for Academic Affairs, UCOP Michael Reese Associate Vice President—Business Operations, UCOP Hans Schöllhammer Professor, Global Economics & Management, UCLA P. Martin Simpson, Jr. Managing Counsel, Office of the General Counsel, UCOP William T. Tucker Executive Director, Innovation Alliances and Services, UCOP Mark W. Warner Associate Vice Chancellor for Administration, UCI A. Eugene Washington Executive Vice Chancellor & Provost, UCSF FISCAL YEAR 2010 Office of the President Executive Vice President, Academic Affairs Innovation Alliances and Services 1111 Franklin Street, 5th Floor Oakland, CA 94607-5200 2 Message from the Executive Director The Obama Administration has made enhancing the commercialization of research from universities and National Laboratories a cornerstone of its innovation strategy. The Office of the President, through Innovation Alliances and Services and through Research Policy, Analysis and Coordination, in coordination with our campus colleagues, has actively participated in this process and UC’s contribution to the national dialog has been recognized by Administration officials. The value generated by UC’s research enterprise to the economic future of our regions, State, and nation is undisputed, but we are increasingly being challenged to both increase and document our impact. This year, UC’s technology transfer program continued to generate significant public benefits, creating new bridges between the University and private industry with notable growth of its overall portfolio of inventions, patents, licenses and startups in spite of serious on-going challenges both in the broader economy and in UC’s budget. UC’s portfolio of active inventions increased by 5.8% to 9,883, while the number of U.S. patents owned by UC increased by 5.1% to 3,802. Active license agreements increased 2.6% to 1,983; and inventions covered by a utility license, option, or letter of intent increased by 2.2% to 2,648. Total income from technology transfer (net of legal settlements) available for distributions to inventors and the University reached a record level of $92.8 million this year, an increase of $10.0 million over the previous year. The increases in these categories points to the continuing strength of our programs. Technology-centric small businesses are a key to economic growth and are the agents of technological change. Many of these companies have their origin in technologies created in university research laboratories. They can create paradigm shifts that transform existing industries, or create entirely new ones. UC is continuing to do its part in spawning startups and supporting the entrepreneurial aspirations of our researchers. In fiscal year 2010, 75 startup companies were founded on UC technologies, as compared to 49 companies in the previous year. Of these 75 companies, 62 are based in California, further emphasizing UC’s contribution to the State’s economy. In our ongoing efforts to implement the Technology Transfer Advisory Committee (TTAC) subcommittee report on metrics for technology transfer operations, this Annual Report includes some additional analyses. We have begun reporting invention disclosures and utility agreements normalized by research expenditures as reported to the NSF (Exhibits 2 and 11 respectively). Also, we have provided additional detail on the nature of agreements with companies seeking to exploit UC-based technologies, in part to reflect the new ways in which campus licensing offices interact with the business community. We hope that this report better reflects their efforts to create public benefit from the breakthroughs made by of UC’s world-leading researchers. Sincerely, William Tucker Executive Director, Innovation Alliances and Services 3 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION INTRODUCTION This document reports technology transfer activity and associated financial results arising under the University of California’s Patent Policy for Fiscal Year 2010. UC’s technology transfer program, administered by the offices listed on the right, operates under a model of distributed responsibilities and authorities that balances activities carried out by the central UC Office of the President (UCOP) with activities carried out by offices at the individual UC campuses and at the Lawrence Berkeley National Laboratory (LBNL), a U.S. Department of Energy (DOE) Laboratory managed by the University. University of California Technology Transfer Offices UC Office of the President (UCOP) Innovation Alliances and Services (IAS) ...................................................................................................... UC Berkeley (UCB) Office of Intellectual Property & Industry Research Alliances (IPIRA) ...................................................................................................... UC Davis (UCD) UC Davis InnovationAccess ...................................................................................................... Under this distributed approach, the campuses and LBNL develop and shape technology licensing programs to fit their unique needs as put forth in memoranda of understanding negotiated with UCOP. In all instances, UCOP retains responsibility for certain functions, such as policy development and guidance, legal oversight, legislative analysis, information management and a variety of other services in support of the overall program. UC Irvine (UCI) Office of Technology Alliances (OTA) UCOP’s activities are coordinated by the Innovation Alliances and Services (IAS) unit within UCOP’s Office of Research and Graduate Studies. Although LBNL manages most of its own inventions, IAS oversees a small portfolio of older inventions from LBNL and another DOE Laboratory historically associated with UC, the Lawrence Livermore National Laboratory. Most of these cases have co-inventors from the UC campuses. Also, IAS manages a portfolio of inventions for UC Merced. UC Riverside (UCR) Office of Technology Commercialization (OTC) ...................................................................................................... UC Los Angeles (UCLA) Office of Intellectual Property & Industry Sponsored Research (OIP-ISR) ...................................................................................................... UC Merced (UCM) Office of Technology Transfer (OTT) ...................................................................................................... This Annual Report covers two distinct technology portfolios: the UC campus portfolio and the LBNL portfolio. Information relating to these two portfolios is reported separately because certain aspects of technology transfer are different at LBNL as compared to the rest of the University. These differences include a reporting period for LBNL that covers a fiscal year ending Sept. 30, 2010, as compared to June 30, 2010, for the rest of the University. Also, while LBNL manages intellectual property in a way that is generally consistent with the principles and practices of the rest of UC, there are some important operational differences, such as LBNL’s greater use of inhouse patent attorneys. A summary of technology transfer activity and associated financial results for both portfolios can be found in Exhibits 28 through 33. 4 ...................................................................................................... UC Santa Barbara (UCSB) Office of Technology & Industry Alliances (TIA) ...................................................................................................... UC Santa Cruz (UCSC) Office for Management of Intellectual Property (OMIP) ...................................................................................................... UC San Diego (UCSD) Technology Transfer Office (TTO) ...................................................................................................... UC San Francisco (UCSF) Office of Technology Management (OTM) ...................................................................................................... Lawrence Berkeley National Laboratory (LBNL) Technology Transfer and Intellectual Property Management (TTIPM) TECHNOLOGY TRANSFER ACTIVITY Invention Reporting During the 12-month period ending June 30, 2010, 1,565 inventions were disclosed by faculty and researchers at the 10 UC campuses; an increase of 5.6% over the number of inventions reported in FY09 (Exhibit 1). As shown in Exhibit 2, the number of disclosures relative to research expenditures has remained quite stable over time, currently at around 3.3 invention disclosures per $10 million in research expenditures. During the 12-month period ending Sept. 30, 2010, 127 inventions were disclosed by inventors at LBNL, an increase of 18 inventions from the 109 disclosed in FY09. Exhibit 1: Invention Disclosures* 1600 1400 1200 1,411 UC Davis increased its new disclosures by 73 inventions (from 172 in FY09 to 245 in FY10). Other campuses with increases included UC Berkeley, with an increase of 11 inventions (from 131 in FY09 to 142 in FY10); UC Irvine, with an increase of 13 inventions (from 112 to 125); UC Los Angeles, with an increase of 46 inventions (from 333 to 379); UC Merced, with an increase of one invention (from 21 to 22); and UC Santa Cruz, with an increase of four inventions (from 27 to 31). Exhibit 3 shows the campus distribution of newly reported inventions for FY10. 1,497 1,482 1,565 Exhibit 2: Invention Disclosures Per $10 Million Research Expenditures* 1,308 1000 4 800 600 3 400 3.34 3.42 3.46 FY06 FY07 FY08 3.27 3.29 FY09 FY10 200 0 2 FY06 FY07 FY08 FY09 FY10 1 * Invention disclosures managed by IAS and by the campus offices. See Exhibit 32 for LBNL’s invention disclosures. 0 * The number of inventions managed by IAS and by the campus offices that were disclosed during the fiscal year, divided by a five-year running average of the research expenditures data reported annually to the National Science Foundation/Division of Science Resources Statistics for its Survey of Research and Development Expenditures at Universities and Colleges. Five-year running averages are calculated as the sum of the expenditures for the fiscal year and the four preceding fiscal years, divided by five. 5 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Patent Activity Exhibit 3: Invention Disclosures by Campus* Year Ending June 30, 2010 UC has received more U.S. patents than any other university in the world. A patent is a form of legal protection granted by the U.S. or a foreign government that gives a patent holder the right to exclude others from making, using, selling, offering for sale or importing the patented invention for a defined period of time, generally 20 years from the date the patent application is first filed. Both U.S. and foreign patent rights often must be pursued for an invention in order to maximize the likelihood of successful commercialization. UCSF 152 UCB 142 UCD 245 UCI 125 Acquiring adequate patent coverage for all aspects of a new technology UCLA 379 UCM 22 UCR 54 UCSB 71 UCSC 31 UCSD 367 * Inventions having inventors from more than one campus are counted multiple times, once for each campus with an inventor. As of June 30, 2010, the systemwide invention portfolio (excluding LBNL) was comprised of 9,883 active inventions. The total for each campus invention portfolio is indicated in Exhibit 4. Exhibit 4: Total Active Inventions by Campus* As of June 30, 2010 UCB 1,173 UCD 1,017 UCI 6 803 UCLA 1,837 UCM 60 UCR 288 UCSB 631 UCSC 163 UCSD 2,660 UCSF 1,416 * Inventions associated with inventors from more than one campus are reported multiple times in this exhibit. may require more than one patent filing for a given invention. Often, a first filing in the U.S. takes the form of a provisional application, a type of filing which preserves U.S. patent rights and secures the benefits of an early filing date for a period of 12 months at a relatively low cost as compared to the cost of filing a regular application. A provisional filing is likely to be made during the time period when the invention is being marketed to potential licensees. Once a license agreement is in place, the licensee usually bears the cost of seeking and maintaining patent protection. Secondary filings frequently lead to the issuance of multiple patents related to a single invention. In addition to being needed for converting a provisional filing into a regular filing, secondary filings are often necessary in order to cover all aspects of the invention and to secure the broadest possible patent protection for it, and may include the filing of divisional applications and of continuation applications where new matter is added. Several years will elapse between a filing and the issuance of a patent by the patent office. Exhibit 5 presents the patent activity at the ten UC campuses for FY10. The number of U.S. first filings decreased by 1.2% compared to 651 in FY09, while the number of secondary filings increased by 3.1% from 524 in FY09. Foreign patents issued decreased by 34.4% from 503 in FY09. Exhibit 5: Patent Activity* Year Ending June 30, 2010 U.S. Applications Filed First Filings—Provisional . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 609 First Filings—Regular . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 34 Secondary Filings—Provisional . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 112 Secondary Filings—Regular . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 428 Total . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,183 Subtotal—First Filings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 643 Subtotal—Secondary Filings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 540 Subtotal—Provisional Filings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 721 Subtotal —Regular Filings . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 462 First Foreign Filings** . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 272 US Patents Issued . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 297 Foreign Patents Issued . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 330 * Patent activity related to inventions managed by IAS and by the campus offices. See Exhibit 32 for LBNL’s patent activity. ** An invention is counted only one time in the first foreign filings category regardless of the number of countries in which foreign patent protection is sought. LBNL’s patent activity is shown in Exhibit 32. U.S. patent filings for the fiscal year ending Sept. 30, 2010, increased by 0.7% over FY09, from 141 to 142. These included 106 first filings, of which 56 were provisional filings; and 36 secondary filings, of which 17 were provisional filings. A total of 27 U.S. patents were issued during the fiscal year ending Sept. 30, 2010 for LBNL inventions, as compared to 26 U.S. patents issued for LBNL inventions in FY09. At the end of FY10, there were 3,802 active U.S. and 3,659 active foreign patents in the systemwide portfolio for its campus inventions (Exhibit 7). For the first time since the end of FY05, the total number of U.S.-issued patents exceeded the total number of foreign-issued patents. The number of U.S. patents in each campus portfolio is presented in Exhibit 8. Because of the substantial lag time between invention disclosure/filing and patent issuance, UC Merced, which received its first invention disclosure in FY06, has not yet had a patent issued for its inventions. Exhibit 7: Total Active Patents* 4000 Exhibit 6 shows the number of U.S. patents issued in the past five years for campus inventions, with the number of U.S. patents issued increasing 21.7% (from 244 to 297) in FY10 as compared to FY09. 3500 3000 3,757 3,692 3,316 3,425 3,546 3,597 3,617 3,696 3,802 3,659 2500 Exhibit 6: U.S. Patents Issued* 2000 1500 350 1000 331 300 297 250 500 270 224 200 0 244 FY06 U.S. 150 100 FY07 FY08 FY09 FY10 Foreign * Total active patents at year end related to inventions managed by IAS and by the campus offices. 50 0 FY06 FY07 FY08 FY09 FY10 * U.S. patents issued related to inventions managed by IAS and by the campus offices. See Exhibit 28 for LBNL’s U.S. patents issued. 7 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Licensing and Related Activity Exhibit 8: Total Active U.S. Patents by Campus* As of June 30, 2010 UCB 611 UCD 419 UCI 302 UCLA 590 UCM 0 UCR 88 UCSB 361 UCSC 77 UCSD 706 UCSF 711 * Patents associated with inventors from more than one campus are reported multiple times in this exhibit. A license agreement grants a licensee access to a University invention in exchange for the licensee’s commitment to further develop and commercialize the invention and to assist UC in gaining patent protection for the invention, often in multiple countries. The provisions of a license define the rights and responsibilities of the two parties. Utility licenses generally cover useful processes, machines, manufactured items, or compositions of matter protected by utility patents, and are often licensed exclusively. In a typical utility license agreement, UC grants to a licensee access to an early stage invention that is protected by a UC patent or patent application. In other instances, such licenses grant property rights to materials developed by UC. In exchange, the licensee makes a commitment to commercialize the invention and to pay UC agreed-upon fees, including reimbursement of patent expenses and royalty payments when products reach the marketplace. The specific terms of the agreement are determined through negotiations. In contrast, plant licenses cover sexually and asexually reproduced plant varieties, and most are licensed non-exclusively to multiple growers and distributors worldwide. UC works closely with some of its foreign plant licensees to explore opportunities for gaining intellectual property protection and commercializing selected strawberry and other plant cultivars in countries where such intellectual property rights had not been available previously. For utility inventions, certain other shorter-term agreements sometimes are made prior to licensing. A secrecy agreement is used in conjunction with marketing and affords a potential licensee access to confidential information that assists the company in determining if it has an interest in pursuing a license for a given technology. In FY10, UC entered into 604 secrecy agreements for its campus inventions (LBNL entered into 184 secrecy agreements during its fiscal year). A letter of intent is a type of agreement generally used to confirm a company’s intent to negotiate a license and often commits a company to pay certain fees or patent costs while negotiations are underway. Option agreements, playing a similar role to letters of intent, offer a more detailed and formal commitment to protect a potential licensee’s interest in an invention while the potential licensee performs in-depth technical or marketing research. 8 Exhibit 9 shows licensing activity for campus inventions in FY10. With regard to agreements, UC entered into 408 new licenses and related technology transfer agreements, including 142 utility licenses, 69 plant licenses, 41 options, and 156 letters of intent. During its fiscal year, LBNL entered into 6 utility license agreements and 4 option agreements (Exhibit 32). Exhibit 9: Licensing Activity* Exhibit 10: Utility Agreements Issued* 400 358 367 37% 37% 300 357 42% 55% Year Ending June 30, 2010 339 49% 46% 8% 12% 43% 42% FY09 FY10 6% 8% 200 340 57% 13% 45% 100 Agreements Issued Letters of Intent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 156 Options . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41 Utility Licenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 142 Plant Licenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 69 0 * Licensing activity related to inventions managed by IAS and by the campus offices. See Exhibit 32 for LBNL’s licensing activity. Overall, the number of utility agreements (utility licenses, options and letters of intent) issued in FY10 was almost the same as in FY09, decreasing from 340 to 339 (Exhibit 10). The FY10 number remains above the 10-year running average of 329. Although the total number of utility agreements issued in FY10 remained essentially unchanged from that of FY09, the proportion of options among these utility agreements increased from 8% in FY09 to 12% in FY10, while the other categories of utility agreements declined. As shown in Exhibit 11, the number of utility agreements relative to research expenditures has declined in recent years, currently at around 0.71 utility agreements per $10 million in research expenditures. FY07 FY08 Letters of Intent Total Active Licenses (year end) Utility Licenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 1,371 Plant Licenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 612 FY06 Options Utility Licenses 10-year running average of all Utility Agreements** * Utility licenses, options, and letters of intent issued during the fiscal year related to inventions managed by IAS and by the campus offices. ** Sum of utility licenses, options, and letters of intent issued during the fiscal year and the nine preceding fiscal years, divided by 10. Exhibit 11: Utility Agreements Issued Per $10 Million Research Expenditures* 1.0 0.8 0.91 0.88 0.82 0.75 0.6 0.71 0.4 0.2 0.0 FY06 FY07 FY08 FY09 FY10 * The number of utility licenses, options and letters of intent issued during the fiscal year related to inventions managed by IAS and by the campus offices, divided by a five-year running average of the research expenditures data reported annually to the National Science Foundation/Division of Science Resources Statistics for its Survey of Research and Development Expenditures at Universities and Colleges. Five-year running averages are calculated as the sum of the expenditures for the fiscal year and the four preceding fiscal years, divided by five. 9 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Exhibit 12 shows the five-year trend in the number of utility licenses issued, with the 142 utility licenses issued in FY10 representing a 4.1% decrease from FY09. Of these 142 utility licenses, 67 were exclusive licenses and 75 were non-exclusive. The proportion of non-exclusive utility licenses among all utility licenses issued increased from 40% in FY09 to 53% in FY10. Exhibits 13 and 14 show the five-year trend in the total number of active utility and plant licenses for campus inventions. Reversing a previous trend, the total number of active utility licenses increased 2.6% to 1,371 at the close of FY10 as compared to the close of FY09. The total number of active plant licenses continued their upward trend, increasing 2.7% to 612 at the close of FY10 as compared to the close of FY09. Exhibit 12: Utility Licenses Issued* Exhibit 13: Total Active Utility Licenses* 250 1400 197 200 50% 209 45% 150 100 50% 159 148 47% 40% 53% FY06 142 FY07 FY08 1,359 1,336 1,371 FY08 FY09 FY10 1,200 800 53% 600 400 60% 47% FY09 1,315 1000 55% 50 0 1200 200 0 FY10 FY06 FY07 Non-exclusive Utility Licenses Exclusive Utility Licenses * Utility licenses issued during the fiscal year related to inventions managed by IAS and by the campus offices. As of June 30, 2010, the systemwide portfolio (excluding LBNL) totaled 1,983 active licenses, an increase of 2.6% over the total at the close of FY09. The LBNL portfolio totaled 60 licenses as of Sept. 30, 2010. In managing these license agreements, UC must collect monies when due and monitor progress to ensure that the licensees exercise due diligence in developing inventions toward commercial application. * Total utility licenses at year end related to inventions managed by IAS and by the campus offices. Exhibit 14: Total Active Plant Licenses* 600 500 596 612 FY09 FY10 554 550 504 400 300 200 100 0 FY06 10 FY07 FY08 * Total plant licenses at year end related to inventions managed by IAS and by the campus offices. Exhibit 15 shows the total number of active utility licenses associated with each campus. In regard to the distribution of plant licenses among the campuses, UC Davis had 460 active plant licenses at the close of FY10 and UC Riverside had 170. Exhibit 15: Total Active Utility Licenses by Campus* Year Ending June 30, 2010 UCB 280 UCD 108 UCI 84 UCLA 220 UCM 3 UCR 32 UCSB 47 UCSC 11 UCSD 287 UCSF 347 Although a new invention typically is the subject of a new agreement when there is commercial interest in it, various related inventions can be the subject of one agreement and new inventions can also be added to existing agreements. In particular, since UC inventors often make follow-on inventions that are closely related to their earlier work, it is common for existing utility licenses and options to be amended in order to incorporate these follow-on inventions. In FY10, new or amended utility licenses covered 316 campus inventions, while new or amended options covered 102 campus inventions (Exhibit 16). Exhibit 16: Inventions Covered Under Agreements* Year Ending June 30, 2010 Number of Inventions Licensed/Optioned Letters of Intent . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 238 Options . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 102 Utility Licenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 316 Plant Licenses . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 20 * Inventions managed by IAS and by the campus offices that were licensed or optioned during the fiscal year. * Licenses associated with inventors from more than one campus are reported multiple times in this exhibit. 11 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION As shown in Exhibit 17, the total number of campus inventions covered under utility agreements (including licenses, options, and letters of intent) at the close of the fiscal year reached 2,648, an increase of 2.2% over the close of FY09. Exhibit 18 shows the campus distribution of these covered inventions. Exhibit 17: Total Inventions Covered Under Utility Agreements* 2500 2,591 2,648 FY09 FY10 2,431 2000 2,234 2,026 1500 1000 500 0 FY06 FY07 FY08 * Total number of inventions managed by IAS and by the campus offices that are subject to one or more utility licenses, options, or letters of intent as of the close of the fiscal year. Inventions associated with multiple utility agreements are counted only once in this exhibit. Exhibit 18: Total Inventions Covered Under Utility Agreements by Campus* As of June 30, 2010 12 UCB 331 UCD 218 UCI 219 UCLA 522 UCM 20 UCR 72 UCSB 310 UCSC 26 UCSD 483 UCSF 484 * Total number of inventions that are subject to one or more utility licenses, options, or letters of intent as of the close of the fiscal year. Inventions associated with inventors from more than one campus are reported multiple times in this exhibit. Inventions associated with multiple utility agreements are counted only once in this exhibit. Startup Company Formation Exhibit 19: Startup Companies Formed* A technology transfer agreement such as a license, an option or a letter of intent can be significant in spurring formation of new startup companies, with invention rights providing an asset that is highly attractive to venture capitalists and angel investors. In the case of startups involving UC technologies, inventors also frequently play a critical role in founding the company. Furthermore, several UC campuses have programs for facilitating new company formation. Startups based on UC technologies play an important role in California’s economy, especially in biotechnology. A 2003 study of California’s biotech firms found that UC scientists founded one-third of them and that one-fourth 80 of all biotech firms in the U.S. are located within 35 miles of a UC campus.* 0 Since 1976, transfer of UC inventions has played a role in the founding of over 500 startup companies. Exhibit 19 shows recent startup company formation involving UC inventions, with 75 UC startup companies formed in FY10, an increase of 53.1% over FY09. Exhibit 20 shows FY10 startup company formation by campus, with UC Los Angeles accounting for over a third of FY10’s activity. 75 60 40 42 41 FY06 FY07 48 49 FY08 FY09** 20 FY10 * Year of startup company formation based on the execution date of the first license, option, or letter of intent granting rights to a UC invention managed by IAS or by a campus office. Prior to FY10, some campuses did not report company formation based on the execution of letters of intent. ** The number of startup companies formed in FY09 has been adjusted upwards in this exhibit from the 47 companies reported in the FY09 Annual Report to 49 to include two additional companies that were founded based on UCSF inventions. Exhibit 20: Startup Companies Formed by Campus* Year Ending June 30, 2010 UCB 6 UCD 9 UCI 7 UCLA 27 UCM 0 UCR 2 UCSB 6 UCSC 0 UCSD 13 UCSF 7 * Year of startup company formation based on the execution date of the first license, option, or letter agreement. * Yarkin, C., & Murray, A. (2003). Assessing the Role of the University of California in the State’s Biotechnology Economy: Heightened Impact Over Time. UC Industry-University Cooperative Research Program Working Paper Series. 13 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION TECHNOLOGY TRANSFER INCOME Total Income From Licensing Total income from licensing for UC’s campus inventions—the income the University receives from its technology agreements with industry— was $125.3 million in FY10 (Exhibit 21). This FY10 total licensing income represents a 3.2% increase over FY09 total licensing income if one excludes $4.6 million received in FY09 for up-front payments in settlement of litigation and for settlement-related reimbursements of legal expenses. There are two components of total licensing income. The royalty and fee income component includes: agreement issue fees, maintenance fees, and other “milestone” payments received on specific dates or at specific points in the product development process. These payments encourage companies to diligently pursue product commercialization. Generally, earned royalties account for the largest portion of royalty and fee income and are received once products and processes using UC inventions reach the marketplace. Reimbursements, the second component of total licensing income, represent the recovery of patent and legal expenses. In the case of pharmaceutical and medical device inventions, successful commercialization requires completion of a lengthy multi-stage process for securing regulatory approval of a licensee’s products from the U.S. Food and Drug Administration. Thus, the introduction of a new FDAapproved product into the marketplace is a significant event. In April of 2010, a UC San Francisco invention achieved this status with a UC startup company’s introduction of a capsaicin patch for the topical treatment of neuropathic pain. This invention also ranked among the top earning UC inventions of FY10 as noted in the next section. Exhibit 21: Total Licensing Income* (Millions) 140 $128.4 120 $110.0 100 16.5 80 93.5 $116.9 24.2 19.3 97.6 104.2 $121.4 22.7 98.7 $125.3 20.8 104.4 60 40 20 0 FY06** FY07 FY08*** FY09**** FY10 Patent/legal reimbursements Royalty and fee income * Total licensing income consists of two components: royalty and fee income, and patent/ legal reimbursements. This exhibit shows total licensing income for inventions managed by IAS and by the campus offices. The totals reported here for each fiscal year have been rounded. See Exhibit 33 for LBNL’s royalty and fee income. ** The total licensing income reported for FY06 ($110 million) does not include an up-front payment of $100 million from the settlement of litigation. *** The total licensing income reported for FY08 ($128.4 million) does not include up-front payments and reimbursements of $42.6 million from the settlement of litigation. **** The total licensing income reported for FY09 ($121.4 million) does not include up-front payments and reimbursements of $4.6 million from the settlement of litigation. 14 Exhibit 22 shows the amount each campus contributed to FY10 total licensing income. While most campuses experienced declines, UC Los Angeles’s contribution to total licensing income rose 12.0% from $29.2 million in FY09 to $32.7 million in FY10. Other campuses with increases from FY09 to FY10 were UC Merced ($63,000 to $132,000) and UC Riverside ($2.5 million to $3.6 million). Exhibit 22: Total Licensing Income by Campus* Year Ending June 30, 2010 (Thousands) UCB $6,778 UCD $10,399 UCI $5,261 UCLA $32,689 UCM $132 UCR $3,596 UCSB $4,309 UCSC $286 UCSD $25,371 UCSF $29,134 Other** $7,304 * Total licensing income consists of two components: royalty and fee income, and patent/ legal reimbursements. ** Total licensing income, primarily from a portfolio of IAS-managed DOE Laboratory inventions, most disclosed prior to the establishment of the Laboratory-based licensing offices. 15 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Royalty and Fee Income Royalty and fee income for campus inventions in the fiscal year ending June 30, 2010, was $104.4 million. This income derived from 1,811 inventions. As compared to FY09, royalty and fee income (excluding $4.4 million for up-front payments in settlement of litigation that were received in FY09) increased by $5.7 million. Exhibit 23: UC Top-Earning Inventions* Year Ending June 30, 2010 (Thousands) Invention (Campus, Year Disclosed) Royalty & Fee Income Hepatitis-B Vaccine (SF, 1979 & 1981) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $12,179 Treatment of Intracranial Aneurysms (LA, 1989) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $10,318 Interstitial Cystitis Therapy (SD, 1980) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $7,813 In FY10, $1,091,932 was realized from the sale of equity previously acquired under nine license agreements, an increase of 78.2% over the equity income realized in FY09. Because of these transactions and the approval of 14 licenses in FY10 that included equity as partial consideration, at the end of the fiscal year UC held equity related to technology transfer activities in 113 companies. Royalty and fee income from the top five commercialized UC inventions (i.e., inventions that had reached the marketplace) contributed $43.2 million in FY10, accounting for 41.4% of total royalty and fee income (Exhibit 23). The top 25 inventions collectively accounted for $71.1 million or 68.1% of total royalties and fees. An invention appearing on this list for the first time is Topical Capsaicin for Pain from UC San Francisco. For the fiscal year ending Sept. 30, 2010, LBNL-managed inventions generated $1.9 million in royalty and fee income for licenses that are under the patent policy, a decrease of 29.0% over the prior year. Copyright income for LBNL decreased 19.0% from $851,000 to $689,000 as compared with FY09 (Exhibit 33). EGF Receptor Antibodies (SD, 1983) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $6,492 Chromosome Painting (LLNL, 1985, 1989 & 1995) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $6,365 Subtotal (Top 5 Inventions) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $43,167 Bovine Growth Hormone (SF, 1980) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $5,015 Biodegradable Implant Coils (LA, 1998) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $3,035 Firefly Luciferase (SD, 1984) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $2,472 Camarosa Strawberry (DA, 1992) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $2,243 Tango Mandarin (RV, 2005) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .$1,846 Albion Strawberry (DA, 2004) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $1,506 Dynamic Skin Cooling Device (IR, 1993) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $1,453 Energy Transfer Primers (BK, 1994) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $1,361 Topical Capsaicin for Pain (SF, 2000) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $1,217 Detection of Mycoplasma (IR, 1984) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $1,041 Aids for Learning Disabled (SF, 1994) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $861 Ventana Strawberry (DA, 2001) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $834 Optical Network Switch (DA, 1997) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $723 Vesicle Loading Method (LBNL, 1984) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $700 Genomic Microarrays (SF, 1995) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $686 Comparative Genomic Hybridization (SF, 1992) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $686 Yeast Expression Vector (SF, 1982) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $616 Magnetic Resonance Imaging (SF, 1976) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $598 Feline AIDS Virus Diagnostic (DA, 1986) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $539 Universal Oligonucleotide Spacer (BK, 1996) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $510 Subtotal (Top 25 Inventions) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $71,109 Total (All Inventions) . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . $104,373 % of Total from Top 5 Inventions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 41.4% % of Total from Top 25 Inventions . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 68.1% 16 * This list is limited to revenue-generating inventions that have been commercialized. The total income from royalties and fees shown here excludes payments from settlement of litigation. ** Because of a tie for 25th place, a total of 26 inventions are listed here. For purposes of calculating “Top 25” total income, only income from one of the 25th place inventions is included. Payments to Joint Holders Income Associated With Patent/Legal Expenses When an invention results from collaboration between UC and non-UC researchers, multiple entities may become joint holders of the inventionrelated patents. In these instances, interinstitutional agreements are often negotiated to establish which entity will manage the patenting and licensing of the invention and the collection and distribution of invention income; such collaborations are relatively common. In FY10, 272 of 1,565 new campus disclosures (17.4%) included non-UC inventors and 68 new interinstitutional agreements were signed, a 19.0% decrease from FY09. Because inventions are highly technical, UC uses specialized outside attorneys to draft and secure patent protection both in the U.S. and abroad. Costs to secure, maintain and protect patent rights associated with an invention are substantial. Obtaining a licensee’s commitment to reimburse these costs is a high priority objective of license negotiations, and reimbursements, therefore, are considered part of total licensing income. In FY10, UC received $20.8 million in patent/legal expense reimbursements related to campus inventions. This is a decrease of 8.3% from reimbursements received for such expenses in FY09 (excluding $0.2 million reimbursements related to legal settlements In FY10, $5.6 million was redistributed to other entities for campus inventions covered by interinstitutional and other income-sharing agreements. For financial reporting purposes, these monies are treated as an offset to income. As shown in Exhibit 24, these redistributions have decreased from FY09 to FY10. received in FY09). Exhibit 24: Payments to Joint Holders* (Millions) $8 6 $5.6 $6.1 $6.2 FY08 FY09 $5.6 $4.3 4 2 0 FY06** FY07*** FY10 * Payments to joint-holders related to inventions managed by IAS and by the campus offices. ** The payments to joint holders reported for FY06 ($5.6 million) do not include payments of $7.9 million for the settlement of litigation. *** The payments to joint holders reported for FY07 ($4.3 million) do not include payments of $0.5 million for the settlement of litigation. 17 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION TECHNOLOGY TRANSFER EXPENSES Legal and Other Direct Expenses Gross legal and other direct expenses totaled $26.9 million in FY10 for campus inventions (Exhibit 25). Most technology transfer legal expenses are associated with patent prosecution and maintenance, defined as payments to outside counsel for drafting patent applications as well as other costs for securing and maintaining patent protection for UC inventions. Other major categories of legal expenses include those for patent interference proceedings, enforcement of patent rights against infringement and defense against litigation in civil proceedings. The extent of reimbursement of legal and other direct expenses is a negotiated term of a license agreement. In FY10, reimbursements of legal expenses for campus inventions totaled $20.8 million, resulting in net legal and other direct expenses of $6.0 million (Exhibit 25). Exhibit 25: Legal Expenses* (Millions) $40 $35.1 30 $32.8 $32.4 $26.9 $26.9 20 $15.8 $10.4 $8.7 10 $9.7 $6.0 0 FY06** FY07 FY08*** FY09**** FY10 Gross legal and other direct expenses Net legal and other direct expenses * Legal and other direct expenses related to inventions managed by IAS and by the campus offices. ** The gross and net legal and other direct expenses reported for FY06 do not include $16.2 million in legal expenses for the settlement of litigation. *** The gross and net legal and other direct expenses reported for FY08 do not include $5.8 million in gross legal expenses and $5.2 million in net legal expenses for the settlement of litigation. **** The gross and net legal and other direct expenses reported for FY09 do not include a credit of $0.9 million against gross legal expenses and do not include $1.2 million in net legal expenses for the settlement of litigation. 18 Exhibit 26 provides a breakdown of FY10 gross legal and other direct expenses by different categories of expenditure. Patent prosecution and maintenance accounted for $26.1 million of gross legal and other direct expenditures (97.1%), while interference and infringement actions accounted for $0.5 million (1.7%), legal defense and other expenditures accounted for $0.3 million (1.2%). As was the case in FY09, patent prosecution activities accounted for a relatively large percentage of gross legal and other direct expenditures in FY10, reflecting the relatively greater reductions in expenditures that have occurred in other expenditure categories since FY07. Exhibit 26: Gross Legal Expenses by Category* It is anticipated that UC’s licensing personnel will continue to be successful in negotiating reimbursement of a substantial amount of patent costs. Nonetheless, it is expected that there will continue to be significant legal and other direct expenses associated with patenting and litigation as the technology transfer program matures, patent activities continue to accelerate, and relationships with inventors, sponsors and licensees become increasingly complex. Information on LBNL patenting and licensing expenses is not provided in this report. In-house patent expenses and operating expenses related to the licensing function are allowable costs under UC’s current contract with DOE and are not readily separable from other LBNL expenses. Year Ending June 30, 2010 Interference & Infringement 1.7% Legal Defense & Other 1.2% Patent Prosecution & Maintenance 97.1% * Gross legal and other direct expenses related to inventions managed by IAS and by the campus offices. The “Net Legal Expenses” exhibit appearing in prior annual reports is not shown this year due to significant net credits against expenses for the “Patent Prosecution & Maintenance” and “Other” categories, which cannot be displayed on a pie chart of expenses. 19 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION INCOME DISTRIBUTIONS The income derived from royalties and fees, less the sum of payments to joint holders and less net legal and other direct expenses, is distributed in various shares as required under UC and campus policies. In FY10, income distributions related to campus inventions totaled $92.8 million, distributed as shown in Exhibit 27. Exhibit 27: Income Distributions* (Millions) 100 80 $89.4 $77.6 33.0 $77.0 38.2 30.0 $92.8 $82.8 38.8 General Fund Share 31.3 35.6 12.6 10.0 35.2 38.8 13.6 10.7 38.9 20 0 1.4 0.7 FY06** FY07 2.5 FY08*** 3.2 FY09**** 12.1 3.0 Inventor shares Research allocation share General fund share * Income distributions related to inventions managed by IAS and by the campus offices. The totals reported here for each fiscal year have been rounded. ** The distributions reported for FY06 do not include a general fund distribution of $10.5 million, inventor share distributions of $29.1 million, nor income after mandatory distributions of $36.2 million related to the settlement of litigation. *** The distributions reported for FY08 do not include a general fund distribution of $6.0 million, inventor share distributions of $12.9 million, nor income after mandatory distributions of $18.0 million related to the settlement of litigation. **** The distributions reported for FY09 do not include a general fund distribution of $0.8 million, inventor share distributions of $2.3 million, nor income after mandatory distributions of $2.4 million related to the settlement of litigation. 20 The portion of UC’s technology transfer income allocated to the UC General Fund totaled $12.1 million in FY10 (Exhibit 27). The General Fund share is equal to 25% of the amount remaining after deducting payments to joint holders, net expenses and inventor share payments from royalty and fee income. FY10 Income after mandatory distributions UC Patent Policy grants inventors the right to receive a portion of net income accruing to individual inventions. In FY10, 2,092 inventors received a total of $38.9 million for IAS- and campus-managed inventions. Under current policy, inventors receive 35% of net invention income. Inventor shares are calculated based on invention income and expense activity through the close of the prior fiscal year. Thus, most of the inventor shares distributed in FY10 were calculated based on invention financial activity through June 30, 2009. Trends related to the amount of inventor share payments are reflected in Exhibit 27. 30.2 60 40 Inventor Shares Research Allocation Share The current Patent Policy requires that 15% of net royalty and fee income from each invention be designated for research-related purposes on the inventor’s campus or Laboratory. These monies are used in accordance with plans developed at each campus and Laboratory. The research allocation for campus-related inventions, which is computed based on inventions disclosed on or after Oct. 1, 1997, totaled $3.0 million in FY10 (Exhibit 27). Income After Mandatory Distributions All income derived from royalties and fees remaining after deductions for payments to joint holders, net legal and direct expenses, and other distributions, is available to the campuses subject to certain other campus-specific debits and credits for patent-related activities (not shown). This category combines expenditures that Annual Reports prior to FY07 showed separately as “Operating Expense” and “Campus Share” distributions. Income after mandatory distributions totaled $38.8 million in FY10 (Exhibit 27). 21 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Exhibit 28: Systemwide Technology Transfer Activity FY06 – FY10* Fiscal Years Ending June 30 Fiscal Year Comparisons FY06 FY07 FY08 FY09 FY10 % CHANGE (FY09-FY10) Inventions Inventions Disclosed Total Active Inventions (year end) 1,308 7,513 1,411 8,272 1,497 8,953 1,482 9,343 1,565 9,883 5.6% 5.8% Patent Prosecution U.S. Applications Filed First Filings Secondary Filings Total U.S. Patents Issued Total Active U.S. Patents (year end) 714 470 1,184 270 3,316 644 564 1,208 331 3,425 623 530 1,153 224 3,546 651 524 1,175 244 3,617 643 540 1,183 297 3,802 -1.2% 3.1% 0.7% 21.7% 5.1% First Foreign Filings Total Active Foreign Patents (year end) 361 3,692 315 3,757 276 3,597 277 3,696 272 3,659 -1.8% -1.0% 132 29 197 115 136 22 209 73 151 47 159 101 166 26 148 63 156 41 142 69 -6.0% 57.7% -4.1% 9.5% 61 1,200 550 69 1,315 504 91 1,359 554 102 1,336 596 113 1,371 612 10.8% 2.6% 2.7% 258 68 329 36 253 59 404 37 223 157 369 24 290 80 356 38 238 102 316 20 -17.9% 27.5% -11.2% -47.4% 402 137 1,589 94 409 156 1,772 95 418 242 1,910 98 493 265 2,001 105 469 288 2,039 114 -4.9% 8.7% 1.9% 8.6% 42 41 48 75 53.1% Licensing Agreements Issued Letters of Intent Options Utility Licenses Plant Licenses Total Active Agreements (year end) Options Utility Licenses Plant Licenses Inventions Covered Under Agreements Inventions Covered Under Letters of Intent Inventions Optioned Inventions Licensed (utility) Inventions Licensed (plant) Total Inventions Covered Under Agreements (year end) Inventions Covered Under Letters of Intent** Inventions Optioned** Inventions Licensed (utility)** Inventions Licensed (plant) Startup Companies Startup Companies Formed 49*** Exhibit 28 reports only technology transfer activity governed by the UC Patent Policy for inventions managed by IAS and by the campus offices. It does not include copyright and material transfer agreement activity that is also carried out by the campus offices. * Technology transfer activity related to a small number of DOE Laboratory inventions managed by IAS is also reflected in these figures. See Exhibit 32 for technology transfer activity related to inventions managed by LBNL’s technology transfer office. ** An invention may be covered by more than one type of utility agreement (utility license, option, and letter of intent), so the sum of these figures for a fiscal year may exceed the values reported in Exhibit 17. *** The number of start-up companies formed in FY09 has been adjusted upwards in this exhibit from the 47 companies reported in the FY09 Annual Report to 49 to include two additional companies that were founded based on UCSF inventions. 22 Exhibit 29: Systemwide Financial Activity FY06 – FY10* Fiscal Years Ending June 30 (Thousands) Fiscal Year Comparisons FY06 FY07 FY08 FY09 FY10 % CHANGE (FY09-FY10) Income from Royalties and Fees Less: Payment to Joint Holders Adjusted Gross Income (A) $193,500 (13,464) 180,036 $97,594 (4,798) 92,796 $146,314 (6,114) 140,200 $103,105 (6,217) 96,888 $104,435 (5,641) 98,794 1.3% -9.3% 2.0% Legal and Other Direct Expenses Less: Reimbursements Net Legal Expenses (B) (43,136) 16,545 (26,951) (35,087) 19,292 (15,795) (38,602) 24,668 (13,934) (31,486) 22,946 (8,540) (26,866) 20,825 (6,040) -14.7% -9.2% -29.3% Income Available for Distribution (A+B) 153,445 77,001 126,226 88,347 92,753 5.0% Income Distributions Inventor Shares (C) Research Allocation Share (D) General Fund Share (E) Income After Mandatory Distributions (F) Total Income Distributions (C+D+E+F) 60,471 722 23,078 69,174 153,445 35,562 1,380 10,045 30,014 77,001 48,087 2,475 19,545 56,160 126,226 41,106 3,160 11,499** 32,583** 88,347** 38,876 2,984 12,087 38,806 92,753 -5.4% -5.6% 5.1% 19.1% 5.0% Exhibit 29 reports only financial activity (not adjusted for legal settlements) governed by the UC Patent Policy for inventions managed by IAS and by the campus offices. Campus offices also generate income through copyright licenses, material transfer agreements, and through research support committed in conjunction with technology transfer activities. This income is not included in this report. * Financial activity related to a small number of DOE Laboratory inventions managed by IAS is also reflected in these figures. See Exhibit 33 for financial activity related to inventions managed by LBNL’s technology transfer office. The totals reported here for each fiscal year have been rounded. ** These figures have been corrected from those reported in the FY09 Annual Report. 23 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Exhibit 30: FY10 Campus Technology Transfer Activity* Year Ending June 30, 2010 UCB UCD UCI UCLA UCM UCR UCSB UCSC UCSD UCSF 142 1,173 245 1,017 125 803 379 1,837 22 60 54 288 71 631 31 163 367 2,660 152 1,416 Patent Prosecution U.S. Applications Filed First Filings Secondary Filings Total U.S. Patents Issued Total Active U.S. Patents (year end) 64 65 129 37 611 59 42 101 29 419 44 41 85 32 302 153 164 317 47 590 22 18 40 0 0 29 36 65 4 88 54 54 108 39 361 19 12 31 6 77 162 138 300 73 706 48 34 82 36 711 First Foreign Filings Total Active Foreign Patents (year end) 24 476 22 403 14 360 78 604 9 0 17 139 26 61 7 21 46 808 34 835 15 6 11 0 18 7 18 42 10 6 12 0 50 17 35 0 0 0 0 0 1 2 4 27 21 2 3 0 1 0 0 0 20 0 36 0 24 2 27 0 21 280 1 17 108 460 15 84 0 23 220 1 1 3 0 9 32 170 18 47 0 1 11 0 3 287 0 9 347 0 27 6 16 0 19 6 64 13 16 15 19 0 86 36 80 0 0 0 6 0 1 2 3 7 40 34 3 0 1 0 0 0 31 0 89 0 23 3 43 0 88 27 238 0 41 17 166 88 43 19 160 0 91 57 385 0 0 0 20 0 17 19 46 29 95 134 139 0 2 2 24 0 29 2 462 0 66 14 426 0 6 9 7 27 0 2 6 0 13 7 Inventions Inventions Disclosed Total Active Inventions (year end) Licensing Agreements Issued Letters of Intent Options Utility Licenses Plant Licenses Total Active Agreements (year end) Options Utility Licenses Plant Licenses Inventions Covered Under Agreements Inventions Covered Under Letters of Intent Inventions Optioned Inventions Licensed (utility) Inventions Licensed (plant) Total Inventions Covered Under Agreements (year end) Inventions Covered Under Letters of Intent** Inventions Optioned** Inventions Licensed (utility)** Inventions Licensed (plant) Startup Companies Startup Companies Formed Exhibit 30 reports only technology transfer activity governed by the UC Patent Policy for inventions managed by IAS and by the campus offices. It does not include copyright and material transfer agreement activity that is also carried out by the campus offices. 24 * Technology transfer activity related to inventions having one or more inventors at each campus. A number of inventions involve inventors from multiple UC campuses. Technology transfer activity statistics for these inventions are reported multiple times, once for each campus involved. Thus, for any given measure of activity, the sum of individual campus numbers may be greater than the systemwide totals reported elsewhere in this report. ** An invention may be covered by more than one type of utility agreement (utility license, option, and letter of intent), so the sum of these figures for a campus may exceed the values reported in Exhibit 18. Exhibit 31: FY10 Campus Financial Activity* Year Ending June 30, 2010 (Thousands) UCB UCD UCI UCLA UCM UCR UCSB UCSC UCSD UCSF Income from Royalties and Fees Less: Payment to Joint Holders Adjusted Gross Income (A) $4,344 (63) 4,281 $9,048 (23) 9,025 $3,998 (51) 3,948 $27,485 (83) 27,402 $33 0 33 $3,160 (8) 3,152 $2,221 (666) 1,555 $153 0 153 Legal and Other Direct Expenses Less: Reimbursements Net Legal Expenses (B) (3,065) 2,434 (631) (2,136) 1,351 (784) (1,985) 1,262 (723) (6,428) 5,204 (1,224) (365) 99 (266) (1,204) 436 (769) (2,485) 2,088 (397) (238) 134 (104) (4,833) 4,403 (429) (3,501) 3,179 (323) Income Available for Distribution (A+B) 3,649 8,241 3,225 26,178 (233) 2,384 1,158 49 20,080 21,344 Income Distributions Inventor Shares (C) Research Allocation Share (D) General Fund Share (E) Income After Mandatory Distributions (F) Total Income Distributions (C+D+E+F) 1,482 85 542 1,541 3,649 3,628 247 1,153 3,212 8,241 1,818 125 352 931 3,225 9,909 167 4,067 12,035 26,178 11 5 (61) (188) (233) 774 14 402 1,194 2,384 972 227 46 (87) 1,158 22 4 7 16 49 9,104 1,934 2,744 6,298 20,080 9,943 177 2,850 8,374 21,344 $20,968 $25,955 (458) (4,289) 20,510 21,666 Exhibit 31 reports only financial activity (not adjusted for legal settlements) governed by the UC Patent Policy for inventions managed by IAS and by the campus offices. Campus offices also generate income through copyright licenses, material transfer agreements, and through research support committed in conjunction with technology transfer activities. This income is not included in this report. * Financial activity related to inventions having one or more inventors at each campus. A number of inventions involve inventors from multiple UC campuses. Financial activity statistics for these inventions are pro-rated among the campuses according to the number of inventors each campus has. Since some financial activity reported here is credited to UC inventors who are not associated with a campus (including staff at the DOE Laboratories), the sum of individual campus numbers may not equal the systemwide totals reported elsewhere in this report. The totals reported here for each campus have been rounded. 25 TECHNOLOGY TRANSFER ACTIVITY AND FINANCIAL INFORMATION Exhibit 32: LBNL Technology Transfer Activity FY06 – FY10 Fiscal Years Ending Sept. 30 Fiscal Year Comparisons Inventions and Patent Prosecution Inventions Disclosed FY06 FY07 FY08 FY09 FY10 % CHANGE (FY09-FY10) 80 126 130 109 127 16.5% 56 2 0 16 74 77 0 14 44 135 58 3 11 69 141 55 3 17 66 141 -5.2% 0% 54.5% -4.3% 0% U.S. Applications Filed First Filings—Provisional First Filings—Regular Secondary Filings—Provisional Secondary Filings—Regular Total U.S. Patents Issued 35 25 18 26 27 3.8% First Foreign Filings 21 29 58 14 47 235.7% Licensing Agreements Issued Secrecy Option License 192 2 8 201 2 3 202 9 8 160 7 10 184 4 6 15.0% -42.9% -40% 5 58 8 61 19 61 13 63 5 60 -61.5% -4.8% Total Active Agreements (year end) Option License 26 Exhibit 33: LBNL Financial Activity FY06–FY10* Fiscal Years Ending Sept. 30 (Thousands) Fiscal Year Comparisons Income from Royalties and Fees Patents and Tangible Research Products Copyrights/Software Total Inventor/Author Shares Paid Patents and Tangible Research Products Copyright/Software, Trademark and Other Total FY06 FY07 FY08 FY09 FY10 % CHANGE (FY09-FY10) $2,267 635 2,902 $2,502 716 3,218 $2,702 512 3,214 $2,700 851 3,551 $1,918 689 2,607 -29.0% -19.0% -26.6% 848 139 987 796 169 965 1,021 93 1,115 1,057 267 1,324 3.5% 187.1% 18.7 N.A.** N.A.** N.A.** * In addition to income reported in this table, the IAS-managed portfolio of DOE Laboratory inventions collectively generated $7,065,179 in FY10 royalty and fee income, including $699,929 for LBNL inventions. The totals reported here for each fiscal year have been rounded. ** Starting in FY08, payment of Inventor/Author Shares is deferred until the following year to match the campus inventor share payment schedule. 27 UC Technology Transfer on the Web Available Technologies University of California Technology Transfer—Available Technologies techtransfer.universityofcalifornia.edu Technology Transfer Offices UC Office of the President: Innovation Alliances and Services (IAS) www.ucop.edu/research/ias/ UC Berkeley: Office of Intellectual Property & Industry Research Alliances (IPIRA) ipira.berkeley.edu UC Davis: UC Davis InnovationAccess innovationaccess.ucdavis.edu UC Irvine: Office of Technology Alliances (OTA) www.ota.uci.edu UC Los Angeles: Office of Intellectual Property & Industry Sponsored Research (OIP-ISR) oip.ucla.edu UC Merced: Office of Technology Transfer (OTT) research.ucmerced.edu UC Riverside: Office of Technology Commercialization (OTC) ora.ucr.edu/ip/ UC Santa Barbara: Office of Technology & Industry Alliances (TIA) tia.ucsb.edu UC Santa Cruz: Office for Management of Intellectual Property (OMIP) research.ucsc.edu/intel_prop.shtml UC San Diego: Technology Transfer Office (TTO) invent.ucsd.edu UC San Francisco: Office of Technology Management (OTM) otm.ucsf.edu Lawrence Berkeley National Laboratory: Technology Transfer and Intellectual Property Management (TTIPM) www.lbl.gov/Tech-Transfer/ 28 BERKELEY DAVIS IRVINE LOS ANGELES MERCED RIVERSIDE SAN DIEGO SAN FRANCISCO SANTA BARBARA SANTA CRUZ LAWRENCE BERKELEY University of California Innovation Alliances and Services 1111 Franklin Street, 5th Floor Oakland, CA 94607-5200