Lasers in Science and Industry: A report to OSTP on the contribution of lasers to American jobs and the American economy Honoring the 50th Anniversary of the Laser Report prepared for LaserFest 2010 Dr. Thomas M. Baer Stanford University President 2009 Optical Society of America Dr. Fred Schlachter Lawrence Berkeley National Laboratory American Physical Society Report date: June 15, 2010 Updated August 4, 1020 Honor Educate Inspire Promote Laser History Timeline Classical Physics Era Quantum Physics Pre-Laser Era Maser Era Bloch Maxwell 1800s Boltzman Planck 1900 Bohr Ladenburg 1910 1920 Einstein Laser Era Gould Lamb 1930 1940 Tolman Townes Kastler 1950 Basov Schawlow Bloembergen Kroemer 1960 1970 Maiman Sorokin Alverov 1980 Javan The theoretical foundation for the laser can be traced back over 100 years. Early in the 20th century modern quantum physics replaced the classical theories of light and matter. Western Europe was the epicenter of this extraordinary scientific revolution until the events surrounding World War II disrupted this remarkably productive period in physics. Many leading Western European scientists involved in quantum mechanics theory and experiment were displaced by the war, often choosing to migrate to the US to continue their research. After the war the US offered unparalleled resources supporting scientific research and innovation: intact and well-funded university, government and industry enterprises, as well as a free-market economy which rewarded entrepreneurship. Prokorov Robert Hall Fred Schlachter and Thomas Baer This dynamic research environment in the US created the perfect setting for the invention of the laser. 1990 Lasers Play a Key Role in the US Economy The laser has moved in fifty years from “a solution looking for a problem” to a key technology which enables major sectors of the US economy. May 16, 1960 Ted Maiman demonstrates the first ruby laser. Early Lasercompatible slit lamp Laser printer HP vintage 1960’s Vintage laser and fiber-optic cable CO2 & Fiber Lasers $1.3 Billion Hughes Research Laboratory 1960 1970 1980 1990 Solid-state & Excimer Lasers $400 Million 2000 Diode & Fiber Lasers $3.2 Billion Vintage Corning fiber-optic cable and laser assembly. Vintage laser barcode scanner Laserdisk and player Laser devices are the core technology in instruments performing vital functions in many industries including transportation, healthcare, and telecom. Fred Schlachter and Thomas Baer Lasers Empower Our World: Enabling Business Creating Jobs Improving Lives Information technology: Telecommunications and internet: Lasers transmit virtually all the Lasers fabricate CPUs and memory integrated circuits, manufacture LCD display screens, and encode/read information to and from optical CDROM and DVD disks. information on the internet and almost all voice communications over fiber-optic networks. Information in a card catalog can be easily stored on a single optical disk. Commerce: Lasers enable e-commerce online transactions. Barcodes printed on the packaging of almost every commercial product are read by laser scanners. Consumers are shifting from “Bricks and mortar” to convenient on-line shopping, saving much time and energy. Lasers power the U.S. telecommunications industry, $1.1 trillion in 2008. Instant news updates,‘anytime’ television and movies, video conference virtual meetings, all depend on lasers. Laser-based CD and DVD players are common features in almost every US household. The US motion picture industry generates $3 Billion selling movies on DVDs Laser produced music CDs yield $5 billion in the US. Newspaper ads Lasers have created a million jobs in the telecommunications Industry in America. Voice and data are encoded onto laser light and transmitted over fiber-optic networks. Manufacturing: Lasers cut sheet metal for cars and airplanes, cloth for clothes, scribe photovoltaic panels for solar energy, print serial and lot numbers on food and medicine packaging, shell peanuts, and sort eggs. Barcode scanner Lasers are essential for more than $3 trillion of e-commerce conducted annually in America Medicine: Lasers help prevent blindness and improve vision, Science, environment, energy, time-keeping: Lasers are the invisible gears in the mechanisms of the world’s most accurate clocks. Lasers provide the fastest strobe lights for studying chemical reactions and are the sources powering research to develop inertial fusion––a limitless carbon-free source of energy. provide personalized medicine by decoding a patient’s genome, and diagnose cancer and AIDS. Next generation Global Positioning Satellites will use lasers to drive atomic clocks for greatly improved accuracy and reliability Laser based gene sequencers are millions of times faster than older methods. Craigslist Lasers save many lives each year and help reduce the cost of medical care. Lasers are used to create the hottest temperatures on earth to study laser fusion (NIF) and the coldest objects on earth to study new states of matter (BEC). Fred Schlachter and Thomas Baer Lasers in Manufacturing: Lasers make light work in heavy industry Engine Clutch Gear box Automobile doors: Lasers weld Laser make cars stronger, safer lighter and cheaper. where classic arc welding does not work. Lasers easily weld materials of different thickness: car doors are made lighter in weight and stronger, improving fuel economy. Lasers make hundreds of parts for a modern car. • weld seat frames Driveshaft Wheel • harden torsion springs Traditional arc welding warps sheet metal when attaching hinges to door frames. • mark parts • cut and weld airbags Hub • weld antilock brakes • cut body parts • drill holes in fuel injectors Courtesy of Tim Morris at TRUMPF Inc Differential gears Turbine engines: Improving efficiency requires advances in cooling. Pre-laser era. 21st century Holes drilled by mechanical means* Lasers drill millions of precision holes Automobile sales in US: $200 billion Lasers quickly drill millions of small holes. Jet engines and gas turbines benefit from laser-drilled holes. Solar panels: Lasers improve fabrication and efficiencies of thinfilm solar cells. Lasers are a tool which never gets dull. Their use produces better products and reduces heavy-metal contamination of the ecosystem. Laserbeam Glass Front Contact Absorber Back Contact • Engine components require hardened steel and ceramic materials which dull drill bits and blunt saw blades. • A laser beam never dulls, and is ideal for precision drilling and cutting. Lasers precisely machine borders on thin-film solar cells and provide accurate dopant profiles to increase solar cell efficiencies. Powerful lasers can be used to drill millions of precisely shaped and accurately located holes in difficult materials. Jet engines and gas turbines for generation of electricity are more efficient because laser-drilled holes improve cooling. Fred Schlachter and Thomas Baer Lasers in Medicine and Biotechnology: Saving Lives Eye surgery: Improving Health Lasers improve health and well-being of patients. Medical devices: Lasers save lives. Lasers produce “impossible” micromachined components Lasers allow ophthalmologists to correct many problems in different locations in the eye, fixing retinas, reshaping corneas, and helping forestall blindness in diabetic patients. Retina Reattach Cataract Surgery Cornea LASIK Ultraviolet Laser Reducing Cost Pulsed Infrared Laser Green Laser Precise sterile machining of hard materials Detached retina repaired with laser: Gold-medal Chinese diver Guo Jingiing (courtesy tksteven) Stents Gene sequencing: Lasers power the latest medical diagnostic instruments. 1975: 2000 base pairs/day One day’s data would fill one half page in a book. 1990’s: 100,000 base pairs/day Today: two billion base pairs/day One day’s data would fill a chapter in a book. One day’s data would fill ten encyclopedias. A new lease on life: laser-made stents. Data Data Pre-laser DNA sequencers (1970’s) could sequence 2000 base pairs per day. Time to sequence a single human genome: 4000 years. 1990’s laser-based DNA sequencers could sequence 100,000 base pairs per day. Time to sequence a single human genome: 80 years. Today’s laser-based DNA sequencers sequence two billion base pairs per day. can Time to sequence a single human genome: 1 day. A million-fold improvement in speed since 1975! Rapid laser-based sequencing of human genomes opens the door to personalized medicine and individualized therapies. Fred Schlachter and Thomas Baer Lasers in Telecom and Information Technology: Internet E-commerce Personal Computers Real-time two-way communication: Lasers and fiber optics have greatly increased the speed of real-time communication. Ancient times through 19th century Information transmitted by smoke and fire 20th century Electrons through copper wires 21st century A case study in enabling technology: Laser light through fiber optics -- Laser Vintage telephone switchboard Watchtower Fire RATE ~ 1 character/10 sec Smoke Time to transmit the Gettysburg Address: hours Electrons carry information through copper wire over 1000s km with moderate bandwidths. RATE~100 characters/sec (1970’s); ~100,000 characters per second (1990’s) Time to transmit the Gettysburg Address: seconds The invention of the laser spurred development of many applications. Diode lasers have an annual impact on the U.S. market of more than $200 billion. Basic research: Laser invented in 1960 Smoke signals Visual information carried over 100 km distance with very low bandwidth. Lasers in information storage: CDs and DVDs High-bandwidth communication using infrared lasers and fiber optics to guide the light. RATE~100 billion characters/sec a million times faster than copper wire Time to transmit the Gettysburg Address: 10’s of nanoseconds The laser in 1960 was deemed: “A solution looking for a problem” Early laser In 2010, 500 million infrared diode lasers will be produced These lasers power many different instruments. Microelectronics: Lasers produce almost all microprocessors and memory chips in personal computers. For example: CDROM/DVD Optical disk drives $3 billion Laser Laser disk drive Laser instruments are built into larger systems UV Lasers in Photolithography Pulsed lasers in redundant memory repair Microprocessor 10 Billion CPUs Produced in 2008 Memory Chip $20 Billion in 2009 Optical drives incorporated into personal computers $60 billion Lasers print the vast majority of IC circuits in the $260 Billion micro electronics industry Fred Schlachter and Thomas Baer Basic Research in Laser Science Continues to Drive Innovation New breakthroughs build upon the unique properties of the laser Femtosecond Chemistry Bose Einstein Condensate Livermore Lab Fusion Laser (NIF) High frequency: encodes enormous amounts of information Application: supercomputing, telecommunication Focusability: focuses to small spots (less than 1/100 of width of hair) Application: optical data storage Cal Tech NIST Power: precisely delivers high intensities to small areas Application: manufacturing, cutting and welding, surgery Short pulses: generates pulses shorter than 1 femtosecond (a million billionth of a second) Application: advancing our understanding of biology, physics, and chemistry, stroboscopic pictures of atoms and molecules in action High fields: produces ultra-strong electric fields Application: compact particle accelerators Large pulse energies: creates pulses shorter than 10 billionths of a second with energies greater than a stick of dynamite Application: drilling, laser fusion 1997 Chu University of Colorado MIT Stanford X-ray Laser Zewail 1999 Cornell Wieman Ke,erle 2005 2001 Phillips Cohen-­‐ Tannoudji Glauber Hall Hänsch Keck telescope Laser Guide Star Monochromaticity: emits ultra-pure colors Application: atomic clocks, astronomy, metrology Coherence: forms highly order light waves Application: holography, astrophysics Stanford Collège de France University NIST Laser Cooling & Trapping Harvard University NIST Max Planck InsJtute Going where no laser has gone before! Optical Frequency Comb Fred Schlachter and Thomas Baer LaserFest 2010 Founding Partners LaserFest 2010 Partners This report is for educational use only. Commercial use is not allowed. The list below shows the web sites where the images were found. http://commons.wikimedia.org/wiki/File:Ruby_laser.jpg http://parts.digikey.com/1/parts-cats/laser-diodes-optoelectronics http://www.supplierlist.com/photo_images/73056/SC_Fiber_Optic_Communication_cable.jpg http://www.psilogo.co.za/Products.asp http://obsoleteblog.com/2009/11/10/laser-disc-players-you-had-a-good-run/ http://www.rewindmuseum.com/philipslaserdisc.htm http://www.google.com/imgres?imgurl=http://www.dreamstime.com/movie-projector-thumb1475529.jpg&imgrefurl=http://www.dreamstime.com/royalty-free-stock-images-movie-projectorimage1475529&usg=__E0szyhfgte3aOWNj9PqHv3wNAA=&h=350&w=248&sz=37&hl=en&start=1&sig2=SLkanHJPCoI8npzJQ7Y0vw&um=1&itbs=1&tbnid=llKcSGXBZLIKaM:&tbnh=120&tbnw=85&prev=/images%3Fq%3Dvintage%2Bmovie%2Bprojector s%26um%3D1%26hl%3Den%26safe%3Doff%26sa%3DN%26tbs%3Disch:1&ei=WWf1S4XlCY67rAfdl8DDCg http://www.google.com/imgres?imgurl=http://www.slipperybrick.com/wp-content/uploads/2006/12/portable-handheld-dvd-player.jpg&imgrefurl=http://www.slipperybrick.com/2006/12/portable-handheld-dvdplayer/&usg=__o_G7RZeEOvIKOrwJq0Fz4EFvpN0=&h=348&w=392&sz=69&hl=en&start=10&sig2=zPmQd1a6Lavs0zwd2tHVdw&um=1&itbs=1&tbnid=p55fp2paHZKO8M:&tbnh=109&tbnw=123&prev=/images%3F q%3Ddvd%2Bplayer%26um%3D1%26hl%3Den%26safe%3Doff%26sa%3DG%26tbs%3Disch:1&ei=wGf1S9SNH5GxrAeCwqXACg http://computer.howstuffworks.com/euvl.htm/printable http://www.google.com/imgres?imgurl=http://greenernews.files.wordpress.com/2009/06/euvl-sandia-wafer.jpg&imgrefurl=http://greenernews.wordpress.com/2009/06/29/imagining-the-tech-world-in2050/&usg=__yILGXEwWiUaHJ8MKHQswiOKC8sw=&h=412&w=400&sz=47&hl=en&start=1&sig2=PR8ug2kRHQ1WzvJoeahWPQ&um=1&itbs=1&tbnid=JST4imXiKHeROM:&tbnh=125&tbnw=121&prev=/images% 3Fq%3Deuvl-sandia%26um%3D1%26hl%3Den%26safe%3Doff%26sa%3DN%26tbs%3Disch:1&ei=rmv1S-yND4jHrAf-5Ji1Cg 3D21%26tbs%3Disch:1&ei=jGz1S83dIJLHrAeA_eC3Cg http://www.google.com/imgres?imgurl=http://www.hewnandhammered.com/.a/6a00d8341c5fc853ef0112790717c328a4300wi&imgrefurl=http://www.hewnandhammered.com/hewn_and_hammered/woodworking/&usg=__z9LODfXmXEVPuc2Y_CEKb6lJAUk=&h=450&w=300&sz=31&hl=en&start=43&sig2=006kvGJccbvjlFvx5B_ifQ&u m=1&itbs=1&tbnid=KQaL5yyqHMuTgM:&tbnh=127&tbnw=85&prev=/images%3Fq%3Dvintage%2Blibrary%2Bcard%2Bcatalog%26start%3D42%26um%3D1%26hl%3Den%26safe%3Doff%26sa%3DN%26ndsp%3D 21%26tbs%3Disch:1&ei=L2r1S4W1BYi4rAeem7iwCg http://www.google.com/imgres?imgurl=http://www.laserfest.org/lasers/images/inncds.jpg&imgrefurl=http://www.laserfest.org/lasers/innovations.cfm&usg=__KuieO3HveGc5D80wzCvJEVF5cyA=&h=281&w=310&sz=16&hl=en&start=1&sig2=6BGpzoz035XksdiXbEhTYw&um=1&itbs=1&tbnid=EXC wsruH8ZTq0M:&tbnh=106&tbnw=117&prev=/images%3Fq%3Dinn-cds%26um%3D1%26hl%3Den%26safe%3Doff%26sa%3DG%26ndsp%3D21%26tbs%3Disch:1&ei=jGz1S83dIJLHrAeA_eC3Cg http://www.usposttoday.com/wp-content/uploads/2009/10/resized_ap_black_friday_04_081128_ssh-150x150.jpg http://cutslist.com/symbol-handheld-point-of-sale-ps2-laser-barcode-scanner/ http://www.commercecarts.com/images/girl_online-shopping.jpg OR http://www.ultimatecoupons.com/blog/2009/12/cyber-monday-sales-soar/ Disclaimer http://en.wikipedia.org/wiki/DNA_sequencing http://www.google.com/imgres?imgurl=http://www.ncbi.nlm.nih.gov/bookshelf/picrender.fcgi%3Fbook%3Dcooper%26part%3DA448%26blobname%3Dch3f25.jpg&imgrefurl=http://www.ncbi.nlm.nih.gov/bookshelf/br.f cgi%?ie=UTF8&s=electronics&qid=1274380997&sr=1-22 (and other amazon sites) http://www.google.com/imgres?imgurl=http://www.alexdavisassoc.com/gallery/king_new_machinery/king_kc712bc_king_bandsaw.jpg&imgrefurl=http://www.alexdavisassoc.com/print/king_kc712bc_metal_bandsaw_ page.htm&usg=__TgCu58YxxefYkOw8gwNulB3VKg=&h=285&w=320&sz=50&hl=en&start=2&sig2=UTdkspdITUvyYPze9_FjKQ&um=1&itbs=1&tbnid=GFuQD4r6uji5lM:&tbnh=105&tbnw=118&prev=/images%3Fq%3Dking%2Bbandsaw%26um%3D1%26hl%3D en%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg 3Fbook%3Dcooper%26part%3DA448&usg=__NaCQguhjHhuytv9wyWQOA3Lpy7w=&h=528&w=701&sz=112&hl=en&start=1&sig2=hiACvvL_67K1tXJmYwVxHA&um=1&itbs=1&tbnid=3qqr1WpTqNW2M:&tbnh=105&tbnw=140&prev=/images%3Fq%3Ddna%2Bsequencing%2Bfluorescence-labeled%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefoxa%26hs%3DPnV%26sa%3DN%26rls%3Dorg.mozilla:en-US:official%26ndsp%3D21%26tbs%3Disch:1&ei=o3_1S7ioM4TysgP3rbCJBQ http://lasikeyesurgery4.blogspot.com/2009/12/cost-lasik-eye-surgery.html http://www.amazon.com/Crosley-Kettle-Classic-Phone-CR62-Black/dp/B000ASKN90/ref=sr_1_22.mozilla:en-US:official%26tbs%3Disch:1&ei=14X1S4nAGMu0rAfPsr26Cg http://www.lanteksms.com/en/noticia.asp?id=473 http://www.boeing.com/commercial/787family/gallery/k63211-1.html http://www.stylehive.com/tag/pure_silk http://www.google.com/imgres?imgurl=http://www.strima.com/image/1021772/DS4-FREESTYLE-3-CO2---200W-Machine-for-laser-engraving-and-cutting-on-fabrics--plastics-and-othermaterials.jpg&imgrefurl=http://www.strima.com/item/1021772/en/&usg=__T8srKrK5plL3Koq8zr5vhiBShnw=&h=865&w=470&sz=122&hl=en&start=1&sig2=i7iBuC7m8csgrJXA17fzQ&um=1&itbs=1&tbnid=LN85lZJV6exv8M:&tbnh=145&tbnw=79&prev=/images%3Fq%3DDS4-freestyle%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:enUS:official%26tbs%3Disch:1&ei=K4f1S9fINITysgP3rbCJBQ Courtesy of Tim Morris at US Trumpf. Email timothy.morris@us.trumpf.com http://www.google.com/imgres?imgurl=http://www.techzonics.com/vintage-hand-drill.jpg&imgrefurl=http://www.techzonics.com/hand-tools-electrictools.htm&usg=__TDoUNbuOSl8J5dct7jezcceYtsc=&h=342&w=400&sz=19&hl=en&start=11&sig2=xd7680oU-_juhcUwfsE_0Q&um=1&itbs=1&tbnid=lekytS_V3FWaM:&tbnh=106&tbnw=124&prev=/images%3Fq%3Dvintage%2Bhand%2Bdrill%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:enUS:official%26tbs%3Disch:1&ei=VY_1S5PvFdG3rAezq63gCg http://boky.en.hisupplier.com/ http://www.google.com/imgres?imgurl=http://images.pennnet.com/articles/ils/thm/th_129369.jpg&imgrefurl=http://www.optoiq.com/index/lasers-for-manufacturing/display/ils-article-display/183493/articles/industrial-laser-solutions/volume-18/issue8/features/drilling-holes-in-turbineengines.html&usg=__VB3rXH4eoqATiMRDJ70DhpBGuL8=&h=236&w=325&sz=13&hl=en&start=57&sig2=IzFI0PHrxzCdrFUSADgENA&um=1&itbs=1&tbnid=_QNfqBwOtIULIM:&tbnh=86&tbnw=118&prev=/images%3Fq%3Dlaser%2Bdrilling%26 start%3D42%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:en-US:official%26ndsp%3D21%26tbs%3Disch:1&ei=-ZL1S9mfIYuStgPBtdiIBQ http://www.google.com/imgres?imgurl=http://www.siemens.com/press/pool/de/pressebilder/2010/photonews/072dpi/PN201002/PN201002-06_072dpi.jpg&imgrefurl=http://www.siemens.com/press/en/presspicture/picturesphotonews/2010/pn201002.php&usg=__MskMtLxdiCXAMXQB0rbAMtBxiLE=&h=400&w=289&sz=77&hl=en&start=12&sig2=6GoSZZlU9XqHFQnqvMEgTg&um=1&itbs=1&tbnid=JeswDe54D_71YM:&tbnh=124&tbnw=90&prev=/images%3Fq%3Dt urbine%2Bblade%2Bholes%2Bsiemens%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26rls%3Dorg.mozilla:en-US:official%26tbs%3Disch:1&ei=mJH1S7XNOcq_rAer-fXCCg http://www.google.com/imgres?imgurl=http://1.bp.blogspot.com/_xCW4Jfa-SWE/Sy7yRRSHFnI/AAAAAAAAIhE/PqfOS5HN5JI/s400/jetengine.jpg&imgrefurl=http://alditta.blogspot.com/2009/12/missing-jetengine.html&usg=__ADig3gsDrhAmMJzx984yowifsy4=&h=297&w=330&sz=21&hl=en&start=64&sig2=HTuUAb0J6q7j9SJEa8pumA&um=1&itbs=1&tbnid=LSFsRFw5axB3TM:&tbnh=107&tbnw=119&prev=/images%3Fq%3Djet%2Bengine%26star t%3D63%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:en-US:official%26ndsp%3D21%26tbs%3Disch:1&ei=QJL1S7iXJ8nGrAfo2tiyCg http://www.siemens.com/innovation/de/publikationen/zeitschriften_pictures_of_the_future/pof_herbst_2007/materialien_fuer_die_umwelt/gasturbine_irsching.htm http://www.twi.co.uk/content/laser_thin.html http://www.metacafe.com/watch/yt-0bkyjZ5j-VQ/diy_cheapest_solar_panel_system_ever_part_2/ Disclaimer con’t http://www.myinkblog.com/2010/01/31/myinktrail-best-of-the-design-community-january-2010/ OR http://www.google.com/imgres?imgurl=http://www.laservisionrepair.co.uk/images/laser_eye_surgery_image_03.jpg&imgrefurl=http://www.laservisionrepair.co.uk/&usg=__R5aPl5es1wu9kLNC_sNviI9d84o=&h=279& w=274&sz=85&hl=en&start=43&sig2=JnGEmrZC_33nu8lLjxJjCQ&um=1&itbs=1&tbnid=1Om_KSsKo9XiHM:&tbnh=114&tbnw=112&prev=/images%3Fq%3Dlaser%2Beye%2Bsurgery%26start%3D42%26um%3D1% 26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:en-US:official%26ndsp%3D21%26tbs%3Disch:1&ei=eK31S62rDIewrAfq_fy1Cg http://www.google.com/imgres?imgurl=http://www.calgaryoptometry.com/images/LaserEyeRGB.jpg&imgrefurl=http://www.calgaryoptometry.com/LaserSurgery.htm&usg=__gs_g3GSQVDA8LwyHcdkUZjOmECs=&h=240&w=320&sz=19&hl=en&start=18&sig2=_uKwFVtzAiBVVBBgTl_fbQ&um=1&itbs=1&tb nid=35dGxA_NFJ-DAM:&tbnh=89&tbnw=118&prev=/images%3Fq%3Dlaser%2Beye%2Bsurgery%26um%3D1%26hl%3Den%26safe%3Doff%26client%3Dfirefox-a%26sa%3DN%26rls%3Dorg.mozilla:enUS:official%26tbs%3Disch:1&ei=S631S4W6JofDrAfYzaneCg http://www.ocalaeye.com/html/cornea.html http://news.ifeng.com/history/1/jishi/200808/0821_2663_736679_2.shtml I SUGGEST OBTAINING PERMISSION TO USE THIS IMAGE http://www.severnbiotech.com/images/seq-3341.JPG http://appliedbiosystems.com/ http://www.amazon.com/Encyclopedia-Britannica-Editors/dp/0852299613/ref=pd_sim_sbs_b_2 http://www.technologyreview.com/biomedicine/19867/ 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