ULM College of Pharmacy
Fall 2014
PATHOPHYSIOLOGY I – 41560 – PHRD 4012
I.
Instructor Contact Information
Chris R. Gissendanner, Ph.D. (Course Coordinator)
Associate Professor of Pharmacology
Department of Basic Pharmaceutical Sciences
E-mail (preferred mode of communication): gissendanner@ulm.edu
Phone: 342-3314
Office: Bienville 362
Office Hours: 2:00-4:30 M to Th, or by appointment
Karen Briski, Ph.D.
Professor of Pharmacology and Neuroanatomy
Department of Basic Pharmaceutical Sciences
E-mail (preferred mode of communication): briski@ulm.edu
Phone: 342-3283
Office: Bienville 356
Office Hours: 10:00-12:00 M to F, or by appointment
Yong-Yu Liu, Ph.D.
Associate Professor of Pharmacology
Department of Basic Pharmaceutical Sciences
E-mail (preferred mode of communication): yliu@ulm.edu
Phone: 342-1709
Office: Bienville 368
Office Hours: 8:00-10:00 M to F, or by appointment
II.
Course Prerequisites/Corequisites
Acceptance into the COP and enrollment or credit in PHRD 4020
III. Course Description
Students will be introduced to disease processes at a cellular level. The course will serve as an
introduction to pathophysiology building on the anatomy and physiology courses that students have
already completed. Credit Hours: 2.
IV. Curricular Objectives and Outcomes
Appropriately Manage and Use Resources of the Health Care System.
11. Apply patient and population specific data, quality assurance strategies, and research processes.
Think Critically.
24. Identify, retrieve, understand, analyze, synthesize, and evaluate information needed to make
informed, rational, and ethical decisions.
25. Solve complex problems that require an integration of one's ideas and values within a context of
scientific, social, cultural, legal, clinical, and ethical issues.
26. Display habits, attitudes, and values associated with mature critical thinking
Demonstrate Appropriate Interpersonal, Professional, and Ethical Behaviors.
27. Maintain professional competence.
28. Represent the profession in an ethical manner.
V.
Course Specific Objectives and Outcomes
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To introduce students to common diseases.
Students should be able to predict physiological reactions to numerous challenges at cellular level.
Students should be able to utilize information to explain the pathological basis of diseases.
VI. Course Topics
• The Cellular Environment: Fluids Electrolytes
• Genes and Genetic Diseases
• Genes, Environment and Common Diseases
• Cancer Epidemiology
• Cancer Biology, clinical manifestation and treatments
• Structure/Function of the Hematologic System
• Alterations of Erythrocyte Function
• Alter. Leukocyte/Lymphoid/Hemostatic Function
• Structure/Function of the Neurologic System
• Neurological System Disorders
VII. Instructional Methods and Activities
Traditional lecture format. Lecture notes will be posted online prior to each class. Students should
review notes and all assigned reading prior to each class.
VIII. Evaluation and Grade Assignment
The course consists of four (4) 75 point unit exams and a 100 point final exam for a total of 400
possible points. 40% of the final exam will be comprehensive. Grades will be determined as follows:
360 - 400pts = A
320 - 359pts = B
280 - 319pts = C
240 - 279pts = D
< 240pts = F
Exams will be given using ExamSoft.
Any student earning a non-passing grade of “D” or “F” on an exam will be required to participate in
mandatory tutoring sessions offered by the course instructor(s) until such a time that they obtain a
passing average in the course.
IX. Class Policies and Procedures
All policies stated in the current ULM Student Policy Manual & Organizational
Handbook should be followed (see http://www.ulm.edu/studentpolicy/). Additional class policies
include:
Examinations: Cell phones should be turned off and left with your belongings in the front of the
room.
Challenging a Test Question: Test question challenges will only be considered within 2 weeks after
the exam grade is posted. Challenges should be first directed to the faculty member who presented
the material.
Exam Question Throw-Out: In the event of an exam question throw-out, exam grades will be
determined based on the percentage of correct answers of the remaining questions.
A. Textbook(s) and Materials:
Required: Pathophysiology-the biological basis for disease in adults and children, 7th Ed. By
Kathryn L McCance and Sue E. Huether, published by Elsevier.
Additional Sources: Additional reading material may be assigned. This is indicated in the
course schedule below or will be announced in class.
B. Attendance Policy:
Class attendance is regarded as an obligation as well as a privilege, and students are expected to
know attendance regulations and to attend regularly and punctually at classes in which they are
enrolled. Failure to do so: (1) may prevent access to the classroom during regularly scheduled
times; (2) may jeopardize a student’s scholastic standing; and (3) may lead to suspension from
the college or University. Students shall submit excuses for all class absences to the course
coordinator within three class days after returning to classes. Course coordinators shall accept
an official University excuse.
With the following exceptions the course coordinator will determine whether absences are
excused or unexcused:
1. Absences arising from authorized trips away from the University or from special duties at the
University shall be excused.
2. Absences arising from a student’s confinement in a hospital or other in-patient facility or
doctor’s excused absences shall be excused. Students are responsible for verifying this
information to the faculty.
3. Absences arising from a death in the immediate family shall be excused. The immediate
family is defined as spouse, child, step-child, mother, father, sister, brother, grandmother,
grandfather, step-mother, step-father, step-brother, step-sister, aunt, uncle, mother-in-law or
father-in-law.
C. Make-up Policy:
Each student is expected to attend each exam at the date and time specified. If a student cannot
attend an exam due to valid University excuse, he/she must speak directly with the course
coordinator, as soon as possible. The course coordinator must be notified prior to the examination
if a student misses the exam, if possible. Failure to attend a scheduled make-up exam will result
in a zero (0) grade for that exam. Make-up exams will be prepared at the same or higher level
than the original exam. The format of the make-up exam may be of the subjective essay or
multiple-choice type. Students missing an exam due to a University approved excuse will take the
make-up exam during the week of finals, or as determined by the course coordinators.
D. Academic Integrity: Faculty and students must observe the ULM published policy on
Academic Dishonesty (see the ULM Student Policy Manual http://www.ulm.edu/studentpolicy/). All professional students will adhere to the standards set forth
in the College of Pharmacy’s Code of Conduct.
http://www.ulm.edu/pharmacy/documents/ospa/codeofconductv82011.pdf
All suspected cases of academic dishonesty will be reported, as described in the Manual.
Consequences for academic dishonesty (cheating and/or plagiarism), as defined in the Manual, WILL
include obtaining a 0 (zero) for the assignment/exam. Additionally, the student may fail the course
and/ or be placed on academic probation or suspension.
E. Course Evaluation Policy: At a minimum, students are expected to complete an on-line course
evaluation.
F. Student Services: Information concerning student services in the College of Pharmacy can be
found in the College of Pharmacy Student Handbook. In particular, students should pay special
attention to the Colleges technical standards and policies concerning students with special needs
(http://www.ulm.edu/studentpolicy/studentpolicy.pdf). ULM student services, such as Student
Success Center (http://ulm.edu/cass/), Counseling Center (http://ulm.edu/counselingcenter/), and
Student Health Services, is available at the following Student Services web site
http://ulm.edu/studentaffairs/.
If you are having problems with emotional, social, and/or behavioral issues please call any of the
mental health clinics on the ULM campus to make an appointment. All services are free to ULM
students, staff, and faculty, and are strictly confidential.
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COP Office of Student and Professional Affairs: 342-3800
ULM Counseling Center: 342-5220
Marriage and Family Therapy Clinic: 342-5678
Community Counseling Center: 342-1263
ULM HELPS (Helping Educators and Learners Prevent Suicide) Project Office: 342-1335
The University of Louisiana at Monroe strives to serve students with special needs through
compliance with Sections 504 of the Rehabilitation Act of 1973 and the Americans with Disabilities
Act. These laws mandate that postsecondary institutions provide equal access to programs and
services for students with disabilities without creating changes to the essential elements of the
curriculum. While students with special needs are expected to meet our institution's academic
standards, they are given the opportunity to fulfill learner outcomes in alternative ways. Examples
of accommodations may include, but are not limited to, testing accommodations (oral testing,
extended time for exams), interpreters, relocation of inaccessible classrooms, permission to audiotape
lectures, note-taking assistance, and course substitutions.
Title IX of the Education Amendments of 1972 prohibits sex discrimination against any participant in
an educational program or activity that receives federal funds, including federal loans and grants.
Furthermore, Title IX prohibits sex discrimination to include sexual misconduct, sexual violence,
sexual harassment and retaliation. If you encounter unlawful sexual harassment or gender-based
discrimination, please contact Student Services at 318-342-5230 or to file a complaint, visit
www.ulm.edu/titleix.
G. Emergency Procedures:
Please review the emergency escape plan in the classrooms and hallways of the Bienville building.
Move quickly and orderly to the appropriate stairwell and exit the building. The meeting place for
this class will be the far end of the north parking lot between Bienville and Broadmoor Blvd. Under
no circumstances is the elevator to be used for emergency evacuation. Any student needing
assistance should notify the professor immediately. For emergencies, to contact University Police,
call 1-911 from landlines and 342-5350 from cell phones.
**The course coordinators reserve the right to adjust the syllabus or schedule, in
accordance with University and College policies and procedures**
X. Tentative Course Schedule: Class 1:00~1:50 PM, B340, Monday and Wednesday
A. Contact information:
Dr. Liu: 342-1709, yliu@ulm.edu, B368, M-F: 8:00-10:00 or appointment.
Dr. Briski: 342-3283, briski@ulm.edu, B356, M-F: 10:00-12:00 or appointment
Dr. Gissendanner: 342-3314, gissendanner@ulm.edu, B362, M-Thu: 2:00-4:30, or appointment
B. Schedule: The instructors reserve the right to adjust the schedule as needed.
Date
Lecture
1.
2.
3.
4.
M; Aug 18
W; Aug 20
M; Aug 25
W; Aug 27
M; Sept 1
Unit I:
The Cellular Environment: Fluids Electrolytes; Ch. 3
The Cellular Environment: Fluids Electrolytes; Ch. 3
The Cellular Environment: Fluids Electrolytes; Ch. 3
Genes and Genetic Diseases; Ch. 4
Labor Day Holiday
Briski
Briski
Briski
Liu
5.
W; Sept 3
Genes, Environment and Common Diseases; Ch. 5
Liu
6.
7.
8.
M; Sept 8
W; Sept 10
M; Sept 15
W; Sept 17
Examination One (Lectures 1-5)
Genes, Environment and Common Diseases; Ch. 5
Cancer epidemiology; Ch. 13
Cancer epidemiology; Ch. 13
Liu
Liu
Liu
9.
M; Sept 22
10. W; Sept 24
Instructor
Cancer biology, clinical manifestation & treatments; Ch. 12
Cancer biology, clinical manifestation & treatments; Ch. 12
Liu
Liu
11.
12.
13.
14.
15.
M; Sept 29
W; Oct 1
M; Oct 6
W; Oct 8
M; Oct 13
W; Oct 15
Examination Two (Lectures 6-10)
Cancer biology, clinical manifestation & treatments; Ch. 12
Structure/Function of the Hematologic System; Ch. 27
Structure/Function of the Hematologic System; Ch. 27
Hemostasis and Hemostatic Disorders; Ch. 27; 29; 30
Hemostasis and Hemostatic Disorders; Ch. 27; 29; 30
Liu
Gissendanner
Gissendanner
Gissendanner
Gissendanner
16.
17.
18.
19.
20.
M; Oct 20
W; Oct 22
M; Oct 27
W; Oct 29
M; Nov 3
W; Nov 5
Examination Three (Lectures 11-15)
Erythrocyte Disorders; Ch. 28; 30
Erythrocyte Disorders; Ch. 28; 30
Erythrocyte Disorders; Ch. 28; 30
Leukocyte and Lymphoid Disorders; Ch. 29
Structure/Function of the Neurologic System; Ch. 15
21.
22.
M; Nov 10
W; Nov 12
M; Nov 17
23.
W; Nov. 19
24.
M; Nov 24
Examination Four (Lectures 16-20)
Pain, Tem. Regulation, Sleep and Sensory Function; Ch. 16
Alterations in Cognitive Systems, Cerebral Hemodynamics,
and Motor Function; Ch. 17
Disorders of the Central and Peripheral Nervous Systems
and the Neuromuscular Junction; Ch. 18
Neurobiology of Schizophrenia, Mood Disorders,
and Anxiety Disorders; Ch. 19
Gissendanner
Gissendanner
Gissendanner
Gissendanner
Briski
Briski
Briski
Briski
Briski
W; Nov 26
Thanksgiving Holidays
M; Dec 1
Final Exam (60pts from Lectures 21-24; 40pts from Lectures 1-20)
9am, B340