Sticks, Stones, and Words: Correlates of Violence and Survival Dr. Inga Schalinski inga.schalinski@uni-konstanz.de Introduction - First Study - Second Study - Third Study - Conclusion What%we%have%learned%from%the%Adverse%Childhood% Experiences%(ACE)%Study%is%that...% % Childhood%AdversiAes% Childhood%AdversiAes% % Early%Death% are%related%to% are%related%to%mental% %overweight,% illness.% Disease,%Disability% % diabetes...% and%Social%Problems% % AdopAon%of%HealthErisk% % Behaviors% % % Social,%EmoAonal,%and%CogniAve%Impairment% % % Neurodevelopmental%and%Biological%AdaptaAon% % %% Adverse%Childhood%Experiences% Anda,&Feli+&&&van&der&Kolk:&see&for&more&details&h8p://acestudy.org& Introduction - First Study - Second Study - Third Study Impact%of%Childhood%AdversiAes% % Early.Death. Disease,.Disability. and.Social.Problems. Adop4on.of.Health=risk. Behaviors. Social,.Emo4onal,.and.Cogni4ve.Impairment. Neurodevelopmental.and.Biological.Adapta4on. Adverse.Childhood.Experiences. - Conclusion Introduction - First Study - Second Study - Third Study - Conclusion Research%QuesAons% First%Study:%Do&childhood&adversiAes&affect&the&CorAsol&stress& response&(in&paAents&with&trauma&spectrum&disorders)?& & Second%Study:%Do&type&and&Aming&of&childhood&adversiAes& ma8er&for&symptoms&of&dissociaAon&(in&paAents&with&psychoAc& spectrum&disorders)?& & Third%Study:%The&third&study&sought&to&clarify&the&impact&of& childhood&adversiAes&on&illness&severity,&outcome&measures&in& paAents&with&psychoAc&spectrum&disorders.& & Introduction - First Study - Second Study - Third Study - First Study: The%corAsol%paradox%of%traumaErelated%disorders Schalinski, Elbert & Kirschbaum Conclusion Introduction - First Study - Second Study - Third Study - Conclusion Background:%The&HPA&axis& & O& & & & Hypothalamus& CRH& +& & & & & O& Pituitary&Gland& ACTH& +& Adrenal&Gland& +& CorAsol& Introduction - First Study - Second Study - Third Study - Conclusion Background:% Individuals&who&present&with&a&trauma&spectrum&disorder& frequently&have&an&altered&regulaAon&of&the&hypothalamicO pituitaryOadrenal&(HPA)&axis&(see&for&a&metaOanalysis&and&reviews:& Meewisse&et&al.,&2008;&Miller,&Chen,&&&Zhou,&2007;&Shea&et&al.,& 2005).&& & But&there&are&inconsistencies&about&the&direcAon& (downregulaAon&vs.&hyperacAvity&of&the&HPA&axis).& & in&shortOterm&measure&of&CorAsol&(Saliva:&Shea&et&al.,&2005)& in&longOterm&measure&of&CorAsol&(Hair:&Steudte&et&al.,&2011;&2013)& & Both&early&life&stress&as&well&as&the&number&of&lifeAme&traumaAc& & experiences&seem&to&be&powerful&modulators&of&individual&HPA& & axis&acAvity.&& Introduction - First Study - Second Study - Third Study - Conclusion ParAcipants:% % N&=&43&female&survivors&of&organised&violence&with&Pos8raumaAc& Stress&Disorder&(PTSD)&and&different&levels&of&Childhood& AdversiAes& & The&following&traumaAc&event&types&were&reported&most& frequently:&Physical&assault&with&life&threat&(72%),&assault&with&a& weapon&(62%)&and&sexual&assault&(58%).&& && & & & & & & Introduction - First Study - Second Study - Third Study - Conclusion Method:%„Phasic%CorAsol%Response“% Schematic Description of the Structured Interview and Physiological Assessment 1. Sociodemographic Data SD = 0:32 min & & & 2. Assessment of Traumatic Experiences and Childhood Adversities SD = 0:49 min SD = 0:49 min 3. Symptom Assessment SD = 0:56 min SD = 0:49 min Introduction - First Study - Second Study Method:%„LongEterm%Levels%of%CorAsol“% & & & - Third Study - Conclusion - First Study Results%% - Third Study - No Childhood Sexual Abuse Childhood Sexual Abuse * * Heart Rate Change (in bpm) -6 -4 -2 0 2 4 6 Heart Rate Change No Childhood Sexual Abuse Childhood Sexual Abuse * * -8 Change in Salivary Cortisol in nmol/l -4 -2 0 2 4 6 & & Second Study Change in Salivary Cortisol -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment Change in Systolic Blood Pressure Change in Diastolic Blood Pressure Change in Systolic Pressure (in mm Hg) -5 0 5 10 & - No Childhood Sexual Abuse Childhood Sexual Abuse -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment Change in Diastolic Pressure (in mm Hg) -6 -4 -2 0 2 4 6 8 Introduction No Childhood Sexual Abuse Childhood Sexual Abuse -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment Conclusion Introduction - First Study - Second Study - Third Study - Conclusion Results% Patient Control 2 0 0 2 Median Quotient 4 6 8 Patient Control 0 10 20 30 40 Severity of Childhood Adversities 0 10 20 30 40 Severity of Childhood Adversities Median Quotient 4 6 8 10 Segment 2 Patient Control 0 2 Patient Control 2 Median Quotient 4 6 8 10 Segment 1 0 & & Segment 2 10 10 Segment 1 Median Quotient 4 6 8 & 0 5 10 15 Number of Different Traumatic Event Types Segment&1&(3&cm)& 0 5 10 15 Number of Different Traumatic Event Types Segment&2&(3&cm)& Introduction - First Study - Second Study - Third Study - Conclusion Results% Patient Control 2 0 0 2 Median Quotient 4 6 8 Patient Control 0 10 20 30 40 Severity of Childhood Adversities 0 10 20 30 40 Severity of Childhood Adversities Median Quotient 4 6 8 10 Segment 2 Patient Control 0 2 Patient Control 2 Median Quotient 4 6 8 10 Segment 1 0 & & Segment 2 10 10 Segment 1 Median Quotient 4 6 8 & 0 5 10 15 Number of Different Traumatic Event Types Segment&1&(3&cm)& 0 5 10 15 Number of Different Traumatic Event Types Segment&2&(3&cm)& Third Study - & & 6 Heart Rate Change * * * -8 * No Childhood Sexual Abuse Childhood Sexual Abuse Heart Rate Change (in bpm) -6 -4 -2 0 2 4 Change in Salivary Cortisol in nmol/l -4 -2 0 2 4 6 Change in Salivary Cortisol No Childhood Sexual Abuse Childhood Sexual Abuse Change in Diastolic Blood Pressure No Childhood Sexual Abuse Childhood Sexual Abuse -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment Change in Diastolic Pressure (in mm Hg) -6 -4 -2 0 2 4 6 8 -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment Change in Systolic Blood Pressure Change in Systolic Pressure (in mm Hg) -5 0 5 10 -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment No Childhood Sexual Abuse Childhood Sexual Abuse -50 0 50 100 150 Time in Minutes in Relation to Trauma Assessment Segment 2 10 10 Segment 1 Patient Control 0 2 Median Quotient 4 6 8 Patient Control Median Quotient 4 6 8 0 10 20 30 40 Severity of Childhood Adversities 0 10 20 30 40 Severity of Childhood Adversities Segment 2 Patient Control 2 Median Quotient 4 6 8 10 Segment 1 Patient Control 0 Conclusion% • ShortOterm:&DisAnct&reacAvity&pa8ern&for&the& group&with&childhood&sexual&abuse&vs.&without& childhood&sexual&abuse& • LongOterm:&PosiAve&relaAonship&between& childhood&adversiAes&as&well&as&traumaAc&stress& load&and&hair&corAsol& • Both&childhood&adversiAes&as&well&as&traumaAc& stress&contribute&to&increased&levels&of&hair& corAsol& • ShortOterm&and&longOterm&corAsol&responses&are& capable&to&show&both,&down&regulaAon&in&shortO term&levels&(saliva&corAsol),&but&increase&in&longO term&(hair&corAsol).&& • Early&exposure&to&adversiAes&may&results&in&a& biological&disAnct&phenotype& Conclusion 2 - 0 Second Study 10 - Median Quotient 4 6 8 First Study 2 - 0 Introduction 0 5 10 15 Number of Different Traumatic Event Types 0 5 10 15 Number of Different Traumatic Event Types Early.Death. Disease,.Disability. and.Social.Problems. Adop4on.of.Health=risk. Behaviors. Social,.Emo4onal,.and.Cogni4ve.Impairment. Neurodevelopmental.and.Biological.Adapta4on. Adverse.Childhood.Experiences. Introduction - First Study - Second Study - Third Study - Conclusion Second Study: Type and Timing of Childhood Maltreatment and Severity of Shutdown Dissociation in Patients with Schizophrenia Spectrum Disorder Schalinski & Teicher, 2014 Introduction - First Study - Second Study - Third Study - Conclusion Background:% & DissociaAon,&parAcularly&the&shu+ng&down&of&sensory,&motor&and& speech&systems,&has&been&proposed&to&emerge&in&suscepAble& individuals&as&a&defensive&response&to&traumaAc&stress&(Schauer&&& Elbert,&2010).& & Compelling&evidence&shows&that&the&exposure&to&adverse& experiences&in&childhood,&leads&to&an&increase&of&dissociaAve& symptoms&in&adults&with&schizophrenia&(e.g.,&Goff&et&al.,&1991)& & & A&history&of&adverse&childhood&experiences&is&common&in&paAents& with&severe&psychopathology,&especially&paAents&diagnosed&with& & psychoAc&disorders&(Holowka,&King,&Saheb,&Pukall&&&Brunet,&2003;& & Sar&et&al.,&2009;&Schäfer&et&al.,&2006).&& & Introduction - First Study - Second Study - Third Study - Conclusion The%defense%Cascade%Model% Shutdown Dissociation Scale- Interview Item: Have you felt like you couldn’t hear for a while, as if you were deaf? When people were talking to you, did they sound far away? Response: (0) not at all (1) once a month/or less (2) several times a month (3) several times a week Schalinski,&Schauer&&&Elbert,&2014;&Schauer&&&Elbert,&2010& Introduction - First Study - Second Study - Third Study - Research%QuesAons:% & Does&the&type&of&Childhood&Adversity&ma8er&for&Shutdown& DissociaAon?& & Does&the&Aming&ma8er&for&Shutdown&DissociaAon?& & & & & & Conclusion Introduction - First Study - Second Study - Third Study - Conclusion Method: ParAcipants:&N&=&75&paAents&with&psychoAc& spectrum&disorder& & Instruments:& MACE&(=&Maltreatment&and&Abuse&Chronology&of& Exposure)O&Scale&(Isele&et&al.,&2014;&Teicher&&& Parigger,&2011)& ShutdownEDissociaAon%Scale%(Schalinski,&Schauer,& &&Elbert,&submi8ed)& Introduction - First Study - Second Study - Third Study - Conclusion Results%„Type%of%Adversity“% Importance (± 95% CI) & Sensitivity by Type of Maltreatment − shutdown_sum (cforest ) 3 & & 2 1 0 Emotional Non−Verbal Neglect Emotional Abuse Parental Verbal Abuse Peer Emotional Abuse Peer Physical Physical Physical Maltreatment Neglect Abuse Types of Maltreatment Sexual Abuse Witnessing Witnessing Interparental Sibling Abuse Abuse Introduction - First Study - Second Study - Third Study - Conclusion Results%„Timing“% & Sensitive Period Analysis − shutdown_sum (cforest ) Importance (± 95% CI) 3 ● 2 & & ● 1 ● ● ● ● ● 1 2 ● ● ● ● 0 3 4 5 6 ● ● ● ● ● 16 17 ● 7 8 9 10 11 12 Recalled Ages of Exposure (years) Explains&31%&of&the&variaAon&of&Shutdown&DissociaAon& 13 14 15 ● 18 Introduction - First Study - Second Study - Third Study - Conclusion Conclusion% & % % % % % Importance (± 95% CI) ● 2 ● 1 ● ● ● ● 1 2 ● ● 4 5 ● ● ● 0 3 6 ● ● ● ● ● 16 17 ● 7 8 9 10 11 12 13 14 15 ● 18 Recalled Ages of Exposure (years) Sensitivity by Type of Maltreatment − shutdown_sum (cforest ) Importance (± 95% CI) We&found&differenAal&Aming&effects&across&the& childhood&with&peak&vulnerability&occurring&at&13O14& years&of&age.&& & The&impact&of&specific&types&of&childhood&adversiAes& on&severity&of&shutdown&dissociaAon:&& EmoAonal&neglect&>&exposure&to&peer&emoAonal& abuse&>parental&nonOverbal&emoAonal&abuse&>& parental&verbal&abuse& Sensitive Period Analysis − shutdown_sum (cforest ) 3 3 2 1 0 Emotional Non−Verbal Neglect Emotional Abuse Parental Verbal Abuse Peer Emotional Abuse Peer Physical Physical Physical Maltreatment Neglect Abuse Types of Maltreatment Sexual Abuse Witnessing Witnessing Interparental Sibling Abuse Abuse Introduction - First Study - Second Study - Third Study - Conclusion Third Study: Impact of Childhood Adversities on the Short-term Course of Illness in Psychotic Spectrum Disorders Schalinski, Fischer & Rockstroh Introduction - First Study - Second Study - Third Study - Conclusion Background% • AccumulaAng&evidence&shows&that&childhood&adversiAes& modify&the&course&of&mental&disorders.&&It&is&sAll&unclear,&how& early&life&stress&affect&the&course&in&psychoAc&paAents.&& • Understanding&factors&that&influence&the&shortOterm&outcome& (in&inpaAent&se+ngs)&are&important&to&unmask&prognosAc& factors,&and&improve&therapeuAc&strategies.&& • By&straAfying&two&groups&of&paAents&with&low&versus&high& childhood&adversiAes,&we&compared&indicators&of&illness& severity&(number&of&current&comorbid&psychiatric&diagnoses),& shortOterm&symptom&course&across&a&4&months&period&of& observaAon.& & Introduction - First Study - Second Study - Third Study - Conclusion Method% ParAcipants&& N&=&62&inpaAents&with&a&diagnosis&of&psychoAc&disorder& Instruments& Using&the%MACE%Maltreatment&and&Abuse&Chronology&of&Exposure& (MACE)&Scale&A&comprehensive&profile&of&types&of&childhood& adversiAes&should&improve&understanding&of&the&pathways&and& consequences&(Isele&et&al.,&2014)" PosiAve%and%NegaAve%Syndrome%Scale%(PANSS;&Kay,&Fiszbein,&&&Opler,& 1987)& &Using&stringent&criteria&proposed&by&Andreasen&and&colleagues& (2005),&symptomaAc&remission&was&defined&with&a&maintaining& period&of&3&months.& % % At& 3&Months& Admission& 1&Month& 1&Month& 3&Months& FollowOup& Introduction Results% % & - First Study - Second Study - Third Study - Conclusion 72%&report&at&least&one&type& of&childhood&adversity& & and& & around&half&(53%)&of&the& sample&fulfilled&the& maltreatment&and&abuse& criteria&of&two&or&more& different&types& Schalinski,&Fischer&&&Rockstroh,&2014& Introduction - First Study - Results% % Second Study - Third Study - Conclusion Severity%of%Illness% Low%Childhood% High% AdversiAes% Childhood% (n%=%29)%% AdversiAes%% (n%=%33)%% StaAsAcs%for% Group% Difference%% Number&of&Individuals&with&Axis&I& ComorbidiAes&& 1&(3%)& 16&(49%)& χ²(1,62)&=&15.73& p&<&.001&& Number&of&Individuals&with&Abuse& 1&(3%)& or&AddicAon&Diagnosis&(ICDO10:& F10O&F19)&& 12&(36%&)& χ²(1,62)&=&10.09& p&=&.002&& & Schalinski,&Fischer&&&Rockstroh,&2014& Introduction - First Study - Second Study - Third Study - Conclusion Results% % & Remission%Rate:% 26%&for&the&group& with&high&Childhood& AdversiAes&vs.& 39%&for&the&group& with&low&Childhood& AdverisAes& Schalinski,&Fischer&&&Rockstroh,&2014& 60 70 - Overall Composite Score 50 Second Study Social Cognition Reasoning and Problem Solving Visual Learning Verbal Learning 40 - Working Memory 30 First Study Attention Vigilance Speed of Processing 20 & 10 Results% % - 0 Introduction Third Study Conclusion MCCB Cognitive Domain Nuechterlein&et&al.,&2008;&Schalinski,&Carolus&&&Rockstroh,&2014& Introduction - First Study - Second Study - Conclusion 100 40 60 80 First Admission Repeated Episode 0 20 60 40 20 & Social Cognition (T Score) 100 First Admission Repeated Episode 80 Third Study Social&CogniAon& 0 Working Memory (T Score) Results% % Working&Memory& - 0 10 20 30 40 50 MACE Sumscore 60 70 0 10 20 30 40 50 60 70 MACE Sumscore Schalinski,&Carolus&&&Rockstroh,&2014& - 100 20 40 60 80 First Admission Repeated Episode 0 Working Memory (T Score) Conclusion%of%the%Third%Study% % • Early&life&stress&was&associated&with&clinical& complexity&(higher&rates&of&comorbidity)& • PosiAve&and&global&symptoms&were&higher&at&4& months&followOup&in&the&group&with&high&compared& to&the&group&with&low&exposure&of&childhood& adversiAes&…&and&predicted&an&unfavorable& symptomaAc&course.& • Childhood&adversiAes&were&related&to&poorer& performance&in&working&memory&and&social& cogniAon.& % Conclusion 0 10 100 Third Study First Admission Repeated Episode 80 - 60 Second Study 40 - 20 First Study Social Cognition (T Score) - 0 Introduction 20 30 40 50 MACE Sumscore 60 70 0 10 20 30 40 50 60 70 MACE Sumscore Schalinski,&Carolus,&&&Rockstroh&in&prep;&Schalinski,&Fischer&&&Rockstroh,&2014& Introduction - First Study - Second Study - Third Study - Conclusion General%Conclusion& Childhood&AdversiAes&are&related&to...& • disAnct&stress&response&(downregulaAon&in&shortOterm,&but& increased&levels&of&CorAsol&in&longOterm)& • type&and&Aming&of&adversiAes&ma8ers&for&symptoms&of& dissociaAon&& • poorer&symptomaAc&outcome& • poorer&cogniAve&performance&(working&memory&&&social& cogniAon)& & & Early.Death. Disease,.Disability. and.Social.Problems. Adop4on.of.Health=risk. Behaviors. Social,.Emo4onal,.and.Cogni4ve.Impairment. Neurodevelopmental.and.Biological.Adapta4on. Adverse.Childhood.Experiences. Introduction - First Study - Second Study - Third Study - Conclusion General%Conclusion& • Childhood&adversiAes&in&mental&illness&may&consAtute&a& subtype&within&various&diagnoses&(see&review&Teicher&&& Samson,&2013)& • The&Aming&and&type&of&early&life&stress&may&contribute&as&well& for&the&striking&variaAon&of&behavioral,&emoAonal&and& cogniAve&psychopathology.& • ...&hurqul&words&will&injure&my&soul& & Early.Death. & Disease,.Disability. and.Social.Problems. Adop4on.of.Health=risk. Behaviors. Social,.Emo4onal,.and.Cogni4ve.Impairment. Neurodevelopmental.and.Biological.Adapta4on. Adverse.Childhood.Experiences. Introduction - First Study - Second Study - Third Study % %Thanks%y‘all% & & - Conclusion DANKE Alexandra Geist Allen Versuchsteilnehmern Almut Carolus Amelie Lehrmann Brigitte Rockstroh Christiane Wolf Deutsche Forschungsgesellschaft Dorothea Isele Europäischer Flüchtlingsfond Franziska Steinmaier Heike Riedke Ken Varner Kompetenzzentrum Traumatologie Maggie Schauer Michael Odenwald Petia Popova Sarah Dölker Team der Station 33 Team der Station 34 Thomas Elbert Universität Konstanz vivo victims‘s voice Yolanda Fischer & References Andreasen,&N.&C.,&Carpenter,&W.&T.,&Kane,&J.&M.,&Lasser,&R.&A.,&Marder,&S.&R.,&&&Weinberger,&D.&R.&(2005).&Remission&in& schizophrenia:&proposed&criteria&and&raAonale&for&consensus.&American"Journal"of"Psychiatry,&162(3),&441O449.& Goff,&D.&C.,&Brotman,&A.&W.,&Kindlon,&D.,&Waites,&M.,&&&Amico,&E.&(1991).&SelfOreports&of&childhood&abuse&in& chronically&psychoAc&paAents.&Psychiatry"research,&37(1),&73O80.& Heim,&C.,&Newport,&D.&J.,&Heit,&S.,&Graham,&Y.&P.,&Wilcox,&M.,&Bonsall,&R.,&...&&&Nemeroff,&C.&B.&(2000).&PituitaryOadrenal& and&autonomic&responses&to&stress&in&women&auer&sexual&and&physical&abuse&in&childhood.&JAMA,&284&(5)& 592O597.& Holowka,&D.&W.,&King,&S.,&Saheb,&D.,&Pukall,&M.,&&&Brunet,&A.&(2003).&Childhood&abuse&and&dissociaAve&symptoms&in& adult&schizophrenia.&Schizophrenia"research,&60(1),&87O90.& Isele,&D.,&Teicher,&M.&H.,&RufOLeuschner,&M.,&Elbert,&T.,&Kolassa,&I.&T.,&Schury,&K.,&&&Schauer,&M.&(2014).&KERF–Ein& &Instrument&zur&umfassenden&Ermi8lung&belastender&Kindheitserfahrungen.&ZeitschriA"für"Klinische" "Psychologie"und"Psychotherapie,&43(2),&121O130.& Kay,&S.&R.,&Fiszbein,&A.,&&&Opler,&L.&A.&(1987).&The&posiAve&and&negaAve&syndrome&scale&(PANSS)&for& &schizophrenia.& &Schizophrenia"BulleHn,&13,&261O276.& Meewisse,&M.&L.,&Reitsma,&J.&B.,&De&Vries,&G.&J.,&Gersons,&B.&P.,&&&Olff,&M.&(2007).&CorAsol&and&postOtraumaAc&&stress& &disorder&in&adults&SystemaAc&review&and&metaOanalysis.&The"BriHsh"Journal"of"Psychiatry,&191(5),& &387O392.& Miller,&G.&E.,&Chen,&E.,&&&Zhou,&E.&S.&(2007).&If&it&goes&up,&must&it&come&down?&Chronic&stress&and&the& &hypothalamicO &pituitaryOadrenocorAcal&axis&in&humans.&Psychological"bulleHn,&133(1),&25O35.& Nuechterlein,&K.,&Green,&M.,&Kern,&R.,&Baade,&L.,&Barch,&D.,&Cohen,&J.,&...&&&Marder,&S.&(2008).&The&MATRICS& &Consensus&CogniAve&Ba8ery,&part&1:&test&selecAon,&reliability,&and&validity.&American"Journal"of"Psychiatry," "165,&203O213.& Sar,&V.,&Taycan,&O.,&Bolat,&N.,&Özmen,&M.,&Duran,&A.,&Öztürk,&E.,&&&ErtemOVehid,&H.&(2009).&Childhood&trauma&and& &dissociaAon&in&schizophrenia.&Psychopathology,&43(1),&33O40.& Schäfer,&I.,&Harfst,&T.,&Aderhold,&V.,&Briken,&P.,&Lehmann,&M.,&Moritz,&S.,&...&&&Naber,&D.&(2006).&Childhood&trauma& &and&dissociaAon&in&female&paAents&with&schizophrenia&spectrum&disorders:&an&exploratory&study.&The& &Journal&of&nervous&and&mental&disease,&194(2),&135O138.& Schalinski,&Carolus,&&&Rockstroh&in&prep.&The&MACTRICS&Consensus&CogniAve&Ba8ery&(MCCB):&Environmental& &Effects&on&CogniAon&in&Schizophrenia& & References Schalinski,&I.,&Fischer,&Y.,&&&Rockstroh,&B.&(2014).&Impact&of&Childhood&AdversiAes&on&the&ShortOterm&Course&of&Illness& in&PsychoAc&Spectrum&Disorders.&Manuscript&submi8ed&for&publicaAon.&& Schalinski,&I.,&Schauer,&M.,&Elbert,&T.&(2014).&The&Shutdown&dissociaAon&scale&(ShutOD).&Manuscript&submi8ed&for& &publicaAon.& Schalinski,&I.,&&&Teicher,&M.&(2014).&Type&and&Aming&of&childhood&maltreatment&and&severity&of&shutdown& &dissociaAon&in&paAents&with&schizophrenia&spectrum&disorder.&Submi8ed.& Schauer,&M.,&&&Elbert,&T.&(2010).&DissociaAon&following&traumaAc&stress:&eAology&and&treatment.&Journal"of" "Psychology,&218,&109–127.&doi:10.1027/0044O&3409/a000018& Shea,&A.,&Walsh,&C.,&Macmillan,&H.,&&&Steiner,&M.&(2005).&Child&maltreatment&and&HPA&axis&dysregulaAon:& &relaAonship&to&major&depressive&disorder&and&post&traumaAc&stress&disorder&in&females.& &Psychoneuroendocrinology,&30(2),&162O178.& Steudte,&S.,&Kirschbaum,&C.,&Gao,&W.,&Alexander,&N.,&Schönfeld,&S.,&Hoyer,&J.,&&&Stalder,&T.&(2013).&Hair&corAsol&as& &a& &biomarker&of&traumaAzaAon&in&healthy&individuals&and&pos8raumaAc&stress&disorder&paAents.&Biological" "psychiatry,&74(9),&639O646.& Steudte,&S.,&Kolassa,&I.&T.,&Stalder,&T.,&Pfeiffer,&A.,&Kirschbaum,&C.,&&&Elbert,&T.&(2011).&Increased&corAsol& &concentraAons&in&hair&of&severely&traumaAzed&Ugandan&individuals&with&PTSD.& &Psychoneuroendocrinology,&36(8),&1193O1200.& Teicher,&M.&H.,&&&Parigger,&A.&(2011).&Modified&Adverse&Childhood&Experience&Scale,&version&0.9;&inspired&by&the& &ACE&Scale.&In&Schauer,&M.,&Neuner,&F.&&&Elbert,&T.&(2011),&NarraAve&Exposure&Therapy&(NET).&A&ShortOTerm& &IntervenAon&for&TraumaAc&Stress,&2.&Aufl.&Cambridge/Gö+ngen:&Huber&Publishers&&&Hogrefe.& Teicher,&M.&H.,&&&Samson,&J.&A.&(2013).&Childhood&maltreatment&and&psychopathology:&A&case&for&ecophenotypic& variants&as&clinically&and&neurobiologically&disAnct&subtypes.&American&Journal&of&Psychiatry,&170(10),& 1114O1133.& & & & & & % the&Maltreatment&and&Abuse&Chronology&of&Exposure&& MACE%Scale& Teicher%&%Parigger,%2011 SomeAmes%parents,%stepparents%or%other%adults%living%in%the%house%do%hurZul%things.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmate%of%your%age%at%the%Ame(s)%of%occurrence.& X X X X X Parental&Verbal&Abuse& X X Teicher%&%Parigger,%2011 SomeAmes%parents,%stepparents%or%other%adults%living%in%the%house%do%hurZul%things.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmate%of%your%age%at%the%Ame(s)%of%occurrence.& X X X X Nonverbal&EmoAonal&Abuse& Teicher%&%Parigger,%2011 SomeAmes%parents,%stepparents%or%other%adults%living%in%the%house%do%hurZul%things.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmate%of%your%age%at%the%Ame(s)%of%occurrence.& X Parental&Physical&Abuse& Teicher%&%Parigger,%2011 Please%indicate%if%the%following%happened%during%your%childhood%(first%18%years%of%your% life).%Please%provide%your%best%esAmates%of%your%age%at%the%Ame(s)%of%occurrence.%% Please%check%all%ages%that%apply.%% X X X X X EmoAonal&Neglect& Teicher%&%Parigger,%2011 Please%indicate%if%the%following%statements%were%true%about%you%and%your%family%during% your%childhood,%and%your%age%at%the%Ame(s)%you%felt%this%to%be%true.%% Please%check%all%ages%that%apply.%% X Physical&Neglect& Teicher%&%Parigger,%2011 SomeAmes%parents,%stepparents%or%other%adults%living%in%the%house%do%hurZul%things%to% your%siblings%(brother,%sister,%stepsiblings).% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmates%of%your%age%at%the%Ame(s)%of%occurrence.%% Please%check%all%ages%that%apply.%% X Witnessing&Violence&to&Siblings& Teicher%&%Parigger,%2011 SomeAmes%children%your%own%age%or%older%do%hurZul%things%like%bully%or%harass%you.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmates%of%your%age%at%the%Ame(s)%of%occurrence.%% Please%check%all%ages%that%apply.%% X X X X X X Peer&EmoAonal&Abuse& Teicher%&%Parigger,%2011 SomeAmes%children%your%own%age%or%older%do%hurZul%things%like%bully%or%harass%you.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmates%of%your%age%at%the%Ame(s)%of%occurrence.%% Please%check%all%ages%that%apply.%% X X X X X X X X X Peer&Physical&Bullying& X Teicher%&%Parigger,%2011 SomeAmes%intense%arguments%or%physical%fights%occur%between%parents,%stepparents%or% other%adults%(boyfriends,%girlfriends,%grandparents)%living%in%the%household.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmates%of%your%age%at%the%Ame(s)%of%occurrence.%% Please%check%all%ages%that%apply.%% X X X X Witnessing&Interparental&Violence& Teicher%&%Parigger,%2011 SomeAmes%adults%or%older%individuals%NOT%living%in%the%house%do%hurZul%things%to%you.% If%this%happened%during%your%childhood%(first%18%years%of%your%life)%please%provide%your% best%esAmates%of%your%age%at%the%Ame(s)%of%occurrence.% Please%check%all%ages%that%apply.% X Sexual&Abuse& Timing&in&RelaAon&to&PosiAve&and&NegaAve&Symptoms&in&Schizophrenia& 1.&What&happens&in&the&brain&and&the&body& during&the&traumaAc&event?& Freeze:& interrupAon&of&the&ongoing&perceptual&and& behavioral&processes;&&turning&all&perceptual& channels&to&the&threatening&sAmulus;&while& the&body&prepares&for&acAve&defense& responses& FAST&but&less&acurate& & 08/26/2013& & 50& 1.&What&happens&in&the&brain&and&the&body& during&the&traumaAc&event?& Flight/&Fight& SympatheAc&arousal&(heart&beat& acceleraAon,&skin&conductance),&release&of& adrenal&hormones& & & 51& 1.&What&happens&in&the&brain&and&the&body& during&the&traumaAc&event?& Fright/&Tonic&immolbility& immobile&behavior/&sensory&sAmuli&are&sAll& perceived,&if&there&is&a&chance&to&escape,& vicAm&may&escape& & & 52& 1.&What&happens&in&the&brain&and&the&body& during&the&traumaAc&event?& Flag/&Faint& ParasympatheAc&dominance:& drop&in&heart&rate,&blood&pressure,& shuAng&down&the&perceptual&processing,& dizziness,&analgesia;&emoAonal&numbness& & 53& 1.&What&happens&in&the&brain&and&the&body&during&the& traumaAc&event? & direct&physical&contact&with&the& perpetrator& presence&of&body&fluids&(e.g.,&blood,& sperm)& depending&on&the&vicAms&own&power& for&defense&(e.g.,&children&are&more& likely&to&show&a&“shutdown”& response& contact&with&sharp&objects&(e.g.,& teeth,&knife)& & 54& First Study - Second Study - Conclusion 100 80 60 60 0 20 40 & First Admission Repeated Episode 40 100 First Admission Repeated Episode 80 Third Study Social&CogniAon& 0 Working Memory (T Score) Results% % Working&Memory& - 20 - Social Cognition (T Score) Introduction 0 10 20 30 40 50 MACE Sumscore 60 70 0 10 20 30 40 50 60 70 MACE Sumscore Schalinski,&Carolus&&&Rockstroh,&2014& pa Type of Childhood Adversity itn ab e to gs ce in en t ec e e us gl us e se us ab bl ol al si vi xu nt al us re se ne ab ab 0 1 Importance 2 3 4 5 Third Study ng pa al al ic ic ys ys ph al ic e ct us bu ab la al rb a ys ve le se eg bu ln la rb na ve ph ph er nt al te r si in es ng itn si w es re pe er nt al ot io m pe re le gs e us ce in en bl ol si na to em ot io e us vi 5 Importance of Exposure to Each Type of Adversity for 'Working Memory' pa ba er ab nt al t ec e e 4 - pa nv ng re gl us ab ne ab se us bu ab al al xu ic al al ic ic se ys ys ys us e ct Importance 2 3 Second Study w no si pa te r ph ph ph la ab se le 1 Results% % Working&Memory& nt al es in nt al er rb a al eg bu ln la rb ve ve na na 0 - re itn ng re er nt al pe re ot io m em ot io le pe pa ba er pa nv si w es no First Study pa itn nt al & - w re Introduction Conclusion Social&CogniAon& Importance of Exposure to Each Type of Adversity for 'Social Cognition' Type of Childhood Adversity Schalinski,&Carolus&&&Rockstroh,&2014&