ULMSchoolofPharmacy I. Spring2016 COURSETITLE:PHRD5037Eyes/Ears/Nose/Throat/Dermatology ContactInformation(*Preferredmodeofcommunication) CourseCoordinators: TibbF.Jacobs,Pharm.D.,BCPS ClinicalAssociateProfessor Office: ShreveportCampus Phone: 318-632-2007ext225 *Email: jacobs@ulm.edu OfficeHours: M-F2-4pm MichelleZagar,Pharm.D.,M.Ed.,CGP ClinicalAssociateProfessor Office: 113Bienville Phone: 318-342-3173 *Email: zagar@ulm.edu OfficeHours: MW2-4pm;TuTh1-4pm;orbyappointment CourseInstructors: RonaldA.Hill,Ph.D. AssociateProfessorofMedicinalChemistry Office: 310Bienville Phone: 318-342-1706 Email: rhill@ulm.edu *OfficeHours: M12-1,5-6pm;TuTh9:30-10am,11-12,5:30-6pm; W12-12:30,4-5:45pm;F12-1:30pm ChrisGissendanner,Ph.D. AssociateProfessor Office: 362Bienville Phone: 318-342-3314 *Email: gissendanner@ulm.edu OfficeHours: M-Th2-4:30pm SamiNazzal,Ph.D. AssociateProfessorofPharmaceutics Office: 378Bienville Phone: 318-342-1726 Email: nazzal@ulm.edu *OfficeHours: M-Th3-5pm;Fribyappointment StephenHill,Pharm.D. ClinicalAssistantProfessor Office: 117Bienville Phone: 318-342-1730 *Email: shill@ulm.edu OfficeHours: M-Th1-4pm JenniferSmith,Pharm.D. AssistantProfessor Office: BatonRougeCampus Phone: 225-219-9660ext209 *Email: smith@ulm.edu OfficeHours: M12-4pm;Tu-Wed1-4pm;orbyappointment II. CoursePrerequisites/Corequisites EnrollmentinthecourserequirescompletionofPHRD4081,5008,and5010.(InfectiousDisease,Self-Care/Patient AssessmentII,andCardiovascularintegratedmodules)withagradeof“C’orbetter. III. CourseDescription PHRD5037.Eyes/Ears/Nose/Throat/Dermatology.2Cr.PrinciplesofPathophysiology,pharmacology,medicine chemistry,clinicalpharmacokinetics,andpharmacotherapy(includingbothprescriptionandnon-prescription medicationsastheyapplytoEENTanddermatologicdrugtherapymanagement. IV. CurricularObjectivesandOutcomes ProvideComprehensivePatientSpecificPharmaceuticalCare. 1.Evaluatetheappropriatenessofagivenprescriptionormedicationorderbasedonpatientanddisease-specific factors. 3.Developandimplementanevidence-basedcareplan. AppropriatelyManageandUseResourcesoftheHealthCareSystem. 11.Applypatientandpopulationspecificdata,qualityassurancestrategies,andresearchprocesses. ThinkCritically. 24.Identify,retrieve,understand,analyze,synthesize,andevaluateinformationneededtomakeinformed, rational,andethicaldecisions. 25.Solvecomplexproblemsthatrequireanintegrationofone’sideasandvalueswithinacontextofscientific, social,cultural,legal,clinical,andethicalissues. 26.Displayhabits,attitudes,andvaluesassociatedwithmaturecriticalthinking. DemonstrateAppropriateInterpersonal,Professional,andEthicalBehaviors. 27.Maintainprofessionalcompetence. 31.Collaborateproactivelywithotherhealthcareprofessionals. 33.Accepttheresponsibilitiesembodiedintheprinciplesofpharmaceuticalcare. 34.Demonstrateappropriateinterpersonal,intergroup,andcross-culturalbehaviorsthatpromoterespectandtrust frompeers,patients,andcommunitymembers. V. CourseSpecificObjectivesandOutcomes Forthediseasestatescovered,thestudentsshouldbeableto: • Demonstrate knowledge of the medicinal chemistry, pharmacological mechanism of action and related pharmaceuticaltopicsofselectedmedicationsandmedicationclassesusedtotreateye,ear,nose,throat,and dermatologicaldisorders. • Recommendappropriatenon-pharmacologictherapybaseduponpatient-anddiseasespecificinformation. • Recommendappropriatepharmacotherapeuticregimensbaseduponpatient-,disease-,anddrugspecific information. • Developaplanformonitoringthepharmacotherapeuticregimenforefficacy,toxicity,andadverseeffects. • Developaplanforeducatingpatientsandcaregiversregardingtheappropriateuse,safety,andefficacyof medications. • Evaluatetheappropriatenessofpatient-specifictherapyandmodifytherapyasneeded. VI. CourseTopics Thiscoursewilladdressthefollowingtopics:glaucoma,maculardegeneration,dryeyedisease,prescription labelingforvisually-impairedpatients,allergicrhinitis,urticaria,allergyshots,acne,psoriasis,eczema,dermatitis, drug-inducedskinreactions,andnailinfections. VII. InstructionalMethodsandActivities Instructionalmethodsmayinclude:traditionallectures,internet-basedlectureswithin-classdiscussion,distance learning,in-classdiscussionofpatientcases,smallgroupdiscussion,problem-basedlearning,case-basedlearning, andindividualprojects.Quizzesorothergradedin-classexercisesmayalsobeadministered. VIII. EvaluationandGradeAssignment • Therewillbe3exams(includingthefinalexam).Therewillbe10pointsperlecture(or20pointsperclass period). • ExamSoftwillbeusedtoadministerexams;therefore,allstudentsarerequiredtohaveaccesstothe mostcurrentversionofthesoftware. • Quizzesmaybegiven,announcedorunannounced,asdeemednecessarybyeachfacultymember.Thepoints availablefromthesequizzesandassignmentswillbeaddedintothedenominatorforthetotalnumberof pointsavailablefromthecourse,andthecoursegradedeterminedaccordingly. • Allexamswillbefrom10:00-11:50,givenduringtheregularlyscheduledclassperiods. • ExamdatesarescheduledinthecoursesyllabusandwillonlybechangedintheeventofaUniversityclosure. • Examsmaybemultiplechoice,fillintheblank,short-answer,caseorscenariobaseddiscussion,essay,orany otherformatdeemednecessarybythelecturersandcoursecoordinator. • Normallabvalueswillbeprovidedforallquestions,unlessotherwisespecifiedduringclass.Labvaluesthat arespecifictoaparticulardiseasestatewillnotbeprovided. • Informationacquiredfrompreviouslecturesinthecourseandfromothercoursesintheprofessional pharmacycurriculummaybeneededinpreparingfortheseexams. • Examsmaycovermaterial(readings,outsideassignments)notcoveredinclass. • Useofprogrammablecalculatorsorcellularphoneswillnotbeallowedduringquizzesorexams. • Studentsarenotallowedtoleavetheclassroomduringanexamination. • Afterexamshavebeengradedandanitemanalysisperformed,questionsmaybediscardedor otherwiseadjustedatthediscretionoftheCourseCoordinatorinconsultationwiththefacultybefore arrivingatfinalscores. ExamBehavior • Onlyawritinginstrumentandcalculatorshouldbeatyourdesk.Allbookbagsandotherbagsshouldbeleft atthefrontoftheroom. • Cellphonesshouldbeturnedoffandleftwithyourbelongingsinthefrontoftheroom. • Useofprogrammablecalculatorsorcellularphoneswillnotbeallowedduringquizzesorexams. • Studentsarenotallowedtoleavetheclassroomduringanexamination. ToChallengeaTestQuestion • Problemsorissueswithquestion(s)shouldbefirstdirected,viaemail,tothefacultymemberwhopresented thematerial.Pleasecopythecoursecoordinatoronthiscommunication.Intheeventthatthefaculty memberandthestudentcannotarriveatanacceptableconclusion,thecoursecoordinatormaybecome involved. • Studentswishingtochallengeaquestionontheexammustprovideawritten(emailpreferred)statementthat identifiesthequestion(s)beingchallenged,whythestudentfeelshisorheranswer(s)is/arecorrectand referencesfromrecent(publishedwithinlast1-2years)primaryortertiaryliteraturetosupporttheclaim. • Challengesoftestquestionswillonlybeconsideredwithin2weeksofwhentestscoresareposted. Assessmentmethod Points Examinations Exam#1 80 Exam#2 60 Exam#3 80 Assignments/quizzes TBD GradingScale(basedupontotalnumberofpointsforsemester): 90.0-100% A 80.0-89.9% B 70.0-79.9% C 60.0-69.9% D <60.0% F Undergraduatemid-termgradeswillbepostedon-lineforstudentstoviewviaBanner.Mid-termgrades indicateastudent’sstatusatmid-semesteronlyanddonotindicatethefinaloutcomeofastudent. StudentSuccess–EarlyInterventionPolicy Studentsscoring<70%onanyexamandanoverallexamaverage<70%(excludesquizzes,assignments,bonus,etc.) willberequiredtosubmittothecoordinatorwritten,narrativeresponsestoselectlectureobjectivesthatwillbe providedwithin24hoursofthepostingoftheirexamgradetoMoodle.Theseobjectiveswillbeintheformofa Moodleassignmentandrepresentunit-orlecture-levelobjectivestobetesteduponinthenextscheduledcourse exam. Writtenresponsesmustbesubmittednolaterthanonecalendarweekbeforethenextscheduledexam.Responses mustbewrittenincompletesentencesandmaynotbecopiedorpastedfromanysource,includingclassnotes, treatmentguidelines,textbooks,oranyinternetsite.Submissionsfoundtocontainresponsesthathavenotbeen writteninastudent’sownwordswillbeconsideredafailuretosubmit. Inaddition,studentswillberequiredtorevieweachfailedexam’sExamSoft-generatedmisseditemreportwiththe instructorresponsibleforeachsectionofmaterial.Thediscussionshouldincludethestudent’sreasoningforthe incorrectansweraswellasthereasonforthecorrectanswer. Failuretosubmitthisrequiredassignmentwillresultinineligibilitytoremediate. IX. ClassPoliciesandProcedures ATAMINIMUM,ALLPOLICIESSTATEDINTHECURRENTULMSTUDENTPOLICYMANUAL& ORGANIZATIONALHANDBOOKSHOULDBEFOLLOWED(SEEHTTP://WWW.ULM.EDU/STUDENTPOLICY/). ADDITIONALCLASSPOLICIESINCLUDE: A.Textbook(s)andMaterials: i. Required 1. LemkeTL,WilliamsDA,RocheVF,ZitoSW,eds.Foye’sPrinciplesofMedicinalChemistry,7thed., LippincottWilliams&Wilkins,2013.ISBN9781609133450 2. BruntonLL,ChabnerBA,KnollmannBC,eds.GoodmanandGilman’s,ThePharmacologicalBasis ofTherapeutics,12thed.,McGraw-Hill,2011.ISBN9780071624428 3. Chisolm-BurnsM,SchwinghammerTL,WellsBG,MalonePM,KolesarJM,DiPiroJT,eds. Pharmacotherapy:PrinciplesandPractice.3rded,NewYork,McGraw-Hill,Inc.,2013.ISBN 9780071780469 ii.Additionalreadingmaterialsmaybepostedbycoursefaculty. B.AttendancePolicy: Classattendanceisrequired.Classattendanceisregardedasanobligationaswellasaprivilege,andstudents areexpectedtoknowattendanceregulationsandtoattendregularlyandpunctuallyatclassesinwhichthey areenrolled.Failuretodoso:(1)maypreventaccesstotheclassroomduringregularlyscheduledtimes;(2) mayjeopardizeastudent’sscholasticstanding;and(3)mayleadtosuspensionfromtheSchool orUniversity.Studentsshallsubmitexcusesforallclassabsencestoprofessorwithinthreeclassdaysafter returningtoclasses.ProfessorsshallacceptanofficialUniversityexcuse.Withthefollowingexceptions professorsaretodeterminewhetherabsencesareexcusedorunexcused:1)Absencesarisingfromauthorized tripsawayfromtheUniversityorfromspecialdutiesattheUniversityshallbeexcused.2)Absencesarising fromastudent’sconfinementinahospitalorotherin-patientfacilityordoctor’sexcusedabsencesshallbe excused.Studentsareresponsibleforverifyingthisinformationtothefaculty.3)Absencesarisingfromadeath intheimmediatefamilyshallbeexcused.Theimmediatefamilyisdefinedasspouse,child,step-child,mother, father,sister,brother,grandmother,grandfather,step-mother,step-father,step-brother,step-sister,aunt, uncle,mother-in-laworfather-in-law. SoPAttendancePolicy: TheprofessionaleducationalexperienceintheSchoolofPharmacyinvolvesmanymultifacetedlearning objectives,includingprofessionalinteractionswithfacultyandpeers,thatdonotlendthemselvestotraditional testingmodalitiesandassignmentoflettergrades.Asaresult,classattendanceismandatoryinallpharmacy courses.Studentsreportedforaccumulatingmorethanthreeunexcusedabsencesinacourseduringan academicsemesterwillbeadministrativelydroppedfromthecoursewitha“W”grade.Inaccordancewith SchoolofPharmacypolicyandprocedure,agradeof“W”willbecountedasan“F”gradewithrespectto academicstandards. C.Make-upPolicy: Eachstudentisexpectedtoattendeachexamatthedateandtimespecified.Ifastudentcannotattend anexamduetovalidUniversityexcuse,he/shemustspeakdirectlywiththecourse coordinator,assoonaspossible.Thecoursecoordinatormustbenotifiedpriortoan examination(ifastudentmissesanexam).TheULMSoPExcusedAbsencePolicymustbefollowed. Pleaserefertotheofficialdocumentfordetails. (http://www.ulm.edu/pharmacy/documents/ospa/excusedabsence.pdf)Incaseofemergency,thecourse coordinatormustbenotifiedwithin48hoursoftheemergency.Failuretodosowillresultinazero(0)grade forthatexam.Make-upexamswillbepreparedatthesameorhigherlevelthantheoriginalexam.Theformat ofthemake-upexammaybewrittenororal.Failuretoattendascheduledmake-upexamwillresultinazero (0)gradeforthatexam.StudentsmissinganexamduetoaUniversityapprovedexcusewilltakethemake-up examasdeterminedbythecoursecoordinator. D.AcademicIntegrity: FacultyandstudentsmustobservetheULMpublishedpolicyonAcademicDishonesty(seetheULMStudent PolicyManual(http://www.ulm.edu/studentpolicy/).Allprofessionalstudentswilladheretothestandardsset forthintheSchoolofPharmacy’sCodeofConduct. http://www.ulm.edu/pharmacy/documents/ospa/codeofconductv82011.pdf Cheating,plagiarism,orotherinappropriateconductwillnotbetolerated.Academiccheatingincludesbutis notlimitedtotheaccomplishmentorattemptedaccomplishmentofthefollowing: 1. Copyingorobtaininginformationfromanotherstudent'stestpaper.* 2. Using,duringatest,materialsnotauthorizedbythepersongivingthetest.** 3. Collaborating,conspiring,orcooperatingduringanin-classortake-hometestwithanyother personbygivingorreceivinginformationwithoutauthority. 4. Stealing,buying,orotherwiseobtainingallorpartofanunadministeredtest. 5. Sellingorgivingawayallorpartofanunadministeredtestoranyinformationconcerningspecific questionsanditemsonanunadministeredtest. 6. Requesting,bribing,blackmailing,orinanyotherwaycausinganyotherpersontoobtainan unadministeredtestorinformationaboutanunadministeredtestoratestintheprocessof beingadministered. 7. Substitutingforanotherstudent,orpermittinganyotherpersontosubstituteforoneselftotake atest. 8. Submittingasone'sown,infulfillmentofacademicrequirements,anyworkpreparedtotallyorin partbyanotherperson. 9. Anyselling,giving,orotherwisesupplyingtoanotherstudentforuseinfulfillingacademic requirementanywork. 10. Submittingartificiallyproduceddataorinformationintheplaceofdescriptive,experimental,or surveyresults. 11. Anyotherdeviousmeansofsecuringanunearnedgradeinanon-creditcourseorinacourse offeredforcredit. 12. Using,duringatest,anyelectronicstoragedevice,wirelessand/orinternet-basedtechnology,or anyothermeansthatprovidesinformationnotauthorizedforuseduringthetestingperiod. *Astudentlookingonanotherstudent'spaperisconsideredcheating. **Thepresenceonone'sperson(orincloseproximitythereto)ofacondensationoftestinformation whichcouldberegardedasa"cheatsheet"willbeconsideredadequateevidencetoestablish cheating. Plagiarismistheuseofanyotherperson'swork(suchworkneednotbecopyrighted)andthe unacknowledgedincorporationofthatworkinone'sownworkofferedforcredit. Censures(Penalties) AcademicdishonestywillresultinareferraltoCommitteeonEthicalandProfessionalStandards witharecommendationforagradeof“F”forthecourseandexpulsionfromtheSchool. Academicdishonestyincludesbutisnotlimitedtotheuseofinformationtakenfromotherswork orideas,theprovisionofhelptoothersonnon-collaborativeevaluations(tests,quizzes,etc.), collaborationontakehomeexams,ortheuseofunapprovedinformationorelectronicdevices toassistinobtainingananswertothequestion. E.CourseEvaluationPolicy: Studentsareexpectedtocompletetheon-linecourseevaluation.Itisrequestedthattheyalsocompletethe SchoolofPharmacycourseandinstructorevaluations,includingprovidingcomments.Inaddition,individual feedbackisencouragedthroughoutthecourse. F.StudentServices: InformationconcerningstudentservicesintheSchoolofPharmacycanbefoundintheSchoolofPharmacy StudentHandbook.Inparticular,studentsshouldpayspecialattentiontotheSchool’stechnicalstandardsand policiesconcerningstudentswithspecialneeds(http://www.ulm.edu/studentpolicy/studentpolicy.pdf).ULM studentservices,suchasStudentSuccessCenter(http://ulm.edu/cass/),CounselingCenter (http://ulm.edu/counselingcenter/),andStudentHealthServices,isavailableatthefollowingStudentServices websitehttp://ulm.edu/studentaffairs/. Ifyouarehavingproblemswithemotional,social,and/orbehavioralissuespleasecallanyofthementalhealth clinicsontheULMcampustomakeanappointment.AllservicesarefreetoULMstudents,staff,andfaculty, andarestrictlyconfidential. • SoPOfficeofStudentandProfessionalAffairs:342-3800 • ULMCounselingCenter:342-5220 • MarriageandFamilyTherapyClinic:342-5678 • CommunityCounselingCenter:342-1263 • ULMHELPS(HelpingEducatorsandLearnersPreventSuicide)ProjectOffice:342-1335 TheUniversityofLouisianaatMonroestrivestoservestudentswithspecialneedsthroughcompliancewith Sections504oftheRehabilitationActof1973andtheAmericanswithDisabilitiesAct.Theselawsmandatethat postsecondaryinstitutionsprovideequalaccesstoprogramsandservicesforstudentswithdisabilitieswithout creatingchangestotheessentialelementsofthecurriculum.Whilestudentswithspecialneedsareexpected tomeetourinstitution'sacademicstandards,theyaregiventheopportunitytofulfilllearneroutcomesin alternativeways.Examplesofaccommodationsmayinclude,butarenotlimitedto,testingaccommodations (oraltesting,extendedtimeforexams),interpreters,relocationofinaccessibleclassrooms,permissionto audiotapelectures,note-takingassistance,andcoursesubstitutions. TitleIXoftheEducationAmendmentsof1972prohibitssexdiscriminationagainstanyparticipantinan educationalprogramoractivitythatreceivesfederalfunds,includingfederalloansandgrants.Furthermore, TitleIXprohibitssexdiscriminationtoincludesexualmisconduct,sexualviolence,sexualharassmentand retaliation.Ifyouencounterunlawfulsexualharassmentorgender-baseddiscrimination,pleasecontact StudentServicesat318-342-5230ortofileacomplaint,visitwww.ulm.edu/titleix. G.EmergencyProcedures: PleasereviewtheemergencyescapeplanintheclassroomsandhallwaysoftheBienvilleBuilding.Move quicklyandorderlytotheappropriatestairwellandexitthebuilding.Themeetingplaceforthisclasswillbeat theULMSchoolofPharmacysignonthelawninthefrontoftheBienvillebuilding.Undernocircumstancesis theelevatortobeusedforemergencyevacuation.Anystudentneedingassistanceshouldnotifytheprofessor immediately.Anystudentneedingassistanceshouldnotifytheprofessorimmediately.Foremergencies,to contactUniversityPolice,call1-911fromlandlinesand342-5350fromcellphones. H.Discipline/CourseSpecificPolicies: StudentsareresponsibleforallinformationonMoodle®and/orinstructorwebsites.Studentsareexpectedto checkthesesourcesregularlytoaccessclassmaterials,requiredreadings,assignments,andotherinformation necessaryforthiscourse. X. TentativeCourseSchedule Schedule:Friday10:00–11:50AM,Room170 Date Lecture 1/22/16 1 2 1/29/16 3 4 2/5/16 2/12/16 5 6 7 8 2/19/16 2/26/16 3/4/16 3/11/16 9 10 11 12 13 14 3/18/16 3/25/16 4/1/16 4/8/16 4/15/16 4/29/16 5/6/16 Reviewofphysiologyoftheeye PharmacologyofprostaglandinF2-αanalogs(glaucoma);vascular endothelialgrowthfactorinhibitors(maculardegeneration); cyclosporine(dryeye);reviewofantibacterials Chemistryofβblockers,α-2agonists,carbonicanhydraseinhibitors, parasympathomimetics,nonselectiveadrenergicagents(glaucoma) ChemistryofprostaglandinF2-αanalogs(glaucoma);vascular endothelialgrowthfactorinhibitors(maculardegeneration); antibacterialsforbacterialconjunctivitis Formulationconsiderations(includingintravitrealinjections, glaucomadosageforms);cyclosporinefordryeye Glaucoma Glaucoma MacularDegeneration Test1(lectures1-8) DryEye PrescriptionLabelingforVisualImpairment BacterialConjunctivitis Pharmacologyofmastcellstabilizers,leukotrienereceptor antagonists,intranasalcorticosteroids Chemistryofmastcellstabilizers,leukotrienereceptorantagonists, antihistamines,intranasalcorticosteroids AllergicRhinitis/Immunotherapy Exam Points 20 2/12/16 R.Hill R.Hill 20 2/12/16 Nazzal Zagar Zagar Zagar 10 2/12/16 30 2/12/16 Zagar Zagar S.Hill Gissendanner 20 3/11/16 10 10 3/11/16 3/11/16 R.Hill 10 3/11/16 J.Smith 10 3/11/16 Gissendanner Gissendanner Gissendanner 30 4/29/16 R.Hill 10 4/29/16 J.Smith Jacobs S.Hill S.Hill 10 10 20 4/29/16 4/29/16 4/29/16 Gissendanner Gissendanner Due Test2(lectures9-14) SPRINGBREAK SPRINGBREAK 15 16 17 18 4/22/16 Thecoordinators/instructorsreservetherighttoadjustthescheduleasneeded. Topic Instructor 19 20 21 22 ImmunologyReview Immunotherapy Pharmacologyoftopicalretinoids,biologicagents,antifungals(nail infections) Chemistryoftopicalretinoids,biologicagents,antifungals(nail infections) NailInfections Eczema/Dermatitis DrugInducedSkinReactions Acne/Psoriasis FinalExam(lectures15-22)